Amino acid dipepetide frequency for Microscilla marina ATCC 23134

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.817AlaAla: 4.817 ± 0.067
0.675AlaCys: 0.675 ± 0.02
3.346AlaAsp: 3.346 ± 0.04
3.769AlaGlu: 3.769 ± 0.049
3.388AlaPhe: 3.388 ± 0.037
4.712AlaGly: 4.712 ± 0.075
1.641AlaHis: 1.641 ± 0.03
4.651AlaIle: 4.651 ± 0.049
5.36AlaLys: 5.36 ± 0.056
7.592AlaLeu: 7.592 ± 0.069
1.615AlaMet: 1.615 ± 0.027
3.896AlaAsn: 3.896 ± 0.064
2.486AlaPro: 2.486 ± 0.037
4.34AlaGln: 4.34 ± 0.05
2.815AlaArg: 2.815 ± 0.037
4.468AlaSer: 4.468 ± 0.053
4.621AlaThr: 4.621 ± 0.087
3.921AlaVal: 3.921 ± 0.041
0.815AlaTrp: 0.815 ± 0.019
3.009AlaTyr: 3.009 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
0.506CysAla: 0.506 ± 0.016
0.106CysCys: 0.106 ± 0.007
0.343CysAsp: 0.343 ± 0.014
0.424CysGlu: 0.424 ± 0.014
0.443CysPhe: 0.443 ± 0.015
0.57CysGly: 0.57 ± 0.019
0.209CysHis: 0.209 ± 0.01
0.537CysIle: 0.537 ± 0.014
0.47CysLys: 0.47 ± 0.013
0.85CysLeu: 0.85 ± 0.016
0.161CysMet: 0.161 ± 0.009
0.387CysAsn: 0.387 ± 0.022
0.314CysPro: 0.314 ± 0.015
0.404CysGln: 0.404 ± 0.012
0.287CysArg: 0.287 ± 0.011
0.478CysSer: 0.478 ± 0.016
0.504CysThr: 0.504 ± 0.023
0.48CysVal: 0.48 ± 0.015
0.116CysTrp: 0.116 ± 0.007
0.332CysTyr: 0.332 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.467AspAla: 3.467 ± 0.045
0.446AspCys: 0.446 ± 0.016
2.387AspAsp: 2.387 ± 0.035
3.079AspGlu: 3.079 ± 0.044
2.949AspPhe: 2.949 ± 0.038
3.155AspGly: 3.155 ± 0.052
0.93AspHis: 0.93 ± 0.02
3.557AspIle: 3.557 ± 0.041
3.974AspLys: 3.974 ± 0.05
4.94AspLeu: 4.94 ± 0.054
1.061AspMet: 1.061 ± 0.021
2.578AspAsn: 2.578 ± 0.034
1.612AspPro: 1.612 ± 0.029
2.213AspGln: 2.213 ± 0.038
1.803AspArg: 1.803 ± 0.03
2.621AspSer: 2.621 ± 0.043
2.617AspThr: 2.617 ± 0.036
2.91AspVal: 2.91 ± 0.034
0.706AspTrp: 0.706 ± 0.019
2.261AspTyr: 2.261 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
4.805GluAla: 4.805 ± 0.048
0.325GluCys: 0.325 ± 0.011
2.674GluAsp: 2.674 ± 0.034
4.201GluGlu: 4.201 ± 0.061
2.326GluPhe: 2.326 ± 0.031
3.575GluGly: 3.575 ± 0.046
1.197GluHis: 1.197 ± 0.024
3.973GluIle: 3.973 ± 0.047
4.898GluLys: 4.898 ± 0.054
5.831GluLeu: 5.831 ± 0.064
1.438GluMet: 1.438 ± 0.024
2.975GluAsn: 2.975 ± 0.039
1.389GluPro: 1.389 ± 0.022
3.084GluGln: 3.084 ± 0.035
2.39GluArg: 2.39 ± 0.031
2.705GluSer: 2.705 ± 0.038
2.851GluThr: 2.851 ± 0.035
4.665GluVal: 4.665 ± 0.054
0.663GluTrp: 0.663 ± 0.019
2.114GluTyr: 2.114 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.308PheAla: 3.308 ± 0.037
0.473PheCys: 0.473 ± 0.013
2.86PheAsp: 2.86 ± 0.038
2.871PheGlu: 2.871 ± 0.036
2.441PhePhe: 2.441 ± 0.041
2.953PheGly: 2.953 ± 0.037
0.807PheHis: 0.807 ± 0.015
3.026PheIle: 3.026 ± 0.038
3.222PheLys: 3.222 ± 0.039
4.022PheLeu: 4.022 ± 0.049
1.141PheMet: 1.141 ± 0.023
2.413PheAsn: 2.413 ± 0.039
1.464PhePro: 1.464 ± 0.024
1.612PheGln: 1.612 ± 0.026
1.921PheArg: 1.921 ± 0.026
3.248PheSer: 3.248 ± 0.039
3.042PheThr: 3.042 ± 0.037
2.965PheVal: 2.965 ± 0.038
0.644PheTrp: 0.644 ± 0.02
2.064PheTyr: 2.064 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
4.343GlyAla: 4.343 ± 0.064
0.596GlyCys: 0.596 ± 0.022
3.027GlyAsp: 3.027 ± 0.042
3.311GlyGlu: 3.311 ± 0.04
3.286GlyPhe: 3.286 ± 0.044
4.503GlyGly: 4.503 ± 0.091
1.234GlyHis: 1.234 ± 0.026
4.296GlyIle: 4.296 ± 0.044
5.678GlyLys: 5.678 ± 0.06
5.68GlyLeu: 5.68 ± 0.059
1.566GlyMet: 1.566 ± 0.025
3.686GlyAsn: 3.686 ± 0.056
0.866GlyPro: 0.866 ± 0.034
2.64GlyGln: 2.64 ± 0.033
2.287GlyArg: 2.287 ± 0.037
3.765GlySer: 3.765 ± 0.065
3.929GlyThr: 3.929 ± 0.106
4.551GlyVal: 4.551 ± 0.047
0.875GlyTrp: 0.875 ± 0.019
2.657GlyTyr: 2.657 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
1.105HisAla: 1.105 ± 0.022
0.24HisCys: 0.24 ± 0.01
0.813HisAsp: 0.813 ± 0.019
1.063HisGlu: 1.063 ± 0.022
1.239HisPhe: 1.239 ± 0.024
1.034HisGly: 1.034 ± 0.022
0.736HisHis: 0.736 ± 0.019
1.491HisIle: 1.491 ± 0.028
1.467HisLys: 1.467 ± 0.026
2.645HisLeu: 2.645 ± 0.039
0.323HisMet: 0.323 ± 0.012
1.056HisAsn: 1.056 ± 0.023
1.146HisPro: 1.146 ± 0.025
1.454HisGln: 1.454 ± 0.025
0.973HisArg: 0.973 ± 0.019
1.203HisSer: 1.203 ± 0.021
1.35HisThr: 1.35 ± 0.024
0.934HisVal: 0.934 ± 0.02
0.381HisTrp: 0.381 ± 0.013
1.142HisTyr: 1.142 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.172IleAla: 5.172 ± 0.055
0.529IleCys: 0.529 ± 0.017
3.927IleAsp: 3.927 ± 0.04
4.303IleGlu: 4.303 ± 0.047
2.686IlePhe: 2.686 ± 0.033
4.173IleGly: 4.173 ± 0.048
1.36IleHis: 1.36 ± 0.023
3.917IleIle: 3.917 ± 0.048
5.046IleLys: 5.046 ± 0.053
5.401IleLeu: 5.401 ± 0.061
1.116IleMet: 1.116 ± 0.019
3.641IleAsn: 3.641 ± 0.04
2.557IlePro: 2.557 ± 0.038
2.85IleGln: 2.85 ± 0.037
2.75IleArg: 2.75 ± 0.035
4.043IleSer: 4.043 ± 0.042
4.213IleThr: 4.213 ± 0.08
3.899IleVal: 3.899 ± 0.044
0.645IleTrp: 0.645 ± 0.016
