Amino acid dipepetide frequency for Halorhabdus sp. CBA1104

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.177AlaAla: 12.177 ± 0.17	0.665AlaCys: 0.665 ± 0.03	9.487AlaAsp: 9.487 ± 0.137	8.764AlaGlu: 8.764 ± 0.134	3.956AlaPhe: 3.956 ± 0.078	9.608AlaGly: 9.608 ± 0.142	1.893AlaHis: 1.893 ± 0.054	6.144AlaIle: 6.144 ± 0.102	2.027AlaLys: 2.027 ± 0.058	10.085AlaLeu: 10.085 ± 0.148	2.186AlaMet: 2.186 ± 0.053	2.418AlaAsn: 2.418 ± 0.064	3.755AlaPro: 3.755 ± 0.074	2.777AlaGln: 2.777 ± 0.06	5.993AlaArg: 5.993 ± 0.103	5.507AlaSer: 5.507 ± 0.096	7.412AlaThr: 7.412 ± 0.116	10.266AlaVal: 10.266 ± 0.163	1.161AlaTrp: 1.161 ± 0.042	2.692AlaTyr: 2.692 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	0.501CysAla: 0.501 ± 0.03	0.069CysCys: 0.069 ± 0.011	0.517CysAsp: 0.517 ± 0.028	0.54CysGlu: 0.54 ± 0.029	0.139CysPhe: 0.139 ± 0.013	0.883CysGly: 0.883 ± 0.045	0.157CysHis: 0.157 ± 0.014	0.227CysIle: 0.227 ± 0.018	0.103CysLys: 0.103 ± 0.014	0.488CysLeu: 0.488 ± 0.027	0.093CysMet: 0.093 ± 0.011	0.162CysAsn: 0.162 ± 0.016	0.563CysPro: 0.563 ± 0.034	0.192CysGln: 0.192 ± 0.014	0.419CysArg: 0.419 ± 0.026	0.427CysSer: 0.427 ± 0.024	0.387CysThr: 0.387 ± 0.025	0.46CysVal: 0.46 ± 0.022	0.073CysTrp: 0.073 ± 0.011	0.174CysTyr: 0.174 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.339AspAla: 9.339 ± 0.153	0.589AspCys: 0.589 ± 0.028	7.08AspAsp: 7.08 ± 0.132	7.345AspGlu: 7.345 ± 0.13	2.19AspPhe: 2.19 ± 0.06	7.915AspGly: 7.915 ± 0.125	1.874AspHis: 1.874 ± 0.057	3.363AspIle: 3.363 ± 0.075	0.861AspLys: 0.861 ± 0.036	7.066AspLeu: 7.066 ± 0.11	1.226AspMet: 1.226 ± 0.046	1.437AspAsn: 1.437 ± 0.051	4.834AspPro: 4.834 ± 0.089	2.132AspGln: 2.132 ± 0.052	6.987AspArg: 6.987 ± 0.104	3.913AspSer: 3.913 ± 0.074	4.085AspThr: 4.085 ± 0.072	8.058AspVal: 8.058 ± 0.133	0.981AspTrp: 0.981 ± 0.039	1.717AspTyr: 1.717 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	9.021GluAla: 9.021 ± 0.141	0.584GluCys: 0.584 ± 0.033	6.22GluAsp: 6.22 ± 0.112	6.082GluGlu: 6.082 ± 0.156	2.615GluPhe: 2.615 ± 0.059	5.284GluGly: 5.284 ± 0.109	2.062GluHis: 2.062 ± 0.058	4.086GluIle: 4.086 ± 0.086	1.858GluLys: 1.858 ± 0.068	6.941GluLeu: 6.941 ± 0.118	1.956GluMet: 1.956 ± 0.056	2.319GluAsn: 2.319 ± 0.062	3.903GluPro: 3.903 ± 0.086	3.508GluGln: 3.508 ± 0.071	7.248GluArg: 7.248 ± 0.119	5.371GluSer: 5.371 ± 0.101	7.493GluThr: 7.493 ± 0.114	5.137GluVal: 5.137 ± 0.097	1.085GluTrp: 1.085 ± 0.041	2.762GluTyr: 2.762 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	3.446PheAla: 3.446 ± 0.084	0.214PheCys: 0.214 ± 0.017	3.212PheAsp: 3.212 ± 0.064	3.613PheGlu: 3.613 ± 0.095	1.018PhePhe: 1.018 ± 0.046	3.241PheGly: 3.241 ± 0.077	0.592PheHis: 0.592 ± 0.03	1.059PheIle: 1.059 ± 0.042	0.456PheLys: 0.456 ± 0.024	2.837PheLeu: 2.837 ± 0.077	0.515PheMet: 0.515 ± 0.031	0.687PheAsn: 0.687 ± 0.033	1.293PhePro: 1.293 ± 0.041	0.861PheGln: 0.861 ± 0.031	1.673PheArg: 1.673 ± 0.055	1.643PheSer: 1.643 ± 0.05	1.896PheThr: 1.896 ± 0.053	3.131PheVal: 3.131 ± 0.082	0.389PheTrp: 0.389 ± 0.027	0.807PheTyr: 0.807 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	7.742GlyAla: 7.742 ± 0.118	0.665GlyCys: 0.665 ± 0.035	6.29GlyAsp: 6.29 ± 0.105	7.12GlyGlu: 7.12 ± 0.117	2.988GlyPhe: 2.988 ± 0.07	7.062GlyGly: 7.062 ± 0.114	1.774GlyHis: 1.774 ± 0.046	4.423GlyIle: 4.423 ± 0.098	1.825GlyLys: 1.825 ± 0.053	7.631GlyLeu: 7.631 ± 0.151	1.649GlyMet: 1.649 ± 0.048	1.917GlyAsn: 1.917 ± 0.054	3.506GlyPro: 3.506 ± 0.074	2.624GlyGln: 2.624 ± 0.07	4.557GlyArg: 4.557 ± 0.083	4.946GlySer: 4.946 ± 0.092	6.014GlyThr: 6.014 ± 0.087	7.219GlyVal: 7.219 ± 0.121	1.076GlyTrp: 1.076 ± 0.039	2.477GlyTyr: 2.477 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.856HisAla: 1.856 ± 0.056	0.212HisCys: 0.212 ± 0.021	1.764HisAsp: 1.764 ± 0.053	1.653HisGlu: 1.653 ± 0.046	0.594HisPhe: 0.594 ± 0.027	1.79HisGly: 1.79 ± 0.053	0.533HisHis: 0.533 ± 0.032	0.734HisIle: 0.734 ± 0.029	0.279HisLys: 0.279 ± 0.018	1.748HisLeu: 1.748 ± 0.049	0.286HisMet: 0.286 ± 0.022	0.529HisAsn: 0.529 ± 0.026	1.231HisPro: 1.231 ± 0.05	0.512HisGln: 0.512 ± 0.028	1.301HisArg: 1.301 ± 0.042	0.926HisSer: 0.926 ± 0.034	1.11HisThr: 1.11 ± 0.045	1.899HisVal: 1.899 ± 0.053	0.242HisTrp: 0.242 ± 0.018	0.559HisTyr: 0.559 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.529IleAla: 5.529 ± 0.107	0.247IleCys: 0.247 ± 0.02	4.755IleAsp: 4.755 ± 0.085	5.376IleGlu: 5.376 ± 0.1	1.09IlePhe: 1.09 ± 0.046	4.252IleGly: 4.252 ± 0.086	0.838IleHis: 0.838 ± 0.036	1.289IleIle: 1.289 ± 0.045	0.787IleLys: 0.787 ± 0.04	3.052IleLeu: 3.052 ± 0.071	0.522IleMet: 0.522 ± 0.028	1.043IleAsn: 1.043 ± 0.041	2.142IlePro: 2.142 ± 0.06	1.231IleGln: 1.231 ± 0.043	2.521IleArg: 2.521 ± 0.07	2.234IleSer: 2.234 ± 0.054	2.546IleThr: 2.546 ± 0.055	4.408IleVal: 4.408 ± 0.094	0.339IleTrp: 0.339 ± 0.022	1.025IleTyr: 1.025 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	1.756LysAla: 1.756 ± 0.049	0.121LysCys: 0.121 ± 0.014	1.155LysAsp: 1.155 ± 0.047	1.312LysGlu: 1.312 ± 0.048	0.506LysPhe: 0.506 ± 0.026	1.235LysGly: 1.235 ± 0.046	0.458LysHis: 0.458 ± 0.026	0.844LysIle: 0.844 ± 0.034	0.44LysLys: 0.44 ± 0.031	1.646LysLeu: 1.646 ± 0.048	0.335LysMet: 0.335 ± 0.022	0.466LysAsn: 0.466 ± 0.03	0.905LysPro: 0.905 ± 0.039	0.842LysGln: 0.842 ± 0.035	1.627LysArg: 1.627 ± 0.047	1.063LysSer: 1.063 ± 0.043	1.342LysThr: 1.342 ± 0.048	1.153LysVal: 1.153 ± 0.042	0.199LysTrp: 0.199 ± 0.016	0.536LysTyr: 0.536 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.496LeuAla: 11.496 ± 0.2	0.5LeuCys: 0.5 ± 0.024	7.675LeuAsp: 7.675 ± 0.129	7.312LeuGlu: 7.312 ± 0.115	2.955LeuPhe: 2.955 ± 0.089	7.624LeuGly: 7.624 ± 0.162	1.315LeuHis: 1.315 ± 0.043	3.146LeuIle: 3.146 ± 0.082	1.537LeuLys: 1.537 ± 0.052	8.751LeuLeu: 8.751 ± 0.188	1.221LeuMet: 1.221 ± 0.045	1.759LeuAsn: 1.759 ± 0.049	4.108LeuPro: 4.108 ± 0.078	2.547LeuGln: 2.547 ± 0.055	5.137LeuArg: 5.137 ± 0.089	5.703LeuSer: 5.703 ± 0.098	5.56LeuThr: 5.56 ± 0.088	8.047LeuVal: 8.047 ± 0.153	0.885LeuTrp: 0.885 ± 0.037	2.119LeuTyr: 2.119 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.04MetAla: 2.04 ± 0.055	0.102MetCys: 0.102 ± 0.011	1.423MetAsp: 1.423 ± 0.045	1.112MetGlu: 1.112 ± 0.041	0.51MetPhe: 0.51 ± 0.025	1.484MetGly: 1.484 ± 0.049	0.356MetHis: 0.356 ± 0.019	0.69MetIle: 0.69 ± 0.036	0.361MetLys: 0.361 ± 0.022	1.524MetLeu: 1.524 ± 0.052	0.313MetMet: 0.313 ± 0.022	0.57MetAsn: 0.57 ± 0.028	0.838MetPro: 0.838 ± 0.035	0.497MetGln: 0.497 ± 0.03	0.966MetArg: 0.966 ± 0.038	1.426MetSer: 1.426 ± 0.043	1.539MetThr: 1.539 ± 0.047	1.294MetVal: 1.294 ± 0.043	0.133MetTrp: 0.133 ± 0.016	0.363MetTyr: 0.363 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.535AsnAla: 2.535 ± 0.057	0.148AsnCys: 0.148 ± 0.014	1.705AsnAsp: 1.705 ± 0.052	1.711AsnGlu: 1.711 ± 0.059	0.728AsnPhe: 0.728 ± 0.03	1.977AsnGly: 1.977 ± 0.061	0.5AsnHis: 0.5 ± 0.029	0.91AsnIle: 0.91 ± 0.042	0.441AsnLys: 0.441 ± 0.027	1.915AsnLeu: 1.915 ± 0.053	0.422AsnMet: 0.422 ± 0.024	0.572AsnAsn: 0.572 ± 0.031	1.452AsnPro: 1.452 ± 0.048	0.731AsnGln: 0.731 ± 0.035	1.568AsnArg: 1.568 ± 0.045	0.944AsnSer: 0.944 ± 0.047	1.302AsnThr: 1.302 ± 0.05	2.382AsnVal: 2.382 ± 0.055	0.353AsnTrp: 0.353 ± 0.024	0.635AsnTyr: 0.635 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.177ProAla: 5.177 ± 0.09	0.228ProCys: 0.228 ± 0.016	4.994ProAsp: 4.994 ± 0.09	4.469ProGlu: 4.469 ± 0.079	1.539ProPhe: 1.539 ± 0.048	3.777ProGly: 3.777 ± 0.075	0.907ProHis: 0.907 ± 0.038	2.158ProIle: 2.158 ± 0.061	0.815ProLys: 0.815 ± 0.034	3.674ProLeu: 3.674 ± 0.083	0.824ProMet: 0.824 ± 0.033	1.085ProAsn: 1.085 ± 0.04	2.193ProPro: 2.193 ± 0.059	1.128ProGln: 1.128 ± 0.04	2.171ProArg: 2.171 ± 0.058	2.582ProSer: 2.582 ± 0.065	3.306ProThr: 3.306 ± 0.069	3.972ProVal: 3.972 ± 0.075	0.5ProTrp: 0.5 ± 0.026	1.074ProTyr: 1.074 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.475GlnAla: 3.475 ± 0.073	0.196GlnCys: 0.196 ± 0.016	1.654GlnAsp: 1.654 ± 0.054	2.017GlnGlu: 2.017 ± 0.06	1.245GlnPhe: 1.245 ± 0.045	1.788GlnGly: 1.788 ± 0.052	0.6GlnHis: 0.6 ± 0.03	1.327GlnIle: 1.327 ± 0.04	0.587GlnLys: 0.587 ± 0.03	2.861GlnLeu: 2.861 ± 0.074	0.622GlnMet: 0.622 ± 0.033	0.746GlnAsn: 0.746 ± 0.032	1.503GlnPro: 1.503 ± 0.053	1.406GlnGln: 1.406 ± 0.053	2.492GlnArg: 2.492 ± 0.058	1.94GlnSer: 1.94 ± 0.052	2.194GlnThr: 2.194 ± 0.057	1.87GlnVal: 1.87 ± 0.059	0.348GlnTrp: 0.348 ± 0.02	0.901GlnTyr: 0.901 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	6.382ArgAla: 6.382 ± 0.103	0.431ArgCys: 0.431 ± 0.03	4.979ArgAsp: 4.979 ± 0.095	6.584ArgGlu: 6.584 ± 0.121	2.174ArgPhe: 2.174 ± 0.063	4.075ArgGly: 4.075 ± 0.07	1.21ArgHis: 1.21 ± 0.04	3.175ArgIle: 3.175 ± 0.068	1.385ArgLys: 1.385 ± 0.05	6.201ArgLeu: 6.201 ± 0.096	1.227ArgMet: 1.227 ± 0.04	1.511ArgAsn: 1.511 ± 0.049	2.565ArgPro: 2.565 ± 0.054	2.211ArgGln: 2.211 ± 0.051	4.491ArgArg: 4.491 ± 0.099	3.521ArgSer: 3.521 ± 0.076	3.976ArgThr: 3.976 ± 0.082	4.747ArgVal: 4.747 ± 0.085	0.739ArgTrp: 0.739 ± 0.036	1.882ArgTyr: 1.882 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.521SerAla: 5.521 ± 0.101	0.309SerCys: 0.309 ± 0.023	4.211SerAsp: 4.211 ± 0.101	4.3SerGlu: 4.3 ± 0.089	1.822SerPhe: 1.822 ± 0.05	5.235SerGly: 5.235 ± 0.089	0.993SerHis: 0.993 ± 0.037	3.027SerIle: 3.027 ± 0.064	1.165SerLys: 1.165 ± 0.042	4.882SerLeu: 4.882 ± 0.087	1.128SerMet: 1.128 ± 0.035	1.286SerAsn: 1.286 ± 0.043	2.619SerPro: 2.619 ± 0.07	1.661SerGln: 1.661 ± 0.05	3.085SerArg: 3.085 ± 0.069	2.874SerSer: 2.874 ± 0.077	3.608SerThr: 3.608 ± 0.074	5.13SerVal: 5.13 ± 0.085	0.569SerTrp: 0.569 ± 0.027	1.364SerTyr: 1.364 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	7.422ThrAla: 7.422 ± 0.122	0.354ThrCys: 0.354 ± 0.022	5.937ThrAsp: 5.937 ± 0.106	4.923ThrGlu: 4.923 ± 0.092	2.3ThrPhe: 2.3 ± 0.055	5.764ThrGly: 5.764 ± 0.111	1.252ThrHis: 1.252 ± 0.04	3.756ThrIle: 3.756 ± 0.085	1.044ThrLys: 1.044 ± 0.045	6.151ThrLeu: 6.151 ± 0.084	1.103ThrMet: 1.103 ± 0.04	1.522ThrAsn: 1.522 ± 0.047	3.182ThrPro: 3.182 ± 0.073	1.597ThrGln: 1.597 ± 0.044	3.236ThrArg: 3.236 ± 0.069	2.962ThrSer: 2.962 ± 0.067	4.687ThrThr: 4.687 ± 0.103	7.386ThrVal: 7.386 ± 0.121	0.669ThrTrp: 0.669 ± 0.032	1.866ThrTyr: 1.866 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	9.917ValAla: 9.917 ± 0.133	0.595ValCys: 0.595 ± 0.031	6.738ValAsp: 6.738 ± 0.097	8.104ValGlu: 8.104 ± 0.134	2.984ValPhe: 2.984 ± 0.082	7.591ValGly: 7.591 ± 0.125	1.573ValHis: 1.573 ± 0.049	3.57ValIle: 3.57 ± 0.086	1.318ValLys: 1.318 ± 0.045	8.145ValLeu: 8.145 ± 0.154	1.357ValMet: 1.357 ± 0.047	1.889ValAsn: 1.889 ± 0.054	4.28ValPro: 4.28 ± 0.079	2.109ValGln: 2.109 ± 0.058	5.17ValArg: 5.17 ± 0.09	5.075ValSer: 5.075 ± 0.101	6.419ValThr: 6.419 ± 0.097	8.388ValVal: 8.388 ± 0.13	0.859ValTrp: 0.859 ± 0.037	1.962ValTyr: 1.962 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.955TrpAla: 0.955 ± 0.04	0.084TrpCys: 0.084 ± 0.011	0.789TrpAsp: 0.789 ± 0.033	0.812TrpGlu: 0.812 ± 0.032	0.419TrpPhe: 0.419 ± 0.024	0.735TrpGly: 0.735 ± 0.032	0.218TrpHis: 0.218 ± 0.017	0.543TrpIle: 0.543 ± 0.029	0.273TrpLys: 0.273 ± 0.02	1.355TrpLeu: 1.355 ± 0.05	0.201TrpMet: 0.201 ± 0.017	0.328TrpAsn: 0.328 ± 0.019	0.448TrpPro: 0.448 ± 0.028	0.426TrpGln: 0.426 ± 0.027	0.85TrpArg: 0.85 ± 0.04	0.547TrpSer: 0.547 ± 0.031	0.78TrpThr: 0.78 ± 0.031	0.813TrpVal: 0.813 ± 0.031	0.195TrpTrp: 0.195 ± 0.018	0.372TrpTyr: 0.372 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.687TyrAla: 2.687 ± 0.061	0.261TyrCys: 0.261 ± 0.018	2.407TyrAsp: 2.407 ± 0.056	2.387TyrGlu: 2.387 ± 0.066	0.816TyrPhe: 0.816 ± 0.031	2.183TyrGly: 2.183 ± 0.052	0.651TyrHis: 0.651 ± 0.03	0.756TyrIle: 0.756 ± 0.038	0.379TyrLys: 0.379 ± 0.021	2.448TyrLeu: 2.448 ± 0.062	0.352TyrMet: 0.352 ± 0.023	0.684TyrAsn: 0.684 ± 0.032	1.253TyrPro: 1.253 ± 0.043	0.779TyrGln: 0.779 ± 0.031	1.976TyrArg: 1.976 ± 0.057	1.183TyrSer: 1.183 ± 0.039	1.455TyrThr: 1.455 ± 0.048	2.281TyrVal: 2.281 ± 0.061	0.349TyrTrp: 0.349 ± 0.023	0.848TyrTyr: 0.848 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2453 proteins (727833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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