Amino acid dipepetide frequency for Natrarchaeobaculum aegyptiacum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.44AlaAla: 12.44 ± 0.145	0.738AlaCys: 0.738 ± 0.028	10.258AlaAsp: 10.258 ± 0.135	8.198AlaGlu: 8.198 ± 0.098	3.75AlaPhe: 3.75 ± 0.066	9.268AlaGly: 9.268 ± 0.114	1.892AlaHis: 1.892 ± 0.041	5.749AlaIle: 5.749 ± 0.083	1.576AlaLys: 1.576 ± 0.043	10.077AlaLeu: 10.077 ± 0.113	1.979AlaMet: 1.979 ± 0.047	2.17AlaAsn: 2.17 ± 0.045	3.628AlaPro: 3.628 ± 0.063	2.106AlaGln: 2.106 ± 0.053	5.99AlaArg: 5.99 ± 0.095	5.481AlaSer: 5.481 ± 0.088	7.163AlaThr: 7.163 ± 0.1	9.964AlaVal: 9.964 ± 0.129	0.96AlaTrp: 0.96 ± 0.033	2.628AlaTyr: 2.628 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.611CysAla: 0.611 ± 0.026	0.095CysCys: 0.095 ± 0.009	0.636CysAsp: 0.636 ± 0.024	0.577CysGlu: 0.577 ± 0.026	0.22CysPhe: 0.22 ± 0.014	0.822CysGly: 0.822 ± 0.03	0.215CysHis: 0.215 ± 0.015	0.269CysIle: 0.269 ± 0.016	0.115CysLys: 0.115 ± 0.01	0.605CysLeu: 0.605 ± 0.024	0.097CysMet: 0.097 ± 0.011	0.174CysAsn: 0.174 ± 0.013	0.525CysPro: 0.525 ± 0.025	0.202CysGln: 0.202 ± 0.015	0.547CysArg: 0.547 ± 0.025	0.436CysSer: 0.436 ± 0.02	0.449CysThr: 0.449 ± 0.02	0.478CysVal: 0.478 ± 0.022	0.093CysTrp: 0.093 ± 0.01	0.23CysTyr: 0.23 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.806AspAla: 9.806 ± 0.137	0.648AspCys: 0.648 ± 0.027	9.809AspAsp: 9.809 ± 0.207	9.077AspGlu: 9.077 ± 0.132	1.859AspPhe: 1.859 ± 0.044	8.52AspGly: 8.52 ± 0.129	2.122AspHis: 2.122 ± 0.054	2.317AspIle: 2.317 ± 0.045	0.722AspLys: 0.722 ± 0.033	7.868AspLeu: 7.868 ± 0.088	1.066AspMet: 1.066 ± 0.033	1.131AspAsn: 1.131 ± 0.035	5.171AspPro: 5.171 ± 0.067	1.988AspGln: 1.988 ± 0.046	7.202AspArg: 7.202 ± 0.105	3.891AspSer: 3.891 ± 0.079	3.654AspThr: 3.654 ± 0.073	8.807AspVal: 8.807 ± 0.115	1.057AspTrp: 1.057 ± 0.032	1.684AspTyr: 1.684 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	9.623GluAla: 9.623 ± 0.114	0.638GluCys: 0.638 ± 0.024	6.88GluAsp: 6.88 ± 0.116	7.587GluGlu: 7.587 ± 0.122	3.001GluPhe: 3.001 ± 0.062	5.922GluGly: 5.922 ± 0.086	2.037GluHis: 2.037 ± 0.038	4.461GluIle: 4.461 ± 0.074	1.744GluLys: 1.744 ± 0.048	7.577GluLeu: 7.577 ± 0.114	1.864GluMet: 1.864 ± 0.037	2.379GluAsn: 2.379 ± 0.057	4.883GluPro: 4.883 ± 0.072	2.884GluGln: 2.884 ± 0.063	7.959GluArg: 7.959 ± 0.087	5.603GluSer: 5.603 ± 0.087	7.325GluThr: 7.325 ± 0.095	6.288GluVal: 6.288 ± 0.093	1.152GluTrp: 1.152 ± 0.036	2.94GluTyr: 2.94 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.556PheAla: 3.556 ± 0.068	0.291PheCys: 0.291 ± 0.017	3.407PheAsp: 3.407 ± 0.064	3.206PheGlu: 3.206 ± 0.06	0.978PhePhe: 0.978 ± 0.037	3.051PheGly: 3.051 ± 0.058	0.617PheHis: 0.617 ± 0.023	0.871PheIle: 0.871 ± 0.033	0.367PheLys: 0.367 ± 0.022	2.779PheLeu: 2.779 ± 0.064	0.49PheMet: 0.49 ± 0.022	0.613PheAsn: 0.613 ± 0.026	1.259PhePro: 1.259 ± 0.039	0.739PheGln: 0.739 ± 0.03	1.614PheArg: 1.614 ± 0.044	1.571PheSer: 1.571 ± 0.041	1.777PheThr: 1.777 ± 0.042	3.502PheVal: 3.502 ± 0.061	0.394PheTrp: 0.394 ± 0.019	0.884PheTyr: 0.884 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.508GlyAla: 7.508 ± 0.099	0.721GlyCys: 0.721 ± 0.027	7.18GlyAsp: 7.18 ± 0.111	7.187GlyGlu: 7.187 ± 0.096	2.986GlyPhe: 2.986 ± 0.06	6.96GlyGly: 6.96 ± 0.099	1.693GlyHis: 1.693 ± 0.046	4.305GlyIle: 4.305 ± 0.08	1.683GlyLys: 1.683 ± 0.045	7.455GlyLeu: 7.455 ± 0.098	1.603GlyMet: 1.603 ± 0.038	1.755GlyAsn: 1.755 ± 0.045	3.523GlyPro: 3.523 ± 0.063	2.025GlyGln: 2.025 ± 0.047	4.75GlyArg: 4.75 ± 0.09	5.202GlySer: 5.202 ± 0.094	5.957GlyThr: 5.957 ± 0.083	7.265GlyVal: 7.265 ± 0.085	1.112GlyTrp: 1.112 ± 0.038	2.585GlyTyr: 2.585 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.013HisAla: 2.013 ± 0.044	0.199HisCys: 0.199 ± 0.013	1.973HisAsp: 1.973 ± 0.045	1.866HisGlu: 1.866 ± 0.046	0.55HisPhe: 0.55 ± 0.023	2.011HisGly: 2.011 ± 0.052	0.547HisHis: 0.547 ± 0.024	0.571HisIle: 0.571 ± 0.024	0.238HisLys: 0.238 ± 0.016	1.786HisLeu: 1.786 ± 0.042	0.291HisMet: 0.291 ± 0.016	0.413HisAsn: 0.413 ± 0.02	1.237HisPro: 1.237 ± 0.032	0.495HisGln: 0.495 ± 0.024	1.338HisArg: 1.338 ± 0.037	0.855HisSer: 0.855 ± 0.028	1.048HisThr: 1.048 ± 0.033	2.075HisVal: 2.075 ± 0.045	0.245HisTrp: 0.245 ± 0.015	0.564HisTyr: 0.564 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.992IleAla: 4.992 ± 0.073	0.29IleCys: 0.29 ± 0.018	4.595IleAsp: 4.595 ± 0.069	4.383IleGlu: 4.383 ± 0.074	1.055IlePhe: 1.055 ± 0.04	3.988IleGly: 3.988 ± 0.078	0.84IleHis: 0.84 ± 0.026	1.224IleIle: 1.224 ± 0.043	0.603IleLys: 0.603 ± 0.025	3.154IleLeu: 3.154 ± 0.054	0.484IleMet: 0.484 ± 0.023	0.899IleAsn: 0.899 ± 0.031	2.017IlePro: 2.017 ± 0.048	1.087IleGln: 1.087 ± 0.033	2.49IleArg: 2.49 ± 0.049	2.096IleSer: 2.096 ± 0.053	2.469IleThr: 2.469 ± 0.051	4.507IleVal: 4.507 ± 0.086	0.351IleTrp: 0.351 ± 0.017	1.002IleTyr: 1.002 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	1.571LysAla: 1.571 ± 0.038	0.105LysCys: 0.105 ± 0.01	0.892LysAsp: 0.892 ± 0.033	1.065LysGlu: 1.065 ± 0.036	0.429LysPhe: 0.429 ± 0.023	1.16LysGly: 1.16 ± 0.037	0.46LysHis: 0.46 ± 0.025	0.765LysIle: 0.765 ± 0.028	0.483LysLys: 0.483 ± 0.024	1.488LysLeu: 1.488 ± 0.043	0.333LysMet: 0.333 ± 0.019	0.456LysAsn: 0.456 ± 0.02	0.83LysPro: 0.83 ± 0.027	0.571LysGln: 0.571 ± 0.027	1.45LysArg: 1.45 ± 0.04	0.958LysSer: 0.958 ± 0.035	1.163LysThr: 1.163 ± 0.038	0.975LysVal: 0.975 ± 0.031	0.17LysTrp: 0.17 ± 0.013	0.477LysTyr: 0.477 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	10.848LeuAla: 10.848 ± 0.121	0.618LeuCys: 0.618 ± 0.024	5.558LeuAsp: 5.558 ± 0.084	13.376LeuGlu: 13.376 ± 0.131	3.063LeuPhe: 3.063 ± 0.072	7.067LeuGly: 7.067 ± 0.098	1.447LeuHis: 1.447 ± 0.037	3.02LeuIle: 3.02 ± 0.058	1.248LeuLys: 1.248 ± 0.038	8.299LeuLeu: 8.299 ± 0.106	1.161LeuMet: 1.161 ± 0.032	1.549LeuAsn: 1.549 ± 0.039	3.965LeuPro: 3.965 ± 0.061	1.965LeuGln: 1.965 ± 0.045	4.801LeuArg: 4.801 ± 0.068	5.011LeuSer: 5.011 ± 0.068	5.113LeuThr: 5.113 ± 0.08	8.427LeuVal: 8.427 ± 0.117	0.884LeuTrp: 0.884 ± 0.031	2.119LeuTyr: 2.119 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.809MetAla: 1.809 ± 0.044	0.126MetCys: 0.126 ± 0.012	1.212MetAsp: 1.212 ± 0.036	1.06MetGlu: 1.06 ± 0.035	0.472MetPhe: 0.472 ± 0.023	1.395MetGly: 1.395 ± 0.033	0.316MetHis: 0.316 ± 0.017	0.737MetIle: 0.737 ± 0.027	0.38MetLys: 0.38 ± 0.017	1.421MetLeu: 1.421 ± 0.038	0.276MetMet: 0.276 ± 0.017	0.552MetAsn: 0.552 ± 0.024	0.751MetPro: 0.751 ± 0.026	0.477MetGln: 0.477 ± 0.021	0.95MetArg: 0.95 ± 0.029	1.305MetSer: 1.305 ± 0.031	1.501MetThr: 1.501 ± 0.041	1.273MetVal: 1.273 ± 0.04	0.158MetTrp: 0.158 ± 0.013	0.439MetTyr: 0.439 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.345AsnAla: 2.345 ± 0.049	0.195AsnCys: 0.195 ± 0.015	1.581AsnAsp: 1.581 ± 0.035	1.732AsnGlu: 1.732 ± 0.043	0.628AsnPhe: 0.628 ± 0.025	1.741AsnGly: 1.741 ± 0.045	0.467AsnHis: 0.467 ± 0.019	0.714AsnIle: 0.714 ± 0.032	0.354AsnLys: 0.354 ± 0.022	1.782AsnLeu: 1.782 ± 0.042	0.375AsnMet: 0.375 ± 0.02	0.426AsnAsn: 0.426 ± 0.02	1.408AsnPro: 1.408 ± 0.039	0.572AsnGln: 0.572 ± 0.022	1.561AsnArg: 1.561 ± 0.039	0.869AsnSer: 0.869 ± 0.033	1.087AsnThr: 1.087 ± 0.034	2.369AsnVal: 2.369 ± 0.049	0.308AsnTrp: 0.308 ± 0.017	0.588AsnTyr: 0.588 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	4.833ProAla: 4.833 ± 0.078	0.25ProCys: 0.25 ± 0.016	5.171ProAsp: 5.171 ± 0.08	4.698ProGlu: 4.698 ± 0.073	1.572ProPhe: 1.572 ± 0.041	4.005ProGly: 4.005 ± 0.073	0.899ProHis: 0.899 ± 0.029	2.214ProIle: 2.214 ± 0.048	0.764ProLys: 0.764 ± 0.03	3.645ProLeu: 3.645 ± 0.055	0.823ProMet: 0.823 ± 0.029	1.047ProAsn: 1.047 ± 0.032	2.287ProPro: 2.287 ± 0.055	0.943ProGln: 0.943 ± 0.031	2.294ProArg: 2.294 ± 0.048	2.501ProSer: 2.501 ± 0.049	3.239ProThr: 3.239 ± 0.056	4.31ProVal: 4.31 ± 0.065	0.503ProTrp: 0.503 ± 0.021	1.11ProTyr: 1.11 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.321GlnAla: 2.321 ± 0.048	0.152GlnCys: 0.152 ± 0.012	1.299GlnAsp: 1.299 ± 0.039	1.765GlnGlu: 1.765 ± 0.049	1.095GlnPhe: 1.095 ± 0.034	1.555GlnGly: 1.555 ± 0.042	0.505GlnHis: 0.505 ± 0.022	1.171GlnIle: 1.171 ± 0.036	0.52GlnLys: 0.52 ± 0.025	2.429GlnLeu: 2.429 ± 0.051	0.492GlnMet: 0.492 ± 0.022	0.67GlnAsn: 0.67 ± 0.029	1.182GlnPro: 1.182 ± 0.032	1.013GlnGln: 1.013 ± 0.044	1.934GlnArg: 1.934 ± 0.045	1.627GlnSer: 1.627 ± 0.046	1.715GlnThr: 1.715 ± 0.041	1.896GlnVal: 1.896 ± 0.048	0.358GlnTrp: 0.358 ± 0.018	0.854GlnTyr: 0.854 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.155ArgAla: 6.155 ± 0.086	0.475ArgCys: 0.475 ± 0.022	5.021ArgAsp: 5.021 ± 0.08	6.802ArgGlu: 6.802 ± 0.104	2.263ArgPhe: 2.263 ± 0.046	4.258ArgGly: 4.258 ± 0.061	1.216ArgHis: 1.216 ± 0.037	3.023ArgIle: 3.023 ± 0.053	1.267ArgLys: 1.267 ± 0.039	6.238ArgLeu: 6.238 ± 0.086	1.26ArgMet: 1.26 ± 0.034	1.571ArgAsn: 1.571 ± 0.042	2.639ArgPro: 2.639 ± 0.06	1.826ArgGln: 1.826 ± 0.044	5.133ArgArg: 5.133 ± 0.082	3.799ArgSer: 3.799 ± 0.063	4.088ArgThr: 4.088 ± 0.068	5.05ArgVal: 5.05 ± 0.077	0.777ArgTrp: 0.777 ± 0.026	1.936ArgTyr: 1.936 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.19SerAla: 5.19 ± 0.074	0.316SerCys: 0.316 ± 0.021	4.482SerAsp: 4.482 ± 0.099	4.106SerGlu: 4.106 ± 0.067	1.809SerPhe: 1.809 ± 0.044	5.067SerGly: 5.067 ± 0.07	1.047SerHis: 1.047 ± 0.031	2.75SerIle: 2.75 ± 0.056	0.974SerLys: 0.974 ± 0.034	4.865SerLeu: 4.865 ± 0.062	1.124SerMet: 1.124 ± 0.035	1.256SerAsn: 1.256 ± 0.038	2.693SerPro: 2.693 ± 0.051	1.369SerGln: 1.369 ± 0.037	3.447SerArg: 3.447 ± 0.061	3.526SerSer: 3.526 ± 0.073	3.516SerThr: 3.516 ± 0.058	4.837SerVal: 4.837 ± 0.077	0.583SerTrp: 0.583 ± 0.025	1.39SerTyr: 1.39 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.676ThrAla: 6.676 ± 0.09	0.451ThrCys: 0.451 ± 0.023	6.179ThrAsp: 6.179 ± 0.101	4.637ThrGlu: 4.637 ± 0.086	2.096ThrPhe: 2.096 ± 0.041	5.827ThrGly: 5.827 ± 0.079	1.252ThrHis: 1.252 ± 0.04	3.646ThrIle: 3.646 ± 0.066	0.939ThrLys: 0.939 ± 0.028	5.798ThrLeu: 5.798 ± 0.078	1.033ThrMet: 1.033 ± 0.029	1.415ThrAsn: 1.415 ± 0.035	3.144ThrPro: 3.144 ± 0.054	1.365ThrGln: 1.365 ± 0.036	3.336ThrArg: 3.336 ± 0.064	2.96ThrSer: 2.96 ± 0.058	4.211ThrThr: 4.211 ± 0.074	6.967ThrVal: 6.967 ± 0.113	0.577ThrTrp: 0.577 ± 0.023	1.652ThrTyr: 1.652 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.1ValAla: 10.1 ± 0.137	0.753ValCys: 0.753 ± 0.028	8.722ValAsp: 8.722 ± 0.097	8.039ValGlu: 8.039 ± 0.111	2.888ValPhe: 2.888 ± 0.066	7.816ValGly: 7.816 ± 0.114	1.807ValHis: 1.807 ± 0.037	3.477ValIle: 3.477 ± 0.068	1.199ValLys: 1.199 ± 0.039	8.476ValLeu: 8.476 ± 0.111	1.273ValMet: 1.273 ± 0.039	1.768ValAsn: 1.768 ± 0.043	4.326ValPro: 4.326 ± 0.068	1.876ValGln: 1.876 ± 0.042	5.295ValArg: 5.295 ± 0.063	5.032ValSer: 5.032 ± 0.069	6.512ValThr: 6.512 ± 0.091	9.443ValVal: 9.443 ± 0.136	0.812ValTrp: 0.812 ± 0.032	2.141ValTyr: 2.141 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.894TrpAla: 0.894 ± 0.036	0.111TrpCys: 0.111 ± 0.01	0.817TrpAsp: 0.817 ± 0.028	0.85TrpGlu: 0.85 ± 0.034	0.447TrpPhe: 0.447 ± 0.019	0.793TrpGly: 0.793 ± 0.029	0.279TrpHis: 0.279 ± 0.017	0.595TrpIle: 0.595 ± 0.025	0.258TrpLys: 0.258 ± 0.017	1.288TrpLeu: 1.288 ± 0.038	0.23TrpMet: 0.23 ± 0.014	0.338TrpAsn: 0.338 ± 0.019	0.407TrpPro: 0.407 ± 0.02	0.349TrpGln: 0.349 ± 0.019	0.752TrpArg: 0.752 ± 0.029	0.554TrpSer: 0.554 ± 0.021	0.729TrpThr: 0.729 ± 0.029	0.777TrpVal: 0.777 ± 0.027	0.186TrpTrp: 0.186 ± 0.014	0.35TrpTyr: 0.35 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.723TyrAla: 2.723 ± 0.049	0.224TyrCys: 0.224 ± 0.015	2.732TyrAsp: 2.732 ± 0.058	2.539TyrGlu: 2.539 ± 0.052	0.806TyrPhe: 0.806 ± 0.029	2.231TyrGly: 2.231 ± 0.048	0.658TyrHis: 0.658 ± 0.026	0.647TyrIle: 0.647 ± 0.03	0.366TyrLys: 0.366 ± 0.017	2.51TyrLeu: 2.51 ± 0.056	0.354TyrMet: 0.354 ± 0.018	0.521TyrAsn: 0.521 ± 0.022	1.228TyrPro: 1.228 ± 0.032	0.698TyrGln: 0.698 ± 0.027	1.955TyrArg: 1.955 ± 0.04	1.069TyrSer: 1.069 ± 0.034	1.444TyrThr: 1.444 ± 0.037	2.545TyrVal: 2.545 ± 0.047	0.325TyrTrp: 0.325 ± 0.018	0.838TyrTyr: 0.838 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3626 proteins (1077767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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