Amino acid dipepetide frequency for Escherichia phage P2 (Bacteriophage P2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.415AlaAla: 10.415 ± 1.971
0.86AlaCys: 0.86 ± 0.337
5.733AlaAsp: 5.733 ± 0.794
5.064AlaGlu: 5.064 ± 0.714
3.058AlaPhe: 3.058 ± 0.528
7.548AlaGly: 7.548 ± 1.187
1.624AlaHis: 1.624 ± 0.328
4.777AlaIle: 4.777 ± 0.626
4.968AlaLys: 4.968 ± 0.698
9.937AlaLeu: 9.937 ± 1.18
1.815AlaMet: 1.815 ± 0.448
2.293AlaAsn: 2.293 ± 0.366
4.3AlaPro: 4.3 ± 0.701
3.058AlaGln: 3.058 ± 0.715
4.682AlaArg: 4.682 ± 0.881
6.879AlaSer: 6.879 ± 0.85
6.306AlaThr: 6.306 ± 1.014
7.739AlaVal: 7.739 ± 0.874
1.624AlaTrp: 1.624 ± 0.372
2.102AlaTyr: 2.102 ± 0.437
0.0AlaXaa: 0.0 ± 0.0
Cys
1.051CysAla: 1.051 ± 0.304
0.0CysCys: 0.0 ± 0.0
0.764CysAsp: 0.764 ± 0.343
0.287CysGlu: 0.287 ± 0.157
0.382CysPhe: 0.382 ± 0.215
0.382CysGly: 0.382 ± 0.187
0.191CysHis: 0.191 ± 0.121
0.573CysIle: 0.573 ± 0.204
0.669CysLys: 0.669 ± 0.327
0.478CysLeu: 0.478 ± 0.195
0.191CysMet: 0.191 ± 0.134
0.287CysAsn: 0.287 ± 0.164
0.478CysPro: 0.478 ± 0.222
0.764CysGln: 0.764 ± 0.286
0.669CysArg: 0.669 ± 0.254
0.573CysSer: 0.573 ± 0.225
0.86CysThr: 0.86 ± 0.317
0.478CysVal: 0.478 ± 0.173
0.096CysTrp: 0.096 ± 0.095
0.478CysTyr: 0.478 ± 0.181
0.0CysXaa: 0.0 ± 0.0
Asp
6.688AspAla: 6.688 ± 0.705
0.573AspCys: 0.573 ± 0.272
3.153AspAsp: 3.153 ± 0.575
4.109AspGlu: 4.109 ± 0.805
3.153AspPhe: 3.153 ± 0.739
4.968AspGly: 4.968 ± 0.525
0.573AspHis: 0.573 ± 0.309
4.395AspIle: 4.395 ± 0.792
2.006AspLys: 2.006 ± 0.375
4.204AspLeu: 4.204 ± 0.655
0.86AspMet: 0.86 ± 0.249
2.389AspAsn: 2.389 ± 0.435
1.624AspPro: 1.624 ± 0.379
1.242AspGln: 1.242 ± 0.457
1.911AspArg: 1.911 ± 0.435
3.058AspSer: 3.058 ± 0.531
3.631AspThr: 3.631 ± 0.564
3.631AspVal: 3.631 ± 0.561
0.764AspTrp: 0.764 ± 0.229
2.389AspTyr: 2.389 ± 0.501
0.0AspXaa: 0.0 ± 0.0
Glu
4.395GluAla: 4.395 ± 0.685
0.478GluCys: 0.478 ± 0.193
2.389GluAsp: 2.389 ± 0.468
3.631GluGlu: 3.631 ± 0.504
1.72GluPhe: 1.72 ± 0.396
2.293GluGly: 2.293 ± 0.353
1.529GluHis: 1.529 ± 0.357
3.726GluIle: 3.726 ± 0.692
3.726GluLys: 3.726 ± 0.608
7.166GluLeu: 7.166 ± 0.662
2.006GluMet: 2.006 ± 0.359
3.535GluAsn: 3.535 ± 0.629
2.866GluPro: 2.866 ± 0.584
2.675GluGln: 2.675 ± 0.604
4.013GluArg: 4.013 ± 0.995
5.255GluSer: 5.255 ± 0.836
3.535GluThr: 3.535 ± 0.54
3.44GluVal: 3.44 ± 0.579
1.338GluTrp: 1.338 ± 0.434
2.962GluTyr: 2.962 ± 0.543
0.0GluXaa: 0.0 ± 0.0
Phe
2.771PheAla: 2.771 ± 0.453
0.382PheCys: 0.382 ± 0.166
1.72PheAsp: 1.72 ± 0.355
2.389PheGlu: 2.389 ± 0.543
1.815PhePhe: 1.815 ± 0.444
1.815PheGly: 1.815 ± 0.383
0.669PheHis: 0.669 ± 0.247
2.006PheIle: 2.006 ± 0.566
2.771PheLys: 2.771 ± 0.479
3.631PheLeu: 3.631 ± 0.747
0.86PheMet: 0.86 ± 0.269
1.433PheAsn: 1.433 ± 0.371
1.529PhePro: 1.529 ± 0.382
1.338PheGln: 1.338 ± 0.292
2.102PheArg: 2.102 ± 0.365
2.866PheSer: 2.866 ± 0.636
3.249PheThr: 3.249 ± 0.466
1.147PheVal: 1.147 ± 0.282
0.669PheTrp: 0.669 ± 0.276
1.338PheTyr: 1.338 ± 0.433
0.0PheXaa: 0.0 ± 0.0
Gly
5.064GlyAla: 5.064 ± 1.007
0.764GlyCys: 0.764 ± 0.316
4.873GlyAsp: 4.873 ± 0.779
4.204GlyGlu: 4.204 ± 0.549
2.293GlyPhe: 2.293 ± 0.433
4.3GlyGly: 4.3 ± 0.723
0.764GlyHis: 0.764 ± 0.245
3.822GlyIle: 3.822 ± 0.571
6.497GlyLys: 6.497 ± 0.808
4.682GlyLeu: 4.682 ± 0.753
2.198GlyMet: 2.198 ± 0.53
1.815GlyAsn: 1.815 ± 0.517
0.287GlyPro: 0.287 ± 0.175
2.293GlyGln: 2.293 ± 0.459
4.491GlyArg: 4.491 ± 0.656
3.153GlySer: 3.153 ± 0.429
4.491GlyThr: 4.491 ± 0.68
5.064GlyVal: 5.064 ± 0.862
0.955GlyTrp: 0.955 ± 0.206
1.911GlyTyr: 1.911 ± 0.387
0.0GlyXaa: 0.0 ± 0.0
His
2.102HisAla: 2.102 ± 0.519
0.382HisCys: 0.382 ± 0.179
0.86HisAsp: 0.86 ± 0.361
1.338HisGlu: 1.338 ± 0.48
0.669HisPhe: 0.669 ± 0.247
1.051HisGly: 1.051 ± 0.354
0.669HisHis: 0.669 ± 0.221
1.529HisIle: 1.529 ± 0.358
0.955HisLys: 0.955 ± 0.278
1.815HisLeu: 1.815 ± 0.465
0.382HisMet: 0.382 ± 0.181
0.955HisAsn: 0.955 ± 0.369
1.147HisPro: 1.147 ± 0.323
0.764HisGln: 0.764 ± 0.25
1.051HisArg: 1.051 ± 0.295
0.764HisSer: 0.764 ± 0.299
1.051HisThr: 1.051 ± 0.396
0.478HisVal: 0.478 ± 0.194
0.287HisTrp: 0.287 ± 0.149
0.573HisTyr: 0.573 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
4.586IleAla: 4.586 ± 0.706
0.573IleCys: 0.573 ± 0.256
3.726IleAsp: 3.726 ± 0.54
3.535IleGlu: 3.535 ± 0.493
2.675IlePhe: 2.675 ± 0.554
3.631IleGly: 3.631 ± 0.681
0.955IleHis: 0.955 ± 0.355
3.249IleIle: 3.249 ± 0.48
3.535IleLys: 3.535 ± 0.923
3.822IleLeu: 3.822 ± 0.655
0.764IleMet: 0.764 ± 0.218
3.44IleAsn: 3.44 ± 0.537
2.198IlePro: 2.198 ± 0.504
2.102IleGln: 2.102 ± 0.5
4.968IleArg: 4.968 ± 0.799
5.446IleSer: 5.446 ± 0.922
4.586IleThr: 4.586 ± 0.553
3.344IleVal: 3.344 ± 0.614
0.955IleTrp: 0.955 ± 0.259
1.529IleTyr: 1.529 ± 0.322
0.0IleXaa: 0.0 ± 0.0
Lys
5.255LysAla: 5.255 ± 0.68
0.191LysCys: 0.191 ± 0.131
2.484LysAsp: 2.484 ± 0.598
2.866LysGlu: 2.866 ± 0.451
2.006LysPhe: 2.006 ± 0.477
3.344LysGly: 3.344 ± 0.571
1.624LysHis: 1.624 ± 0.383
3.822LysIle: 3.822 ± 0.732
5.064LysLys: 5.064 ± 0.887
5.351LysLeu: 5.351 ± 0.912
0.86LysMet: 0.86 ± 0.219
4.013LysAsn: 4.013 ± 0.727
2.771LysPro: 2.771 ± 0.582
2.006LysGln: 2.006 ± 0.426
4.013LysArg: 4.013 ± 0.676
4.013LysSer: 4.013 ± 0.793
3.822LysThr: 3.822 ± 0.5
3.822LysVal: 3.822 ± 0.554
1.051LysTrp: 1.051 ± 0.31
2.58LysTyr: 2.58 ± 0.448
0.0LysXaa: 0.0 ± 0.0
Leu
9.841LeuAla: 9.841 ± 0.9
0.86LeuCys: 0.86 ± 0.274
4.873LeuAsp: 4.873 ± 0.689
5.924LeuGlu: 5.924 ± 0.731
3.726LeuPhe: 3.726 ± 0.709
4.491LeuGly: 4.491 ± 0.797
2.102LeuHis: 2.102 ± 0.525
4.873LeuIle: 4.873 ± 0.671
5.542LeuLys: 5.542 ± 0.894
6.306LeuLeu: 6.306 ± 0.982
3.344LeuMet: 3.344 ± 0.598
5.351LeuAsn: 5.351 ± 0.654
3.631LeuPro: 3.631 ± 0.61
2.866LeuGln: 2.866 ± 0.533
4.491LeuArg: 4.491 ± 0.542
7.644LeuSer: 7.644 ± 0.994
7.453LeuThr: 7.453 ± 0.728
4.3LeuVal: 4.3 ± 0.572
0.86LeuTrp: 0.86 ± 0.286
2.484LeuTyr: 2.484 ± 0.577
0.0LeuXaa: 0.0 ± 0.0
Met
2.962MetAla: 2.962 ± 0.521
0.287MetCys: 0.287 ± 0.165
0.669MetAsp: 0.669 ± 0.308
1.242MetGlu: 1.242 ± 0.302
0.955MetPhe: 0.955 ± 0.298
0.669MetGly: 0.669 ± 0.252
0.478MetHis: 0.478 ± 0.246
1.433MetIle: 1.433 ± 0.417
1.338MetLys: 1.338 ± 0.344
2.771MetLeu: 2.771 ± 0.557
1.051MetMet: 1.051 ± 0.331
1.72MetAsn: 1.72 ± 0.429
0.955MetPro: 0.955 ± 0.287
0.764MetGln: 0.764 ± 0.239
2.102MetArg: 2.102 ± 0.511
1.529MetSer: 1.529 ± 0.29
2.866MetThr: 2.866 ± 0.508
1.147MetVal: 1.147 ± 0.31
0.382MetTrp: 0.382 ± 0.183
0.478MetTyr: 0.478 ± 0.176
0.0MetXaa: 0.0 ± 0.0
Asn
3.153AsnAla: 3.153 ± 0.535
0.382AsnCys: 0.382 ± 0.175
2.58AsnAsp: 2.58 ± 0.553
2.484AsnGlu: 2.484 ± 0.565
1.338AsnPhe: 1.338 ± 0.35
3.917AsnGly: 3.917 ± 0.86
0.86AsnHis: 0.86 ± 0.406
3.058AsnIle: 3.058 ± 0.573
3.058AsnLys: 3.058 ± 0.605
2.675AsnLeu: 2.675 ± 0.418
1.051AsnMet: 1.051 ± 0.297
2.006AsnAsn: 2.006 ± 0.502
1.911AsnPro: 1.911 ± 0.523
1.529AsnGln: 1.529 ± 0.404
2.675AsnArg: 2.675 ± 0.57
2.675AsnSer: 2.675 ± 0.613
2.675AsnThr: 2.675 ± 0.562
2.771AsnVal: 2.771 ± 0.606
0.287AsnTrp: 0.287 ± 0.169
1.242AsnTyr: 1.242 ± 0.41
0.0AsnXaa: 0.0 ± 0.0
Pro
3.631ProAla: 3.631 ± 0.76
0.287ProCys: 0.287 ± 0.166
3.344ProAsp: 3.344 ± 0.575
3.058ProGlu: 3.058 ± 0.504
1.051ProPhe: 1.051 ± 0.427
1.911ProGly: 1.911 ± 0.394
1.147ProHis: 1.147 ± 0.406
1.624ProIle: 1.624 ± 0.362
2.389ProLys: 2.389 ± 0.533
3.344ProLeu: 3.344 ± 0.534
0.669ProMet: 0.669 ± 0.287
0.86ProAsn: 0.86 ± 0.271
1.529ProPro: 1.529 ± 0.367
1.815ProGln: 1.815 ± 0.363
2.484ProArg: 2.484 ± 0.661
2.675ProSer: 2.675 ± 0.547
2.102ProThr: 2.102 ± 0.37
4.491ProVal: 4.491 ± 0.72
0.573ProTrp: 0.573 ± 0.229
1.051ProTyr: 1.051 ± 0.288
0.0ProXaa: 0.0 ± 0.0
Gln
3.726GlnAla: 3.726 ± 1.211
0.191GlnCys: 0.191 ± 0.124
1.911GlnAsp: 1.911 ± 0.482
2.771GlnGlu: 2.771 ± 0.5
0.955GlnPhe: 0.955 ± 0.306
1.815GlnGly: 1.815 ± 0.373
0.478GlnHis: 0.478 ± 0.232
2.389GlnIle: 2.389 ± 0.587
2.484GlnLys: 2.484 ± 0.427
3.822GlnLeu: 3.822 ± 0.631
1.147GlnMet: 1.147 ± 0.275
1.051GlnAsn: 1.051 ± 0.348
1.624GlnPro: 1.624 ± 0.468
2.293GlnGln: 2.293 ± 0.489
3.822GlnArg: 3.822 ± 0.737
2.102GlnSer: 2.102 ± 0.515
1.911GlnThr: 1.911 ± 0.368
2.198GlnVal: 2.198 ± 0.437
0.382GlnTrp: 0.382 ± 0.228
0.669GlnTyr: 0.669 ± 0.239
0.0GlnXaa: 0.0 ± 0.0
Arg
5.351ArgAla: 5.351 ± 0.785
0.86ArgCys: 0.86 ± 0.304
3.249ArgAsp: 3.249 ± 0.462
4.395ArgGlu: 4.395 ± 0.698
1.911ArgPhe: 1.911 ± 0.37
3.344ArgGly: 3.344 ± 0.72
1.242ArgHis: 1.242 ± 0.289
3.535ArgIle: 3.535 ± 0.631
3.344ArgLys: 3.344 ± 0.579
5.924ArgLeu: 5.924 ± 0.79
1.529ArgMet: 1.529 ± 0.398
2.484ArgAsn: 2.484 ± 0.457
2.293ArgPro: 2.293 ± 0.391
3.535ArgGln: 3.535 ± 0.667
4.777ArgArg: 4.777 ± 0.667
2.962ArgSer: 2.962 ± 0.465
2.962ArgThr: 2.962 ± 0.473
4.204ArgVal: 4.204 ± 0.938
1.147ArgTrp: 1.147 ± 0.304
2.484ArgTyr: 2.484 ± 0.509
0.0ArgXaa: 0.0 ± 0.0
Ser
5.637SerAla: 5.637 ± 0.948
0.382SerCys: 0.382 ± 0.196
3.44SerAsp: 3.44 ± 0.573
4.682SerGlu: 4.682 ± 0.772
2.389SerPhe: 2.389 ± 0.58
4.586SerGly: 4.586 ± 0.632
1.051SerHis: 1.051 ± 0.473
3.344SerIle: 3.344 ± 0.556
3.535SerLys: 3.535 ± 0.573
7.357SerLeu: 7.357 ± 1.002
1.624SerMet: 1.624 ± 0.383
2.866SerAsn: 2.866 ± 0.664
2.962SerPro: 2.962 ± 0.667
2.58SerGln: 2.58 ± 0.38
3.822SerArg: 3.822 ± 0.607
3.058SerSer: 3.058 ± 0.728
4.109SerThr: 4.109 ± 0.556
5.064SerVal: 5.064 ± 0.763
0.382SerTrp: 0.382 ± 0.153
1.529SerTyr: 1.529 ± 0.449
0.0SerXaa: 0.0 ± 0.0
Thr
7.262ThrAla: 7.262 ± 1.195
0.764ThrCys: 0.764 ± 0.243
3.726ThrAsp: 3.726 ± 0.514
3.344ThrGlu: 3.344 ± 0.623
2.102ThrPhe: 2.102 ± 0.353
7.262ThrGly: 7.262 ± 0.876
1.147ThrHis: 1.147 ± 0.343
3.153ThrIle: 3.153 ± 0.519
3.058ThrLys: 3.058 ± 0.547
7.644ThrLeu: 7.644 ± 0.892
2.006ThrMet: 2.006 ± 0.361
2.198ThrAsn: 2.198 ± 0.631
3.249ThrPro: 3.249 ± 0.467
1.911ThrGln: 1.911 ± 0.493
4.013ThrArg: 4.013 ± 0.559
3.344ThrSer: 3.344 ± 0.362
4.204ThrThr: 4.204 ± 0.844
4.873ThrVal: 4.873 ± 0.723
0.478ThrTrp: 0.478 ± 0.188
0.86ThrTyr: 0.86 ± 0.267
0.0ThrXaa: 0.0 ± 0.0
Val
6.879ValAla: 6.879 ± 0.973
1.051ValCys: 1.051 ± 0.374
3.344ValAsp: 3.344 ± 0.586
4.013ValGlu: 4.013 ± 0.681
2.389ValPhe: 2.389 ± 0.453
4.013ValGly: 4.013 ± 0.664
0.669ValHis: 0.669 ± 0.211
5.16ValIle: 5.16 ± 0.756
4.3ValLys: 4.3 ± 0.637
5.351ValLeu: 5.351 ± 0.713
2.198ValMet: 2.198 ± 0.433
2.198ValAsn: 2.198 ± 0.463
2.389ValPro: 2.389 ± 0.443
2.006ValGln: 2.006 ± 0.424
2.58ValArg: 2.58 ± 0.456
4.395ValSer: 4.395 ± 0.526
5.16ValThr: 5.16 ± 0.988
4.013ValVal: 4.013 ± 0.821
0.573ValTrp: 0.573 ± 0.233
1.72ValTyr: 1.72 ± 0.416
0.0ValXaa: 0.0 ± 0.0
Trp
1.051TrpAla: 1.051 ± 0.249
0.096TrpCys: 0.096 ± 0.095
1.147TrpAsp: 1.147 ± 0.269
0.86TrpGlu: 0.86 ± 0.219
0.382TrpPhe: 0.382 ± 0.164
0.669TrpGly: 0.669 ± 0.335
0.478TrpHis: 0.478 ± 0.208
0.573TrpIle: 0.573 ± 0.214
0.764TrpLys: 0.764 ± 0.286
1.815TrpLeu: 1.815 ± 0.433
0.382TrpMet: 0.382 ± 0.206
0.478TrpAsn: 0.478 ± 0.287
1.051TrpPro: 1.051 ± 0.338
0.382TrpGln: 0.382 ± 0.17
1.433TrpArg: 1.433 ± 0.333
0.478TrpSer: 0.478 ± 0.194
0.287TrpThr: 0.287 ± 0.194
0.573TrpVal: 0.573 ± 0.177
0.478TrpTrp: 0.478 ± 0.191
0.573TrpTyr: 0.573 ± 0.229
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.962TyrAla: 2.962 ± 0.61
0.287TyrCys: 0.287 ± 0.161
1.433TyrAsp: 1.433 ± 0.389
2.484TyrGlu: 2.484 ± 0.511
1.529TyrPhe: 1.529 ± 0.433
1.911TyrGly: 1.911 ± 0.423
0.573TyrHis: 0.573 ± 0.221
2.58TyrIle: 2.58 ± 0.472
0.955TyrLys: 0.955 ± 0.357
2.866TyrLeu: 2.866 ± 0.613
0.764TyrMet: 0.764 ± 0.244
0.955TyrAsn: 0.955 ± 0.201
1.242TyrPro: 1.242 ± 0.345
1.815TyrGln: 1.815 ± 0.411
1.433TyrArg: 1.433 ± 0.434
1.529TyrSer: 1.529 ± 0.45
1.338TyrThr: 1.338 ± 0.345
1.624TyrVal: 1.624 ± 0.382
0.669TyrTrp: 0.669 ± 0.264
1.051TyrTyr: 1.051 ± 0.346
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (10467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski