Amino acid dipepetide frequency for Dichomitus squalens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.81AlaAla: 9.81 ± 0.059	1.201AlaCys: 1.201 ± 0.015	4.537AlaAsp: 4.537 ± 0.029	5.09AlaGlu: 5.09 ± 0.04	3.43AlaPhe: 3.43 ± 0.029	5.866AlaGly: 5.866 ± 0.037	2.339AlaHis: 2.339 ± 0.021	4.162AlaIle: 4.162 ± 0.027	3.705AlaLys: 3.705 ± 0.03	8.96AlaLeu: 8.96 ± 0.041	1.898AlaMet: 1.898 ± 0.017	2.766AlaAsn: 2.766 ± 0.024	5.959AlaPro: 5.959 ± 0.043	3.605AlaGln: 3.605 ± 0.028	6.154AlaArg: 6.154 ± 0.04	8.287AlaSer: 8.287 ± 0.048	5.535AlaThr: 5.535 ± 0.035	5.909AlaVal: 5.909 ± 0.034	1.256AlaTrp: 1.256 ± 0.016	2.351AlaTyr: 2.351 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.149CysAla: 1.149 ± 0.015	0.304CysCys: 0.304 ± 0.008	0.663CysAsp: 0.663 ± 0.012	0.602CysGlu: 0.602 ± 0.01	0.501CysPhe: 0.501 ± 0.01	0.981CysGly: 0.981 ± 0.017	0.37CysHis: 0.37 ± 0.01	0.671CysIle: 0.671 ± 0.011	0.457CysLys: 0.457 ± 0.009	1.28CysLeu: 1.28 ± 0.017	0.3CysMet: 0.3 ± 0.007	0.367CysAsn: 0.367 ± 0.01	0.869CysPro: 0.869 ± 0.012	0.419CysGln: 0.419 ± 0.008	0.913CysArg: 0.913 ± 0.014	1.074CysSer: 1.074 ± 0.017	0.805CysThr: 0.805 ± 0.012	0.893CysVal: 0.893 ± 0.014	0.202CysTrp: 0.202 ± 0.006	0.367CysTyr: 0.367 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.257AspAla: 5.257 ± 0.033	0.623AspCys: 0.623 ± 0.01	4.093AspAsp: 4.093 ± 0.039	4.22AspGlu: 4.22 ± 0.041	1.964AspPhe: 1.964 ± 0.019	4.073AspGly: 4.073 ± 0.029	1.227AspHis: 1.227 ± 0.014	2.755AspIle: 2.755 ± 0.021	1.994AspLys: 1.994 ± 0.021	4.763AspLeu: 4.763 ± 0.03	1.134AspMet: 1.134 ± 0.015	1.481AspAsn: 1.481 ± 0.017	3.606AspPro: 3.606 ± 0.025	1.514AspGln: 1.514 ± 0.017	3.033AspArg: 3.033 ± 0.029	3.803AspSer: 3.803 ± 0.027	2.881AspThr: 2.881 ± 0.022	4.241AspVal: 4.241 ± 0.03	0.899AspTrp: 0.899 ± 0.013	1.466AspTyr: 1.466 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.087GluAla: 5.087 ± 0.042	0.611GluCys: 0.611 ± 0.011	4.182GluAsp: 4.182 ± 0.037	5.099GluGlu: 5.099 ± 0.051	1.765GluPhe: 1.765 ± 0.018	3.709GluGly: 3.709 ± 0.033	1.524GluHis: 1.524 ± 0.016	2.482GluIle: 2.482 ± 0.021	2.817GluLys: 2.817 ± 0.028	5.234GluLeu: 5.234 ± 0.037	1.189GluMet: 1.189 ± 0.015	1.672GluAsn: 1.672 ± 0.018	2.789GluPro: 2.789 ± 0.025	2.194GluGln: 2.194 ± 0.022	4.257GluArg: 4.257 ± 0.035	3.729GluSer: 3.729 ± 0.03	2.945GluThr: 2.945 ± 0.022	3.604GluVal: 3.604 ± 0.027	0.903GluTrp: 0.903 ± 0.012	1.527GluTyr: 