2.433IleTyr: 2.433 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
6.092LysAla: 6.092 ± 0.066
0.323LysCys: 0.323 ± 0.012
3.911LysAsp: 3.911 ± 0.049
5.019LysGlu: 5.019 ± 0.059
2.579LysPhe: 2.579 ± 0.033
4.703LysGly: 4.703 ± 0.056
1.659LysHis: 1.659 ± 0.029
5.203LysIle: 5.203 ± 0.053
7.384LysLys: 7.384 ± 0.089
6.923LysLeu: 6.923 ± 0.06
2.066LysMet: 2.066 ± 0.029
4.575LysAsn: 4.575 ± 0.055
2.697LysPro: 2.697 ± 0.039
3.873LysGln: 3.873 ± 0.046
3.195LysArg: 3.195 ± 0.042
4.047LysSer: 4.047 ± 0.049
4.629LysThr: 4.629 ± 0.046
5.572LysVal: 5.572 ± 0.053
0.774LysTrp: 0.774 ± 0.02
3.037LysTyr: 3.037 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
7.06LeuAla: 7.06 ± 0.062
0.836LeuCys: 0.836 ± 0.029
4.891LeuAsp: 4.891 ± 0.052
5.808LeuGlu: 5.808 ± 0.058
4.29LeuPhe: 4.29 ± 0.045
5.919LeuGly: 5.919 ± 0.055
2.157LeuHis: 2.157 ± 0.038
5.69LeuIle: 5.69 ± 0.061
7.994LeuLys: 7.994 ± 0.07
9.617LeuLeu: 9.617 ± 0.088
2.227LeuMet: 2.227 ± 0.034
5.216LeuAsn: 5.216 ± 0.051
4.755LeuPro: 4.755 ± 0.052
4.557LeuGln: 4.557 ± 0.054
4.209LeuArg: 4.209 ± 0.048
6.682LeuSer: 6.682 ± 0.058
5.611LeuThr: 5.611 ± 0.049
5.795LeuVal: 5.795 ± 0.051
1.131LeuTrp: 1.131 ± 0.027
3.583LeuTyr: 3.583 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
1.69MetAla: 1.69 ± 0.029
0.15MetCys: 0.15 ± 0.007
0.989MetAsp: 0.989 ± 0.02
1.192MetGlu: 1.192 ± 0.023
0.891MetPhe: 0.891 ± 0.024
1.446MetGly: 1.446 ± 0.027
0.494MetHis: 0.494 ± 0.013
1.354MetIle: 1.354 ± 0.025
1.805MetLys: 1.805 ± 0.025
2.237MetLeu: 2.237 ± 0.033
0.585MetMet: 0.585 ± 0.016
1.132MetAsn: 1.132 ± 0.024
0.968MetPro: 0.968 ± 0.021
1.039MetGln: 1.039 ± 0.022
0.953MetArg: 0.953 ± 0.021
1.353MetSer: 1.353 ± 0.021
1.155MetThr: 1.155 ± 0.019
1.52MetVal: 1.52 ± 0.023
0.193MetTrp: 0.193 ± 0.009
0.753MetTyr: 0.753 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.78AsnAla: 3.78 ± 0.057
0.391AsnCys: 0.391 ± 0.014
2.71AsnAsp: 2.71 ± 0.041
3.078AsnGlu: 3.078 ± 0.037
2.37AsnPhe: 2.37 ± 0.034
3.461AsnGly: 3.461 ± 0.063
1.237AsnHis: 1.237 ± 0.022
3.914AsnIle: 3.914 ± 0.039
3.902AsnLys: 3.902 ± 0.053
5.162AsnLeu: 5.162 ± 0.053
1.014AsnMet: 1.014 ± 0.021
3.435AsnAsn: 3.435 ± 0.049
2.572AsnPro: 2.572 ± 0.037
2.972AsnGln: 2.972 ± 0.038
2.252AsnArg: 2.252 ± 0.035
2.913AsnSer: 2.913 ± 0.038
3.598AsnThr: 3.598 ± 0.055
2.938AsnVal: 2.938 ± 0.057
0.634AsnTrp: 0.634 ± 0.018
2.393AsnTyr: 2.393 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
2.729ProAla: 2.729 ± 0.036
0.236ProCys: 0.236 ± 0.009
2.145ProAsp: 2.145 ± 0.03
2.605ProGlu: 2.605 ± 0.033
1.616ProPhe: 1.616 ± 0.026
2.058ProGly: 2.058 ± 0.04
0.896ProHis: 0.896 ± 0.023
2.163ProIle: 2.163 ± 0.03
2.711ProLys: 2.711 ± 0.038
3.383ProLeu: 3.383 ± 0.043
0.688ProMet: 0.688 ± 0.017
2.051ProAsn: 2.051 ± 0.034
1.42ProPro: 1.42 ± 0.027
1.846ProGln: 1.846 ± 0.029
1.233ProArg: 1.233 ± 0.025
2.129ProSer: 2.129 ± 0.034
2.411ProThr: 2.411 ± 0.085
2.55ProVal: 2.55 ± 0.033
0.379ProTrp: 0.379 ± 0.013
1.425ProTyr: 1.425 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
4.079GlnAla: 4.079 ± 0.049
0.266GlnCys: 0.266 ± 0.01
2.065GlnAsp: 2.065 ± 0.029
2.912GlnGlu: 2.912 ± 0.044
1.658GlnPhe: 1.658 ± 0.023
3.079GlnGly: 3.079 ± 0.041
1.158GlnHis: 1.158 ± 0.022
2.834GlnIle: 2.834 ± 0.042
4.278GlnLys: 4.278 ± 0.05
5.176GlnLeu: 5.176 ± 0.063
1.129GlnMet: 1.129 ± 0.023
2.777GlnAsn: 2.777 ± 0.038
1.7GlnPro: 1.7 ± 0.028
3.198GlnGln: 3.198 ± 0.051
2.255GlnArg: 2.255 ± 0.033
2.646GlnSer: 2.646 ± 0.036
2.901GlnThr: 2.901 ± 0.039
3.456GlnVal: 3.456 ± 0.036
0.65GlnTrp: 0.65 ± 0.019
1.811GlnTyr: 1.811 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
2.518ArgAla: 2.518 ± 0.034
0.27ArgCys: 0.27 ± 0.01
1.812ArgAsp: 1.812 ± 0.03
2.227ArgGlu: 2.227 ± 0.032
2.242ArgPhe: 2.242 ± 0.029
2.128ArgGly: 2.128 ± 0.031
0.891ArgHis: 0.891 ± 0.023
2.639ArgIle: 2.639 ± 0.034
3.509ArgLys: 3.509 ± 0.046
4.426ArgLeu: 4.426 ± 0.047
1.004ArgMet: 1.004 ± 0.02
2.113ArgAsn: 2.113 ± 0.036
1.313ArgPro: 1.313 ± 0.024
2.194ArgGln: 2.194 ± 0.038
1.941ArgArg: 1.941 ± 0.034
2.114ArgSer: 2.114 ± 0.031
2.027ArgThr: 2.027 ± 0.03
2.687ArgVal: 2.687 ± 0.035
0.629ArgTrp: 0.629 ± 0.021
1.903ArgTyr: 1.903 ± 0.029
0.0ArgXaa: 0.0 ± 0.0
Ser
3.834SerAla: 3.834 ± 0.054
0.5SerCys: 0.5 ± 0.017
2.806SerAsp: 2.806 ± 0.036
3.054SerGlu: 3.054 ± 0.037
3.354SerPhe: 3.354 ± 0.044
4.229SerGly: 4.229 ± 0.068
1.147SerHis: 1.147 ± 0.022
4.178SerIle: 4.178 ± 0.04
4.219SerLys: 4.219 ± 0.052
6.249SerLeu: 6.249 ± 0.059
1.223SerMet: 1.223 ± 0.022
3.227SerAsn: 3.227 ± 0.042
2.366SerPro: 2.366 ± 0.035
2.621SerGln: 2.621 ± 0.036
2.237SerArg: 2.237 ± 0.031
3.857SerSer: 3.857 ± 0.05
3.513SerThr: 3.513 ± 0.069
3.693SerVal: 3.693 ± 0.04
0.717SerTrp: 0.717 ± 0.017
2.346SerTyr: 2.346 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
4.108ThrAla: 4.108 ± 0.073
0.446ThrCys: 0.446 ± 0.016
2.819ThrAsp: 2.819 ± 0.043
2.933ThrGlu: 2.933 ± 0.035
2.668ThrPhe: 2.668 ± 0.037
4.129ThrGly: 4.129 ± 0.103
1.446ThrHis: 1.446 ± 0.024
4.059ThrIle: 4.059 ± 0.074
3.885ThrLys: 3.885 ± 0.046
6.185ThrLeu: 6.185 ± 0.059
1.048ThrMet: 1.048 ± 0.02
3.332ThrAsn: 3.332 ± 0.059
3.015ThrPro: 3.015 ± 0.063
3.235ThrGln: 3.235 ± 0.039
2.136ThrArg: 2.136 ± 0.029
3.802ThrSer: 3.802 ± 0.058
4.127ThrThr: 4.127 ± 0.118
3.672ThrVal: 3.672 ± 0.116
0.65ThrTrp: 0.65 ± 0.018
2.463ThrTyr: 2.463 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
4.924ValAla: 4.924 ± 0.045
0.604ValCys: 0.604 ± 0.016
3.068ValAsp: 3.068 ± 0.036
3.414ValGlu: 3.414 ± 0.045
3.269ValPhe: 3.269 ± 0.038
3.929ValGly: 3.929 ± 0.047
1.257ValHis: 1.257 ± 0.023
4.036ValIle: 4.036 ± 0.044
4.764ValLys: 4.764 ± 0.049
6.147ValLeu: 6.147 ± 0.054
1.421ValMet: 1.421 ± 0.023
3.384ValAsn: 3.384 ± 0.047
2.364ValPro: 2.364 ± 0.032
2.559ValGln: 2.559 ± 0.035
2.451ValArg: 2.451 ± 0.034
4.277ValSer: 4.277 ± 0.055
3.876ValThr: 3.876 ± 0.092
4.68ValVal: 4.68 ± 0.053
0.865ValTrp: 0.865 ± 0.017
2.726ValTyr: 2.726 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.85TrpAla: 0.85 ± 0.023
0.113TrpCys: 0.113 ± 0.008
0.549TrpAsp: 0.549 ± 0.018
0.646TrpGlu: 0.646 ± 0.016
0.592TrpPhe: 0.592 ± 0.018
0.806TrpGly: 0.806 ± 0.022
0.298TrpHis: 0.298 ± 0.01
0.666TrpIle: 0.666 ± 0.017
0.843TrpLys: 0.843 ± 0.022
1.431TrpLeu: 1.431 ± 0.025
0.32TrpMet: 0.32 ± 0.01
0.612TrpAsn: 0.612 ± 0.017
0.127TrpPro: 0.127 ± 0.008
0.905TrpGln: 0.905 ± 0.02
0.542TrpArg: 0.542 ± 0.016
0.679TrpSer: 0.679 ± 0.018
0.633TrpThr: 0.633 ± 0.028
1.016TrpVal: 1.016 ± 0.031
0.208TrpTrp: 0.208 ± 0.009
0.478TrpTyr: 0.478 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.75TyrAla: 2.75 ± 0.032
0.396TyrCys: 0.396 ± 0.015
2.123TyrAsp: 2.123 ± 0.031
2.172TyrGlu: 2.172 ± 0.032
2.212TyrPhe: 2.212 ± 0.033
2.214TyrGly: 2.214 ± 0.034
1.04TyrHis: 1.04 ± 0.023
2.477TyrIle: 2.477 ± 0.033
2.853TyrLys: 2.853 ± 0.039
4.132TyrLeu: 4.132 ± 0.043
0.749TyrMet: 0.749 ± 0.021
2.239TyrAsn: 2.239 ± 0.03
1.545TyrPro: 1.545 ± 0.027
2.429TyrGln: 2.429 ± 0.035
1.957TyrArg: 1.957 ± 0.029
2.342TyrSer: 2.342 ± 0.033
2.55TyrThr: 2.55 ± 0.039
2.111TyrVal: 2.111 ± 0.035
0.638TyrTrp: 0.638 ± 0.018
2.071TyrTyr: 2.071 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8248 proteins (2646701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski