Amino acid dipepetide frequency for Lachnospiraceae bacterium XBB2008

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.806AlaAla: 6.806 ± 0.115	1.114AlaCys: 1.114 ± 0.036	5.744AlaAsp: 5.744 ± 0.09	5.511AlaGlu: 5.511 ± 0.095	3.053AlaPhe: 3.053 ± 0.054	6.225AlaGly: 6.225 ± 0.094	1.236AlaHis: 1.236 ± 0.033	5.164AlaIle: 5.164 ± 0.089	4.038AlaLys: 4.038 ± 0.072	6.889AlaLeu: 6.889 ± 0.093	2.201AlaMet: 2.201 ± 0.044	2.535AlaAsn: 2.535 ± 0.055	2.284AlaPro: 2.284 ± 0.077	2.085AlaGln: 2.085 ± 0.046	3.337AlaArg: 3.337 ± 0.061	4.553AlaSer: 4.553 ± 0.083	3.388AlaThr: 3.388 ± 0.074	5.851AlaVal: 5.851 ± 0.082	0.595AlaTrp: 0.595 ± 0.023	3.085AlaTyr: 3.085 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.121CysAla: 1.121 ± 0.034	0.213CysCys: 0.213 ± 0.014	1.0CysAsp: 1.0 ± 0.032	0.862CysGlu: 0.862 ± 0.03	0.604CysPhe: 0.604 ± 0.022	1.365CysGly: 1.365 ± 0.039	0.276CysHis: 0.276 ± 0.015	1.244CysIle: 1.244 ± 0.033	0.656CysLys: 0.656 ± 0.025	1.114CysLeu: 1.114 ± 0.039	0.432CysMet: 0.432 ± 0.02	0.558CysAsn: 0.558 ± 0.025	0.572CysPro: 0.572 ± 0.027	0.23CysGln: 0.23 ± 0.014	0.713CysArg: 0.713 ± 0.024	0.762CysSer: 0.762 ± 0.026	0.662CysThr: 0.662 ± 0.024	1.078CysVal: 1.078 ± 0.031	0.111CysTrp: 0.111 ± 0.011	0.509CysTyr: 0.509 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	5.128AspAla: 5.128 ± 0.086	0.798AspCys: 0.798 ± 0.031	4.814AspAsp: 4.814 ± 0.085	6.123AspGlu: 6.123 ± 0.081	2.718AspPhe: 2.718 ± 0.053	4.97AspGly: 4.97 ± 0.097	1.419AspHis: 1.419 ± 0.039	5.594AspIle: 5.594 ± 0.084	3.927AspLys: 3.927 ± 0.066	5.383AspLeu: 5.383 ± 0.071	2.414AspMet: 2.414 ± 0.052	2.728AspAsn: 2.728 ± 0.058	2.855AspPro: 2.855 ± 0.059	1.43AspGln: 1.43 ± 0.042	3.572AspArg: 3.572 ± 0.071	4.082AspSer: 4.082 ± 0.074	3.866AspThr: 3.866 ± 0.068	4.321AspVal: 4.321 ± 0.063	0.666AspTrp: 0.666 ± 0.024	3.403AspTyr: 3.403 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	5.861GluAla: 5.861 ± 0.111	0.849GluCys: 0.849 ± 0.023	4.825GluAsp: 4.825 ± 0.08	6.781GluGlu: 6.781 ± 0.108	2.764GluPhe: 2.764 ± 0.051	4.307GluGly: 4.307 ± 0.067	1.38GluHis: 1.38 ± 0.035	5.221GluIle: 5.221 ± 0.079	5.116GluLys: 5.116 ± 0.084	6.599GluLeu: 6.599 ± 0.086	2.301GluMet: 2.301 ± 0.044	3.473GluAsn: 3.473 ± 0.057	2.099GluPro: 2.099 ± 0.094	2.186GluGln: 2.186 ± 0.046	3.329GluArg: 3.329 ± 0.065	3.805GluSer: 3.805 ± 0.062	3.787GluThr: 3.787 ± 0.06	4.198GluVal: 4.198 ± 0.065	0.708GluTrp: 0.708 ± 0.028	3.752GluTyr: 3.752 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.018PheAla: 3.018 ± 0.054	0.643PheCys: 0.643 ± 0.022	3.146PheAsp: 3.146 ± 0.058	2.595PheGlu: 2.595 ± 0.054	1.936PhePhe: 1.936 ± 0.055	2.967PheGly: 2.967 ± 0.061	0.73PheHis: 0.73 ± 0.023	3.069PheIle: 3.069 ± 0.063	2.109PheLys: 2.109 ± 0.047	3.479PheLeu: 3.479 ± 0.074	1.333PheMet: 1.333 ± 0.037	1.599PheAsn: 1.599 ± 0.037	1.313PhePro: 1.313 ± 0.038	0.758PheGln: 0.758 ± 0.026	1.803PheArg: 1.803 ± 0.051	2.791PheSer: 2.791 ± 0.057	2.376PheThr: 2.376 ± 0.049	2.85PheVal: 2.85 ± 0.065	0.43PheTrp: 0.43 ± 0.019	1.708PheTyr: 1.708 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.074GlyAla: 5.074 ± 0.091	1.226GlyCys: 1.226 ± 0.036	4.308GlyAsp: 4.308 ± 0.072	4.609GlyGlu: 4.609 ± 0.074	3.284GlyPhe: 3.284 ± 0.064	4.561GlyGly: 4.561 ± 0.095	1.3GlyHis: 1.3 ± 0.042	6.015GlyIle: 6.015 ± 0.08	4.205GlyLys: 4.205 ± 0.067	6.04GlyLeu: 6.04 ± 0.076	2.439GlyMet: 2.439 ± 0.051	2.951GlyAsn: 2.951 ± 0.064	1.499GlyPro: 1.499 ± 0.042	1.747GlyGln: 1.747 ± 0.044	3.503GlyArg: 3.503 ± 0.061	4.424GlySer: 4.424 ± 0.083	4.165GlyThr: 4.165 ± 0.088	4.83GlyVal: 4.83 ± 0.076	0.689GlyTrp: 0.689 ± 0.027	3.566GlyTyr: 3.566 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.173HisAla: 1.173 ± 0.034	0.25HisCys: 0.25 ± 0.015	1.242HisAsp: 1.242 ± 0.034	1.2HisGlu: 1.2 ± 0.034	0.776HisPhe: 0.776 ± 0.029	1.28HisGly: 1.28 ± 0.04	0.395HisHis: 0.395 ± 0.024	1.498HisIle: 1.498 ± 0.041	0.909HisLys: 0.909 ± 0.032	1.429HisLeu: 1.429 ± 0.037	0.633HisMet: 0.633 ± 0.025	0.736HisAsn: 0.736 ± 0.026	0.849HisPro: 0.849 ± 0.03	0.395HisGln: 0.395 ± 0.02	0.87HisArg: 0.87 ± 0.028	1.025HisSer: 1.025 ± 0.035	0.975HisThr: 0.975 ± 0.031	1.177HisVal: 1.177 ± 0.032	0.16HisTrp: 0.16 ± 0.012	0.732HisTyr: 0.732 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.765IleAla: 5.765 ± 0.085	1.387IleCys: 1.387 ± 0.041	5.125IleAsp: 5.125 ± 0.061	5.079IleGlu: 5.079 ± 0.073	2.81IlePhe: 2.81 ± 0.071	5.226IleGly: 5.226 ± 0.079	1.341IleHis: 1.341 ± 0.04	5.633IleIle: 5.633 ± 0.093	3.907IleLys: 3.907 ± 0.068	6.776IleLeu: 6.776 ± 0.106	2.236IleMet: 2.236 ± 0.054	3.24IleAsn: 3.24 ± 0.052	3.373IlePro: 3.373 ± 0.055	1.696IleGln: 1.696 ± 0.04	4.521IleArg: 4.521 ± 0.086	5.494IleSer: 5.494 ± 0.087	4.293IleThr: 4.293 ± 0.072	5.146IleVal: 5.146 ± 0.073	0.733IleTrp: 0.733 ± 0.025	3.054IleTyr: 3.054 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.597LysAla: 4.597 ± 0.073	0.664LysCys: 0.664 ± 0.027	4.019LysAsp: 4.019 ± 0.077	4.857LysGlu: 4.857 ± 0.085	1.67LysPhe: 1.67 ± 0.04	3.474LysGly: 3.474 ± 0.066	0.923LysHis: 0.923 ± 0.028	3.99LysIle: 3.99 ± 0.059	4.494LysLys: 4.494 ± 0.103	4.985LysLeu: 4.985 ± 0.079	1.737LysMet: 1.737 ± 0.044	2.826LysAsn: 2.826 ± 0.053	1.917LysPro: 1.917 ± 0.052	1.598LysGln: 1.598 ± 0.038	2.762LysArg: 2.762 ± 0.065	3.172LysSer: 3.172 ± 0.064	3.335LysThr: 3.335 ± 0.06	3.545LysVal: 3.545 ± 0.059	0.56LysTrp: 0.56 ± 0.023	2.697LysTyr: 2.697 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.29LeuAla: 6.29 ± 0.083	1.356LeuCys: 1.356 ± 0.04	5.618LeuAsp: 5.618 ± 0.077	5.339LeuGlu: 5.339 ± 0.072	3.725LeuPhe: 3.725 ± 0.071	5.642LeuGly: 5.642 ± 0.086	1.432LeuHis: 1.432 ± 0.038	6.905LeuIle: 6.905 ± 0.108	5.55LeuLys: 5.55 ± 0.082	7.25LeuLeu: 7.25 ± 0.112	2.698LeuMet: 2.698 ± 0.058	3.784LeuAsn: 3.784 ± 0.061	3.224LeuPro: 3.224 ± 0.061	2.011LeuGln: 2.011 ± 0.044	3.687LeuArg: 3.687 ± 0.066	6.123LeuSer: 6.123 ± 0.076	5.092LeuThr: 5.092 ± 0.072	5.137LeuVal: 5.137 ± 0.07	0.802LeuTrp: 0.802 ± 0.033	3.592LeuTyr: 3.592 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.299MetAla: 2.299 ± 0.043	0.407MetCys: 0.407 ± 0.019	2.15MetAsp: 2.15 ± 0.045	1.997MetGlu: 1.997 ± 0.044	1.12MetPhe: 1.12 ± 0.035	1.928MetGly: 1.928 ± 0.047	0.553MetHis: 0.553 ± 0.023	2.569MetIle: 2.569 ± 0.056	2.162MetLys: 2.162 ± 0.042	2.694MetLeu: 2.694 ± 0.055	1.01MetMet: 1.01 ± 0.034	1.668MetAsn: 1.668 ± 0.034	1.151MetPro: 1.151 ± 0.031	0.832MetGln: 0.832 ± 0.027	1.415MetArg: 1.415 ± 0.033	2.206MetSer: 2.206 ± 0.042	1.845MetThr: 1.845 ± 0.04	1.855MetVal: 1.855 ± 0.052	0.239MetTrp: 0.239 ± 0.015	1.142MetTyr: 1.142 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.258AsnAla: 3.258 ± 0.056	0.546AsnCys: 0.546 ± 0.022	2.717AsnAsp: 2.717 ± 0.053	2.95AsnGlu: 2.95 ± 0.051	1.384AsnPhe: 1.384 ± 0.035	3.229AsnGly: 3.229 ± 0.072	0.661AsnHis: 0.661 ± 0.025	3.409AsnIle: 3.409 ± 0.064	2.285AsnLys: 2.285 ± 0.05	3.437AsnLeu: 3.437 ± 0.06	1.424AsnMet: 1.424 ± 0.035	1.867AsnAsn: 1.867 ± 0.055	1.854AsnPro: 1.854 ± 0.044	0.945AsnGln: 0.945 ± 0.03	2.191AsnArg: 2.191 ± 0.042	2.507AsnSer: 2.507 ± 0.047	2.426AsnThr: 2.426 ± 0.055	2.755AsnVal: 2.755 ± 0.057	0.396AsnTrp: 0.396 ± 0.018	1.784AsnTyr: 1.784 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.865ProAla: 2.865 ± 0.078	0.407ProCys: 0.407 ± 0.021	3.277ProAsp: 3.277 ± 0.055	3.593ProGlu: 3.593 ± 0.081	1.437ProPhe: 1.437 ± 0.039	2.639ProGly: 2.639 ± 0.061	0.571ProHis: 0.571 ± 0.024	2.122ProIle: 2.122 ± 0.048	1.588ProLys: 1.588 ± 0.042	2.538ProLeu: 2.538 ± 0.049	0.885ProMet: 0.885 ± 0.028	1.178ProAsn: 1.178 ± 0.039	0.728ProPro: 0.728 ± 0.026	0.899ProGln: 0.899 ± 0.033	1.046ProArg: 1.046 ± 0.029	1.865ProSer: 1.865 ± 0.042	1.484ProThr: 1.484 ± 0.043	3.105ProVal: 3.105 ± 0.063	0.326ProTrp: 0.326 ± 0.02	1.546ProTyr: 1.546 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.983GlnAla: 1.983 ± 0.042	0.274GlnCys: 0.274 ± 0.017	1.375GlnAsp: 1.375 ± 0.034	1.643GlnGlu: 1.643 ± 0.049	1.014GlnPhe: 1.014 ± 0.031	1.575GlnGly: 1.575 ± 0.043	0.332GlnHis: 0.332 ± 0.018	2.232GlnIle: 2.232 ± 0.052	1.68GlnLys: 1.68 ± 0.046	2.016GlnLeu: 2.016 ± 0.054	0.911GlnMet: 0.911 ± 0.033	1.105GlnAsn: 1.105 ± 0.033	0.722GlnPro: 0.722 ± 0.031	0.802GlnGln: 0.802 ± 0.031	1.044GlnArg: 1.044 ± 0.031	1.359GlnSer: 1.359 ± 0.037	1.49GlnThr: 1.49 ± 0.038	1.537GlnVal: 1.537 ± 0.041	0.233GlnTrp: 0.233 ± 0.017	1.188GlnTyr: 1.188 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.02ArgAla: 3.02 ± 0.055	0.626ArgCys: 0.626 ± 0.023	3.123ArgAsp: 3.123 ± 0.054	3.739ArgGlu: 3.739 ± 0.077	2.23ArgPhe: 2.23 ± 0.043	2.672ArgGly: 2.672 ± 0.053	0.88ArgHis: 0.88 ± 0.026	4.372ArgIle: 4.372 ± 0.076	3.155ArgLys: 3.155 ± 0.059	3.97ArgLeu: 3.97 ± 0.066	1.618ArgMet: 1.618 ± 0.041	2.185ArgAsn: 2.185 ± 0.051	1.368ArgPro: 1.368 ± 0.039	1.329ArgGln: 1.329 ± 0.037	2.521ArgArg: 2.521 ± 0.059	2.861ArgSer: 2.861 ± 0.057	2.439ArgThr: 2.439 ± 0.046	2.93ArgVal: 2.93 ± 0.05	0.381ArgTrp: 0.381 ± 0.019	2.22ArgTyr: 2.22 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.814SerAla: 4.814 ± 0.074	0.737SerCys: 0.737 ± 0.029	4.858SerAsp: 4.858 ± 0.074	4.584SerGlu: 4.584 ± 0.067	2.767SerPhe: 2.767 ± 0.046	5.556SerGly: 5.556 ± 0.08	1.098SerHis: 1.098 ± 0.039	4.289SerIle: 4.289 ± 0.062	3.143SerLys: 3.143 ± 0.059	5.334SerLeu: 5.334 ± 0.08	1.853SerMet: 1.853 ± 0.04	2.314SerAsn: 2.314 ± 0.054	1.859SerPro: 1.859 ± 0.041	1.511SerGln: 1.511 ± 0.039	2.952SerArg: 2.952 ± 0.052	4.029SerSer: 4.029 ± 0.092	2.966SerThr: 2.966 ± 0.06	4.825SerVal: 4.825 ± 0.071	0.534SerTrp: 0.534 ± 0.024	2.674SerTyr: 2.674 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.265ThrAla: 4.265 ± 0.066	0.669ThrCys: 0.669 ± 0.028	4.463ThrAsp: 4.463 ± 0.081	3.876ThrGlu: 3.876 ± 0.069	2.092ThrPhe: 2.092 ± 0.053	5.05ThrGly: 5.05 ± 0.082	0.936ThrHis: 0.936 ± 0.03	4.016ThrIle: 4.016 ± 0.077	2.367ThrLys: 2.367 ± 0.051	4.547ThrLeu: 4.547 ± 0.07	1.415ThrMet: 1.415 ± 0.037	1.892ThrAsn: 1.892 ± 0.046	2.277ThrPro: 2.277 ± 0.061	1.295ThrGln: 1.295 ± 0.032	2.239ThrArg: 2.239 ± 0.042	3.119ThrSer: 3.119 ± 0.073	2.724ThrThr: 2.724 ± 0.07	4.487ThrVal: 4.487 ± 0.092	0.506ThrTrp: 0.506 ± 0.022	2.334ThrTyr: 2.334 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.718ValAla: 4.718 ± 0.079	1.169ValCys: 1.169 ± 0.037	4.318ValAsp: 4.318 ± 0.071	4.121ValGlu: 4.121 ± 0.076	3.067ValPhe: 3.067 ± 0.063	3.978ValGly: 3.978 ± 0.073	1.142ValHis: 1.142 ± 0.035	5.546ValIle: 5.546 ± 0.087	3.781ValLys: 3.781 ± 0.075	6.044ValLeu: 6.044 ± 0.086	2.063ValMet: 2.063 ± 0.047	2.967ValAsn: 2.967 ± 0.062	2.428ValPro: 2.428 ± 0.051	1.458ValGln: 1.458 ± 0.036	3.381ValArg: 3.381 ± 0.061	5.015ValSer: 5.015 ± 0.077	4.294ValThr: 4.294 ± 0.081	4.448ValVal: 4.448 ± 0.085	0.635ValTrp: 0.635 ± 0.025	2.982ValTyr: 2.982 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.584TrpAla: 0.584 ± 0.025	0.142TrpCys: 0.142 ± 0.012	0.616TrpAsp: 0.616 ± 0.024	0.61TrpGlu: 0.61 ± 0.026	0.442TrpPhe: 0.442 ± 0.021	0.7TrpGly: 0.7 ± 0.03	0.23TrpHis: 0.23 ± 0.016	0.751TrpIle: 0.751 ± 0.029	0.537TrpLys: 0.537 ± 0.021	0.824TrpLeu: 0.824 ± 0.031	0.291TrpMet: 0.291 ± 0.016	0.5TrpAsn: 0.5 ± 0.024	0.243TrpPro: 0.243 ± 0.015	0.265TrpGln: 0.265 ± 0.016	0.372TrpArg: 0.372 ± 0.018	0.512TrpSer: 0.512 ± 0.021	0.483TrpThr: 0.483 ± 0.024	0.545TrpVal: 0.545 ± 0.02	0.14TrpTrp: 0.14 ± 0.011	0.427TrpTyr: 0.427 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.056TyrAla: 3.056 ± 0.059	0.606TyrCys: 0.606 ± 0.024	3.473TyrAsp: 3.473 ± 0.06	3.272TyrGlu: 3.272 ± 0.055	1.761TyrPhe: 1.761 ± 0.045	3.092TyrGly: 3.092 ± 0.05	0.87TyrHis: 0.87 ± 0.027	3.194TyrIle: 3.194 ± 0.053	2.211TyrLys: 2.211 ± 0.051	3.909TyrLeu: 3.909 ± 0.07	1.349TyrMet: 1.349 ± 0.035	1.918TyrAsn: 1.918 ± 0.046	1.481TyrPro: 1.481 ± 0.037	1.043TyrGln: 1.043 ± 0.039	2.381TyrArg: 2.381 ± 0.047	2.994TyrSer: 2.994 ± 0.061	2.478TyrThr: 2.478 ± 0.073	2.937TyrVal: 2.937 ± 0.061	0.37TyrTrp: 0.37 ± 0.022	2.012TyrTyr: 2.012 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3048 proteins (1097907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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