Amino acid dipepetide frequency for Bifidobacterium mongoliense DSM 21395

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.055AlaAla: 13.055 ± 0.198	1.021AlaCys: 1.021 ± 0.04	7.1AlaAsp: 7.1 ± 0.129	5.112AlaGlu: 5.112 ± 0.113	3.43AlaPhe: 3.43 ± 0.076	9.486AlaGly: 9.486 ± 0.157	2.671AlaHis: 2.671 ± 0.075	5.601AlaIle: 5.601 ± 0.095	3.982AlaLys: 3.982 ± 0.113	10.881AlaLeu: 10.881 ± 0.133	3.49AlaMet: 3.49 ± 0.087	2.887AlaAsn: 2.887 ± 0.07	4.578AlaPro: 4.578 ± 0.089	4.442AlaGln: 4.442 ± 0.098	7.021AlaArg: 7.021 ± 0.12	7.153AlaSer: 7.153 ± 0.12	6.233AlaThr: 6.233 ± 0.108	9.171AlaVal: 9.171 ± 0.141	1.549AlaTrp: 1.549 ± 0.052	2.568AlaTyr: 2.568 ± 0.063	0.002AlaXaa: 0.002 ± 0.002
Cys	0.966CysAla: 0.966 ± 0.042	0.113CysCys: 0.113 ± 0.013	0.54CysAsp: 0.54 ± 0.034	0.417CysGlu: 0.417 ± 0.026	0.272CysPhe: 0.272 ± 0.02	0.978CysGly: 0.978 ± 0.042	0.215CysHis: 0.215 ± 0.022	0.417CysIle: 0.417 ± 0.029	0.167CysLys: 0.167 ± 0.016	0.728CysLeu: 0.728 ± 0.035	0.217CysMet: 0.217 ± 0.016	0.175CysAsn: 0.175 ± 0.014	0.499CysPro: 0.499 ± 0.032	0.199CysGln: 0.199 ± 0.017	0.581CysArg: 0.581 ± 0.037	0.577CysSer: 0.577 ± 0.033	0.505CysThr: 0.505 ± 0.022	0.698CysVal: 0.698 ± 0.035	0.119CysTrp: 0.119 ± 0.016	0.212CysTyr: 0.212 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	7.885AspAla: 7.885 ± 0.146	0.441AspCys: 0.441 ± 0.027	5.095AspAsp: 5.095 ± 0.111	4.466AspGlu: 4.466 ± 0.095	2.075AspPhe: 2.075 ± 0.06	6.277AspGly: 6.277 ± 0.136	1.8AspHis: 1.8 ± 0.053	3.334AspIle: 3.334 ± 0.081	1.816AspLys: 1.816 ± 0.065	5.371AspLeu: 5.371 ± 0.102	1.714AspMet: 1.714 ± 0.058	1.547AspAsn: 1.547 ± 0.057	3.773AspPro: 3.773 ± 0.082	1.996AspGln: 1.996 ± 0.058	4.217AspArg: 4.217 ± 0.094	3.16AspSer: 3.16 ± 0.081	3.795AspThr: 3.795 ± 0.085	5.025AspVal: 5.025 ± 0.097	0.904AspTrp: 0.904 ± 0.037	1.685AspTyr: 1.685 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	5.768GluAla: 5.768 ± 0.104	0.346GluCys: 0.346 ± 0.026	2.869GluAsp: 2.869 ± 0.08	2.681GluGlu: 2.681 ± 0.085	1.562GluPhe: 1.562 ± 0.058	3.749GluGly: 3.749 ± 0.081	1.851GluHis: 1.851 ± 0.06	2.404GluIle: 2.404 ± 0.069	1.357GluLys: 1.357 ± 0.057	4.67GluLeu: 4.67 ± 0.102	1.282GluMet: 1.282 ± 0.047	1.386GluAsn: 1.386 ± 0.057	2.584GluPro: 2.584 ± 0.071	2.319GluGln: 2.319 ± 0.069	4.779GluArg: 4.779 ± 0.108	3.091GluSer: 3.091 ± 0.074	2.854GluThr: 2.854 ± 0.067	3.48GluVal: 3.48 ± 0.073	0.497GluTrp: 0.497 ± 0.031	1.364GluTyr: 1.364 