Amino acid dipepetide frequency for Arenimonas donghaensis DSM 18148 = HO3-R19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.937AlaAla: 17.937 ± 0.211
1.338AlaCys: 1.338 ± 0.043
7.56AlaAsp: 7.56 ± 0.102
7.671AlaGlu: 7.671 ± 0.121
4.101AlaPhe: 4.101 ± 0.077
12.324AlaGly: 12.324 ± 0.144
2.42AlaHis: 2.42 ± 0.053
4.983AlaIle: 4.983 ± 0.077
3.228AlaLys: 3.228 ± 0.086
16.044AlaLeu: 16.044 ± 0.185
3.5AlaMet: 3.5 ± 0.059
2.893AlaAsn: 2.893 ± 0.065
6.482AlaPro: 6.482 ± 0.104
4.486AlaGln: 4.486 ± 0.076
10.523AlaArg: 10.523 ± 0.149
6.595AlaSer: 6.595 ± 0.114
6.119AlaThr: 6.119 ± 0.103
8.873AlaVal: 8.873 ± 0.123
2.427AlaTrp: 2.427 ± 0.061
2.423AlaTyr: 2.423 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.987CysAla: 0.987 ± 0.045
0.096CysCys: 0.096 ± 0.011
0.457CysAsp: 0.457 ± 0.022
0.484CysGlu: 0.484 ± 0.022
0.286CysPhe: 0.286 ± 0.019
0.854CysGly: 0.854 ± 0.038
0.242CysHis: 0.242 ± 0.017
0.31CysIle: 0.31 ± 0.02
0.149CysLys: 0.149 ± 0.012
0.948CysLeu: 0.948 ± 0.033
0.119CysMet: 0.119 ± 0.01
0.19CysAsn: 0.19 ± 0.013
0.444CysPro: 0.444 ± 0.026
0.268CysGln: 0.268 ± 0.018
0.633CysArg: 0.633 ± 0.029
0.426CysSer: 0.426 ± 0.02
0.463CysThr: 0.463 ± 0.023
0.598CysVal: 0.598 ± 0.035
0.098CysTrp: 0.098 ± 0.009
0.201CysTyr: 0.201 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
7.992AspAla: 7.992 ± 0.117
0.486AspCys: 0.486 ± 0.026
3.576AspAsp: 3.576 ± 0.079
3.626AspGlu: 3.626 ± 0.07
2.196AspPhe: 2.196 ± 0.05
5.769AspGly: 5.769 ± 0.097
1.101AspHis: 1.101 ± 0.04
2.434AspIle: 2.434 ± 0.055
1.487AspLys: 1.487 ± 0.042
6.135AspLeu: 6.135 ± 0.095
1.101AspMet: 1.101 ± 0.038
1.182AspAsn: 1.182 ± 0.045
3.931AspPro: 3.931 ± 0.075
2.056AspGln: 2.056 ± 0.05
4.203AspArg: 4.203 ± 0.081
2.347AspSer: 2.347 ± 0.048
2.735AspThr: 2.735 ± 0.051
4.339AspVal: 4.339 ± 0.074
1.141AspTrp: 1.141 ± 0.039
1.663AspTyr: 1.663 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
8.171GluAla: 8.171 ± 0.106
0.345GluCys: 0.345 ± 0.023
2.812GluAsp: 2.812 ± 0.065
2.64GluGlu: 2.64 ± 0.072
1.824GluPhe: 1.824 ± 0.052
4.549GluGly: 4.549 ± 0.08
1.397GluHis: 1.397 ± 0.04
2.458GluIle: 2.458 ± 0.049
1.668GluLys: 1.668 ± 0.046
6.499GluLeu: 6.499 ± 0.096
1.166GluMet: 1.166 ± 0.04
1.279GluAsn: 1.279 ± 0.041
3.129GluPro: 3.129 ± 0.082
2.423GluGln: 2.423 ± 0.056
5.319GluArg: 5.319 ± 0.087
2.73GluSer: 2.73 ± 0.053
2.695GluThr: 2.695 ± 0.055
4.418GluVal: 4.418 ± 0.076
0.65GluTrp: 0.65 ± 0.031
1.003GluTyr: 1.003 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.069PheAla: 4.069 ± 0.067
0.328PheCys: 0.328 ± 0.018
2.585PheAsp: 2.585 ± 0.055
2.224PheGlu: 2.224 ± 0.048
1.179PhePhe: 1.179 ± 0.047
3.377PheGly: 3.377 ± 0.065
0.794PheHis: 0.794 ± 0.031
1.248PheIle: 1.248 ± 0.042
0.836PheLys: 0.836 ± 0.032
3.198PheLeu: 3.198 ± 0.073
0.639PheMet: 0.639 ± 0.028
0.955PheAsn: 0.955 ± 0.036
1.521PhePro: 1.521 ± 0.041
1.022PheGln: 1.022 ± 0.034
2.254PheArg: 2.254 ± 0.054
2.0PheSer: 2.0 ± 0.052
1.839PheThr: 1.839 ± 0.044
2.515PheVal: 2.515 ± 0.056
0.514PheTrp: 0.514 ± 0.024
0.768PheTyr: 0.768 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
8.964GlyAla: 8.964 ± 0.114
0.825GlyCys: 0.825 ± 0.036
5.345GlyAsp: 5.345 ± 0.112
5.604GlyGlu: 5.604 ± 0.085
3.566GlyPhe: 3.566 ± 0.058
7.514GlyGly: 7.514 ± 0.139
2.149GlyHis: 2.149 ± 0.053
3.688GlyIle: 3.688 ± 0.069
3.087GlyLys: 3.087 ± 0.076
10.236GlyLeu: 10.236 ± 0.143
2.316GlyMet: 2.316 ± 0.051
2.341GlyAsn: 2.341 ± 0.052
3.728GlyPro: 3.728 ± 0.073
3.551GlyGln: 3.551 ± 0.057
6.725GlyArg: 6.725 ± 0.103
4.692GlySer: 4.692 ± 0.086
4.15GlyThr: 4.15 ± 0.096
6.441GlyVal: 6.441 ± 0.099
1.676GlyTrp: 1.676 ± 0.043
2.245GlyTyr: 2.245 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.902HisAla: 2.902 ± 0.062
0.269HisCys: 0.269 ± 0.017
1.311HisAsp: 1.311 ± 0.043
1.188HisGlu: 1.188 ± 0.039
0.86HisPhe: 0.86 ± 0.037
2.233HisGly: 2.233 ± 0.057
0.575HisHis: 0.575 ± 0.029
0.657HisIle: 0.657 ± 0.028
0.443HisLys: 0.443 ± 0.025
2.291HisLeu: 2.291 ± 0.051
0.369HisMet: 0.369 ± 0.024
0.427HisAsn: 0.427 ± 0.022
1.491HisPro: 1.491 ± 0.04
0.634HisGln: 0.634 ± 0.024
1.672HisArg: 1.672 ± 0.048
0.838HisSer: 0.838 ± 0.036
0.852HisThr: 0.852 ± 0.032
1.565HisVal: 1.565 ± 0.048
0.433HisTrp: 0.433 ± 0.021
0.591HisTyr: 0.591 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.275IleAla: 5.275 ± 0.088
0.304IleCys: 0.304 ± 0.017
2.624IleAsp: 2.624 ± 0.055
2.923IleGlu: 2.923 ± 0.069
1.022IlePhe: 1.022 ± 0.045
3.747IleGly: 3.747 ± 0.076
0.774IleHis: 0.774 ± 0.032
1.302IleIle: 1.302 ± 0.043
1.022IleLys: 1.022 ± 0.037
2.955IleLeu: 2.955 ± 0.068
0.521IleMet: 0.521 ± 0.025
1.158IleAsn: 1.158 ± 0.038
1.832IlePro: 1.832 ± 0.047
1.031IleGln: 1.031 ± 0.034
2.5IleArg: 2.5 ± 0.055
1.884IleSer: 1.884 ± 0.051
2.115IleThr: 2.115 ± 0.058
2.917IleVal: 2.917 ± 0.059
0.375IleTrp: 0.375 ± 0.022
