Amino acid dipepetide frequency for Mycobacterium riyadhense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.972AlaAla: 20.972 ± 0.193	1.03AlaCys: 1.03 ± 0.028	7.7AlaAsp: 7.7 ± 0.077	7.218AlaGlu: 7.218 ± 0.084	3.394AlaPhe: 3.394 ± 0.049	14.057AlaGly: 14.057 ± 0.327	2.515AlaHis: 2.515 ± 0.038	5.39AlaIle: 5.39 ± 0.058	2.981AlaLys: 2.981 ± 0.049	12.343AlaLeu: 12.343 ± 0.115	2.918AlaMet: 2.918 ± 0.044	3.233AlaAsn: 3.233 ± 0.065	6.129AlaPro: 6.129 ± 0.082	4.179AlaGln: 4.179 ± 0.062	8.394AlaArg: 8.394 ± 0.092	6.28AlaSer: 6.28 ± 0.06	7.332AlaThr: 7.332 ± 0.087	10.879AlaVal: 10.879 ± 0.099	1.628AlaTrp: 1.628 ± 0.034	2.25AlaTyr: 2.25 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.107CysAla: 1.107 ± 0.025	0.109CysCys: 0.109 ± 0.008	0.564CysAsp: 0.564 ± 0.023	0.433CysGlu: 0.433 ± 0.014	0.232CysPhe: 0.232 ± 0.012	0.94CysGly: 0.94 ± 0.026	0.187CysHis: 0.187 ± 0.01	0.251CysIle: 0.251 ± 0.012	0.131CysLys: 0.131 ± 0.008	0.669CysLeu: 0.669 ± 0.019	0.152CysMet: 0.152 ± 0.009	0.178CysAsn: 0.178 ± 0.01	0.498CysPro: 0.498 ± 0.018	0.245CysGln: 0.245 ± 0.012	0.612CysArg: 0.612 ± 0.019	0.49CysSer: 0.49 ± 0.017	0.462CysThr: 0.462 ± 0.017	0.666CysVal: 0.666 ± 0.023	0.128CysTrp: 0.128 ± 0.008	0.21CysTyr: 0.21 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.109AspAla: 7.109 ± 0.068	0.442AspCys: 0.442 ± 0.019	3.712AspAsp: 3.712 ± 0.055	3.658AspGlu: 3.658 ± 0.051	1.724AspPhe: 1.724 ± 0.03	6.036AspGly: 6.036 ± 0.117	1.379AspHis: 1.379 ± 0.03	2.566AspIle: 2.566 ± 0.043	1.225AspLys: 1.225 ± 0.029	5.515AspLeu: 5.515 ± 0.066	0.963AspMet: 0.963 ± 0.022	1.275AspAsn: 1.275 ± 0.028	4.067AspPro: 4.067 ± 0.054	1.756AspGln: 1.756 ± 0.032	4.228AspArg: 4.228 ± 0.056	2.671AspSer: 2.671 ± 0.038	2.973AspThr: 2.973 ± 0.045	4.854AspVal: 4.854 ± 0.053	0.923AspTrp: 0.923 ± 0.026	1.379AspTyr: 1.379 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.709GluAla: 5.709 ± 0.069	0.38GluCys: 0.38 ± 0.015	2.09GluAsp: 2.09 ± 0.038	2.203GluGlu: 2.203 ± 0.047	1.725GluPhe: 1.725 ± 0.039	2.989GluGly: 2.989 ± 0.042	1.442GluHis: 1.442 ± 0.03	2.51GluIle: 2.51 ± 0.035	1.112GluLys: 1.112 ± 0.025	6.337GluLeu: 6.337 ± 0.076	1.042GluMet: 1.042 ± 0.023	0.973GluAsn: 0.973 ± 0.025	2.764GluPro: 2.764 ± 0.045	2.107GluGln: 2.107 ± 0.037	4.105GluArg: 4.105 ± 0.056	2.531GluSer: 2.531 ± 0.043	2.449GluThr: 2.449 ± 0.041	4.094GluVal: 4.094 ± 0.058	0.676GluTrp: 0.676 ± 0.021	