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.79PheAla: 3.79 ± 0.088	0.312PheCys: 0.312 ± 0.021	2.481PheAsp: 2.481 ± 0.06	1.55PheGlu: 1.55 ± 0.053	1.087PhePhe: 1.087 ± 0.045	3.155PheGly: 3.155 ± 0.072	0.765PheHis: 0.765 ± 0.032	1.661PheIle: 1.661 ± 0.061	0.87PheLys: 0.87 ± 0.037	2.761PheLeu: 2.761 ± 0.081	0.754PheMet: 0.754 ± 0.034	1.159PheAsn: 1.159 ± 0.044	1.307PhePro: 1.307 ± 0.042	0.859PheGln: 0.859 ± 0.034	1.619PheArg: 1.619 ± 0.053	2.351PheSer: 2.351 ± 0.076	2.086PheThr: 2.086 ± 0.058	2.565PheVal: 2.565 ± 0.068	0.404PheTrp: 0.404 ± 0.029	0.774PheTyr: 0.774 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	8.48GlyAla: 8.48 ± 0.146	0.73GlyCys: 0.73 ± 0.037	5.307GlyAsp: 5.307 ± 0.102	4.448GlyGlu: 4.448 ± 0.092	3.176GlyPhe: 3.176 ± 0.073	6.386GlyGly: 6.386 ± 0.116	2.092GlyHis: 2.092 ± 0.064	4.717GlyIle: 4.717 ± 0.096	3.311GlyLys: 3.311 ± 0.084	7.634GlyLeu: 7.634 ± 0.12	2.414GlyMet: 2.414 ± 0.066	2.456GlyAsn: 2.456 ± 0.077	3.035GlyPro: 3.035 ± 0.068	2.734GlyGln: 2.734 ± 0.074	5.464GlyArg: 5.464 ± 0.095	5.949GlySer: 5.949 ± 0.117	5.344GlyThr: 5.344 ± 0.107	6.783GlyVal: 6.783 ± 0.116	1.254GlyTrp: 1.254 ± 0.05	2.608GlyTyr: 2.608 ± 0.071	0.002GlyXaa: 0.002 ± 0.002
His	2.829HisAla: 2.829 ± 0.069	0.214HisCys: 0.214 ± 0.016	2.126HisAsp: 2.126 ± 0.059	1.479HisGlu: 1.479 ± 0.055	0.585HisPhe: 0.585 ± 0.033	2.563HisGly: 2.563 ± 0.061	0.735HisHis: 0.735 ± 0.04	1.259HisIle: 1.259 ± 0.048	0.486HisLys: 0.486 ± 0.028	1.894HisLeu: 1.894 ± 0.063	0.687HisMet: 0.687 ± 0.033	0.609HisAsn: 0.609 ± 0.028	1.55HisPro: 1.55 ± 0.053	0.759HisGln: 0.759 ± 0.034	1.964HisArg: 1.964 ± 0.063	1.073HisSer: 1.073 ± 0.037	1.52HisThr: 1.52 ± 0.061	1.888HisVal: 1.888 ± 0.06	0.384HisTrp: 0.384 ± 0.029	0.637HisTyr: 0.637 ± 0.031	0.002HisXaa: 0.002 ± 0.002
Ile	6.55IleAla: 6.55 ± 0.104	0.486IleCys: 0.486 ± 0.027	3.938IleAsp: 3.938 ± 0.076	2.763IleGlu: 2.763 ± 0.079	1.388IlePhe: 1.388 ± 0.053	4.586IleGly: 4.586 ± 0.106	1.05IleHis: 1.05 ± 0.042	2.655IleIle: 2.655 ± 0.078	1.488IleLys: 1.488 ± 0.055	3.815IleLeu: 3.815 ± 0.088	1.156IleMet: 1.156 ± 0.049	1.537IleAsn: 1.537 ± 0.049	2.735IlePro: 2.735 ± 0.066	1.205IleGln: 1.205 ± 0.045	3.113IleArg: 3.113 ± 0.072	3.075IleSer: 3.075 ± 0.064	3.176IleThr: 3.176 ± 0.075	4.712IleVal: 4.712 ± 0.097	0.629IleTrp: 0.629 ± 0.034	1.063IleTyr: 1.063 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.072LysAla: 4.072 ± 0.113	0.113LysCys: 0.113 ± 0.014	2.128LysAsp: 2.128 ± 0.07	1.676LysGlu: 1.676 ± 0.062	0.741LysPhe: 0.741 ± 0.032	2.457LysGly: 2.457 ± 0.079	0.749LysHis: 0.749 ± 0.032	1.533LysIle: 1.533 ± 0.058	1.163LysLys: 1.163 ± 0.054	2.491LysLeu: 2.491 ± 0.075	0.69LysMet: 0.69 ± 0.035	1.053LysAsn: 1.053 ± 0.046	1.812LysPro: 1.812 ± 0.061	1.224LysGln: 1.224 ± 0.05	2.091LysArg: 2.091 ± 0.057	1.857LysSer: 1.857 ± 0.068	2.132LysThr: 2.132 ± 0.078	2.306LysVal: 2.306 ± 0.063	0.323LysTrp: 0.323 ± 0.022	0.703LysTyr: 0.703 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.241LeuAla: 10.241 ± 0.148	0.917LeuCys: 0.917 ± 0.042	6.143LeuAsp: 6.143 ± 0.122	4.163LeuGlu: 4.163 ± 0.097	3.01LeuPhe: 3.01 ± 0.072	7.386LeuGly: 7.386 ± 0.137	2.222LeuHis: 2.222 ± 0.069	4.685LeuIle: 4.685 ± 0.103	2.858LeuLys: 2.858 ± 0.07	8.05LeuLeu: 8.05 ± 0.143	2.147LeuMet: 2.147 ± 0.064	2.571LeuAsn: 2.571 ± 0.063	4.461LeuPro: 4.461 ± 0.09	2.591LeuGln: 2.591 ± 0.069	6.039LeuArg: 6.039 ± 0.102	5.918LeuSer: 5.918 ± 0.114	5.526LeuThr: 5.526 ± 0.091	6.889LeuVal: 6.889 ± 0.132	1.047LeuTrp: 1.047 ± 0.049	1.902LeuTyr: 1.902 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	3.027MetAla: 3.027 ± 0.066	0.224MetCys: 0.224 ± 0.023	1.504MetAsp: 1.504 ± 0.048	0.95MetGlu: 0.95 ± 0.041	0.775MetPhe: 0.775 ± 0.037	1.989MetGly: 1.989 ± 0.057	0.669MetHis: 0.669 ± 0.032	1.235MetIle: 1.235 ± 0.049	0.852MetLys: 0.852 ± 0.04	2.658MetLeu: 2.658 ± 0.068	0.696MetMet: 0.696 ± 0.035	0.965MetAsn: 0.965 ± 0.04	1.516MetPro: 1.516 ± 0.056	0.88MetGln: 0.88 ± 0.04	2.042MetArg: 2.042 ± 0.067	1.952MetSer: 1.952 ± 0.055	2.06MetThr: 2.06 ± 0.067	2.038MetVal: 2.038 ± 0.063	0.275MetTrp: 0.275 ± 0.019	0.503MetTyr: 0.503 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.409AsnAla: 3.409 ± 0.085	0.182AsnCys: 0.182 ± 0.018	1.886AsnAsp: 1.886 ± 0.059	1.409AsnGlu: 1.409 ± 0.045	0.844AsnPhe: 0.844 ± 0.047	2.904AsnGly: 2.904 ± 0.077	0.664AsnHis: 0.664 ± 0.03	1.307AsnIle: 1.307 ± 0.046	0.847AsnLys: 0.847 ± 0.041	2.38AsnLeu: 2.38 ± 0.056	0.701AsnMet: 0.701 ± 0.034	0.881AsnAsn: 0.881 ± 0.05	1.938AsnPro: 1.938 ± 0.058	0.975AsnGln: 0.975 ± 0.04	1.865AsnArg: 1.865 ± 0.062	1.447AsnSer: 1.447 ± 0.048	1.841AsnThr: 1.841 ± 0.064	2.036AsnVal: 2.036 ± 0.061	0.376AsnTrp: 0.376 ± 0.027	0.741AsnTyr: 0.741 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.927ProAla: 4.927 ± 0.099	0.37ProCys: 0.37 ± 0.026	3.559ProAsp: 3.559 ± 0.089	3.147ProGlu: 3.147 ± 0.083	1.523ProPhe: 1.523 ± 0.051	4.017ProGly: 4.017 ± 0.076	1.177ProHis: 1.177 ± 0.046	2.194ProIle: 2.194 ± 0.054	1.642ProLys: 1.642 ± 0.059	3.737ProLeu: 3.737 ± 0.092	1.253ProMet: 1.253 ± 0.041	1.431ProAsn: 1.431 ± 0.056	1.359ProPro: 1.359 ± 0.051	1.965ProGln: 1.965 ± 0.062	2.945ProArg: 2.945 ± 0.076	3.419ProSer: 3.419 ± 0.087	3.166ProThr: 3.166 ± 0.07	4.102ProVal: 4.102 ± 0.08	0.767ProTrp: 0.767 ± 0.038	1.34ProTyr: 1.34 ± 0.051	0.003ProXaa: 0.003 ± 0.002
Gln	4.004GlnAla: 4.004 ± 0.082	0.275GlnCys: 0.275 ± 0.022	1.853GlnAsp: 1.853 ± 0.055	1.631GlnGlu: 1.631 ± 0.053	0.994GlnPhe: 0.994 ± 0.039	2.867GlnGly: 2.867 ± 0.075	0.918GlnHis: 0.918 ± 0.038	1.801GlnIle: 1.801 ± 0.051	0.856GlnLys: 0.856 ± 0.046	2.978GlnLeu: 2.978 ± 0.066	0.838GlnMet: 0.838 ± 0.04	0.864GlnAsn: 0.864 ± 0.039	1.603GlnPro: 1.603 ± 0.058	1.677GlnGln: 1.677 ± 0.067	2.845GlnArg: 2.845 ± 0.072	2.148GlnSer: 2.148 ± 0.059	1.83GlnThr: 1.83 ± 0.053	2.53GlnVal: 2.53 ± 0.068	0.655GlnTrp: 0.655 ± 0.033	1.021GlnTyr: 1.021 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	6.193ArgAla: 6.193 ± 0.124	0.603ArgCys: 0.603 ± 0.033	4.26ArgAsp: 4.26 ± 0.095	3.827ArgGlu: 3.827 ± 0.087	2.475ArgPhe: 2.475 ± 0.067	4.625ArgGly: 4.625 ± 0.104	2.231ArgHis: 2.231 ± 0.062	3.813ArgIle: 3.813 ± 0.083	2.057ArgLys: 2.057 ± 0.062	6.211ArgLeu: 6.211 ± 0.111	2.2ArgMet: 2.2 ± 0.054	1.976ArgAsn: 1.976 ± 0.059	3.084ArgPro: 3.084 ± 0.081	2.449ArgGln: 2.449 ± 0.065	6.278ArgArg: 6.278 ± 0.145	4.231ArgSer: 4.231 ± 0.097	4.078ArgThr: 4.078 ± 0.085	4.746ArgVal: 4.746 ± 0.085	0.966ArgTrp: 0.966 ± 0.043	2.203ArgTyr: 2.203 ± 0.061	0.002ArgXaa: 0.002 ± 0.002
Ser	6.72SerAla: 6.72 ± 0.125	0.507SerCys: 0.507 ± 0.031	3.983SerAsp: 3.983 ± 0.083	2.764SerGlu: 2.764 ± 0.074	2.203SerPhe: 2.203 ± 0.063	6.204SerGly: 6.204 ± 0.131	1.52SerHis: 1.52 ± 0.05	3.221SerIle: 3.221 ± 0.076	2.124SerLys: 2.124 ± 0.067	5.455SerLeu: 5.455 ± 0.1	1.817SerMet: 1.817 ± 0.051	1.811SerAsn: 1.811 ± 0.05	2.888SerPro: 2.888 ± 0.076	2.269SerGln: 2.269 ± 0.06	4.226SerArg: 4.226 ± 0.102	4.656SerSer: 4.656 ± 0.111	4.012SerThr: 4.012 ± 0.086	4.85SerVal: 4.85 ± 0.089	0.995SerTrp: 0.995 ± 0.044	1.595SerTyr: 1.595 ± 0.046	0.005SerXaa: 0.005 ± 0.003
Thr	6.843ThrAla: 6.843 ± 0.111	0.45ThrCys: 0.45 ± 0.031	3.681ThrAsp: 3.681 ± 0.081	2.488ThrGlu: 2.488 ± 0.073	1.904ThrPhe: 1.904 ± 0.058	5.547ThrGly: 5.547 ± 0.109	1.356ThrHis: 1.356 ± 0.047	3.38ThrIle: 3.38 ± 0.085	1.93ThrLys: 1.93 ± 0.064	5.815ThrLeu: 5.815 ± 0.103	1.697ThrMet: 1.697 ± 0.049	1.754ThrAsn: 1.754 ± 0.066	3.696ThrPro: 3.696 ± 0.084	1.893ThrGln: 1.893 ± 0.055	3.385ThrArg: 3.385 ± 0.073	3.919ThrSer: 3.919 ± 0.096	4.332ThrThr: 4.332 ± 0.098	5.41ThrVal: 5.41 ± 0.087	0.802ThrTrp: 0.802 ± 0.041	1.488ThrTyr: 1.488 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	8.613ValAla: 8.613 ± 0.125	0.87ValCys: 0.87 ± 0.041	5.403ValAsp: 5.403 ± 0.103	3.971ValGlu: 3.971 ± 0.097	2.837ValPhe: 2.837 ± 0.08	5.754ValGly: 5.754 ± 0.114	1.655ValHis: 1.655 ± 0.054	4.241ValIle: 4.241 ± 0.101	2.473ValLys: 2.473 ± 0.072	7.534ValLeu: 7.534 ± 0.127	2.103ValMet: 2.103 ± 0.06	2.377ValAsn: 2.377 ± 0.075	3.863ValPro: 3.863 ± 0.073	2.192ValGln: 2.192 ± 0.064	4.916ValArg: 4.916 ± 0.082	5.482ValSer: 5.482 ± 0.102	4.992ValThr: 4.992 ± 0.113	6.955ValVal: 6.955 ± 0.139	0.971ValTrp: 0.971 ± 0.045	1.745ValTyr: 1.745 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	1.153TrpAla: 1.153 ± 0.045	0.188TrpCys: 0.188 ± 0.018	0.743TrpAsp: 0.743 ± 0.034	0.531TrpGlu: 0.531 ± 0.035	0.54TrpPhe: 0.54 ± 0.032	1.013TrpGly: 1.013 ± 0.045	0.334TrpHis: 0.334 ± 0.022	0.64TrpIle: 0.64 ± 0.034	0.476TrpLys: 0.476 ± 0.031	1.377TrpLeu: 1.377 ± 0.06	0.436TrpMet: 0.436 ± 0.026	0.527TrpAsn: 0.527 ± 0.034	0.544TrpPro: 0.544 ± 0.034	0.595TrpGln: 0.595 ± 0.031	1.11TrpArg: 1.11 ± 0.053	1.01TrpSer: 1.01 ± 0.044	0.802TrpThr: 0.802 ± 0.04	0.886TrpVal: 0.886 ± 0.042	0.312TrpTrp: 0.312 ± 0.025	0.412TrpTyr: 0.412 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.906TyrAla: 2.906 ± 0.074	0.236TyrCys: 0.236 ± 0.021	1.774TyrAsp: 1.774 ± 0.05	1.42TyrGlu: 1.42 ± 0.051	0.891TyrPhe: 0.891 ± 0.042	2.377TyrGly: 2.377 ± 0.068	0.568TyrHis: 0.568 ± 0.033	1.023TyrIle: 1.023 ± 0.047	0.56TyrLys: 0.56 ± 0.03	2.325TyrLeu: 2.325 ± 0.061	0.519TyrMet: 0.519 ± 0.029	0.666TyrAsn: 0.666 ± 0.043	1.217TyrPro: 1.217 ± 0.048	0.966TyrGln: 0.966 ± 0.042	2.005TyrArg: 2.005 ± 0.066	1.356TyrSer: 1.356 ± 0.053	1.481TyrThr: 1.481 ± 0.058	1.875TyrVal: 1.875 ± 0.056	0.399TyrTrp: 0.399 ± 0.026	0.677TyrTyr: 0.677 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.002	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.003	0.003XaaSer: 0.003 ± 0.002	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.006

Statistics based on 1798 proteins (621834 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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