1.527 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.336PheAla: 3.336 ± 0.023	0.547PheCys: 0.547 ± 0.011	2.149PheAsp: 2.149 ± 0.02	1.873PheGlu: 1.873 ± 0.018	1.467PhePhe: 1.467 ± 0.021	2.658PheGly: 2.658 ± 0.027	0.878PheHis: 0.878 ± 0.015	1.598PheIle: 1.598 ± 0.018	1.323PheLys: 1.323 ± 0.015	3.455PheLeu: 3.455 ± 0.029	0.702PheMet: 0.702 ± 0.012	1.185PheAsn: 1.185 ± 0.016	2.192PhePro: 2.192 ± 0.02	1.158PheGln: 1.158 ± 0.013	2.055PheArg: 2.055 ± 0.022	3.011PheSer: 3.011 ± 0.024	2.105PheThr: 2.105 ± 0.021	2.59PheVal: 2.59 ± 0.024	0.607PheTrp: 0.607 ± 0.01	1.003PheTyr: 1.003 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.597GlyAla: 5.597 ± 0.039	0.912GlyCys: 0.912 ± 0.013	3.496GlyAsp: 3.496 ± 0.023	3.575GlyGlu: 3.575 ± 0.024	2.464GlyPhe: 2.464 ± 0.025	5.415GlyGly: 5.415 ± 0.055	1.746GlyHis: 1.746 ± 0.02	3.067GlyIle: 3.067 ± 0.027	3.106GlyLys: 3.106 ± 0.028	5.625GlyLeu: 5.625 ± 0.036	1.397GlyMet: 1.397 ± 0.019	2.048GlyAsn: 2.048 ± 0.021	3.659GlyPro: 3.659 ± 0.029	2.343GlyGln: 2.343 ± 0.023	4.498GlyArg: 4.498 ± 0.032	5.639GlySer: 5.639 ± 0.038	4.173GlyThr: 4.173 ± 0.033	4.403GlyVal: 4.403 ± 0.033	1.13GlyTrp: 1.13 ± 0.014	1.849GlyTyr: 1.849 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.382HisAla: 2.382 ± 0.021	0.382HisCys: 0.382 ± 0.008	1.371HisAsp: 1.371 ± 0.018	1.328HisGlu: 1.328 ± 0.016	0.951HisPhe: 0.951 ± 0.013	1.746HisGly: 1.746 ± 0.019	0.866HisHis: 0.866 ± 0.013	1.291HisIle: 1.291 ± 0.016	0.86HisLys: 0.86 ± 0.013	2.581HisLeu: 2.581 ± 0.022	0.497HisMet: 0.497 ± 0.01	0.772HisAsn: 0.772 ± 0.013	2.092HisPro: 2.092 ± 0.023	0.859HisGln: 0.859 ± 0.012	1.79HisArg: 1.79 ± 0.017	2.1HisSer: 2.1 ± 0.024	1.53HisThr: 1.53 ± 0.017	1.789HisVal: 1.789 ± 0.018	0.363HisTrp: 0.363 ± 0.009	0.699HisTyr: 0.699 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.185IleAla: 4.185 ± 0.031	0.692IleCys: 0.692 ± 0.012	2.543IleAsp: 2.543 ± 0.022	2.404IleGlu: 2.404 ± 0.02	1.7IlePhe: 1.7 ± 0.022	2.831IleGly: 2.831 ± 0.028	1.17IleHis: 1.17 ± 0.015	2.072IleIle: 2.072 ± 0.023	1.661IleLys: 1.661 ± 0.02	4.303IleLeu: 4.303 ± 0.028	0.866IleMet: 0.866 ± 0.013	1.347IleAsn: 1.347 ± 0.017	3.179IlePro: 3.179 ± 0.025	1.557IleGln: 1.557 ± 0.018	2.805IleArg: 2.805 ± 0.024	3.526IleSer: 3.526 ± 0.028	2.554IleThr: 2.554 ± 0.022	3.256IleVal: 3.256 ± 0.023	0.674IleTrp: 0.674 ± 0.012	1.204IleTyr: 1.204 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.95LysAla: 