0.809IleTyr: 0.809 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.485LysAla: 3.485 ± 0.079
0.129LysCys: 0.129 ± 0.014
1.44LysAsp: 1.44 ± 0.05
1.145LysGlu: 1.145 ± 0.046
0.707LysPhe: 0.707 ± 0.031
1.911LysGly: 1.911 ± 0.056
0.591LysHis: 0.591 ± 0.024
1.006LysIle: 1.006 ± 0.042
1.04LysLys: 1.04 ± 0.059
2.876LysLeu: 2.876 ± 0.063
0.566LysMet: 0.566 ± 0.026
0.567LysAsn: 0.567 ± 0.028
1.844LysPro: 1.844 ± 0.061
0.946LysGln: 0.946 ± 0.037
2.01LysArg: 2.01 ± 0.054
1.323LysSer: 1.323 ± 0.045
1.266LysThr: 1.266 ± 0.039
2.142LysVal: 2.142 ± 0.057
0.255LysTrp: 0.255 ± 0.016
0.57LysTyr: 0.57 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
18.368LeuAla: 18.368 ± 0.216
0.889LeuCys: 0.889 ± 0.034
6.998LeuAsp: 6.998 ± 0.106
5.992LeuGlu: 5.992 ± 0.094
3.417LeuPhe: 3.417 ± 0.07
9.771LeuGly: 9.771 ± 0.129
2.337LeuHis: 2.337 ± 0.055
3.0LeuIle: 3.0 ± 0.063
2.676LeuLys: 2.676 ± 0.057
12.25LeuLeu: 12.25 ± 0.201
2.367LeuMet: 2.367 ± 0.061
2.001LeuAsn: 2.001 ± 0.052
6.906LeuPro: 6.906 ± 0.099
3.652LeuGln: 3.652 ± 0.08
9.17LeuArg: 9.17 ± 0.136
5.876LeuSer: 5.876 ± 0.097
4.433LeuThr: 4.433 ± 0.146
9.621LeuVal: 9.621 ± 0.112
1.454LeuTrp: 1.454 ± 0.049
2.05LeuTyr: 2.05 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.051MetAla: 3.051 ± 0.059
0.143MetCys: 0.143 ± 0.013
1.221MetAsp: 1.221 ± 0.038
0.877MetGlu: 0.877 ± 0.028
0.633MetPhe: 0.633 ± 0.029
1.644MetGly: 1.644 ± 0.048
0.451MetHis: 0.451 ± 0.022
0.801MetIle: 0.801 ± 0.033
0.806MetLys: 0.806 ± 0.029
2.343MetLeu: 2.343 ± 0.053
0.453MetMet: 0.453 ± 0.024
0.659MetAsn: 0.659 ± 0.027
1.434MetPro: 1.434 ± 0.04
0.843MetGln: 0.843 ± 0.029
1.62MetArg: 1.62 ± 0.042
1.437MetSer: 1.437 ± 0.043
1.185MetThr: 1.185 ± 0.041
1.538MetVal: 1.538 ± 0.049
0.196MetTrp: 0.196 ± 0.016
0.35MetTyr: 0.35 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.898AsnAla: 2.898 ± 0.07
0.213AsnCys: 0.213 ± 0.015
1.3AsnAsp: 1.3 ± 0.043
1.108AsnGlu: 1.108 ± 0.036
0.826AsnPhe: 0.826 ± 0.034
1.983AsnGly: 1.983 ± 0.061
0.482AsnHis: 0.482 ± 0.023
0.976AsnIle: 0.976 ± 0.035
0.547AsnLys: 0.547 ± 0.026
2.454AsnLeu: 2.454 ± 0.053
0.359AsnMet: 0.359 ± 0.018
0.606AsnAsn: 0.606 ± 0.036
1.698AsnPro: 1.698 ± 0.045
0.835AsnGln: 0.835 ± 0.028
1.654AsnArg: 1.654 ± 0.047
0.959AsnSer: 0.959 ± 0.041
1.249AsnThr: 1.249 ± 0.093
1.641AsnVal: 1.641 ± 0.043
0.356AsnTrp: 0.356 ± 0.02
0.602AsnTyr: 0.602 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
8.199ProAla: 8.199 ± 0.143
0.306ProCys: 0.306 ± 0.019
3.969ProAsp: 3.969 ± 0.076
3.786ProGlu: 3.786 ± 0.085
1.595ProPhe: 1.595 ± 0.044
6.037ProGly: 6.037 ± 0.095
1.018ProHis: 1.018 ± 0.034
1.712ProIle: 1.712 ± 0.053
1.23ProLys: 1.23 ± 0.037
5.492ProLeu: 5.492 ± 0.077
1.418ProMet: 1.418 ± 0.039
1.049ProAsn: 1.049 ± 0.037
3.112ProPro: 3.112 ± 0.086
1.671ProGln: 1.671 ± 0.042
3.689ProArg: 3.689 ± 0.076
2.494ProSer: 2.494 ± 0.051
2.336ProThr: 2.336 ± 0.055
4.786ProVal: 4.786 ± 0.08
0.893ProTrp: 0.893 ± 0.033
1.043ProTyr: 1.043 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
5.949GlnAla: 5.949 ± 0.095
0.206GlnCys: 0.206 ± 0.015
1.684GlnAsp: 1.684 ± 0.044
1.419GlnGlu: 1.419 ± 0.038
1.071GlnPhe: 1.071 ± 0.039
2.992GlnGly: 2.992 ± 0.052
0.731GlnHis: 0.731 ± 0.027
1.174GlnIle: 1.174 ± 0.034
0.803GlnLys: 0.803 ± 0.032
3.915GlnLeu: 3.915 ± 0.071
0.749GlnMet: 0.749 ± 0.027
0.619GlnAsn: 0.619 ± 0.029
2.067GlnPro: 2.067 ± 0.051
1.359GlnGln: 1.359 ± 0.043
3.259GlnArg: 3.259 ± 0.067
1.627GlnSer: 1.627 ± 0.041
1.308GlnThr: 1.308 ± 0.036
3.311GlnVal: 3.311 ± 0.079
0.536GlnTrp: 0.536 ± 0.026
0.605GlnTyr: 0.605 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
8.607ArgAla: 8.607 ± 0.114
0.606ArgCys: 0.606 ± 0.026
4.794ArgAsp: 4.794 ± 0.083
5.257ArgGlu: 5.257 ± 0.084
3.065ArgPhe: 3.065 ± 0.06
5.565ArgGly: 5.565 ± 0.088
1.965ArgHis: 1.965 ± 0.057
3.547ArgIle: 3.547 ± 0.073
2.07ArgLys: 2.07 ± 0.048
9.637ArgLeu: 9.637 ± 0.127
1.771ArgMet: 1.771 ± 0.046
1.737ArgAsn: 1.737 ± 0.04
3.807ArgPro: 3.807 ± 0.079
3.199ArgGln: 3.199 ± 0.071
6.536ArgArg: 6.536 ± 0.114
3.534ArgSer: 3.534 ± 0.067
3.014ArgThr: 3.014 ± 0.064
5.513ArgVal: 5.513 ± 0.083
1.441ArgTrp: 1.441 ± 0.048
2.079ArgTyr: 2.079 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
5.861SerAla: 5.861 ± 0.078
0.381SerCys: 0.381 ± 0.028
2.616SerAsp: 2.616 ± 0.058
2.603SerGlu: 2.603 ± 0.059
1.826SerPhe: 1.826 ± 0.045
4.982SerGly: 4.982 ± 0.1
1.132SerHis: 1.132 ± 0.036
1.804SerIle: 1.804 ± 0.047
1.237SerLys: 1.237 ± 0.041
5.955SerLeu: 5.955 ± 0.084
0.994SerMet: 0.994 ± 0.038
1.23SerAsn: 1.23 ± 0.053
2.99SerPro: 2.99 ± 0.061
1.737SerGln: 1.737 ± 0.044
3.714SerArg: 3.714 ± 0.065
2.297SerSer: 2.297 ± 0.055
2.393SerThr: 2.393 ± 0.069
3.632SerVal: 3.632 ± 0.086
0.697SerTrp: 0.697 ± 0.029
1.113SerTyr: 1.113 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.335ThrAla: 5.335 ± 0.083
0.436ThrCys: 0.436 ± 0.038
2.546ThrAsp: 2.546 ± 0.063
2.252ThrGlu: 2.252 ± 0.061
1.407ThrPhe: 1.407 ± 0.046
4.752ThrGly: 4.752 ± 0.095
0.99ThrHis: 0.99 ± 0.041
1.713ThrIle: 1.713 ± 0.059
0.856ThrLys: 0.856 ± 0.037
5.807ThrLeu: 5.807 ± 0.13
0.838ThrMet: 0.838 ± 0.029
0.975ThrAsn: 0.975 ± 0.052
3.272ThrPro: 3.272 ± 0.08
1.385ThrGln: 1.385 ± 0.04
3.313ThrArg: 3.313 ± 0.063
2.192ThrSer: 2.192 ± 0.078
2.283ThrThr: 2.283 ± 0.073
3.898ThrVal: 3.898 ± 0.103
0.749ThrTrp: 0.749 ± 0.029
0.98ThrTyr: 0.98 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.935ValAla: 9.935 ± 0.123
0.617ValCys: 0.617 ± 0.028
4.71ValAsp: 4.71 ± 0.072
4.576ValGlu: 4.576 ± 0.087
2.824ValPhe: 2.824 ± 0.059
5.877ValGly: 5.877 ± 0.097
1.656ValHis: 1.656 ± 0.046
3.104ValIle: 3.104 ± 0.059
1.814ValLys: 1.814 ± 0.056
9.192ValLeu: 9.192 ± 0.113
1.697ValMet: 1.697 ± 0.044
1.95ValAsn: 1.95 ± 0.062
4.164ValPro: 4.164 ± 0.083
2.684ValGln: 2.684 ± 0.059
5.559ValArg: 5.559 ± 0.085
4.025ValSer: 4.025 ± 0.083
3.649ValThr: 3.649 ± 0.115
6.767ValVal: 6.767 ± 0.168
0.842ValTrp: 0.842 ± 0.034
1.518ValTyr: 1.518 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.33TrpAla: 1.33 ± 0.042
0.161TrpCys: 0.161 ± 0.013
0.679TrpAsp: 0.679 ± 0.029
0.606TrpGlu: 0.606 ± 0.029
0.605TrpPhe: 0.605 ± 0.027
0.943TrpGly: 0.943 ± 0.036
0.376TrpHis: 0.376 ± 0.021
0.588TrpIle: 0.588 ± 0.023
0.375TrpLys: 0.375 ± 0.023
2.464TrpLeu: 2.464 ± 0.065
0.373TrpMet: 0.373 ± 0.019
0.406TrpAsn: 0.406 ± 0.023
0.884TrpPro: 0.884 ± 0.037
0.787TrpGln: 0.787 ± 0.032
1.47TrpArg: 1.47 ± 0.052
0.81TrpSer: 0.81 ± 0.033
0.786TrpThr: 0.786 ± 0.034
1.111TrpVal: 1.111 ± 0.041
0.306TrpTrp: 0.306 ± 0.02
0.354TrpTyr: 0.354 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.612TyrAla: 2.612 ± 0.053
0.178TyrCys: 0.178 ± 0.015
1.27TyrAsp: 1.27 ± 0.04
1.194TyrGlu: 1.194 ± 0.041
0.853TyrPhe: 0.853 ± 0.032
2.018TyrGly: 2.018 ± 0.05
0.422TyrHis: 0.422 ± 0.023
0.585TyrIle: 0.585 ± 0.026
0.448TyrLys: 0.448 ± 0.023
2.538TyrLeu: 2.538 ± 0.059
0.369TyrMet: 0.369 ± 0.021
0.525TyrAsn: 0.525 ± 0.029
1.099TyrPro: 1.099 ± 0.041
0.814TyrGln: 0.814 ± 0.032
1.92TyrArg: 1.92 ± 0.052
1.11TyrSer: 1.11 ± 0.036
1.109TyrThr: 1.109 ± 0.049
1.534TyrVal: 1.534 ± 0.047
0.371TyrTrp: 0.371 ± 0.018
0.588TyrTyr: 0.588 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2685 proteins (904662 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski