Amino acid dipepetide frequency for Mesorhizobium sp. WSM3876

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.474AlaAla: 17.474 ± 0.148	1.037AlaCys: 1.037 ± 0.024	6.894AlaAsp: 6.894 ± 0.057	7.883AlaGlu: 7.883 ± 0.079	4.641AlaPhe: 4.641 ± 0.057	11.215AlaGly: 11.215 ± 0.095	2.167AlaHis: 2.167 ± 0.037	6.72AlaIle: 6.72 ± 0.071	4.776AlaLys: 4.776 ± 0.065	12.973AlaLeu: 12.973 ± 0.101	3.581AlaMet: 3.581 ± 0.051	3.092AlaAsn: 3.092 ± 0.043	5.135AlaPro: 5.135 ± 0.075	3.569AlaGln: 3.569 ± 0.05	8.399AlaArg: 8.399 ± 0.086	6.887AlaSer: 6.887 ± 0.076	5.781AlaThr: 5.781 ± 0.056	8.99AlaVal: 8.99 ± 0.08	1.47AlaTrp: 1.47 ± 0.032	2.673AlaTyr: 2.673 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.94CysAla: 0.94 ± 0.023	0.133CysCys: 0.133 ± 0.01	0.532CysAsp: 0.532 ± 0.019	0.445CysGlu: 0.445 ± 0.017	0.36CysPhe: 0.36 ± 0.015	0.924CysGly: 0.924 ± 0.026	0.212CysHis: 0.212 ± 0.012	0.39CysIle: 0.39 ± 0.013	0.198CysLys: 0.198 ± 0.011	0.815CysLeu: 0.815 ± 0.021	0.15CysMet: 0.15 ± 0.008	0.206CysAsn: 0.206 ± 0.01	0.413CysPro: 0.413 ± 0.017	0.233CysGln: 0.233 ± 0.012	0.633CysArg: 0.633 ± 0.023	0.496CysSer: 0.496 ± 0.017	0.424CysThr: 0.424 ± 0.018	0.604CysVal: 0.604 ± 0.019	0.142CysTrp: 0.142 ± 0.009	0.218CysTyr: 0.218 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.614AspAla: 6.614 ± 0.074	0.502AspCys: 0.502 ± 0.018	2.996AspAsp: 2.996 ± 0.045	3.501AspGlu: 3.501 ± 0.046	2.257AspPhe: 2.257 ± 0.041	5.034AspGly: 5.034 ± 0.067	1.269AspHis: 1.269 ± 0.028	3.194AspIle: 3.194 ± 0.045	1.992AspLys: 1.992 ± 0.032	5.574AspLeu: 5.574 ± 0.061	1.322AspMet: 1.322 ± 0.026	1.405AspAsn: 1.405 ± 0.034	3.324AspPro: 3.324 ± 0.042	1.782AspGln: 1.782 ± 0.036	4.343AspArg: 4.343 ± 0.052	2.17AspSer: 2.17 ± 0.035	2.482AspThr: 2.482 ± 0.039	4.018AspVal: 4.018 ± 0.042	0.947AspTrp: 0.947 ± 0.024	1.468AspTyr: 1.468 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.606GluAla: 7.606 ± 0.082	0.368GluCys: 0.368 ± 0.015	2.67GluAsp: 2.67 ± 0.044	3.144GluGlu: 3.144 ± 0.052	1.898GluPhe: 1.898 ± 0.037	4.013GluGly: 4.013 ± 0.054	1.243GluHis: 1.243 ± 0.032	3.526GluIle: 3.526 ± 0.046	2.611GluLys: 2.611 ± 0.042	5.461GluLeu: 5.461 ± 0.067	1.576GluMet: 1.576 ± 0.028	1.659GluAsn: 1.659 ± 0.036	2.801GluPro: 2.801 ± 0.047	2.156GluGln: 2.156 ± 0.036	4.967GluArg: 4.967 ± 0.058	2.232GluSer: 2.232 ± 0.033	3.374GluThr: 3.374 ± 0.045	3.784GluVal: 3.784 ± 0.05	0.663GluTrp: 0.663 ± 0.02	0.984GluTyr: 0.984 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.841PheAla: 4.841 ± 0.054	0.413PheCys: 0.413 ± 0.016	2.709PheAsp: 2.709 ± 0.044	2.269PheGlu: 2.269 ± 0.037	1.542PhePhe: 1.542 ± 0.033	3.804PheGly: 3.804 ± 0.049	0.795PheHis: 0.795 ± 0.021	1.835PheIle: 1.835 ± 0.038	1.071PheLys: 1.071 ± 0.024	3.488PheLeu: 3.488 ± 0.047	0.836PheMet: 0.836 ± 0.023	1.027PheAsn: 1.027 ± 0.026	1.638PhePro: 1.638 ± 0.034	1.073PheGln: 1.073 ± 0.027	2.377PheArg: 2.377 ± 0.038	2.402PheSer: 2.402 ± 0.035	1.778PheThr: 1.778 ± 0.03	3.03PheVal: 3.03 ± 0.044	0.565PheTrp: 0.565 ± 0.021	0.923PheTyr: 0.923 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	9.121GlyAla: 9.121 ± 0.08	0.816GlyCys: 0.816 ± 0.023	4.383GlyAsp: 4.383 ± 0.057	4.759GlyGlu: 4.759 ± 0.057	3.676GlyPhe: 3.676 ± 0.042	7.228GlyGly: 7.228 ± 0.079	1.972GlyHis: 1.972 ± 0.032	4.862GlyIle: 4.862 ± 0.062	3.851GlyLys: 3.851 ± 0.052	8.797GlyLeu: 8.797 ± 0.081	2.395GlyMet: 2.395 ± 0.039	2.332GlyAsn: 2.332 ± 0.04	3.459GlyPro: 3.459 ± 0.056	2.807GlyGln: 2.807 ± 0.036	5.9GlyArg: 5.9 ± 0.069	4.882GlySer: 4.882 ± 0.047	4.478GlyThr: 4.478 ± 0.052	6.028GlyVal: 6.028 ± 0.058	1.38GlyTrp: 1.38 ± 0.028	2.295GlyTyr: 2.295 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.276HisAla: 2.276 ± 0.04	0.241HisCys: 0.241 ± 0.012	1.252HisAsp: 1.252 ± 0.029	1.099HisGlu: 1.099 ± 0.027	0.887HisPhe: 0.887 ± 0.024	1.938HisGly: 1.938 ± 0.036	0.575HisHis: 0.575 ± 0.022	0.996HisIle: 0.996 ± 0.027	0.556HisLys: 0.556 ± 0.019	1.973HisLeu: 1.973 ± 0.036	0.525HisMet: 0.525 ± 0.017	0.485HisAsn: 0.485 ± 0.016	1.291HisPro: 1.291 ± 0.026	0.621HisGln: 0.621 ± 0.02	1.46HisArg: 1.46 ± 0.034	1.009HisSer: 1.009 ± 0.024	0.803HisThr: 0.803 ± 0.022	1.558HisVal: 1.558 ± 0.032	0.337HisTrp: 0.337 ± 0.015	0.553HisTyr: 0.553 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.64IleAla: 7.64 ± 0.076	0.523IleCys: 0.523 ± 0.018	3.69IleAsp: 3.69 ± 0.042	3.64IleGlu: 3.64 ± 0.051	1.859IlePhe: 1.859 ± 0.033	5.187IleGly: 5.187 ± 0.061	1.026IleHis: 1.026 ± 0.024	2.471IleIle: 2.471 ± 0.043	1.585IleLys: 1.585 ± 0.034	4.477IleLeu: 4.477 ± 0.057	1.047IleMet: 1.047 ± 0.029	1.49IleAsn: 1.49 ± 0.032	2.304IlePro: 2.304 ± 0.038	1.213IleGln: 1.213 ± 0.027	3.294IleArg: 3.294 ± 0.048	3.104IleSer: 3.104 ± 0.045	2.503IleThr: 2.503 ± 0.043	4.632IleVal: 4.632 ± 0.053	0.608IleTrp: 0.608 ± 0.021	1.209IleTyr: 1.209 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	4.97LysAla: 4.97 ± 0.054	0.181LysCys: 0.181 ± 0.01	1.926LysAsp: 1.926 ± 0.037	1.794LysGlu: 1.794 ± 0.034	1.03LysPhe: 1.03 ± 0.028	2.869LysGly: 2.869 ± 0.053	0.674LysHis: 0.674 ± 0.02	1.957LysIle: 1.957 ± 0.035	1.62LysLys: 1.62 ± 0.037	3.807LysLeu: 3.807 ± 0.05	0.887LysMet: 0.887 ± 0.028	1.041LysAsn: 1.041 ± 0.024	2.455LysPro: 2.455 ± 0.04	1.193LysGln: 1.193 ± 0.027	2.632LysArg: 2.632 ± 0.038	2.135LysSer: 2.135 ± 0.035	2.113LysThr: 2.113 ± 0.039	2.757LysVal: 2.757 ± 0.046	0.439LysTrp: 0.439 ± 0.016	0.685LysTyr: 0.685 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.691LeuAla: 13.691 ± 0.116	0.908LeuCys: 0.908 ± 0.02	5.878LeuAsp: 5.878 ± 0.066	5.252LeuGlu: 5.252 ± 0.07	3.705LeuPhe: 3.705 ± 0.056	8.284LeuGly: 8.284 ± 0.077	1.825LeuHis: 1.825 ± 0.034	5.028LeuIle: 5.028 ± 0.064	3.985LeuLys: 3.985 ± 0.051	9.297LeuLeu: 9.297 ± 0.114	2.267LeuMet: 2.267 ± 0.038	2.514LeuAsn: 2.514 ± 0.036	5.329LeuPro: 5.329 ± 0.068	2.721LeuGln: 2.721 ± 0.042	6.383LeuArg: 6.383 ± 0.07	6.589LeuSer: 6.589 ± 0.063	5.236LeuThr: 5.236 ± 0.064	7.434LeuVal: 7.434 ± 0.079	1.117LeuTrp: 1.117 ± 0.029	2.049LeuTyr: 2.049 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	3.222MetAla: 3.222 ± 0.044	0.142MetCys: 0.142 ± 0.01	1.103MetAsp: 1.103 ± 0.025	1.116MetGlu: 1.116 ± 0.025	0.735MetPhe: 0.735 ± 0.02	1.697MetGly: 1.697 ± 0.036	0.48MetHis: 0.48 ± 0.016	1.389MetIle: 1.389 ± 0.027	1.101MetLys: 1.101 ± 0.027	2.621MetLeu: 2.621 ± 0.044	0.679MetMet: 0.679 ± 0.022	0.816MetAsn: 0.816 ± 0.022	1.517MetPro: 1.517 ± 0.025	0.818MetGln: 0.818 ± 0.021	1.855MetArg: 1.855 ± 0.033	1.675MetSer: 1.675 ± 0.034	1.806MetThr: 1.806 ± 0.035	1.745MetVal: 1.745 ± 0.032	0.21MetTrp: 0.21 ± 0.01	0.303MetTyr: 0.303 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.228AsnAla: 3.228 ± 0.043	0.265AsnCys: 0.265 ± 0.013	1.451AsnAsp: 1.451 ± 0.033	1.358AsnGlu: 1.358 ± 0.03	1.053AsnPhe: 1.053 ± 0.029	2.519AsnGly: 2.519 ± 0.047	0.52AsnHis: 0.52 ± 0.018	1.436AsnIle: 1.436 ± 0.025	0.791AsnLys: 0.791 ± 0.025	2.535AsnLeu: 2.535 ± 0.035	0.637AsnMet: 0.637 ± 0.019	0.719AsnAsn: 0.719 ± 0.022	1.858AsnPro: 1.858 ± 0.036	0.794AsnGln: 0.794 ± 0.022	1.798AsnArg: 1.798 ± 0.033	1.372AsnSer: 1.372 ± 0.032	1.241AsnThr: 1.241 ± 0.026	2.006AsnVal: 2.006 ± 0.035	0.449AsnTrp: 0.449 ± 0.016	0.709AsnTyr: 0.709 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.317ProAla: 6.317 ± 0.072	0.321ProCys: 0.321 ± 0.016	3.447ProAsp: 3.447 ± 0.048	3.432ProGlu: 3.432 ± 0.05	1.999ProPhe: 1.999 ± 0.036	4.41ProGly: 4.41 ± 0.052	1.011ProHis: 1.011 ± 0.024	2.375ProIle: 2.375 ± 0.039	1.918ProLys: 1.918 ± 0.037	4.636ProLeu: 4.636 ± 0.054	1.171ProMet: 1.171 ± 0.025	1.374ProAsn: 1.374 ± 0.03	2.368ProPro: 2.368 ± 0.051	1.691ProGln: 1.691 ± 0.038	2.765ProArg: 2.765 ± 0.042	2.869ProSer: 2.869 ± 0.039	2.338ProThr: 2.338 ± 0.038	4.042ProVal: 4.042 ± 0.048	0.698ProTrp: 0.698 ± 0.02	1.225ProTyr: 1.225 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.045GlnAla: 4.045 ± 0.051	0.223GlnCys: 0.223 ± 0.011	1.391GlnAsp: 1.391 ± 0.03	1.472GlnGlu: 1.472 ± 0.028	1.088GlnPhe: 1.088 ± 0.029	2.32GlnGly: 2.32 ± 0.036	0.613GlnHis: 0.613 ± 0.019	1.757GlnIle: 1.757 ± 0.03	1.267GlnLys: 1.267 ± 0.03	2.887GlnLeu: 2.887 ± 0.044	0.89GlnMet: 0.89 ± 0.023	0.867GlnAsn: 0.867 ± 0.023	1.76GlnPro: 1.76 ± 0.039	1.208GlnGln: 1.208 ± 0.04	2.341GlnArg: 2.341 ± 0.039	1.774GlnSer: 1.774 ± 0.037	1.637GlnThr: 1.637 ± 0.034	2.115GlnVal: 2.115 ± 0.033	0.422GlnTrp: 0.422 ± 0.016	0.605GlnTyr: 0.605 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.586ArgAla: 7.586 ± 0.074	0.498ArgCys: 0.498 ± 0.018	3.873ArgAsp: 3.873 ± 0.051	3.942ArgGlu: 3.942 ± 0.058	2.926ArgPhe: 2.926 ± 0.044	4.648ArgGly: 4.648 ± 0.052	1.748ArgHis: 1.748 ± 0.034	4.021ArgIle: 4.021 ± 0.051	2.632ArgLys: 2.632 ± 0.041	7.736ArgLeu: 7.736 ± 0.086	1.861ArgMet: 1.861 ± 0.031	1.973ArgAsn: 1.973 ± 0.032	3.494ArgPro: 3.494 ± 0.047	2.637ArgGln: 2.637 ± 0.041	5.628ArgArg: 5.628 ± 0.067	3.851ArgSer: 3.851 ± 0.048	3.278ArgThr: 3.278 ± 0.043	4.36ArgVal: 4.36 ± 0.058	0.98ArgTrp: 0.98 ± 0.024	1.672ArgTyr: 1.672 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.541SerAla: 6.541 ± 0.067	0.438SerCys: 0.438 ± 0.017	3.069SerAsp: 3.069 ± 0.049	2.897SerGlu: 2.897 ± 0.045	2.468SerPhe: 2.468 ± 0.029	5.799SerGly: 5.799 ± 0.05	1.145SerHis: 1.145 ± 0.027	2.951SerIle: 2.951 ± 0.046	1.825SerLys: 1.825 ± 0.032	5.662SerLeu: 5.662 ± 0.064	1.381SerMet: 1.381 ± 0.028	1.455SerAsn: 1.455 ± 0.029	2.803SerPro: 2.803 ± 0.04	1.669SerGln: 1.669 ± 0.033	3.839SerArg: 3.839 ± 0.05	3.148SerSer: 3.148 ± 0.054	2.698SerThr: 2.698 ± 0.035	4.174SerVal: 4.174 ± 0.055	0.791SerTrp: 0.791 ± 0.023	1.318SerTyr: 1.318 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.125ThrAla: 6.125 ± 0.069	0.412ThrCys: 0.412 ± 0.016	2.636ThrAsp: 2.636 ± 0.045	2.455ThrGlu: 2.455 ± 0.034	1.952ThrPhe: 1.952 ± 0.032	4.864ThrGly: 4.864 ± 0.056	0.943ThrHis: 0.943 ± 0.024	3.032ThrIle: 3.032 ± 0.044	1.647ThrLys: 1.647 ± 0.031	5.37ThrLeu: 5.37 ± 0.054	1.236ThrMet: 1.236 ± 0.025	1.259ThrAsn: 1.259 ± 0.027	2.933ThrPro: 2.933 ± 0.035	1.3ThrGln: 1.3 ± 0.027	3.032ThrArg: 3.032 ± 0.045	2.879ThrSer: 2.879 ± 0.041	2.712ThrThr: 2.712 ± 0.048	4.25ThrVal: 4.25 ± 0.052	0.616ThrTrp: 0.616 ± 0.019	1.144ThrTyr: 1.144 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	9.415ValAla: 9.415 ± 0.085	0.642ValCys: 0.642 ± 0.02	4.217ValAsp: 4.217 ± 0.054	4.527ValGlu: 4.527 ± 0.052	2.844ValPhe: 2.844 ± 0.041	5.711ValGly: 5.711 ± 0.064	1.371ValHis: 1.371 ± 0.029	3.929ValIle: 3.929 ± 0.05	2.553ValLys: 2.553 ± 0.043	7.4ValLeu: 7.4 ± 0.068	1.804ValMet: 1.804 ± 0.036	1.937ValAsn: 1.937 ± 0.033	3.738ValPro: 3.738 ± 0.047	1.918ValGln: 1.918 ± 0.035	4.809ValArg: 4.809 ± 0.054	4.489ValSer: 4.489 ± 0.053	4.302ValThr: 4.302 ± 0.049	6.04ValVal: 6.04 ± 0.066	0.893ValTrp: 0.893 ± 0.022	1.501ValTyr: 1.501 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.233TrpAla: 1.233 ± 0.029	0.143TrpCys: 0.143 ± 0.007	0.606TrpAsp: 0.606 ± 0.02	0.518TrpGlu: 0.518 ± 0.016	0.541TrpPhe: 0.541 ± 0.019	0.862TrpGly: 0.862 ± 0.023	0.349TrpHis: 0.349 ± 0.015	0.691TrpIle: 0.691 ± 0.017	0.511TrpLys: 0.511 ± 0.021	1.675TrpLeu: 1.675 ± 0.037	0.348TrpMet: 0.348 ± 0.016	0.502TrpAsn: 0.502 ± 0.02	0.706TrpPro: 0.706 ± 0.022	0.578TrpGln: 0.578 ± 0.018	1.153TrpArg: 1.153 ± 0.025	0.834TrpSer: 0.834 ± 0.022	0.752TrpThr: 0.752 ± 0.021	0.785TrpVal: 0.785 ± 0.022	0.222TrpTrp: 0.222 ± 0.013	0.286TrpTyr: 0.286 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.469TyrAla: 2.469 ± 0.037	0.261TyrCys: 0.261 ± 0.012	1.471TyrAsp: 1.471 ± 0.032	1.23TyrGlu: 1.23 ± 0.029	0.956TyrPhe: 0.956 ± 0.023	2.095TyrGly: 2.095 ± 0.039	0.498TyrHis: 0.498 ± 0.017	0.939TyrIle: 0.939 ± 0.025	0.677TyrLys: 0.677 ± 0.021	2.305TyrLeu: 2.305 ± 0.036	0.439TyrMet: 0.439 ± 0.017	0.589TyrAsn: 0.589 ± 0.019	1.082TyrPro: 1.082 ± 0.028	0.703TyrGln: 0.703 ± 0.022	1.735TyrArg: 1.735 ± 0.034	1.271TyrSer: 1.271 ± 0.025	1.062TyrThr: 1.062 ± 0.026	1.687TyrVal: 1.687 ± 0.036	0.351TyrTrp: 0.351 ± 0.016	0.583TyrTyr: 0.583 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5672 proteins (1736559 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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