3.95 ± 0.031	0.428LysCys: 0.428 ± 0.008	2.264LysAsp: 2.264 ± 0.023	2.739LysGlu: 2.739 ± 0.03	1.186LysPhe: 1.186 ± 0.017	2.599LysGly: 2.599 ± 0.022	1.047LysHis: 1.047 ± 0.013	1.716LysIle: 1.716 ± 0.019	2.528LysLys: 2.528 ± 0.037	3.593LysLeu: 3.593 ± 0.03	0.766LysMet: 0.766 ± 0.009	1.217LysAsn: 1.217 ± 0.018	2.41LysPro: 2.41 ± 0.026	1.454LysGln: 1.454 ± 0.018	3.217LysArg: 3.217 ± 0.025	2.761LysSer: 2.761 ± 0.026	2.344LysThr: 2.344 ± 0.021	2.49LysVal: 2.49 ± 0.023	0.614LysTrp: 0.614 ± 0.009	1.149LysTyr: 1.149 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.631LeuAla: 8.631 ± 0.044	1.334LeuCys: 1.334 ± 0.016	5.047LeuAsp: 5.047 ± 0.03	5.236LeuGlu: 5.236 ± 0.04	3.398LeuPhe: 3.398 ± 0.029	5.717LeuGly: 5.717 ± 0.037	2.652LeuHis: 2.652 ± 0.022	3.619LeuIle: 3.619 ± 0.028	3.632LeuLys: 3.632 ± 0.031	8.884LeuLeu: 8.884 ± 0.056	1.645LeuMet: 1.645 ± 0.019	2.799LeuAsn: 2.799 ± 0.02	6.548LeuPro: 6.548 ± 0.04	3.702LeuGln: 3.702 ± 0.03	6.618LeuArg: 6.618 ± 0.042	8.049LeuSer: 8.049 ± 0.043	5.232LeuThr: 5.232 ± 0.03	5.972LeuVal: 5.972 ± 0.038	1.277LeuTrp: 1.277 ± 0.016	2.401LeuTyr: 2.401 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.859MetAla: 1.859 ± 0.019	0.259MetCys: 0.259 ± 0.007	1.095MetAsp: 1.095 ± 0.014	1.029MetGlu: 1.029 ± 0.014	0.727MetPhe: 0.727 ± 0.012	1.205MetGly: 1.205 ± 0.016	0.542MetHis: 0.542 ± 0.009	0.826MetIle: 0.826 ± 0.013	0.793MetLys: 0.793 ± 0.011	1.833MetLeu: 1.833 ± 0.021	0.467MetMet: 0.467 ± 0.01	0.663MetAsn: 0.663 ± 0.011	1.314MetPro: 1.314 ± 0.018	0.769MetGln: 0.769 ± 0.012	1.362MetArg: 1.362 ± 0.018	1.983MetSer: 1.983 ± 0.02	1.176MetThr: 1.176 ± 0.015	1.134MetVal: 1.134 ± 0.013	0.266MetTrp: 0.266 ± 0.006	0.539MetTyr: 0.539 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.07AsnAla: 3.07 ± 0.023	0.366AsnCys: 0.366 ± 0.008	1.55AsnAsp: 1.55 ± 0.017	1.52AsnGlu: 1.52 ± 0.016	1.101AsnPhe: 1.101 ± 0.015	2.497AsnGly: 2.497 ± 0.03	0.712AsnHis: 0.712 ± 0.012	1.619AsnIle: 1.619 ± 0.018	1.113AsnLys: 1.113 ± 0.014	2.784AsnLeu: 2.784 ± 0.026	0.661AsnMet: 0.661 ± 0.012	1.011AsnAsn: 1.011 ± 0.016	2.124AsnPro: 2.124 ± 0.02	0.944AsnGln: 0.944 ± 0.016	1.6AsnArg: 1.6 ± 0.015	2.194AsnSer: 2.194 ± 0.022	1.792AsnThr: 1.792 ± 0.02	2.338AsnVal: 2.338 ± 0.022	0.445AsnTrp: 0.445 ± 0.008	0.786AsnTyr: 0.786 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.372ProAla: 6.372 ± 0.045	0.661ProCys: 0.661 ± 0.013	3.432ProAsp: 3.432 ± 0.023	3.818ProGlu: 3.818 ± 0.031	2.232ProPhe: 2.232 ± 0.021	4.096ProGly: 4.096 ± 0.033	1.786ProHis: 1.786 ± 0.02	2.682ProIle: 2.682 ± 0.022	2.353ProLys: 2.353 ± 0.023	5.641ProLeu: 5.641 ± 0.033	1.126ProMet: 1.126 ± 0.015	2.042ProAsn: 2.042 ± 0.019	7.085ProPro: 7.085 ± 0.086	2.534ProGln: 2.534 ± 0.027	4.281ProArg: 4.281 ± 0.033	7.62ProSer: 7.62 ± 0.057	4.612ProThr: 4.612 ± 0.034	4.138ProVal: 4.138 ± 0.035	0.771ProTrp: 0.771 ± 0.012	1.633ProTyr: 1.633 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.436GlnAla: 3.436 ± 0.029	0.482GlnCys: 0.482 ± 0.01	1.847GlnAsp: 1.847 ± 0.016	2.083GlnGlu: 2.083 ± 0.021	1.179GlnPhe: 1.179 ± 0.014	2.172GlnGly: 2.172 ± 0.022	1.047GlnHis: 1.047 ± 0.015	1.544GlnIle: 1.544 ± 0.018	1.466GlnLys: 1.466 ± 0.019	3.323GlnLeu: 3.323 ± 0.026	0.756GlnMet: 0.756 ± 0.011	1.156GlnAsn: 1.156 ± 0.016	2.491GlnPro: 2.491 ± 0.027	1.9GlnGln: 1.9 ± 0.038	2.617GlnArg: 2.617 ± 0.023	2.901GlnSer: 2.901 ± 0.024	2.155GlnThr: 2.155 ± 0.018	2.128GlnVal: 2.128 ± 0.019	0.566GlnTrp: 0.566 ± 0.01	1.093GlnTyr: 1.093 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	6.09ArgAla: 6.09 ± 0.04	0.938ArgCys: 0.938 ± 0.015	3.426ArgAsp: 3.426 ± 0.031	4.0ArgGlu: 4.0 ± 0.039	2.213ArgPhe: 2.213 ± 0.02	4.019ArgGly: 4.019 ± 0.029	1.799ArgHis: 1.799 ± 0.021	2.908ArgIle: 2.908 ± 0.024	3.225ArgLys: 3.225 ± 0.029	6.155ArgLeu: 6.155 ± 0.039	1.458ArgMet: 1.458 ± 0.015	1.954ArgAsn: 1.954 ± 0.019	4.28ArgPro: 4.28 ± 0.033	2.431ArgGln: 2.431 ± 0.023	6.092ArgArg: 6.092 ± 0.041	5.539ArgSer: 5.539 ± 0.036	4.052ArgThr: 4.052 ± 0.026	4.06ArgVal: 4.06 ± 0.024	1.063ArgTrp: 1.063 ± 0.014	1.774ArgTyr: 1.774 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	7.807SerAla: 7.807 ± 0.046	1.056SerCys: 1.056 ± 0.015	4.241SerAsp: 4.241 ± 0.029	3.883SerGlu: 3.883 ± 0.027	2.976SerPhe: 2.976 ± 0.023	5.718SerGly: 5.718 ± 0.04	2.143SerHis: 2.143 ± 0.022	3.699SerIle: 3.699 ± 0.028	3.008SerLys: 3.008 ± 0.027	7.76SerLeu: 7.76 ± 0.046	1.68SerMet: 1.68 ± 0.018	2.401SerAsn: 2.401 ± 0.023	6.735SerPro: 6.735 ± 0.061	3.052SerGln: 3.052 ± 0.026	5.642SerArg: 5.642 ± 0.036	9.831SerSer: 9.831 ± 0.084	5.89SerThr: 5.89 ± 0.038	5.31SerVal: 5.31 ± 0.031	1.105SerTrp: 1.105 ± 0.014	1.981SerTyr: 1.981 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.385ThrAla: 5.385 ± 0.033	0.818ThrCys: 0.818 ± 0.015	2.73ThrAsp: 2.73 ± 0.022	2.721ThrGlu: 2.721 ± 0.022	2.446ThrPhe: 2.446 ± 0.022	3.905ThrGly: 3.905 ± 0.026	1.542ThrHis: 1.542 ± 0.015	2.911ThrIle: 2.911 ± 0.023	2.086ThrLys: 2.086 ± 0.017	5.908ThrLeu: 5.908 ± 0.035	1.124ThrMet: 1.124 ± 0.013	1.802ThrAsn: 1.802 ± 0.021	4.779ThrPro: 4.779 ± 0.034	1.978ThrGln: 1.978 ± 0.019	3.607ThrArg: 3.607 ± 0.026	5.755ThrSer: 5.755 ± 0.043	4.14ThrThr: 4.14 ± 0.037	4.029ThrVal: 4.029 ± 0.031	0.853ThrTrp: 0.853 ± 0.013	1.604ThrTyr: 1.604 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.847ValAla: 5.847 ± 0.036	0.968ValCys: 0.968 ± 0.014	3.857ValAsp: 3.857 ± 0.029	3.821ValGlu: 3.821 ± 0.03	2.545ValPhe: 2.545 ± 0.025	4.088ValGly: 4.088 ± 0.032	1.731ValHis: 1.731 ± 0.018	2.904ValIle: 2.904 ± 0.025	2.662ValLys: 2.662 ± 0.025	6.427ValLeu: 6.427 ± 0.035	1.272ValMet: 1.272 ± 0.016	2.061ValAsn: 2.061 ± 0.021	4.49ValPro: 4.49 ± 0.027	2.46ValGln: 2.46 ± 0.023	4.22ValArg: 4.22 ± 0.028	5.114ValSer: 5.114 ± 0.032	3.675ValThr: 3.675 ± 0.027	4.857ValVal: 4.857 ± 0.031	1.027ValTrp: 1.027 ± 0.015	1.836ValTyr: 1.836 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.164TrpAla: 1.164 ± 0.015	0.207TrpCys: 0.207 ± 0.006	0.91TrpAsp: 0.91 ± 0.014	0.866TrpGlu: 0.866 ± 0.013	0.56TrpPhe: 0.56 ± 0.009	0.896TrpGly: 0.896 ± 0.013	0.388TrpHis: 0.388 ± 0.009	0.704TrpIle: 0.704 ± 0.011	0.74TrpLys: 0.74 ± 0.012	1.337TrpLeu: 1.337 ± 0.016	0.358TrpMet: 0.358 ± 0.008	0.546TrpAsn: 0.546 ± 0.01	0.697TrpPro: 0.697 ± 0.012	0.54TrpGln: 0.54 ± 0.01	1.105TrpArg: 1.105 ± 0.016	1.097TrpSer: 1.097 ± 0.015	0.96TrpThr: 0.96 ± 0.014	0.895TrpVal: 0.895 ± 0.014	0.28TrpTrp: 0.28 ± 0.007	0.452TrpTyr: 0.452 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.406TyrAla: 2.406 ± 0.018	0.398TyrCys: 0.398 ± 0.008	1.593TyrAsp: 1.593 ± 0.019	1.41TyrGlu: 1.41 ± 0.016	1.088TyrPhe: 1.088 ± 0.016	1.951TyrGly: 1.951 ± 0.021	0.737TyrHis: 0.737 ± 0.012	1.301TyrIle: 1.301 ± 0.014	0.945TyrLys: 0.945 ± 0.014	2.545TyrLeu: 2.545 ± 0.022	0.546TyrMet: 0.546 ± 0.01	0.936TyrAsn: 0.936 ± 0.014	1.619TyrPro: 1.619 ± 0.017	0.931TyrGln: 0.931 ± 0.012	1.61TyrArg: 1.61 ± 0.019	1.903TyrSer: 1.903 ± 0.02	1.565TyrThr: 1.565 ± 0.018	1.828TyrVal: 1.828 ± 0.019	0.401TyrTrp: 0.401 ± 0.009	0.848TyrTyr: 0.848 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 15221 proteins (5826635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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