1.059GluTyr: 1.059 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.958PheAla: 3.958 ± 0.056	0.313PheCys: 0.313 ± 0.014	2.332PheAsp: 2.332 ± 0.041	1.476PheGlu: 1.476 ± 0.032	1.069PhePhe: 1.069 ± 0.031	3.887PheGly: 3.887 ± 0.078	0.661PheHis: 0.661 ± 0.02	1.072PheIle: 1.072 ± 0.025	0.53PheLys: 0.53 ± 0.021	2.354PheLeu: 2.354 ± 0.043	0.468PheMet: 0.468 ± 0.017	1.081PheAsn: 1.081 ± 0.063	1.407PhePro: 1.407 ± 0.027	0.713PheGln: 0.713 ± 0.02	1.654PheArg: 1.654 ± 0.032	1.702PheSer: 1.702 ± 0.032	1.96PheThr: 1.96 ± 0.035	2.518PheVal: 2.518 ± 0.042	0.424PheTrp: 0.424 ± 0.017	0.687PheTyr: 0.687 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.997GlyAla: 11.997 ± 0.296	0.852GlyCys: 0.852 ± 0.025	5.37GlyAsp: 5.37 ± 0.115	4.007GlyGlu: 4.007 ± 0.052	3.449GlyPhe: 3.449 ± 0.095	14.305GlyGly: 14.305 ± 0.951	2.17GlyHis: 2.17 ± 0.05	4.448GlyIle: 4.448 ± 0.056	2.368GlyLys: 2.368 ± 0.04	8.98GlyLeu: 8.98 ± 0.089	2.148GlyMet: 2.148 ± 0.036	4.277GlyAsn: 4.277 ± 0.249	4.714GlyPro: 4.714 ± 0.063	3.292GlyGln: 3.292 ± 0.107	5.996GlyArg: 5.996 ± 0.062	6.405GlySer: 6.405 ± 0.129	6.33GlyThr: 6.33 ± 0.232	7.698GlyVal: 7.698 ± 0.086	1.674GlyTrp: 1.674 ± 0.032	2.374GlyTyr: 2.374 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.511HisAla: 2.511 ± 0.04	0.232HisCys: 0.232 ± 0.011	1.348HisAsp: 1.348 ± 0.03	1.032HisGlu: 1.032 ± 0.024	0.657HisPhe: 0.657 ± 0.019	2.198HisGly: 2.198 ± 0.046	0.639HisHis: 0.639 ± 0.021	0.833HisIle: 0.833 ± 0.023	0.371HisLys: 0.371 ± 0.015	2.049HisLeu: 2.049 ± 0.041	0.346HisMet: 0.346 ± 0.015	0.542HisAsn: 0.542 ± 0.019	1.64HisPro: 1.64 ± 0.034	0.707HisGln: 0.707 ± 0.023	1.847HisArg: 1.847 ± 0.038	1.077HisSer: 1.077 ± 0.027	1.225HisThr: 1.225 ± 0.025	1.654HisVal: 1.654 ± 0.03	0.389HisTrp: 0.389 ± 0.016	0.562HisTyr: 0.562 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.345IleAla: 6.345 ± 0.063	0.403IleCys: 0.403 ± 0.016	3.349IleAsp: 3.349 ± 0.048	2.555IleGlu: 2.555 ± 0.042	1.06IlePhe: 1.06 ± 0.024	5.02IleGly: 5.02 ± 0.1	0.829IleHis: 0.829 ± 0.021	1.411IleIle: 1.411 ± 0.034	0.903IleLys: 0.903 ± 0.024	2.918IleLeu: 2.918 ± 0.048	0.595IleMet: 0.595 ± 0.017	1.33IleAsn: 1.33 ± 0.033	2.509IlePro: 2.509 ± 0.051	0.995IleGln: 0.995 ± 0.022	2.641IleArg: 2.641 ± 0.042	2.426IleSer: 2.426 ± 0.041	2.828IleThr: 2.828 ± 0.052	3.603IleVal: 3.603 ± 0.055	0.47IleTrp: 0.47 ± 0.017	0.825IleTyr: 0.825 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.594LysAla: 2.594 ± 0.047	0.122LysCys: 0.122 ± 0.008	0.991LysAsp: 0.991 ± 0.027	0.841LysGlu: 0.841 ± 0.024	0.594LysPhe: 0.594 ± 0.016	1.537LysGly: 1.537 ± 0.04	0.518LysHis: 0.518 ± 0.019	0.97LysIle: 0.97 ± 0.024	0.569LysLys: 0.569 ± 0.026	2.205LysLeu: 2.205 ± 0.037	0.442LysMet: 0.442 ± 0.019	0.499LysAsn: 0.499 ± 0.018	1.461LysPro: 1.461 ± 0.032	0.724LysGln: 0.724 ± 0.023	1.593LysArg: 1.593 ± 0.036	1.188LysSer: 1.188 ± 0.028	1.341LysThr: 1.341 ± 0.028	1.82LysVal: 1.82 ± 0.037	0.296LysTrp: 0.296 ± 0.015	0.464LysTyr: 0.464 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	13.917LeuAla: 13.917 ± 0.114	0.828LeuCys: 0.828 ± 0.023	6.094LeuAsp: 6.094 ± 0.07	4.131LeuGlu: 4.131 ± 0.058	2.708LeuPhe: 2.708 ± 0.046	8.681LeuGly: 8.681 ± 0.077	2.023LeuHis: 2.023 ± 0.038	4.215LeuIle: 4.215 ± 0.05	1.734LeuLys: 1.734 ± 0.036	9.546LeuLeu: 9.546 ± 0.096	1.722LeuMet: 1.722 ± 0.032	2.386LeuAsn: 2.386 ± 0.045	5.732LeuPro: 5.732 ± 0.074	2.612LeuGln: 2.612 ± 0.044	7.419LeuArg: 7.419 ± 0.08	5.613LeuSer: 5.613 ± 0.072	6.105LeuThr: 6.105 ± 0.064	8.116LeuVal: 8.116 ± 0.095	1.211LeuTrp: 1.211 ± 0.028	1.682LeuTyr: 1.682 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.526MetAla: 2.526 ± 0.046	0.177MetCys: 0.177 ± 0.01	0.85MetAsp: 0.85 ± 0.022	0.67MetGlu: 0.67 ± 0.02	0.691MetPhe: 0.691 ± 0.019	1.558MetGly: 1.558 ± 0.034	0.437MetHis: 0.437 ± 0.016	0.85MetIle: 0.85 ± 0.02	0.437MetLys: 0.437 ± 0.016	2.085MetLeu: 2.085 ± 0.039	0.414MetMet: 0.414 ± 0.017	0.479MetAsn: 0.479 ± 0.018	1.207MetPro: 1.207 ± 0.027	0.557MetGln: 0.557 ± 0.02	1.543MetArg: 1.543 ± 0.029	1.529MetSer: 1.529 ± 0.031	1.678MetThr: 1.678 ± 0.035	1.588MetVal: 1.588 ± 0.029	0.299MetTrp: 0.299 ± 0.013	0.343MetTyr: 0.343 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.134AsnAla: 3.134 ± 0.054	0.202AsnCys: 0.202 ± 0.011	1.235AsnAsp: 1.235 ± 0.03	0.989AsnGlu: 0.989 ± 0.024	0.856AsnPhe: 0.856 ± 0.036	3.719AsnGly: 3.719 ± 0.209	0.545AsnHis: 0.545 ± 0.017	1.282AsnIle: 1.282 ± 0.063	0.472AsnLys: 0.472 ± 0.018	2.358AsnLeu: 2.358 ± 0.049	0.423AsnMet: 0.423 ± 0.016	0.854AsnAsn: 0.854 ± 0.045	1.891AsnPro: 1.891 ± 0.034	0.765AsnGln: 0.765 ± 0.024	1.613AsnArg: 1.613 ± 0.033	1.659AsnSer: 1.659 ± 0.076	1.822AsnThr: 1.822 ± 0.088	2.012AsnVal: 2.012 ± 0.062	0.412AsnTrp: 0.412 ± 0.015	0.634AsnTyr: 0.634 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.127ProAla: 7.127 ± 0.089	0.315ProCys: 0.315 ± 0.012	3.966ProAsp: 3.966 ± 0.053	3.385ProGlu: 3.385 ± 0.045	1.639ProPhe: 1.639 ± 0.029	5.827ProGly: 5.827 ± 0.069	1.174ProHis: 1.174 ± 0.027	2.317ProIle: 2.317 ± 0.041	1.295ProLys: 1.295 ± 0.028	4.877ProLeu: 4.877 ± 0.056	1.182ProMet: 1.182 ± 0.026	1.405ProAsn: 1.405 ± 0.035	3.919ProPro: 3.919 ± 0.092	1.864ProGln: 1.864 ± 0.036	3.337ProArg: 3.337 ± 0.049	3.065ProSer: 3.065 ± 0.05	3.503ProThr: 3.503 ± 0.057	4.724ProVal: 4.724 ± 0.062	0.846ProTrp: 0.846 ± 0.027	1.146ProTyr: 1.146 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.025GlnAla: 4.025 ± 0.06	0.221GlnCys: 0.221 ± 0.012	1.238GlnAsp: 1.238 ± 0.027	1.118GlnGlu: 1.118 ± 0.026	1.0GlnPhe: 1.0 ± 0.026	2.34GlnGly: 2.34 ± 0.102	0.781GlnHis: 0.781 ± 0.021	1.568GlnIle: 1.568 ± 0.033	0.536GlnLys: 0.536 ± 0.021	3.833GlnLeu: 3.833 ± 0.058	0.673GlnMet: 0.673 ± 0.02	0.664GlnAsn: 0.664 ± 0.022	1.927GlnPro: 1.927 ± 0.043	1.383GlnGln: 1.383 ± 0.034	2.903GlnArg: 2.903 ± 0.046	1.514GlnSer: 1.514 ± 0.03	1.691GlnThr: 1.691 ± 0.033	2.6GlnVal: 2.6 ± 0.042	0.526GlnTrp: 0.526 ± 0.017	0.627GlnTyr: 0.627 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.014ArgAla: 8.014 ± 0.097	0.648ArgCys: 0.648 ± 0.02	3.976ArgAsp: 3.976 ± 0.066	3.499ArgGlu: 3.499 ± 0.049	2.369ArgPhe: 2.369 ± 0.039	5.086ArgGly: 5.086 ± 0.055	1.766ArgHis: 1.766 ± 0.037	3.366ArgIle: 3.366 ± 0.044	1.509ArgLys: 1.509 ± 0.032	7.585ArgLeu: 7.585 ± 0.084	1.741ArgMet: 1.741 ± 0.033	1.738ArgAsn: 1.738 ± 0.032	3.868ArgPro: 3.868 ± 0.045	2.378ArgGln: 2.378 ± 0.043	6.451ArgArg: 6.451 ± 0.086	3.939ArgSer: 3.939 ± 0.055	3.701ArgThr: 3.701 ± 0.054	5.387ArgVal: 5.387 ± 0.064	1.289ArgTrp: 1.289 ± 0.03	1.925ArgTyr: 1.925 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.225SerAla: 7.225 ± 0.074	0.435SerCys: 0.435 ± 0.015	3.048SerAsp: 3.048 ± 0.038	2.467SerGlu: 2.467 ± 0.044	1.673SerPhe: 1.673 ± 0.03	6.86SerGly: 6.86 ± 0.153	1.034SerHis: 1.034 ± 0.026	2.219SerIle: 2.219 ± 0.038	1.125SerLys: 1.125 ± 0.028	4.903SerLeu: 4.903 ± 0.059	1.284SerMet: 1.284 ± 0.03	1.36SerAsn: 1.36 ± 0.035	3.06SerPro: 3.06 ± 0.052	1.628SerGln: 1.628 ± 0.035	3.706SerArg: 3.706 ± 0.052	3.292SerSer: 3.292 ± 0.049	3.379SerThr: 3.379 ± 0.041	4.532SerVal: 4.532 ± 0.052	0.946SerTrp: 0.946 ± 0.022	1.31SerTyr: 1.31 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.657ThrAla: 7.657 ± 0.082	0.415ThrCys: 0.415 ± 0.018	3.366ThrAsp: 3.366 ± 0.051	2.792ThrGlu: 2.792 ± 0.042	1.728ThrPhe: 1.728 ± 0.035	7.347ThrGly: 7.347 ± 0.231	1.143ThrHis: 1.143 ± 0.024	2.561ThrIle: 2.561 ± 0.045	1.21ThrLys: 1.21 ± 0.029	5.388ThrLeu: 5.388 ± 0.067	1.207ThrMet: 1.207 ± 0.031	1.466ThrAsn: 1.466 ± 0.036	3.67ThrPro: 3.67 ± 0.052	1.646ThrGln: 1.646 ± 0.035	3.497ThrArg: 3.497 ± 0.049	3.253ThrSer: 3.253 ± 0.048	3.896ThrThr: 3.896 ± 0.07	5.498ThrVal: 5.498 ± 0.075	0.773ThrTrp: 0.773 ± 0.022	1.257ThrTyr: 1.257 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.01ValAla: 11.01 ± 0.111	0.766ValCys: 0.766 ± 0.024	5.214ValAsp: 5.214 ± 0.059	4.114ValGlu: 4.114 ± 0.057	2.459ValPhe: 2.459 ± 0.044	7.342ValGly: 7.342 ± 0.084	1.723ValHis: 1.723 ± 0.033	3.873ValIle: 3.873 ± 0.052	1.615ValLys: 1.615 ± 0.033	8.465ValLeu: 8.465 ± 0.089	1.573ValMet: 1.573 ± 0.034	2.152ValAsn: 2.152 ± 0.041	4.461ValPro: 4.461 ± 0.062	2.128ValGln: 2.128 ± 0.031	5.622ValArg: 5.622 ± 0.068	4.787ValSer: 4.787 ± 0.059	5.142ValThr: 5.142 ± 0.059	8.001ValVal: 8.001 ± 0.093	1.012ValTrp: 1.012 ± 0.023	1.47ValTyr: 1.47 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.507TrpAla: 1.507 ± 0.03	0.147TrpCys: 0.147 ± 0.01	0.759TrpAsp: 0.759 ± 0.026	0.654TrpGlu: 0.654 ± 0.022	0.494TrpPhe: 0.494 ± 0.018	1.001TrpGly: 1.001 ± 0.024	0.371TrpHis: 0.371 ± 0.012	0.652TrpIle: 0.652 ± 0.02	0.3TrpLys: 0.3 ± 0.012	1.821TrpLeu: 1.821 ± 0.037	0.342TrpMet: 0.342 ± 0.015	0.418TrpAsn: 0.418 ± 0.017	0.787TrpPro: 0.787 ± 0.022	0.655TrpGln: 0.655 ± 0.018	1.245TrpArg: 1.245 ± 0.029	0.925TrpSer: 0.925 ± 0.024	0.833TrpThr: 0.833 ± 0.024	1.055TrpVal: 1.055 ± 0.024	0.331TrpTrp: 0.331 ± 0.014	0.321TrpTyr: 0.321 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.378TyrAla: 2.378 ± 0.034	0.227TyrCys: 0.227 ± 0.011	1.253TyrAsp: 1.253 ± 0.031	1.054TyrGlu: 1.054 ± 0.026	0.747TyrPhe: 0.747 ± 0.024	2.126TyrGly: 2.126 ± 0.034	0.523TyrHis: 0.523 ± 0.017	0.659TyrIle: 0.659 ± 0.022	0.345TyrLys: 0.345 ± 0.013	2.244TyrLeu: 2.244 ± 0.04	0.282TyrMet: 0.282 ± 0.012	0.568TyrAsn: 0.568 ± 0.039	1.203TyrPro: 1.203 ± 0.028	0.833TyrGln: 0.833 ± 0.022	1.83TyrArg: 1.83 ± 0.035	1.143TyrSer: 1.143 ± 0.026	1.12TyrThr: 1.12 ± 0.024	1.629TyrVal: 1.629 ± 0.034	0.362TyrTrp: 0.362 ± 0.015	0.491TyrTyr: 0.491 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5166 proteins (1738609 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---