Amino acid dipepetide frequency for Peptococcaceae bacterium SCADC1_2_3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.894AlaAla: 7.894 ± 0.15
0.993AlaCys: 0.993 ± 0.04
3.29AlaAsp: 3.29 ± 0.078
5.347AlaGlu: 5.347 ± 0.118
2.952AlaPhe: 2.952 ± 0.083
7.12AlaGly: 7.12 ± 0.123
1.362AlaHis: 1.362 ± 0.052
5.271AlaIle: 5.271 ± 0.109
5.059AlaLys: 5.059 ± 0.096
9.023AlaLeu: 9.023 ± 0.143
1.705AlaMet: 1.705 ± 0.055
2.7AlaAsn: 2.7 ± 0.074
2.56AlaPro: 2.56 ± 0.073
3.35AlaGln: 3.35 ± 0.088
4.666AlaArg: 4.666 ± 0.102
3.62AlaSer: 3.62 ± 0.072
3.498AlaThr: 3.498 ± 0.085
6.453AlaVal: 6.453 ± 0.116
0.723AlaTrp: 0.723 ± 0.036
2.421AlaTyr: 2.421 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.869CysAla: 0.869 ± 0.042
0.228CysCys: 0.228 ± 0.02
0.458CysAsp: 0.458 ± 0.03
0.493CysGlu: 0.493 ± 0.029
0.625CysPhe: 0.625 ± 0.033
1.127CysGly: 1.127 ± 0.052
0.246CysHis: 0.246 ± 0.023
0.59CysIle: 0.59 ± 0.038
0.514CysLys: 0.514 ± 0.029
1.447CysLeu: 1.447 ± 0.052
0.239CysMet: 0.239 ± 0.02
0.417CysAsn: 0.417 ± 0.026
0.746CysPro: 0.746 ± 0.042
0.451CysGln: 0.451 ± 0.03
0.804CysArg: 0.804 ± 0.042
0.659CysSer: 0.659 ± 0.037
0.532CysThr: 0.532 ± 0.036
0.659CysVal: 0.659 ± 0.031
0.134CysTrp: 0.134 ± 0.016
0.378CysTyr: 0.378 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.889AspAla: 2.889 ± 0.077
0.558AspCys: 0.558 ± 0.034
1.8AspAsp: 1.8 ± 0.061
3.145AspGlu: 3.145 ± 0.072
2.406AspPhe: 2.406 ± 0.065
2.829AspGly: 2.829 ± 0.077
0.749AspHis: 0.749 ± 0.031
3.606AspIle: 3.606 ± 0.08
2.979AspLys: 2.979 ± 0.077
5.514AspLeu: 5.514 ± 0.094
0.912AspMet: 0.912 ± 0.038
1.686AspAsn: 1.686 ± 0.051
2.156AspPro: 2.156 ± 0.067
1.413AspGln: 1.413 ± 0.048
2.055AspArg: 2.055 ± 0.061
1.742AspSer: 1.742 ± 0.049
2.074AspThr: 2.074 ± 0.056
2.945AspVal: 2.945 ± 0.077
0.571AspTrp: 0.571 ± 0.038
1.988AspTyr: 1.988 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
5.995GluAla: 5.995 ± 0.118
0.546GluCys: 0.546 ± 0.031
3.034GluAsp: 3.034 ± 0.079
6.924GluGlu: 6.924 ± 0.146
2.274GluPhe: 2.274 ± 0.068
4.338GluGly: 4.338 ± 0.102
1.168GluHis: 1.168 ± 0.05
6.601GluIle: 6.601 ± 0.118
6.981GluLys: 6.981 ± 0.138
7.262GluLeu: 7.262 ± 0.119
1.977GluMet: 1.977 ± 0.059
3.255GluAsn: 3.255 ± 0.078
2.235GluPro: 2.235 ± 0.068
2.654GluGln: 2.654 ± 0.077
3.684GluArg: 3.684 ± 0.093
2.475GluSer: 2.475 ± 0.076
3.279GluThr: 3.279 ± 0.076
5.848GluVal: 5.848 ± 0.115
0.588GluTrp: 0.588 ± 0.039
2.035GluTyr: 2.035 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.919PheAla: 2.919 ± 0.072
0.673PheCys: 0.673 ± 0.036
1.954PheAsp: 1.954 ± 0.063
2.353PheGlu: 2.353 ± 0.066
2.202PhePhe: 2.202 ± 0.073
2.869PheGly: 2.869 ± 0.082
0.756PheHis: 0.756 ± 0.033
3.209PheIle: 3.209 ± 0.088
2.661PheLys: 2.661 ± 0.072
4.839PheLeu: 4.839 ± 0.121
0.908PheMet: 0.908 ± 0.042
1.861PheAsn: 1.861 ± 0.057
1.827PhePro: 1.827 ± 0.061
1.412PheGln: 1.412 ± 0.049
1.705PheArg: 1.705 ± 0.059
2.643PheSer: 2.643 ± 0.073
2.497PheThr: 2.497 ± 0.076
2.332PheVal: 2.332 ± 0.075
0.585PheTrp: 0.585 ± 0.033
1.601PheTyr: 1.601 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
5.428GlyAla: 5.428 ± 0.103
1.009GlyCys: 1.009 ± 0.051
2.818GlyAsp: 2.818 ± 0.079
5.0GlyGlu: 5.0 ± 0.105
3.166GlyPhe: 3.166 ± 0.074
5.203GlyGly: 5.203 ± 0.129
1.323GlyHis: 1.323 ± 0.052
5.551GlyIle: 5.551 ± 0.118
5.378GlyLys: 5.378 ± 0.102
7.686GlyLeu: 7.686 ± 0.132
1.785GlyMet: 1.785 ± 0.06
2.576GlyAsn: 2.576 ± 0.082
2.177GlyPro: 2.177 ± 0.068
2.889GlyGln: 2.889 ± 0.085
3.845GlyArg: 3.845 ± 0.081
3.555GlySer: 3.555 ± 0.069
3.797GlyThr: 3.797 ± 0.08
5.255GlyVal: 5.255 ± 0.099
0.85GlyTrp: 0.85 ± 0.042
2.703GlyTyr: 2.703 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
0.998HisAla: 0.998 ± 0.04
0.295HisCys: 0.295 ± 0.023
0.723HisAsp: 0.723 ± 0.033
0.951HisGlu: 0.951 ± 0.041
0.784HisPhe: 0.784 ± 0.038
1.304HisGly: 1.304 ± 0.047
0.482HisHis: 0.482 ± 0.03
1.235HisIle: 1.235 ± 0.038
0.995HisLys: 0.995 ± 0.045
2.198HisLeu: 2.198 ± 0.071
0.256HisMet: 0.256 ± 0.021
0.719HisAsn: 0.719 ± 0.037
1.094HisPro: 1.094 ± 0.045
0.818HisGln: 0.818 ± 0.042
1.019HisArg: 1.019 ± 0.047
0.8HisSer: 0.8 ± 0.038
0.875HisThr: 0.875 ± 0.041
0.928HisVal: 0.928 ± 0.035
0.27HisTrp: 0.27 ± 0.024
0.686HisTyr: 0.686 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.58IleAla: 5.58 ± 0.111
0.908IleCys: 0.908 ± 0.039
3.315IleAsp: 3.315 ± 0.088
4.882IleGlu: 4.882 ± 0.107
3.297IlePhe: 3.297 ± 0.089
4.672IleGly: 4.672 ± 0.103
1.173IleHis: 1.173 ± 0.05
6.027IleIle: 6.027 ± 0.118
5.283IleLys: 5.283 ± 0.118
7.601IleLeu: 7.601 ± 0.128
1.686IleMet: 1.686 ± 0.066
3.555IleAsn: 3.555 ± 0.08
3.366IlePro: 3.366 ± 0.078
2.164IleGln: 2.164 ± 0.065
3.322IleArg: 3.322 ± 0.081
4.316IleSer: 4.316 ± 0.09
4.304IleThr: 4.304 ± 0.095
4.61IleVal: 4.61 ± 0.102
0.615IleTrp: 0.615 ± 0.034
2.468IleTyr: 2.468 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.112LysAla: 5.112 ± 0.102
0.56LysCys: 0.56 ± 0.031
3.398LysAsp: 3.398 ± 0.081
7.124LysGlu: 7.124 ± 0.133
2.007LysPhe: 2.007 ± 0.062
4.507LysGly: 4.507 ± 0.095
1.062LysHis: 1.062 ± 0.048
5.917LysIle: 5.917 ± 0.101
5.783LysLys: 5.783 ± 0.124
6.021LysLeu: 6.021 ± 0.128
1.751LysMet: 1.751 ± 0.058
3.391LysAsn: 3.391 ± 0.084
2.539LysPro: 2.539 ± 0.072
2.765LysGln: 2.765 ± 0.074
3.272LysArg: 3.272 ± 0.092
2.903LysSer: 2.903 ± 0.066
3.555LysThr: 3.555 ± 0.082
5.11LysVal: 5.11 ± 0.115
0.624LysTrp: 0.624 ± 0.039
2.253LysTyr: 2.253 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
10.149LeuAla: 10.149 ± 0.151
1.041LeuCys: 1.041 ± 0.044
4.871LeuAsp: 4.871 ± 0.096
7.363LeuGlu: 7.363 ± 0.139
4.29LeuPhe: 4.29 ± 0.112
7.357LeuGly: 7.357 ± 0.114
1.565LeuHis: 1.565 ± 0.055
7.385LeuIle: 7.385 ± 0.124
8.333LeuLys: 8.333 ± 0.125
10.25LeuLeu: 10.25 ± 0.173
2.095LeuMet: 2.095 ± 0.059
4.705LeuAsn: 4.705 ± 0.099
5.283LeuPro: 5.283 ± 0.12
3.26LeuGln: 3.26 ± 0.086
5.285LeuArg: 5.285 ± 0.101
6.195LeuSer: 6.195 ± 0.105
6.188LeuThr: 6.188 ± 0.119
7.698LeuVal: 7.698 ± 0.138
1.062LeuTrp: 1.062 ± 0.049
3.11LeuTyr: 3.11 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
2.224MetAla: 2.224 ± 0.069
0.2MetCys: 0.2 ± 0.022
0.965MetAsp: 0.965 ± 0.039
1.675MetGlu: 1.675 ± 0.06
0.76MetPhe: 0.76 ± 0.042
1.585MetGly: 1.585 ± 0.063
0.371MetHis: 0.371 ± 0.022
1.299MetIle: 1.299 ± 0.054
1.408MetLys: 1.408 ± 0.051
2.299MetLeu: 2.299 ± 0.073
0.421MetMet: 0.421 ± 0.027
0.839MetAsn: 0.839 ± 0.035
0.986MetPro: 0.986 ± 0.044
0.774MetGln: 0.774 ± 0.035
1.228MetArg: 1.228 ± 0.048
1.078MetSer: 1.078 ± 0.042
1.062MetThr: 1.062 ± 0.046
1.896MetVal: 1.896 ± 0.059
0.159MetTrp: 0.159 ± 0.016
0.502MetTyr: 0.502 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.482AsnAla: 2.482 ± 0.068
0.505AsnCys: 0.505 ± 0.036
1.624AsnAsp: 1.624 ± 0.046
2.5AsnGlu: 2.5 ± 0.064
1.914AsnPhe: 1.914 ± 0.059
2.491AsnGly: 2.491 ± 0.079
0.747AsnHis: 0.747 ± 0.037
3.557AsnIle: 3.557 ± 0.087
2.698AsnLys: 2.698 ± 0.073
5.071AsnLeu: 5.071 ± 0.09
0.825AsnMet: 0.825 ± 0.036
1.8AsnAsn: 1.8 ± 0.062
2.369AsnPro: 2.369 ± 0.07
1.677AsnGln: 1.677 ± 0.061
2.037AsnArg: 2.037 ± 0.058
1.813AsnSer: 1.813 ± 0.055
1.928AsnThr: 1.928 ± 0.052
2.392AsnVal: 2.392 ± 0.066
0.481AsnTrp: 0.481 ± 0.032
1.673AsnTyr: 1.673 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
3.901ProAla: 3.901 ± 0.094
0.421ProCys: 0.421 ± 0.028
2.449ProAsp: 2.449 ± 0.068
3.944ProGlu: 3.944 ± 0.082
1.933ProPhe: 1.933 ± 0.056
3.839ProGly: 3.839 ± 0.083
0.813ProHis: 0.813 ± 0.04
1.995ProIle: 1.995 ± 0.058
2.15ProLys: 2.15 ± 0.068
4.452ProLeu: 4.452 ± 0.085
0.673ProMet: 0.673 ± 0.036
1.258ProAsn: 1.258 ± 0.051
1.914ProPro: 1.914 ± 0.071
1.603ProGln: 1.603 ± 0.053
1.912ProArg: 1.912 ± 0.062
1.936ProSer: 1.936 ± 0.06
1.832ProThr: 1.832 ± 0.061
4.179ProVal: 4.179 ± 0.095
0.463ProTrp: 0.463 ± 0.03
1.44ProTyr: 1.44 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.608GlnAla: 3.608 ± 0.088
0.258GlnCys: 0.258 ± 0.023
1.587GlnAsp: 1.587 ± 0.056
3.617GlnGlu: 3.617 ± 0.089
1.057GlnPhe: 1.057 ± 0.047
2.52GlnGly: 2.52 ± 0.071
0.597GlnHis: 0.597 ± 0.034
2.597GlnIle: 2.597 ± 0.068
3.2GlnLys: 3.2 ± 0.081
3.237GlnLeu: 3.237 ± 0.081
0.882GlnMet: 0.882 ± 0.039
1.482GlnAsn: 1.482 ± 0.048
1.359GlnPro: 1.359 ± 0.055
1.518GlnGln: 1.518 ± 0.064
2.039GlnArg: 2.039 ± 0.059
1.534GlnSer: 1.534 ± 0.053
1.765GlnThr: 1.765 ± 0.065
3.14GlnVal: 3.14 ± 0.08
0.307GlnTrp: 0.307 ± 0.023
0.936GlnTyr: 0.936 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
3.636ArgAla: 3.636 ± 0.091
0.581ArgCys: 0.581 ± 0.032
2.214ArgAsp: 2.214 ± 0.07
4.226ArgGlu: 4.226 ± 0.09
2.147ArgPhe: 2.147 ± 0.053
3.163ArgGly: 3.163 ± 0.082
1.067ArgHis: 1.067 ± 0.046
3.391ArgIle: 3.391 ± 0.072
3.239ArgLys: 3.239 ± 0.073
6.233ArgLeu: 6.233 ± 0.116
1.09ArgMet: 1.09 ± 0.047
1.829ArgAsn: 1.829 ± 0.057
2.154ArgPro: 2.154 ± 0.062
2.753ArgGln: 2.753 ± 0.083
3.094ArgArg: 3.094 ± 0.101
2.18ArgSer: 2.18 ± 0.064
2.276ArgThr: 2.276 ± 0.064
3.65ArgVal: 3.65 ± 0.08
0.608ArgTrp: 0.608 ± 0.034
1.928ArgTyr: 1.928 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
3.247SerAla: 3.247 ± 0.083
0.652SerCys: 0.652 ± 0.035
1.984SerAsp: 1.984 ± 0.056
2.921SerGlu: 2.921 ± 0.078
2.52SerPhe: 2.52 ± 0.076
4.26SerGly: 4.26 ± 0.089
0.898SerHis: 0.898 ± 0.038
3.15SerIle: 3.15 ± 0.065
2.781SerLys: 2.781 ± 0.072
6.242SerLeu: 6.242 ± 0.113
1.148SerMet: 1.148 ± 0.044
1.671SerAsn: 1.671 ± 0.064
2.452SerPro: 2.452 ± 0.074
1.785SerGln: 1.785 ± 0.056
2.739SerArg: 2.739 ± 0.074
2.869SerSer: 2.869 ± 0.07
2.33SerThr: 2.33 ± 0.073
2.921SerVal: 2.921 ± 0.078
0.663SerTrp: 0.663 ± 0.042
1.753SerTyr: 1.753 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.219ThrAla: 4.219 ± 0.095
0.611ThrCys: 0.611 ± 0.034
2.145ThrAsp: 2.145 ± 0.062
2.982ThrGlu: 2.982 ± 0.077
1.979ThrPhe: 1.979 ± 0.065
5.036ThrGly: 5.036 ± 0.097
0.878ThrHis: 0.878 ± 0.04
3.421ThrIle: 3.421 ± 0.073
2.866ThrLys: 2.866 ± 0.064
5.064ThrLeu: 5.064 ± 0.099
1.009ThrMet: 1.009 ± 0.047
1.838ThrAsn: 1.838 ± 0.065
2.618ThrPro: 2.618 ± 0.079
1.62ThrGln: 1.62 ± 0.061
2.693ThrArg: 2.693 ± 0.073
2.578ThrSer: 2.578 ± 0.069
2.631ThrThr: 2.631 ± 0.073
3.991ThrVal: 3.991 ± 0.11
0.521ThrTrp: 0.521 ± 0.033
1.691ThrTyr: 1.691 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
5.806ValAla: 5.806 ± 0.118
0.896ValCys: 0.896 ± 0.036
3.361ValAsp: 3.361 ± 0.074
4.937ValGlu: 4.937 ± 0.117
3.265ValPhe: 3.265 ± 0.09
4.548ValGly: 4.548 ± 0.087
1.087ValHis: 1.087 ± 0.045
5.87ValIle: 5.87 ± 0.116
5.053ValLys: 5.053 ± 0.093
7.447ValLeu: 7.447 ± 0.121
1.631ValMet: 1.631 ± 0.054
3.35ValAsn: 3.35 ± 0.077
2.998ValPro: 2.998 ± 0.064
2.187ValGln: 2.187 ± 0.056
3.332ValArg: 3.332 ± 0.092
3.991ValSer: 3.991 ± 0.083
3.903ValThr: 3.903 ± 0.082
5.656ValVal: 5.656 ± 0.118
0.622ValTrp: 0.622 ± 0.031
2.318ValTyr: 2.318 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.71TrpAla: 0.71 ± 0.037
0.104TrpCys: 0.104 ± 0.013
0.527TrpAsp: 0.527 ± 0.031
0.822TrpGlu: 0.822 ± 0.038
0.421TrpPhe: 0.421 ± 0.029
0.777TrpGly: 0.777 ± 0.034
0.228TrpHis: 0.228 ± 0.025
0.507TrpIle: 0.507 ± 0.031
0.585TrpLys: 0.585 ± 0.033
1.299TrpLeu: 1.299 ± 0.056
0.228TrpMet: 0.228 ± 0.021
0.376TrpAsn: 0.376 ± 0.027
0.484TrpPro: 0.484 ± 0.031
0.565TrpGln: 0.565 ± 0.032
0.7TrpArg: 0.7 ± 0.04
0.484TrpSer: 0.484 ± 0.03
0.436TrpThr: 0.436 ± 0.029
0.735TrpVal: 0.735 ± 0.039
0.17TrpTrp: 0.17 ± 0.018
0.27TrpTyr: 0.27 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.339TyrAla: 2.339 ± 0.061
0.576TyrCys: 0.576 ± 0.039
1.504TyrAsp: 1.504 ± 0.053
1.949TyrGlu: 1.949 ± 0.065
1.808TyrPhe: 1.808 ± 0.058
2.449TyrGly: 2.449 ± 0.062
0.857TyrHis: 0.857 ± 0.04
1.965TyrIle: 1.965 ± 0.063
1.709TyrLys: 1.709 ± 0.062
4.299TyrLeu: 4.299 ± 0.092
0.507TyrMet: 0.507 ± 0.029
1.277TyrAsn: 1.277 ± 0.05
1.79TyrPro: 1.79 ± 0.056
1.581TyrGln: 1.581 ± 0.059
2.028TyrArg: 2.028 ± 0.063
1.613TyrSer: 1.613 ± 0.065
1.629TyrThr: 1.629 ± 0.052
1.861TyrVal: 1.861 ± 0.058
0.413TyrTrp: 0.413 ± 0.027
1.364TyrTyr: 1.364 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2187 proteins (565976 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski