Amino acid dipepetide frequency for Cutibacterium acnes JCM 18909

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.742AlaAla: 12.742 ± 0.177	1.33AlaCys: 1.33 ± 0.037	6.397AlaAsp: 6.397 ± 0.096	5.893AlaGlu: 5.893 ± 0.12	2.853AlaPhe: 2.853 ± 0.067	9.558AlaGly: 9.558 ± 0.113	2.57AlaHis: 2.57 ± 0.059	5.389AlaIle: 5.389 ± 0.086	3.232AlaLys: 3.232 ± 0.074	9.782AlaLeu: 9.782 ± 0.134	3.218AlaMet: 3.218 ± 0.06	2.524AlaAsn: 2.524 ± 0.062	4.785AlaPro: 4.785 ± 0.082	3.315AlaGln: 3.315 ± 0.079	7.467AlaArg: 7.467 ± 0.106	6.932AlaSer: 6.932 ± 0.102	6.719AlaThr: 6.719 ± 0.101	9.154AlaVal: 9.154 ± 0.138	1.746AlaTrp: 1.746 ± 0.05	1.804AlaTyr: 1.804 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.23CysAla: 1.23 ± 0.042	0.344CysCys: 0.344 ± 0.025	0.706CysAsp: 0.706 ± 0.031	0.525CysGlu: 0.525 ± 0.026	0.337CysPhe: 0.337 ± 0.023	1.313CysGly: 1.313 ± 0.05	0.399CysHis: 0.399 ± 0.025	0.425CysIle: 0.425 ± 0.026	0.196CysLys: 0.196 ± 0.018	1.123CysLeu: 1.123 ± 0.04	0.304CysMet: 0.304 ± 0.02	0.236CysAsn: 0.236 ± 0.017	0.813CysPro: 0.813 ± 0.036	0.412CysGln: 0.412 ± 0.023	1.212CysArg: 1.212 ± 0.042	1.008CysSer: 1.008 ± 0.043	0.711CysThr: 0.711 ± 0.031	0.896CysVal: 0.896 ± 0.034	0.301CysTrp: 0.301 ± 0.024	0.246CysTyr: 0.246 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	6.274AspAla: 6.274 ± 0.097	0.486AspCys: 0.486 ± 0.03	4.31AspAsp: 4.31 ± 0.104	4.101AspGlu: 4.101 ± 0.091	1.507AspPhe: 1.507 ± 0.043	5.281AspGly: 5.281 ± 0.1	1.701AspHis: 1.701 ± 0.048	2.587AspIle: 2.587 ± 0.058	1.581AspLys: 1.581 ± 0.048	6.158AspLeu: 6.158 ± 0.095	1.265AspMet: 1.265 ± 0.036	1.326AspAsn: 1.326 ± 0.042	3.945AspPro: 3.945 ± 0.074	1.824AspGln: 1.824 ± 0.047	4.068AspArg: 4.068 ± 0.091	3.026AspSer: 3.026 ± 0.068	2.849AspThr: 2.849 ± 0.073	5.308AspVal: 5.308 ± 0.08	0.859AspTrp: 0.859 ± 0.032	1.227AspTyr: 1.227 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.724GluAla: 5.724 ± 0.109	0.412GluCys: 0.412 ± 0.024	2.628GluAsp: 2.628 ± 0.063	2.955GluGlu: 2.955 ± 0.067	1.491GluPhe: 1.491 ± 0.046	3.556GluGly: 3.556 ± 0.075	1.353GluHis: 1.353 ± 0.046	2.621GluIle: 2.621 ± 0.071	1.713GluLys: 1.713 ± 0.055	5.22GluLeu: 5.22 ± 0.096	1.257GluMet: 1.257 ± 0.044	1.255GluAsn: 1.255 ± 0.042	2.647GluPro: 2.647 ± 0.06	1.795GluGln: 1.795 ± 0.054	3.588GluArg: 3.588 ± 0.065	2.905GluSer: 2.905 ± 0.066	2.671GluThr: 2.671 ± 0.061	4.57GluVal: 4.57 ± 0.088	0.752GluTrp: 0.752 ± 0.03	1.042GluTyr: 1.042 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	2.931PheAla: 2.931 ± 0.063	0.429PheCys: 0.429 ± 0.026	1.963PheAsp: 1.963 ± 0.051	1.241PheGlu: 1.241 ± 0.046	1.286PhePhe: 1.286 ± 0.048	2.81PheGly: 2.81 ± 0.069	0.658PheHis: 0.658 ± 0.028	1.367PheIle: 1.367 ± 0.04	0.63PheLys: 0.63 ± 0.032	2.657PheLeu: 2.657 ± 0.059	0.714PheMet: 0.714 ± 0.035	0.833PheAsn: 0.833 ± 0.032	1.343PhePro: 1.343 ± 0.043	0.77PheGln: 0.77 ± 0.036	1.64PheArg: 1.64 ± 0.049	1.991PheSer: 1.991 ± 0.053	1.859PheThr: 1.859 ± 0.053	2.492PheVal: 2.492 ± 0.065	0.485PheTrp: 0.485 ± 0.025	0.567PheTyr: 0.567 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.916GlyAla: 7.916 ± 0.116	1.13GlyCys: 1.13 ± 0.043	4.382GlyAsp: 4.382 ± 0.082	3.926GlyGlu: 3.926 ± 0.077	2.779GlyPhe: 2.779 ± 0.071	6.401GlyGly: 6.401 ± 0.113	2.425GlyHis: 2.425 ± 0.068	4.52GlyIle: 4.52 ± 0.086	2.806GlyLys: 2.806 ± 0.068	8.223GlyLeu: 8.223 ± 0.121	2.482GlyMet: 2.482 ± 0.06	2.001GlyAsn: 2.001 ± 0.057	3.858GlyPro: 3.858 ± 0.074	2.751GlyGln: 2.751 ± 0.071	6.146GlyArg: 6.146 ± 0.097	5.576GlySer: 5.576 ± 0.096	5.056GlyThr: 5.056 ± 0.084	7.211GlyVal: 7.211 ± 0.101	1.834GlyTrp: 1.834 ± 0.055	2.041GlyTyr: 2.041 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.32HisAla: 2.32 ± 0.059	0.321HisCys: 0.321 ± 0.019	1.782HisAsp: 1.782 ± 0.058	1.295HisGlu: 1.295 ± 0.042	0.645HisPhe: 0.645 ± 0.032	2.273HisGly: 2.273 ± 0.056	0.883HisHis: 0.883 ± 0.04	1.079HisIle: 1.079 ± 0.04	0.526HisLys: 0.526 ± 0.027	2.286HisLeu: 2.286 ± 0.06	0.59HisMet: 0.59 ± 0.027	0.637HisAsn: 0.637 ± 0.029	1.807HisPro: 1.807 ± 0.055	0.876HisGln: 0.876 ± 0.031	2.172HisArg: 2.172 ± 0.059	1.369HisSer: 1.369 ± 0.041	1.383HisThr: 1.383 ± 0.045	1.94HisVal: 1.94 ± 0.053	0.374HisTrp: 0.374 ± 0.023	0.522HisTyr: 0.522 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.674IleAla: 5.674 ± 0.094	0.706IleCys: 0.706 ± 0.031	3.636IleAsp: 3.636 ± 0.08	2.409IleGlu: 2.409 ± 0.057	1.384IlePhe: 1.384 ± 0.054	4.61IleGly: 4.61 ± 0.087	1.029IleHis: 1.029 ± 0.037	2.496IleIle: 2.496 ± 0.062	1.257IleLys: 1.257 ± 0.046	4.035IleLeu: 4.035 ± 0.079	1.102IleMet: 1.102 ± 0.043	1.349IleAsn: 1.349 ± 0.042	2.662IlePro: 2.662 ± 0.061	1.042IleGln: 1.042 ± 0.037	2.921IleArg: 2.921 ± 0.057	2.965IleSer: 2.965 ± 0.069	3.158IleThr: 3.158 ± 0.065	4.507IleVal: 4.507 ± 0.076	0.586IleTrp: 0.586 ± 0.029	0.824IleTyr: 0.824 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.498LysAla: 3.498 ± 0.084	0.195LysCys: 0.195 ± 0.016	1.514LysAsp: 1.514 ± 0.051	1.343LysGlu: 1.343 ± 0.044	0.684LysPhe: 0.684 ± 0.034	1.991LysGly: 1.991 ± 0.061	0.56LysHis: 0.56 ± 0.029	1.477LysIle: 1.477 ± 0.049	1.466LysLys: 1.466 ± 0.054	2.503LysLeu: 2.503 ± 0.063	0.661LysMet: 0.661 ± 0.033	0.699LysAsn: 0.699 ± 0.036	1.69LysPro: 1.69 ± 0.05	0.834LysGln: 0.834 ± 0.037	1.885LysArg: 1.885 ± 0.058	1.67LysSer: 1.67 ± 0.047	1.657LysThr: 1.657 ± 0.047	2.715LysVal: 2.715 ± 0.067	0.331LysTrp: 0.331 ± 0.024	0.615LysTyr: 0.615 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.581LeuAla: 11.581 ± 0.14	1.066LeuCys: 1.066 ± 0.037	6.115LeuAsp: 6.115 ± 0.094	4.269LeuGlu: 4.269 ± 0.087	2.48LeuPhe: 2.48 ± 0.067	7.987LeuGly: 7.987 ± 0.119	1.93LeuHis: 1.93 ± 0.062	4.115LeuIle: 4.115 ± 0.082	2.289LeuLys: 2.289 ± 0.064	8.522LeuLeu: 8.522 ± 0.146	2.219LeuMet: 2.219 ± 0.061	2.196LeuAsn: 2.196 ± 0.054	5.373LeuPro: 5.373 ± 0.091	2.065LeuGln: 2.065 ± 0.05	6.364LeuArg: 6.364 ± 0.096	6.32LeuSer: 6.32 ± 0.111	6.419LeuThr: 6.419 ± 0.104	8.809LeuVal: 8.809 ± 0.122	1.251LeuTrp: 1.251 ± 0.048	1.413LeuTyr: 1.413 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.359MetAla: 3.359 ± 0.065	0.316MetCys: 0.316 ± 0.023	1.232MetAsp: 1.232 ± 0.044	1.012MetGlu: 1.012 ± 0.038	0.685MetPhe: 0.685 ± 0.029	2.037MetGly: 2.037 ± 0.057	0.526MetHis: 0.526 ± 0.03	1.325MetIle: 1.325 ± 0.042	0.803MetLys: 0.803 ± 0.035	2.321MetLeu: 2.321 ± 0.059	0.635MetMet: 0.635 ± 0.03	0.759MetAsn: 0.759 ± 0.032	1.534MetPro: 1.534 ± 0.05	0.581MetGln: 0.581 ± 0.03	1.777MetArg: 1.777 ± 0.052	2.222MetSer: 2.222 ± 0.06	2.351MetThr: 2.351 ± 0.06	2.252MetVal: 2.252 ± 0.053	0.445MetTrp: 0.445 ± 0.026	0.408MetTyr: 0.408 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.475AsnAla: 2.475 ± 0.071	0.263AsnCys: 0.263 ± 0.022	1.511AsnAsp: 1.511 ± 0.049	1.203AsnGlu: 1.203 ± 0.043	0.704AsnPhe: 0.704 ± 0.034	2.171AsnGly: 2.171 ± 0.056	0.743AsnHis: 0.743 ± 0.033	1.066AsnIle: 1.066 ± 0.04	0.709AsnLys: 0.709 ± 0.037	2.428AsnLeu: 2.428 ± 0.061	0.482AsnMet: 0.482 ± 0.028	0.672AsnAsn: 0.672 ± 0.03	1.939AsnPro: 1.939 ± 0.048	0.803AsnGln: 0.803 ± 0.033	1.711AsnArg: 1.711 ± 0.046	1.463AsnSer: 1.463 ± 0.041	1.457AsnThr: 1.457 ± 0.044	1.832AsnVal: 1.832 ± 0.051	0.381AsnTrp: 0.381 ± 0.023	0.611AsnTyr: 0.611 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.613ProAla: 5.613 ± 0.088	0.695ProCys: 0.695 ± 0.035	3.864ProAsp: 3.864 ± 0.076	3.265ProGlu: 3.265 ± 0.077	1.451ProPhe: 1.451 ± 0.038	4.856ProGly: 4.856 ± 0.093	1.527ProHis: 1.527 ± 0.055	2.26ProIle: 2.26 ± 0.057	1.493ProLys: 1.493 ± 0.045	4.455ProLeu: 4.455 ± 0.079	1.403ProMet: 1.403 ± 0.043	1.382ProAsn: 1.382 ± 0.044	2.439ProPro: 2.439 ± 0.073	1.932ProGln: 1.932 ± 0.056	3.972ProArg: 3.972 ± 0.083	4.254ProSer: 4.254 ± 0.084	3.912ProThr: 3.912 ± 0.079	4.635ProVal: 4.635 ± 0.085	1.048ProTrp: 1.048 ± 0.037	1.089ProTyr: 1.089 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.628GlnAla: 3.628 ± 0.082	0.296GlnCys: 0.296 ± 0.02	1.284GlnAsp: 1.284 ± 0.047	1.349GlnGlu: 1.349 ± 0.045	0.807GlnPhe: 0.807 ± 0.035	2.173GlnGly: 2.173 ± 0.051	0.637GlnHis: 0.637 ± 0.03	1.665GlnIle: 1.665 ± 0.048	0.772GlnLys: 0.772 ± 0.037	3.066GlnLeu: 3.066 ± 0.061	0.844GlnMet: 0.844 ± 0.031	0.66GlnAsn: 0.66 ± 0.032	1.667GlnPro: 1.667 ± 0.052	1.068GlnGln: 1.068 ± 0.042	2.486GlnArg: 2.486 ± 0.054	1.595GlnSer: 1.595 ± 0.05	1.714GlnThr: 1.714 ± 0.049	2.809GlnVal: 2.809 ± 0.063	0.553GlnTrp: 0.553 ± 0.029	0.596GlnTyr: 0.596 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.655ArgAla: 6.655 ± 0.098	1.288ArgCys: 1.288 ± 0.047	3.798ArgAsp: 3.798 ± 0.071	3.477ArgGlu: 3.477 ± 0.068	2.028ArgPhe: 2.028 ± 0.053	5.076ArgGly: 5.076 ± 0.078	2.28ArgHis: 2.28 ± 0.059	3.728ArgIle: 3.728 ± 0.074	1.885ArgLys: 1.885 ± 0.059	6.682ArgLeu: 6.682 ± 0.097	2.425ArgMet: 2.425 ± 0.054	1.801ArgAsn: 1.801 ± 0.048	4.209ArgPro: 4.209 ± 0.076	2.563ArgGln: 2.563 ± 0.064	7.403ArgArg: 7.403 ± 0.114	5.008ArgSer: 5.008 ± 0.093	4.36ArgThr: 4.36 ± 0.078	5.237ArgVal: 5.237 ± 0.09	1.582ArgTrp: 1.582 ± 0.051	1.515ArgTyr: 1.515 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	6.361SerAla: 6.361 ± 0.111	0.905SerCys: 0.905 ± 0.033	3.373SerAsp: 3.373 ± 0.069	2.809SerGlu: 2.809 ± 0.072	1.949SerPhe: 1.949 ± 0.042	6.114SerGly: 6.114 ± 0.103	1.711SerHis: 1.711 ± 0.052	2.657SerIle: 2.657 ± 0.073	1.699SerLys: 1.699 ± 0.051	5.863SerLeu: 5.863 ± 0.085	2.078SerMet: 2.078 ± 0.053	1.461SerAsn: 1.461 ± 0.049	4.107SerPro: 4.107 ± 0.085	2.138SerGln: 2.138 ± 0.057	5.352SerArg: 5.352 ± 0.092	5.602SerSer: 5.602 ± 0.104	4.681SerThr: 4.681 ± 0.104	5.1SerVal: 5.1 ± 0.096	1.447SerTrp: 1.447 ± 0.046	1.267SerTyr: 1.267 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.574ThrAla: 6.574 ± 0.122	0.866ThrCys: 0.866 ± 0.03	3.595ThrAsp: 3.595 ± 0.07	2.758ThrGlu: 2.758 ± 0.061	1.972ThrPhe: 1.972 ± 0.054	5.437ThrGly: 5.437 ± 0.092	1.421ThrHis: 1.421 ± 0.051	3.376ThrIle: 3.376 ± 0.068	1.719ThrLys: 1.719 ± 0.047	5.481ThrLeu: 5.481 ± 0.096	1.728ThrMet: 1.728 ± 0.051	1.571ThrAsn: 1.571 ± 0.042	4.087ThrPro: 4.087 ± 0.091	1.508ThrGln: 1.508 ± 0.045	4.153ThrArg: 4.153 ± 0.082	4.77ThrSer: 4.77 ± 0.09	4.857ThrThr: 4.857 ± 0.112	5.862ThrVal: 5.862 ± 0.094	1.238ThrTrp: 1.238 ± 0.043	1.22ThrTyr: 1.22 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	9.494ValAla: 9.494 ± 0.136	1.122ValCys: 1.122 ± 0.043	5.552ValAsp: 5.552 ± 0.091	4.837ValGlu: 4.837 ± 0.068	2.364ValPhe: 2.364 ± 0.059	6.864ValGly: 6.864 ± 0.115	1.797ValHis: 1.797 ± 0.053	4.704ValIle: 4.704 ± 0.083	2.34ValLys: 2.34 ± 0.066	8.044ValLeu: 8.044 ± 0.111	2.334ValMet: 2.334 ± 0.061	2.311ValAsn: 2.311 ± 0.06	4.516ValPro: 4.516 ± 0.083	1.987ValGln: 1.987 ± 0.06	5.568ValArg: 5.568 ± 0.078	5.504ValSer: 5.504 ± 0.098	6.246ValThr: 6.246 ± 0.097	8.779ValVal: 8.779 ± 0.133	1.231ValTrp: 1.231 ± 0.04	1.365ValTyr: 1.365 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.524TrpAla: 1.524 ± 0.05	0.314TrpCys: 0.314 ± 0.023	0.724TrpAsp: 0.724 ± 0.033	0.59TrpGlu: 0.59 ± 0.029	0.641TrpPhe: 0.641 ± 0.032	1.227TrpGly: 1.227 ± 0.045	0.482TrpHis: 0.482 ± 0.023	0.854TrpIle: 0.854 ± 0.035	0.458TrpLys: 0.458 ± 0.02	1.842TrpLeu: 1.842 ± 0.055	0.498TrpMet: 0.498 ± 0.028	0.479TrpAsn: 0.479 ± 0.024	1.029TrpPro: 1.029 ± 0.042	0.699TrpGln: 0.699 ± 0.028	1.478TrpArg: 1.478 ± 0.045	1.24TrpSer: 1.24 ± 0.042	1.072TrpThr: 1.072 ± 0.041	1.305TrpVal: 1.305 ± 0.044	0.463TrpTrp: 0.463 ± 0.027	0.353TrpTyr: 0.353 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.839TyrAla: 1.839 ± 0.041	0.253TyrCys: 0.253 ± 0.017	1.315TyrAsp: 1.315 ± 0.053	0.9TyrGlu: 0.9 ± 0.033	0.62TyrPhe: 0.62 ± 0.032	1.73TyrGly: 1.73 ± 0.041	0.445TyrHis: 0.445 ± 0.027	0.644TyrIle: 0.644 ± 0.034	0.419TyrLys: 0.419 ± 0.028	2.091TyrLeu: 2.091 ± 0.051	0.34TyrMet: 0.34 ± 0.024	0.47TyrAsn: 0.47 ± 0.026	1.095TyrPro: 1.095 ± 0.039	0.704TyrGln: 0.704 ± 0.035	1.636TyrArg: 1.636 ± 0.052	1.252TyrSer: 1.252 ± 0.041	1.06TyrThr: 1.06 ± 0.044	1.545TyrVal: 1.545 ± 0.047	0.365TyrTrp: 0.365 ± 0.022	0.446TyrTyr: 0.446 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3752 proteins (703508 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---