Amino acid dipepetide frequency for Guaroa virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.018AlaAla: 2.018 ± 1.863
1.261AlaCys: 1.261 ± 0.479
2.27AlaAsp: 2.27 ± 0.572
1.261AlaGlu: 1.261 ± 0.543
2.018AlaPhe: 2.018 ± 0.47
1.261AlaGly: 1.261 ± 1.295
0.505AlaHis: 0.505 ± 0.136
3.28AlaIle: 3.28 ± 0.918
2.018AlaLys: 2.018 ± 0.379
3.532AlaLeu: 3.532 ± 0.433
1.261AlaMet: 1.261 ± 0.811
3.027AlaAsn: 3.027 ± 0.519
1.009AlaPro: 1.009 ± 0.548
1.514AlaGln: 1.514 ± 0.54
2.018AlaArg: 2.018 ± 1.952
2.523AlaSer: 2.523 ± 1.087
2.523AlaThr: 2.523 ± 0.995
2.018AlaVal: 2.018 ± 0.545
0.252AlaTrp: 0.252 ± 0.162
2.27AlaTyr: 2.27 ± 0.538
0.0AlaXaa: 0.0 ± 0.0
Cys
1.009CysAla: 1.009 ± 0.649
0.0CysCys: 0.0 ± 0.0
0.505CysAsp: 0.505 ± 0.462
1.009CysGlu: 1.009 ± 0.273
1.261CysPhe: 1.261 ± 0.798
2.523CysGly: 2.523 ± 1.95
0.505CysHis: 0.505 ± 0.462
2.523CysIle: 2.523 ± 1.253
2.775CysLys: 2.775 ± 1.825
2.523CysLeu: 2.523 ± 1.253
1.261CysMet: 1.261 ± 0.468
2.775CysAsn: 2.775 ± 1.151
1.009CysPro: 1.009 ± 0.273
1.261CysGln: 1.261 ± 0.289
1.009CysArg: 1.009 ± 0.569
1.514CysSer: 1.514 ± 0.409
1.514CysThr: 1.514 ± 1.028
0.757CysVal: 0.757 ± 0.191
0.0CysTrp: 0.0 ± 0.0
1.514CysTyr: 1.514 ± 0.686
0.0CysXaa: 0.0 ± 0.0
Asp
1.514AspAla: 1.514 ± 0.54
0.757AspCys: 0.757 ± 0.343
2.018AspAsp: 2.018 ± 0.703
2.523AspGlu: 2.523 ± 0.697
2.775AspPhe: 2.775 ± 0.657
1.514AspGly: 1.514 ± 0.451
1.514AspHis: 1.514 ± 0.409
6.811AspIle: 6.811 ± 1.613
2.523AspLys: 2.523 ± 0.697
4.793AspLeu: 4.793 ± 1.265
1.261AspMet: 1.261 ± 0.775
4.541AspAsn: 4.541 ± 0.459
1.766AspPro: 1.766 ± 0.872
2.775AspGln: 2.775 ± 0.657
2.27AspArg: 2.27 ± 0.572
3.28AspSer: 3.28 ± 0.56
3.027AspThr: 3.027 ± 0.248
3.784AspVal: 3.784 ± 0.641
0.757AspTrp: 0.757 ± 0.191
3.28AspTyr: 3.28 ± 1.433
0.0AspXaa: 0.0 ± 0.0
Glu
3.532GluAla: 3.532 ± 0.936
1.009GluCys: 1.009 ± 0.569
3.28GluAsp: 3.28 ± 0.333
5.55GluGlu: 5.55 ± 1.272
2.775GluPhe: 2.775 ± 1.681
1.261GluGly: 1.261 ± 0.798
2.018GluHis: 2.018 ± 0.545
5.802GluIle: 5.802 ± 1.6
4.793GluLys: 4.793 ± 0.59
6.054GluLeu: 6.054 ± 0.697
2.775GluMet: 2.775 ± 0.708
3.532GluAsn: 3.532 ± 0.845
2.018GluPro: 2.018 ± 0.47
2.018GluGln: 2.018 ± 1.096
3.532GluArg: 3.532 ± 1.168
6.559GluSer: 6.559 ± 1.263
3.532GluThr: 3.532 ± 0.779
2.27GluVal: 2.27 ± 1.375
0.252GluTrp: 0.252 ± 0.162
1.514GluTyr: 1.514 ± 0.637
0.0GluXaa: 0.0 ± 0.0
Phe
1.261PheAla: 1.261 ± 0.468
2.27PheCys: 2.27 ± 0.73
2.775PheAsp: 2.775 ± 0.731
1.766PheGlu: 1.766 ± 0.51
2.775PhePhe: 2.775 ± 1.533
3.28PheGly: 3.28 ± 1.711
0.757PheHis: 0.757 ± 0.191
3.532PheIle: 3.532 ± 0.781
6.811PheLys: 6.811 ± 1.329
6.307PheLeu: 6.307 ± 2.622
1.009PheMet: 1.009 ± 0.649
2.523PheAsn: 2.523 ± 0.952
1.766PhePro: 1.766 ± 1.262
1.514PheGln: 1.514 ± 0.409
2.018PheArg: 2.018 ± 0.956
3.28PheSer: 3.28 ± 0.757
3.28PheThr: 3.28 ± 0.333
2.018PheVal: 2.018 ± 0.956
0.505PheTrp: 0.505 ± 0.136
1.514PheTyr: 1.514 ± 1.239
0.0PheXaa: 0.0 ± 0.0
Gly
1.261GlyAla: 1.261 ± 1.156
2.523GlyCys: 2.523 ± 0.936
3.027GlyAsp: 3.027 ± 0.696
2.27GlyGlu: 2.27 ± 0.675
1.514GlyPhe: 1.514 ± 0.409
2.27GlyGly: 2.27 ± 0.803
1.261GlyHis: 1.261 ± 0.289
6.307GlyIle: 6.307 ± 1.048
1.514GlyLys: 1.514 ± 0.814
3.027GlyLeu: 3.027 ± 1.529
0.505GlyMet: 0.505 ± 0.462
2.775GlyAsn: 2.775 ± 1.092
1.261GlyPro: 1.261 ± 0.52
1.514GlyGln: 1.514 ± 0.381
1.514GlyArg: 1.514 ± 0.743
2.523GlySer: 2.523 ± 0.936
2.018GlyThr: 2.018 ± 1.519
1.514GlyVal: 1.514 ± 0.409
1.009GlyTrp: 1.009 ± 1.329
2.018GlyTyr: 2.018 ± 1.316
0.0GlyXaa: 0.0 ± 0.0
His
1.766HisAla: 1.766 ± 0.598
1.514HisCys: 1.514 ± 1.028
0.757HisAsp: 0.757 ± 0.343
0.757HisGlu: 0.757 ± 0.487
1.514HisPhe: 1.514 ± 1.334
1.261HisGly: 1.261 ± 0.811
0.757HisHis: 0.757 ± 0.487
2.27HisIle: 2.27 ± 0.747
2.27HisLys: 2.27 ± 0.538
2.018HisLeu: 2.018 ± 0.949
0.505HisMet: 0.505 ± 0.136
0.757HisAsn: 0.757 ± 0.191
1.009HisPro: 1.009 ± 0.569
0.252HisGln: 0.252 ± 0.231
1.514HisArg: 1.514 ± 0.934
1.261HisSer: 1.261 ± 0.961
2.018HisThr: 2.018 ± 0.47
1.261HisVal: 1.261 ± 0.289
0.252HisTrp: 0.252 ± 0.162
1.009HisTyr: 1.009 ± 0.273
0.0HisXaa: 0.0 ± 0.0
Ile
4.036IleAla: 4.036 ± 0.758
2.27IleCys: 2.27 ± 1.366
6.811IleAsp: 6.811 ± 1.561
7.82IleGlu: 7.82 ± 0.756
4.793IlePhe: 4.793 ± 0.764
4.036IleGly: 4.036 ± 0.439
3.784IleHis: 3.784 ± 1.584
6.559IleIle: 6.559 ± 1.83
8.073IleLys: 8.073 ± 1.849
9.334IleLeu: 9.334 ± 1.52
1.766IleMet: 1.766 ± 0.41
7.316IleAsn: 7.316 ± 0.759
3.027IlePro: 3.027 ± 0.701
1.766IleGln: 1.766 ± 0.51
3.784IleArg: 3.784 ± 0.866
6.811IleSer: 6.811 ± 1.488
6.054IleThr: 6.054 ± 0.447
3.784IleVal: 3.784 ± 0.867
0.505IleTrp: 0.505 ± 0.324
2.523IleTyr: 2.523 ± 0.65
0.0IleXaa: 0.0 ± 0.0
Lys
2.27LysAla: 2.27 ± 0.48
1.514LysCys: 1.514 ± 1.387
5.298LysAsp: 5.298 ± 1.291
5.802LysGlu: 5.802 ± 1.814
3.027LysPhe: 3.027 ± 0.368
3.28LysGly: 3.28 ± 1.763
2.27LysHis: 2.27 ± 0.538
7.064LysIle: 7.064 ± 2.223
7.568LysLys: 7.568 ± 0.676
7.568LysLeu: 7.568 ± 2.091
2.018LysMet: 2.018 ± 0.422
3.027LysAsn: 3.027 ± 0.763
2.018LysPro: 2.018 ± 0.654
2.775LysGln: 2.775 ± 0.669
4.289LysArg: 4.289 ± 1.441
4.289LysSer: 4.289 ± 1.071
4.793LysThr: 4.793 ± 0.558
5.298LysVal: 5.298 ± 0.538
0.252LysTrp: 0.252 ± 0.162
2.27LysTyr: 2.27 ± 1.805
0.0LysXaa: 0.0 ± 0.0
Leu
3.784LeuAla: 3.784 ± 1.63
1.766LeuCys: 1.766 ± 0.598
5.802LeuAsp: 5.802 ± 0.911
7.568LeuGlu: 7.568 ± 2.887
5.802LeuPhe: 5.802 ± 0.936
4.036LeuGly: 4.036 ± 0.306
2.27LeuHis: 2.27 ± 1.034
10.595LeuIle: 10.595 ± 1.797
8.325LeuLys: 8.325 ± 1.911
6.307LeuLeu: 6.307 ± 0.942
2.523LeuMet: 2.523 ± 0.926
8.325LeuAsn: 8.325 ± 1.249
4.036LeuPro: 4.036 ± 0.941
1.261LeuGln: 1.261 ± 0.52
2.27LeuArg: 2.27 ± 0.797
6.307LeuSer: 6.307 ± 2.311
7.82LeuThr: 7.82 ± 1.122
3.784LeuVal: 3.784 ± 0.867
1.009LeuTrp: 1.009 ± 0.807
4.036LeuTyr: 4.036 ± 1.075
0.0LeuXaa: 0.0 ± 0.0
Met
0.757MetAla: 0.757 ± 0.798
1.261MetCys: 1.261 ± 0.468
1.766MetAsp: 1.766 ± 0.51
1.766MetGlu: 1.766 ± 0.606
1.766MetPhe: 1.766 ± 0.406
1.009MetGly: 1.009 ± 0.807
0.505MetHis: 0.505 ± 0.136
3.027MetIle: 3.027 ± 0.657
1.766MetLys: 1.766 ± 0.51
3.027MetLeu: 3.027 ± 1.754
1.009MetMet: 1.009 ± 0.548
1.261MetAsn: 1.261 ± 0.479
0.505MetPro: 0.505 ± 0.324
1.514MetGln: 1.514 ± 0.845
1.261MetArg: 1.261 ± 0.543
2.27MetSer: 2.27 ± 0.572
1.261MetThr: 1.261 ± 0.811
1.261MetVal: 1.261 ± 0.289
0.0MetTrp: 0.0 ± 0.0
1.009MetTyr: 1.009 ± 0.327
0.0MetXaa: 0.0 ± 0.0
Asn
3.28AsnAla: 3.28 ± 1.136
2.27AsnCys: 2.27 ± 1.366
3.784AsnAsp: 3.784 ± 1.161
4.289AsnGlu: 4.289 ± 0.441
5.045AsnPhe: 5.045 ± 0.523
1.766AsnGly: 1.766 ± 1.159
1.766AsnHis: 1.766 ± 0.41
5.298AsnIle: 5.298 ± 0.538
5.802AsnLys: 5.802 ± 1.333
5.802AsnLeu: 5.802 ± 1.582
2.27AsnMet: 2.27 ± 0.797
4.541AsnAsn: 4.541 ± 1.104
2.523AsnPro: 2.523 ± 1.039
2.523AsnGln: 2.523 ± 0.681
2.018AsnArg: 2.018 ± 1.148
4.289AsnSer: 4.289 ± 1.269
3.027AsnThr: 3.027 ± 1.26
1.766AsnVal: 1.766 ± 1.22
0.757AsnTrp: 0.757 ± 0.343
4.289AsnTyr: 4.289 ± 1.634
0.0AsnXaa: 0.0 ± 0.0
Pro
1.766ProAla: 1.766 ± 0.51
0.252ProCys: 0.252 ± 0.231
1.766ProAsp: 1.766 ± 0.51
3.532ProGlu: 3.532 ± 1.602
1.261ProPhe: 1.261 ± 0.479
2.27ProGly: 2.27 ± 1.067
0.505ProHis: 0.505 ± 0.136
3.28ProIle: 3.28 ± 0.56
2.018ProLys: 2.018 ± 0.744
4.036ProLeu: 4.036 ± 0.306
0.757ProMet: 0.757 ± 0.343
0.757ProAsn: 0.757 ± 0.191
0.505ProPro: 0.505 ± 0.136
0.252ProGln: 0.252 ± 0.231
0.505ProArg: 0.505 ± 0.324
3.027ProSer: 3.027 ± 1.274
0.757ProThr: 0.757 ± 0.191
1.766ProVal: 1.766 ± 1.172
0.757ProTrp: 0.757 ± 0.191
0.757ProTyr: 0.757 ± 0.191
0.0ProXaa: 0.0 ± 0.0
Gln
1.261GlnAla: 1.261 ± 0.52
0.505GlnCys: 0.505 ± 0.136
1.766GlnAsp: 1.766 ± 0.598
1.009GlnGlu: 1.009 ± 0.649
1.009GlnPhe: 1.009 ± 0.649
1.514GlnGly: 1.514 ± 0.819
1.009GlnHis: 1.009 ± 0.569
2.018GlnIle: 2.018 ± 0.545
3.28GlnLys: 3.28 ± 1.834
2.775GlnLeu: 2.775 ± 0.864
0.252GlnMet: 0.252 ± 0.162
1.766GlnAsn: 1.766 ± 0.406
0.505GlnPro: 0.505 ± 0.462
2.018GlnGln: 2.018 ± 2.008
1.009GlnArg: 1.009 ± 0.649
2.523GlnSer: 2.523 ± 1.043
2.523GlnThr: 2.523 ± 0.681
2.523GlnVal: 2.523 ± 0.689
0.757GlnTrp: 0.757 ± 0.798
1.766GlnTyr: 1.766 ± 0.606
0.0GlnXaa: 0.0 ± 0.0
Arg
1.766ArgAla: 1.766 ± 0.41
1.766ArgCys: 1.766 ± 0.41
2.775ArgAsp: 2.775 ± 1.281
3.28ArgGlu: 3.28 ± 0.916
1.766ArgPhe: 1.766 ± 0.406
0.505ArgGly: 0.505 ± 0.324
0.757ArgHis: 0.757 ± 0.487
3.027ArgIle: 3.027 ± 1.33
2.523ArgLys: 2.523 ± 0.578
5.298ArgLeu: 5.298 ± 1.848
1.261ArgMet: 1.261 ± 0.468
3.027ArgAsn: 3.027 ± 0.248
0.757ArgPro: 0.757 ± 0.191
1.009ArgGln: 1.009 ± 0.548
1.261ArgArg: 1.261 ± 0.479
4.289ArgSer: 4.289 ± 1.933
2.018ArgThr: 2.018 ± 0.96
2.018ArgVal: 2.018 ± 0.703
0.505ArgTrp: 0.505 ± 0.324
2.775ArgTyr: 2.775 ± 1.154
0.0ArgXaa: 0.0 ± 0.0
Ser
2.523SerAla: 2.523 ± 1.039
2.775SerCys: 2.775 ± 1.825
3.784SerAsp: 3.784 ± 1.438
4.793SerGlu: 4.793 ± 0.59
2.27SerPhe: 2.27 ± 1.056
2.27SerGly: 2.27 ± 0.803
1.261SerHis: 1.261 ± 0.793
7.316SerIle: 7.316 ± 1.67
5.802SerLys: 5.802 ± 1.118
9.334SerLeu: 9.334 ± 0.497
2.775SerMet: 2.775 ± 1.529
4.036SerAsn: 4.036 ± 1.106
2.27SerPro: 2.27 ± 0.31
1.766SerGln: 1.766 ± 0.606
3.784SerArg: 3.784 ± 1.438
5.55SerSer: 5.55 ± 2.88
3.784SerThr: 3.784 ± 0.316
5.298SerVal: 5.298 ± 1.33
0.505SerTrp: 0.505 ± 0.136
2.523SerTyr: 2.523 ± 0.697
0.0SerXaa: 0.0 ± 0.0
Thr
1.261ThrAla: 1.261 ± 0.289
2.018ThrCys: 2.018 ± 1.138
2.775ThrAsp: 2.775 ± 0.669
3.28ThrGlu: 3.28 ± 0.915
3.027ThrPhe: 3.027 ± 1.689
3.027ThrGly: 3.027 ± 2.503
1.261ThrHis: 1.261 ± 0.52
6.307ThrIle: 6.307 ± 0.997
2.775ThrLys: 2.775 ± 0.835
4.036ThrLeu: 4.036 ± 1.268
1.514ThrMet: 1.514 ± 0.54
5.55ThrAsn: 5.55 ± 0.875
1.009ThrPro: 1.009 ± 0.273
2.27ThrGln: 2.27 ± 1.165
2.018ThrArg: 2.018 ± 0.744
5.298ThrSer: 5.298 ± 0.683
3.784ThrThr: 3.784 ± 0.713
2.775ThrVal: 2.775 ± 1.104
1.009ThrTrp: 1.009 ± 0.928
3.027ThrTyr: 3.027 ± 0.763
0.0ThrXaa: 0.0 ± 0.0
Val
1.514ValAla: 1.514 ± 0.451
1.009ValCys: 1.009 ± 0.273
1.514ValAsp: 1.514 ± 0.637
2.775ValGlu: 2.775 ± 0.864
3.784ValPhe: 3.784 ± 0.867
3.027ValGly: 3.027 ± 0.763
0.757ValHis: 0.757 ± 0.191
3.532ValIle: 3.532 ± 0.819
2.523ValLys: 2.523 ± 0.697
4.036ValLeu: 4.036 ± 0.759
1.009ValMet: 1.009 ± 0.649
2.775ValAsn: 2.775 ± 1.353
2.018ValPro: 2.018 ± 1.298
1.766ValGln: 1.766 ± 2.158
2.523ValArg: 2.523 ± 0.876
6.054ValSer: 6.054 ± 1.805
1.514ValThr: 1.514 ± 0.686
2.775ValVal: 2.775 ± 1.919
0.0ValTrp: 0.0 ± 0.0
2.775ValTyr: 2.775 ± 0.503
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.505TrpCys: 0.505 ± 0.136
0.252TrpAsp: 0.252 ± 0.231
0.757TrpGlu: 0.757 ± 0.619
0.757TrpPhe: 0.757 ± 0.343
0.252TrpGly: 0.252 ± 0.231
0.0TrpHis: 0.0 ± 0.0
1.261TrpIle: 1.261 ± 0.289
0.505TrpLys: 0.505 ± 0.721
2.018TrpLeu: 2.018 ± 0.744
0.0TrpMet: 0.0 ± 0.0
0.505TrpAsn: 0.505 ± 0.324
0.0TrpPro: 0.0 ± 0.0
0.252TrpGln: 0.252 ± 0.162
0.757TrpArg: 0.757 ± 0.619
1.009TrpSer: 1.009 ± 0.649
0.252TrpThr: 0.252 ± 0.714
0.252TrpVal: 0.252 ± 0.231
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.261TyrAla: 1.261 ± 1.292
0.0TyrCys: 0.0 ± 0.0
0.757TyrAsp: 0.757 ± 0.619
2.523TyrGlu: 2.523 ± 0.959
2.018TyrPhe: 2.018 ± 0.654
1.261TyrGly: 1.261 ± 0.289
1.261TyrHis: 1.261 ± 0.289
5.045TyrIle: 5.045 ± 1.156
3.027TyrLys: 3.027 ± 1.431
5.802TyrLeu: 5.802 ± 3.351
2.018TyrMet: 2.018 ± 0.47
4.289TyrAsn: 4.289 ± 0.441
1.514TyrPro: 1.514 ± 0.54
1.766TyrGln: 1.766 ± 0.796
3.027TyrArg: 3.027 ± 0.763
1.766TyrSer: 1.766 ± 0.51
2.523TyrThr: 2.523 ± 0.681
0.757TyrVal: 0.757 ± 0.343
0.252TyrTrp: 0.252 ± 0.162
0.757TyrTyr: 0.757 ± 0.343
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3965 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski