Amino acid dipepetide frequency for Oxalobacter formigenes OXCC13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.656AlaAla: 8.656 ± 0.178
1.02AlaCys: 1.02 ± 0.045
5.269AlaAsp: 5.269 ± 0.099
5.488AlaGlu: 5.488 ± 0.118
3.61AlaPhe: 3.61 ± 0.08
7.043AlaGly: 7.043 ± 0.124
1.549AlaHis: 1.549 ± 0.046
5.963AlaIle: 5.963 ± 0.107
4.873AlaLys: 4.873 ± 0.102
8.96AlaLeu: 8.96 ± 0.13
2.629AlaMet: 2.629 ± 0.062
3.353AlaAsn: 3.353 ± 0.076
2.96AlaPro: 2.96 ± 0.071
3.411AlaGln: 3.411 ± 0.089
4.905AlaArg: 4.905 ± 0.09
5.555AlaSer: 5.555 ± 0.096
4.213AlaThr: 4.213 ± 0.086
6.12AlaVal: 6.12 ± 0.115
0.938AlaTrp: 0.938 ± 0.043
2.366AlaTyr: 2.366 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.823CysAla: 0.823 ± 0.032
0.163CysCys: 0.163 ± 0.018
0.578CysAsp: 0.578 ± 0.03
0.592CysGlu: 0.592 ± 0.03
0.446CysPhe: 0.446 ± 0.03
0.953CysGly: 0.953 ± 0.042
0.263CysHis: 0.263 ± 0.019
0.665CysIle: 0.665 ± 0.033
0.406CysLys: 0.406 ± 0.023
0.92CysLeu: 0.92 ± 0.038
0.264CysMet: 0.264 ± 0.019
0.319CysAsn: 0.319 ± 0.022
0.526CysPro: 0.526 ± 0.027
0.334CysGln: 0.334 ± 0.021
0.601CysArg: 0.601 ± 0.032
0.636CysSer: 0.636 ± 0.03
0.497CysThr: 0.497 ± 0.027
0.636CysVal: 0.636 ± 0.032
0.126CysTrp: 0.126 ± 0.013
0.289CysTyr: 0.289 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
5.003AspAla: 5.003 ± 0.106
0.555AspCys: 0.555 ± 0.025
3.165AspAsp: 3.165 ± 0.069
3.945AspGlu: 3.945 ± 0.081
2.447AspPhe: 2.447 ± 0.059
4.389AspGly: 4.389 ± 0.118
1.036AspHis: 1.036 ± 0.04
4.224AspIle: 4.224 ± 0.091
3.287AspLys: 3.287 ± 0.082
4.959AspLeu: 4.959 ± 0.085
1.817AspMet: 1.817 ± 0.051
2.375AspAsn: 2.375 ± 0.072
2.512AspPro: 2.512 ± 0.066
1.645AspGln: 1.645 ± 0.051
3.024AspArg: 3.024 ± 0.065
3.245AspSer: 3.245 ± 0.077
2.925AspThr: 2.925 ± 0.079
3.999AspVal: 3.999 ± 0.081
0.919AspTrp: 0.919 ± 0.037
1.969AspTyr: 1.969 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
5.472GluAla: 5.472 ± 0.118
0.501GluCys: 0.501 ± 0.027
2.772GluAsp: 2.772 ± 0.064
4.269GluGlu: 4.269 ± 0.101
2.246GluPhe: 2.246 ± 0.067
3.812GluGly: 3.812 ± 0.085
1.13GluHis: 1.13 ± 0.041
4.104GluIle: 4.104 ± 0.099
5.589GluLys: 5.589 ± 0.109
6.023GluLeu: 6.023 ± 0.108
1.949GluMet: 1.949 ± 0.054
3.373GluAsn: 3.373 ± 0.067
2.096GluPro: 2.096 ± 0.056
2.491GluGln: 2.491 ± 0.063
3.513GluArg: 3.513 ± 0.085
3.337GluSer: 3.337 ± 0.073
3.661GluThr: 3.661 ± 0.09
3.609GluVal: 3.609 ± 0.088
0.831GluTrp: 0.831 ± 0.035
1.764GluTyr: 1.764 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.464PheAla: 3.464 ± 0.068
0.556PheCys: 0.556 ± 0.033
2.782PheAsp: 2.782 ± 0.061
2.475PheGlu: 2.475 ± 0.066
1.882PhePhe: 1.882 ± 0.073
3.304PheGly: 3.304 ± 0.084
0.776PheHis: 0.776 ± 0.033
2.511PheIle: 2.511 ± 0.067
1.583PheLys: 1.583 ± 0.053
3.797PheLeu: 3.797 ± 0.091
1.112PheMet: 1.112 ± 0.045
1.721PheAsn: 1.721 ± 0.057
1.666PhePro: 1.666 ± 0.053
1.073PheGln: 1.073 ± 0.038
2.095PheArg: 2.095 ± 0.058
3.194PheSer: 3.194 ± 0.07
2.209PheThr: 2.209 ± 0.063
2.681PheVal: 2.681 ± 0.059
0.529PheTrp: 0.529 ± 0.034
1.367PheTyr: 1.367 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
5.82GlyAla: 5.82 ± 0.122
0.875GlyCys: 0.875 ± 0.038
3.953GlyAsp: 3.953 ± 0.104
4.192GlyGlu: 4.192 ± 0.093
3.37GlyPhe: 3.37 ± 0.067
5.539GlyGly: 5.539 ± 0.189
1.619GlyHis: 1.619 ± 0.048
5.526GlyIle: 5.526 ± 0.092
5.404GlyLys: 5.404 ± 0.102
6.917GlyLeu: 6.917 ± 0.112
2.395GlyMet: 2.395 ± 0.058
3.623GlyAsn: 3.623 ± 0.134
1.832GlyPro: 1.832 ± 0.056
2.738GlyGln: 2.738 ± 0.068
3.562GlyArg: 3.562 ± 0.079
4.903GlySer: 4.903 ± 0.146
4.694GlyThr: 4.694 ± 0.163
5.228GlyVal: 5.228 ± 0.101
1.046GlyTrp: 1.046 ± 0.045
2.566GlyTyr: 2.566 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.774HisAla: 1.774 ± 0.05
0.26HisCys: 0.26 ± 0.021
1.122HisAsp: 1.122 ± 0.041
1.164HisGlu: 1.164 ± 0.04
1.024HisPhe: 1.024 ± 0.045
1.546HisGly: 1.546 ± 0.051
0.522HisHis: 0.522 ± 0.029
1.261HisIle: 1.261 ± 0.046
0.821HisLys: 0.821 ± 0.035
1.855HisLeu: 1.855 ± 0.051
0.517HisMet: 0.517 ± 0.027
0.667HisAsn: 0.667 ± 0.033
1.211HisPro: 1.211 ± 0.041
0.724HisGln: 0.724 ± 0.035
1.004HisArg: 1.004 ± 0.045
1.115HisSer: 1.115 ± 0.043
0.917HisThr: 0.917 ± 0.034
1.251HisVal: 1.251 ± 0.045
0.312HisTrp: 0.312 ± 0.023
0.722HisTyr: 0.722 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.403IleAla: 6.403 ± 0.1
0.718IleCys: 0.718 ± 0.036
4.354IleAsp: 4.354 ± 0.096
4.293IleGlu: 4.293 ± 0.104
2.293IlePhe: 2.293 ± 0.067
5.267IleGly: 5.267 ± 0.09
1.345IleHis: 1.345 ± 0.047
3.477IleIle: 3.477 ± 0.077
2.749IleLys: 2.749 ± 0.08
5.654IleLeu: 5.654 ± 0.098
1.472IleMet: 1.472 ± 0.051
2.527IleAsn: 2.527 ± 0.066
3.12IlePro: 3.12 ± 0.075
1.864IleGln: 1.864 ± 0.056
3.85IleArg: 3.85 ± 0.079
4.278IleSer: 4.278 ± 0.09
3.184IleThr: 3.184 ± 0.077
4.656IleVal: 4.656 ± 0.097
0.686IleTrp: 0.686 ± 0.036
1.677IleTyr: 1.677 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
5.334LysAla: 5.334 ± 0.136
0.338LysCys: 0.338 ± 0.023
3.015LysAsp: 3.015 ± 0.084
3.642LysGlu: 3.642 ± 0.084
1.385LysPhe: 1.385 ± 0.044
3.812LysGly: 3.812 ± 0.086
0.949LysHis: 0.949 ± 0.043
3.463LysIle: 3.463 ± 0.079
4.344LysLys: 4.344 ± 0.109
5.072LysLeu: 5.072 ± 0.086
1.892LysMet: 1.892 ± 0.059
3.291LysAsn: 3.291 ± 0.069
2.625LysPro: 2.625 ± 0.069
2.265LysGln: 2.265 ± 0.066
3.128LysArg: 3.128 ± 0.07
3.084LysSer: 3.084 ± 0.073
3.726LysThr: 3.726 ± 0.068
3.359LysVal: 3.359 ± 0.077
0.706LysTrp: 0.706 ± 0.031
1.455LysTyr: 1.455 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
9.022LeuAla: 9.022 ± 0.14
0.951LeuCys: 0.951 ± 0.034
5.556LeuAsp: 5.556 ± 0.087
5.786LeuGlu: 5.786 ± 0.118
3.967LeuPhe: 3.967 ± 0.1
6.774LeuGly: 6.774 ± 0.116
1.799LeuHis: 1.799 ± 0.05
5.611LeuIle: 5.611 ± 0.105
5.867LeuLys: 5.867 ± 0.098
8.778LeuLeu: 8.778 ± 0.144
2.691LeuMet: 2.691 ± 0.06
3.948LeuAsn: 3.948 ± 0.089
4.874LeuPro: 4.874 ± 0.094
3.216LeuGln: 3.216 ± 0.072
4.572LeuArg: 4.572 ± 0.093
6.931LeuSer: 6.931 ± 0.099
5.261LeuThr: 5.261 ± 0.099
6.267LeuVal: 6.267 ± 0.109
1.0LeuTrp: 1.0 ± 0.044
2.579LeuTyr: 2.579 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.839MetAla: 2.839 ± 0.066
0.221MetCys: 0.221 ± 0.018
1.531MetAsp: 1.531 ± 0.046
1.667MetGlu: 1.667 ± 0.055
0.888MetPhe: 0.888 ± 0.041
1.897MetGly: 1.897 ± 0.053
0.562MetHis: 0.562 ± 0.029
1.683MetIle: 1.683 ± 0.049
1.93MetLys: 1.93 ± 0.052
2.571MetLeu: 2.571 ± 0.062
0.897MetMet: 0.897 ± 0.038
1.445MetAsn: 1.445 ± 0.048
1.456MetPro: 1.456 ± 0.047
1.227MetGln: 1.227 ± 0.044
1.404MetArg: 1.404 ± 0.046
1.927MetSer: 1.927 ± 0.059
1.897MetThr: 1.897 ± 0.054
1.638MetVal: 1.638 ± 0.058
0.214MetTrp: 0.214 ± 0.017
0.624MetTyr: 0.624 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.958AsnAla: 3.958 ± 0.09
0.402AsnCys: 0.402 ± 0.03
2.573AsnAsp: 2.573 ± 0.069
2.576AsnGlu: 2.576 ± 0.063
1.398AsnPhe: 1.398 ± 0.052
3.704AsnGly: 3.704 ± 0.119
0.829AsnHis: 0.829 ± 0.041
2.771AsnIle: 2.771 ± 0.073
1.907AsnLys: 1.907 ± 0.051
3.88AsnLeu: 3.88 ± 0.077
1.193AsnMet: 1.193 ± 0.041
1.793AsnAsn: 1.793 ± 0.08
2.436AsnPro: 2.436 ± 0.058
1.39AsnGln: 1.39 ± 0.044
2.677AsnArg: 2.677 ± 0.068
2.109AsnSer: 2.109 ± 0.084
2.307AsnThr: 2.307 ± 0.075
2.899AsnVal: 2.899 ± 0.078
0.6AsnTrp: 0.6 ± 0.029
1.208AsnTyr: 1.208 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.772ProAla: 3.772 ± 0.096
0.39ProCys: 0.39 ± 0.024
3.557ProAsp: 3.557 ± 0.088
3.799ProGlu: 3.799 ± 0.088
2.005ProPhe: 2.005 ± 0.059
3.149ProGly: 3.149 ± 0.072
0.81ProHis: 0.81 ± 0.032
2.142ProIle: 2.142 ± 0.07
1.942ProLys: 1.942 ± 0.059
3.905ProLeu: 3.905 ± 0.083
1.02ProMet: 1.02 ± 0.039
1.424ProAsn: 1.424 ± 0.044
1.498ProPro: 1.498 ± 0.054
1.413ProGln: 1.413 ± 0.046
1.554ProArg: 1.554 ± 0.056
2.301ProSer: 2.301 ± 0.062
1.807ProThr: 1.807 ± 0.057
4.266ProVal: 4.266 ± 0.094
0.436ProTrp: 0.436 ± 0.027
1.313ProTyr: 1.313 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.271GlnAla: 3.271 ± 0.075
0.328GlnCys: 0.328 ± 0.019
1.628GlnAsp: 1.628 ± 0.057
2.053GlnGlu: 2.053 ± 0.065
1.456GlnPhe: 1.456 ± 0.045
2.303GlnGly: 2.303 ± 0.069
0.614GlnHis: 0.614 ± 0.029
2.293GlnIle: 2.293 ± 0.059
2.342GlnLys: 2.342 ± 0.067
3.519GlnLeu: 3.519 ± 0.08
1.115GlnMet: 1.115 ± 0.044
1.732GlnAsn: 1.732 ± 0.058
1.394GlnPro: 1.394 ± 0.047
1.404GlnGln: 1.404 ± 0.057
1.758GlnArg: 1.758 ± 0.055
2.092GlnSer: 2.092 ± 0.058
2.186GlnThr: 2.186 ± 0.069
2.235GlnVal: 2.235 ± 0.066
0.485GlnTrp: 0.485 ± 0.03
1.26GlnTyr: 1.26 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.909ArgAla: 3.909 ± 0.087
0.403ArgCys: 0.403 ± 0.027
2.675ArgAsp: 2.675 ± 0.061
3.667ArgGlu: 3.667 ± 0.082
2.667ArgPhe: 2.667 ± 0.074
3.06ArgGly: 3.06 ± 0.065
1.299ArgHis: 1.299 ± 0.041
3.85ArgIle: 3.85 ± 0.081
3.191ArgLys: 3.191 ± 0.071
5.764ArgLeu: 5.764 ± 0.098
1.647ArgMet: 1.647 ± 0.047
2.232ArgAsn: 2.232 ± 0.061
2.092ArgPro: 2.092 ± 0.073
2.56ArgGln: 2.56 ± 0.063
2.898ArgArg: 2.898 ± 0.084
2.775ArgSer: 2.775 ± 0.062
2.407ArgThr: 2.407 ± 0.067
3.34ArgVal: 3.34 ± 0.068
0.659ArgTrp: 0.659 ± 0.031
1.93ArgTyr: 1.93 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.436SerAla: 5.436 ± 0.105
0.604SerCys: 0.604 ± 0.032
3.567SerAsp: 3.567 ± 0.076
3.544SerGlu: 3.544 ± 0.067
2.735SerPhe: 2.735 ± 0.065
5.965SerGly: 5.965 ± 0.162
1.377SerHis: 1.377 ± 0.049
3.827SerIle: 3.827 ± 0.071
2.827SerLys: 2.827 ± 0.069
6.226SerLeu: 6.226 ± 0.102
1.7SerMet: 1.7 ± 0.053
2.337SerAsn: 2.337 ± 0.059
2.622SerPro: 2.622 ± 0.059
2.063SerGln: 2.063 ± 0.061
3.484SerArg: 3.484 ± 0.071
3.977SerSer: 3.977 ± 0.1
2.953SerThr: 2.953 ± 0.084
4.483SerVal: 4.483 ± 0.085
0.786SerTrp: 0.786 ± 0.041
1.703SerTyr: 1.703 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.812ThrAla: 4.812 ± 0.089
0.471ThrCys: 0.471 ± 0.028
3.203ThrAsp: 3.203 ± 0.086
2.988ThrGlu: 2.988 ± 0.077
2.083ThrPhe: 2.083 ± 0.068
5.328ThrGly: 5.328 ± 0.123
1.082ThrHis: 1.082 ± 0.044
3.544ThrIle: 3.544 ± 0.091
1.97ThrLys: 1.97 ± 0.055
5.562ThrLeu: 5.562 ± 0.108
1.172ThrMet: 1.172 ± 0.045
1.819ThrAsn: 1.819 ± 0.056
2.834ThrPro: 2.834 ± 0.06
1.697ThrGln: 1.697 ± 0.055
2.727ThrArg: 2.727 ± 0.058
3.129ThrSer: 3.129 ± 0.079
2.813ThrThr: 2.813 ± 0.085
4.624ThrVal: 4.624 ± 0.118
0.532ThrTrp: 0.532 ± 0.031
1.456ThrTyr: 1.456 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
5.836ValAla: 5.836 ± 0.1
0.812ValCys: 0.812 ± 0.039
3.937ValAsp: 3.937 ± 0.085
4.036ValGlu: 4.036 ± 0.09
2.927ValPhe: 2.927 ± 0.066
4.559ValGly: 4.559 ± 0.087
1.319ValHis: 1.319 ± 0.04
4.539ValIle: 4.539 ± 0.084
3.694ValLys: 3.694 ± 0.08
6.543ValLeu: 6.543 ± 0.118
1.97ValMet: 1.97 ± 0.065
2.976ValAsn: 2.976 ± 0.097
2.982ValPro: 2.982 ± 0.065
2.242ValGln: 2.242 ± 0.053
3.628ValArg: 3.628 ± 0.08
5.053ValSer: 5.053 ± 0.092
4.142ValThr: 4.142 ± 0.114
4.769ValVal: 4.769 ± 0.104
0.816ValTrp: 0.816 ± 0.036
1.856ValTyr: 1.856 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.77TrpAla: 0.77 ± 0.033
0.127TrpCys: 0.127 ± 0.014
0.511TrpAsp: 0.511 ± 0.03
0.578TrpGlu: 0.578 ± 0.032
0.628TrpPhe: 0.628 ± 0.036
0.812TrpGly: 0.812 ± 0.044
0.306TrpHis: 0.306 ± 0.021
0.877TrpIle: 0.877 ± 0.039
0.748TrpLys: 0.748 ± 0.036
1.563TrpLeu: 1.563 ± 0.061
0.418TrpMet: 0.418 ± 0.022
0.588TrpAsn: 0.588 ± 0.032
0.416TrpPro: 0.416 ± 0.029
0.574TrpGln: 0.574 ± 0.03
0.657TrpArg: 0.657 ± 0.029
0.631TrpSer: 0.631 ± 0.031
0.601TrpThr: 0.601 ± 0.032
0.782TrpVal: 0.782 ± 0.037
0.152TrpTrp: 0.152 ± 0.016
0.468TrpTyr: 0.468 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.504TyrAla: 2.504 ± 0.062
0.342TyrCys: 0.342 ± 0.021
1.692TyrAsp: 1.692 ± 0.054
1.788TyrGlu: 1.788 ± 0.068
1.316TyrPhe: 1.316 ± 0.044
2.587TyrGly: 2.587 ± 0.076
0.605TyrHis: 0.605 ± 0.028
1.537TyrIle: 1.537 ± 0.054
1.411TyrLys: 1.411 ± 0.052
2.982TyrLeu: 2.982 ± 0.074
0.644TyrMet: 0.644 ± 0.035
1.066TyrAsn: 1.066 ± 0.049
1.354TyrPro: 1.354 ± 0.05
1.138TyrGln: 1.138 ± 0.043
1.982TyrArg: 1.982 ± 0.055
1.943TyrSer: 1.943 ± 0.054
1.448TyrThr: 1.448 ± 0.052
1.796TyrVal: 1.796 ± 0.051
0.436TyrTrp: 0.436 ± 0.027
0.923TyrTyr: 0.923 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2076 proteins (692213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski