Amino acid dipepetide frequency for Gordonia phage Skog

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.393AlaAla: 10.393 ± 0.671
0.884AlaCys: 0.884 ± 0.18
6.438AlaAsp: 6.438 ± 0.46
6.796AlaGlu: 6.796 ± 0.457
2.693AlaPhe: 2.693 ± 0.277
7.89AlaGly: 7.89 ± 0.622
2.083AlaHis: 2.083 ± 0.228
4.671AlaIle: 4.671 ± 0.363
3.703AlaLys: 3.703 ± 0.293
6.88AlaLeu: 6.88 ± 0.373
2.398AlaMet: 2.398 ± 0.207
3.514AlaAsn: 3.514 ± 0.27
5.113AlaPro: 5.113 ± 0.497
4.229AlaGln: 4.229 ± 0.397
6.038AlaArg: 6.038 ± 0.379
5.723AlaSer: 5.723 ± 0.362
5.807AlaThr: 5.807 ± 0.438
6.88AlaVal: 6.88 ± 0.395
1.62AlaTrp: 1.62 ± 0.198
2.988AlaTyr: 2.988 ± 0.251
0.0AlaXaa: 0.0 ± 0.0
Cys
0.736CysAla: 0.736 ± 0.144
0.189CysCys: 0.189 ± 0.07
0.547CysAsp: 0.547 ± 0.115
0.547CysGlu: 0.547 ± 0.106
0.358CysPhe: 0.358 ± 0.092
1.073CysGly: 1.073 ± 0.173
0.337CysHis: 0.337 ± 0.084
0.4CysIle: 0.4 ± 0.093
0.105CysLys: 0.105 ± 0.045
0.547CysLeu: 0.547 ± 0.12
0.168CysMet: 0.168 ± 0.059
0.231CysAsn: 0.231 ± 0.066
0.736CysPro: 0.736 ± 0.149
0.231CysGln: 0.231 ± 0.071
0.442CysArg: 0.442 ± 0.099
0.484CysSer: 0.484 ± 0.099
0.442CysThr: 0.442 ± 0.096
0.421CysVal: 0.421 ± 0.092
0.316CysTrp: 0.316 ± 0.085
0.295CysTyr: 0.295 ± 0.081
0.0CysXaa: 0.0 ± 0.0
Asp
6.712AspAla: 6.712 ± 0.444
0.547AspCys: 0.547 ± 0.112
5.618AspAsp: 5.618 ± 0.78
5.07AspGlu: 5.07 ± 0.424
2.672AspPhe: 2.672 ± 0.263
5.618AspGly: 5.618 ± 0.36
1.767AspHis: 1.767 ± 0.232
2.882AspIle: 2.882 ± 0.249
2.756AspLys: 2.756 ± 0.283
5.807AspLeu: 5.807 ± 0.351
1.262AspMet: 1.262 ± 0.211
2.104AspAsn: 2.104 ± 0.215
4.523AspPro: 4.523 ± 0.406
2.63AspGln: 2.63 ± 0.22
4.839AspArg: 4.839 ± 0.38
3.808AspSer: 3.808 ± 0.3
4.103AspThr: 4.103 ± 0.364
4.881AspVal: 4.881 ± 0.291
1.494AspTrp: 1.494 ± 0.252
2.104AspTyr: 2.104 ± 0.204
0.0AspXaa: 0.0 ± 0.0
Glu
6.754GluAla: 6.754 ± 0.413
0.631GluCys: 0.631 ± 0.121
4.04GluAsp: 4.04 ± 0.365
4.502GluGlu: 4.502 ± 0.453
2.125GluPhe: 2.125 ± 0.202
4.019GluGly: 4.019 ± 0.31
1.746GluHis: 1.746 ± 0.186
3.85GluIle: 3.85 ± 0.345
2.967GluLys: 2.967 ± 0.291
5.155GluLeu: 5.155 ± 0.38
2.062GluMet: 2.062 ± 0.265
2.146GluAsn: 2.146 ± 0.264
3.661GluPro: 3.661 ± 0.282
2.819GluGln: 2.819 ± 0.234
4.839GluArg: 4.839 ± 0.436
3.619GluSer: 3.619 ± 0.3
3.493GluThr: 3.493 ± 0.257
4.692GluVal: 4.692 ± 0.356
1.389GluTrp: 1.389 ± 0.188
1.978GluTyr: 1.978 ± 0.244
0.0GluXaa: 0.0 ± 0.0
Phe
2.609PheAla: 2.609 ± 0.246
0.4PheCys: 0.4 ± 0.098
2.672PheAsp: 2.672 ± 0.257
1.915PheGlu: 1.915 ± 0.199
0.884PhePhe: 0.884 ± 0.123
2.714PheGly: 2.714 ± 0.217
0.736PheHis: 0.736 ± 0.126
0.905PheIle: 0.905 ± 0.14
0.757PheLys: 0.757 ± 0.155
2.462PheLeu: 2.462 ± 0.266
0.736PheMet: 0.736 ± 0.145
1.157PheAsn: 1.157 ± 0.172
1.599PhePro: 1.599 ± 0.206
1.557PheGln: 1.557 ± 0.212
1.999PheArg: 1.999 ± 0.209
2.062PheSer: 2.062 ± 0.195
1.978PheThr: 1.978 ± 0.204
2.441PheVal: 2.441 ± 0.231
0.589PheTrp: 0.589 ± 0.095
1.01PheTyr: 1.01 ± 0.168
0.0PheXaa: 0.0 ± 0.0
Gly
6.165GlyAla: 6.165 ± 0.496
0.631GlyCys: 0.631 ± 0.13
5.575GlyAsp: 5.575 ± 0.595
5.134GlyGlu: 5.134 ± 0.319
2.462GlyPhe: 2.462 ± 0.212
8.037GlyGly: 8.037 ± 0.739
1.83GlyHis: 1.83 ± 0.193
3.892GlyIle: 3.892 ± 0.31
3.408GlyLys: 3.408 ± 0.309
6.122GlyLeu: 6.122 ± 0.45
2.146GlyMet: 2.146 ± 0.219
2.777GlyAsn: 2.777 ± 0.335
4.713GlyPro: 4.713 ± 0.588
3.598GlyGln: 3.598 ± 0.318
4.629GlyArg: 4.629 ± 0.28
5.807GlySer: 5.807 ± 0.41
5.639GlyThr: 5.639 ± 0.531
5.786GlyVal: 5.786 ± 0.325
1.809GlyTrp: 1.809 ± 0.19
2.567GlyTyr: 2.567 ± 0.229
0.0GlyXaa: 0.0 ± 0.0
His
2.02HisAla: 2.02 ± 0.216
0.231HisCys: 0.231 ± 0.068
1.851HisAsp: 1.851 ± 0.233
1.641HisGlu: 1.641 ± 0.196
0.863HisPhe: 0.863 ± 0.158
1.725HisGly: 1.725 ± 0.225
0.715HisHis: 0.715 ± 0.14
0.863HisIle: 0.863 ± 0.152
0.842HisLys: 0.842 ± 0.157
1.83HisLeu: 1.83 ± 0.203
0.358HisMet: 0.358 ± 0.085
0.715HisAsn: 0.715 ± 0.129
1.662HisPro: 1.662 ± 0.216
1.22HisGln: 1.22 ± 0.201
1.494HisArg: 1.494 ± 0.21
0.842HisSer: 0.842 ± 0.123
1.452HisThr: 1.452 ± 0.182
1.494HisVal: 1.494 ± 0.16
0.379HisTrp: 0.379 ± 0.094
0.842HisTyr: 0.842 ± 0.134
0.0HisXaa: 0.0 ± 0.0
Ile
4.65IleAla: 4.65 ± 0.317
0.337IleCys: 0.337 ± 0.081
3.535IleAsp: 3.535 ± 0.311
3.703IleGlu: 3.703 ± 0.354
1.325IlePhe: 1.325 ± 0.173
3.114IleGly: 3.114 ± 0.376
0.905IleHis: 0.905 ± 0.132
1.41IleIle: 1.41 ± 0.194
1.641IleLys: 1.641 ± 0.225
2.903IleLeu: 2.903 ± 0.282
0.61IleMet: 0.61 ± 0.112
1.473IleAsn: 1.473 ± 0.213
2.441IlePro: 2.441 ± 0.247
1.452IleGln: 1.452 ± 0.205
2.798IleArg: 2.798 ± 0.324
2.609IleSer: 2.609 ± 0.328
2.988IleThr: 2.988 ± 0.283
3.661IleVal: 3.661 ± 0.273
0.61IleTrp: 0.61 ± 0.101
1.283IleTyr: 1.283 ± 0.162
0.0IleXaa: 0.0 ± 0.0
Lys
3.976LysAla: 3.976 ± 0.355
0.168LysCys: 0.168 ± 0.062
2.146LysAsp: 2.146 ± 0.293
1.809LysGlu: 1.809 ± 0.218
0.989LysPhe: 0.989 ± 0.159
3.03LysGly: 3.03 ± 0.442
0.715LysHis: 0.715 ± 0.118
1.62LysIle: 1.62 ± 0.163
1.494LysLys: 1.494 ± 0.222
3.324LysLeu: 3.324 ± 0.252
0.736LysMet: 0.736 ± 0.124
1.01LysAsn: 1.01 ± 0.151
2.209LysPro: 2.209 ± 0.219
1.304LysGln: 1.304 ± 0.196
2.903LysArg: 2.903 ± 0.29
1.915LysSer: 1.915 ± 0.234
2.125LysThr: 2.125 ± 0.265
3.156LysVal: 3.156 ± 0.26
0.442LysTrp: 0.442 ± 0.113
0.968LysTyr: 0.968 ± 0.136
0.0LysXaa: 0.0 ± 0.0
Leu
7.932LeuAla: 7.932 ± 0.447
0.694LeuCys: 0.694 ± 0.124
5.849LeuAsp: 5.849 ± 0.324
3.955LeuGlu: 3.955 ± 0.339
2.104LeuPhe: 2.104 ± 0.248
5.723LeuGly: 5.723 ± 0.427
1.578LeuHis: 1.578 ± 0.181
2.714LeuIle: 2.714 ± 0.239
2.946LeuLys: 2.946 ± 0.322
4.818LeuLeu: 4.818 ± 0.4
1.83LeuMet: 1.83 ± 0.189
2.735LeuAsn: 2.735 ± 0.286
3.85LeuPro: 3.85 ± 0.297
3.303LeuGln: 3.303 ± 0.349
5.491LeuArg: 5.491 ± 0.36
5.512LeuSer: 5.512 ± 0.381
4.902LeuThr: 4.902 ± 0.397
5.239LeuVal: 5.239 ± 0.402
0.947LeuTrp: 0.947 ± 0.144
2.272LeuTyr: 2.272 ± 0.198
0.0LeuXaa: 0.0 ± 0.0
Met
2.567MetAla: 2.567 ± 0.231
0.231MetCys: 0.231 ± 0.083
1.031MetAsp: 1.031 ± 0.16
1.136MetGlu: 1.136 ± 0.191
0.715MetPhe: 0.715 ± 0.117
1.915MetGly: 1.915 ± 0.219
0.421MetHis: 0.421 ± 0.095
1.136MetIle: 1.136 ± 0.187
0.884MetLys: 0.884 ± 0.151
1.431MetLeu: 1.431 ± 0.199
0.505MetMet: 0.505 ± 0.121
0.715MetAsn: 0.715 ± 0.134
1.452MetPro: 1.452 ± 0.177
0.652MetGln: 0.652 ± 0.117
1.515MetArg: 1.515 ± 0.21
2.42MetSer: 2.42 ± 0.236
2.293MetThr: 2.293 ± 0.196
1.662MetVal: 1.662 ± 0.176
0.295MetTrp: 0.295 ± 0.081
0.526MetTyr: 0.526 ± 0.099
0.0MetXaa: 0.0 ± 0.0
Asn
3.135AsnAla: 3.135 ± 0.314
0.295AsnCys: 0.295 ± 0.092
2.272AsnAsp: 2.272 ± 0.224
1.83AsnGlu: 1.83 ± 0.19
1.136AsnPhe: 1.136 ± 0.146
3.682AsnGly: 3.682 ± 0.362
0.694AsnHis: 0.694 ± 0.139
1.325AsnIle: 1.325 ± 0.217
1.157AsnLys: 1.157 ± 0.187
2.356AsnLeu: 2.356 ± 0.267
0.884AsnMet: 0.884 ± 0.164
1.325AsnAsn: 1.325 ± 0.185
2.398AsnPro: 2.398 ± 0.203
1.157AsnGln: 1.157 ± 0.15
1.915AsnArg: 1.915 ± 0.23
1.999AsnSer: 1.999 ± 0.234
2.188AsnThr: 2.188 ± 0.293
1.83AsnVal: 1.83 ± 0.206
0.778AsnTrp: 0.778 ± 0.165
0.926AsnTyr: 0.926 ± 0.143
0.0AsnXaa: 0.0 ± 0.0
Pro
4.881ProAla: 4.881 ± 0.41
0.4ProCys: 0.4 ± 0.101
4.839ProAsp: 4.839 ± 0.34
4.713ProGlu: 4.713 ± 0.384
1.536ProPhe: 1.536 ± 0.19
5.828ProGly: 5.828 ± 0.529
1.578ProHis: 1.578 ± 0.242
2.293ProIle: 2.293 ± 0.221
2.146ProLys: 2.146 ± 0.325
3.64ProLeu: 3.64 ± 0.273
1.199ProMet: 1.199 ± 0.14
1.515ProAsn: 1.515 ± 0.231
3.619ProPro: 3.619 ± 0.399
1.957ProGln: 1.957 ± 0.184
2.777ProArg: 2.777 ± 0.27
3.345ProSer: 3.345 ± 0.339
3.303ProThr: 3.303 ± 0.265
4.019ProVal: 4.019 ± 0.338
0.989ProTrp: 0.989 ± 0.15
1.683ProTyr: 1.683 ± 0.219
0.0ProXaa: 0.0 ± 0.0
Gln
4.692GlnAla: 4.692 ± 0.346
0.274GlnCys: 0.274 ± 0.082
2.314GlnAsp: 2.314 ± 0.267
2.23GlnGlu: 2.23 ± 0.21
1.347GlnPhe: 1.347 ± 0.173
3.135GlnGly: 3.135 ± 0.517
0.884GlnHis: 0.884 ± 0.144
2.272GlnIle: 2.272 ± 0.265
1.283GlnLys: 1.283 ± 0.143
3.03GlnLeu: 3.03 ± 0.258
1.599GlnMet: 1.599 ± 0.209
1.157GlnAsn: 1.157 ± 0.203
1.767GlnPro: 1.767 ± 0.211
2.104GlnGln: 2.104 ± 0.336
3.387GlnArg: 3.387 ± 0.281
2.062GlnSer: 2.062 ± 0.229
2.104GlnThr: 2.104 ± 0.199
3.219GlnVal: 3.219 ± 0.309
0.736GlnTrp: 0.736 ± 0.109
1.094GlnTyr: 1.094 ± 0.177
0.0GlnXaa: 0.0 ± 0.0
Arg
5.723ArgAla: 5.723 ± 0.372
0.589ArgCys: 0.589 ± 0.126
4.061ArgAsp: 4.061 ± 0.339
5.702ArgGlu: 5.702 ± 0.459
1.957ArgPhe: 1.957 ± 0.213
4.313ArgGly: 4.313 ± 0.268
1.83ArgHis: 1.83 ± 0.216
3.156ArgIle: 3.156 ± 0.312
2.588ArgLys: 2.588 ± 0.326
5.176ArgLeu: 5.176 ± 0.346
1.473ArgMet: 1.473 ± 0.179
2.335ArgAsn: 2.335 ± 0.188
2.988ArgPro: 2.988 ± 0.251
2.819ArgGln: 2.819 ± 0.281
4.86ArgArg: 4.86 ± 0.476
3.85ArgSer: 3.85 ± 0.258
3.724ArgThr: 3.724 ± 0.226
4.923ArgVal: 4.923 ± 0.273
1.283ArgTrp: 1.283 ± 0.189
2.398ArgTyr: 2.398 ± 0.248
0.0ArgXaa: 0.0 ± 0.0
Ser
5.512SerAla: 5.512 ± 0.449
0.505SerCys: 0.505 ± 0.089
5.092SerAsp: 5.092 ± 0.352
3.535SerGlu: 3.535 ± 0.283
2.314SerPhe: 2.314 ± 0.236
5.618SerGly: 5.618 ± 0.426
1.052SerHis: 1.052 ± 0.157
3.009SerIle: 3.009 ± 0.294
1.767SerLys: 1.767 ± 0.203
4.608SerLeu: 4.608 ± 0.292
1.788SerMet: 1.788 ± 0.216
1.746SerAsn: 1.746 ± 0.212
3.135SerPro: 3.135 ± 0.267
2.377SerGln: 2.377 ± 0.234
3.366SerArg: 3.366 ± 0.259
4.103SerSer: 4.103 ± 0.296
4.355SerThr: 4.355 ± 0.403
4.46SerVal: 4.46 ± 0.294
1.325SerTrp: 1.325 ± 0.171
1.999SerTyr: 1.999 ± 0.22
0.0SerXaa: 0.0 ± 0.0
Thr
6.627ThrAla: 6.627 ± 0.633
0.484ThrCys: 0.484 ± 0.106
3.955ThrAsp: 3.955 ± 0.353
4.019ThrGlu: 4.019 ± 0.306
1.873ThrPhe: 1.873 ± 0.201
5.702ThrGly: 5.702 ± 0.563
1.41ThrHis: 1.41 ± 0.171
2.672ThrIle: 2.672 ± 0.241
2.293ThrLys: 2.293 ± 0.2
5.323ThrLeu: 5.323 ± 0.326
1.115ThrMet: 1.115 ± 0.159
2.42ThrAsn: 2.42 ± 0.283
4.46ThrPro: 4.46 ± 0.332
2.209ThrGln: 2.209 ± 0.204
3.766ThrArg: 3.766 ± 0.259
3.829ThrSer: 3.829 ± 0.325
4.292ThrThr: 4.292 ± 0.444
4.881ThrVal: 4.881 ± 0.361
1.094ThrTrp: 1.094 ± 0.143
1.578ThrTyr: 1.578 ± 0.168
0.0ThrXaa: 0.0 ± 0.0
Val
7.343ValAla: 7.343 ± 0.379
0.715ValCys: 0.715 ± 0.146
5.323ValAsp: 5.323 ± 0.349
5.344ValGlu: 5.344 ± 0.374
2.041ValPhe: 2.041 ± 0.228
5.491ValGly: 5.491 ± 0.378
1.767ValHis: 1.767 ± 0.237
2.567ValIle: 2.567 ± 0.249
1.999ValLys: 1.999 ± 0.185
5.239ValLeu: 5.239 ± 0.429
1.62ValMet: 1.62 ± 0.198
2.567ValAsn: 2.567 ± 0.264
3.976ValPro: 3.976 ± 0.304
3.156ValGln: 3.156 ± 0.316
4.692ValArg: 4.692 ± 0.463
4.418ValSer: 4.418 ± 0.343
5.744ValThr: 5.744 ± 0.339
6.059ValVal: 6.059 ± 0.42
1.157ValTrp: 1.157 ± 0.185
1.936ValTyr: 1.936 ± 0.208
0.0ValXaa: 0.0 ± 0.0
Trp
1.641TrpAla: 1.641 ± 0.174
0.21TrpCys: 0.21 ± 0.074
1.494TrpAsp: 1.494 ± 0.222
1.115TrpGlu: 1.115 ± 0.153
0.715TrpPhe: 0.715 ± 0.136
1.368TrpGly: 1.368 ± 0.186
0.337TrpHis: 0.337 ± 0.105
0.757TrpIle: 0.757 ± 0.13
0.778TrpLys: 0.778 ± 0.138
1.368TrpLeu: 1.368 ± 0.179
0.4TrpMet: 0.4 ± 0.102
0.694TrpAsn: 0.694 ± 0.124
0.442TrpPro: 0.442 ± 0.104
0.631TrpGln: 0.631 ± 0.105
1.788TrpArg: 1.788 ± 0.289
1.031TrpSer: 1.031 ± 0.167
0.926TrpThr: 0.926 ± 0.143
1.41TrpVal: 1.41 ± 0.153
0.442TrpTrp: 0.442 ± 0.099
0.505TrpTyr: 0.505 ± 0.101
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.672TyrAla: 2.672 ± 0.232
0.189TyrCys: 0.189 ± 0.068
2.546TyrAsp: 2.546 ± 0.243
1.788TyrGlu: 1.788 ± 0.212
1.073TyrPhe: 1.073 ± 0.141
2.735TyrGly: 2.735 ± 0.236
0.652TyrHis: 0.652 ± 0.125
1.052TyrIle: 1.052 ± 0.164
0.526TyrLys: 0.526 ± 0.117
2.377TyrLeu: 2.377 ± 0.256
0.589TyrMet: 0.589 ± 0.108
0.968TyrAsn: 0.968 ± 0.157
1.515TyrPro: 1.515 ± 0.179
1.283TyrGln: 1.283 ± 0.164
2.209TyrArg: 2.209 ± 0.219
2.23TyrSer: 2.23 ± 0.188
2.146TyrThr: 2.146 ± 0.233
2.041TyrVal: 2.041 ± 0.18
0.358TyrTrp: 0.358 ± 0.076
0.842TyrTyr: 0.842 ± 0.126
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 226 proteins (47531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski