Amino acid dipepetide frequency for Measles virus (strain Edmonston-Zagreb vaccine) (MeV) (Subacute sclerose panencephalitis virus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.274AlaAla: 4.274 ± 0.711
0.855AlaCys: 0.855 ± 0.314
2.351AlaAsp: 2.351 ± 0.716
4.061AlaGlu: 4.061 ± 1.444
2.137AlaPhe: 2.137 ± 0.761
3.206AlaGly: 3.206 ± 0.804
1.069AlaHis: 1.069 ± 0.494
4.702AlaIle: 4.702 ± 1.054
2.778AlaLys: 2.778 ± 0.453
7.053AlaLeu: 7.053 ± 1.081
1.496AlaMet: 1.496 ± 0.618
2.351AlaAsn: 2.351 ± 0.621
2.992AlaPro: 2.992 ± 1.009
1.069AlaGln: 1.069 ± 0.374
4.274AlaArg: 4.274 ± 1.258
5.343AlaSer: 5.343 ± 1.787
2.137AlaThr: 2.137 ± 0.754
5.343AlaVal: 5.343 ± 1.511
0.855AlaTrp: 0.855 ± 0.453
1.923AlaTyr: 1.923 ± 1.004
0.0AlaXaa: 0.0 ± 0.0
Cys
1.282CysAla: 1.282 ± 0.402
0.641CysCys: 0.641 ± 0.469
0.427CysAsp: 0.427 ± 0.243
0.855CysGlu: 0.855 ± 0.278
1.496CysPhe: 1.496 ± 0.433
1.069CysGly: 1.069 ± 0.482
0.641CysHis: 0.641 ± 0.456
0.855CysIle: 0.855 ± 0.387
1.069CysLys: 1.069 ± 0.605
1.496CysLeu: 1.496 ± 0.449
0.214CysMet: 0.214 ± 0.261
1.069CysAsn: 1.069 ± 0.344
0.855CysPro: 0.855 ± 0.32
1.069CysGln: 1.069 ± 0.652
1.069CysArg: 1.069 ± 0.679
1.282CysSer: 1.282 ± 0.306
1.069CysThr: 1.069 ± 0.527
1.71CysVal: 1.71 ± 0.572
0.0CysTrp: 0.0 ± 0.0
1.282CysTyr: 1.282 ± 0.365
0.0CysXaa: 0.0 ± 0.0
Asp
2.778AspAla: 2.778 ± 0.82
0.641AspCys: 0.641 ± 0.233
3.847AspAsp: 3.847 ± 0.988
2.137AspGlu: 2.137 ± 0.385
0.641AspPhe: 0.641 ± 0.336
1.923AspGly: 1.923 ± 0.409
1.923AspHis: 1.923 ± 0.587
3.633AspIle: 3.633 ± 1.038
2.351AspLys: 2.351 ± 0.545
6.412AspLeu: 6.412 ± 1.107
0.855AspMet: 0.855 ± 0.338
3.847AspAsn: 3.847 ± 0.726
3.633AspPro: 3.633 ± 0.588
1.71AspGln: 1.71 ± 0.489
3.633AspArg: 3.633 ± 1.015
3.42AspSer: 3.42 ± 0.72
3.42AspThr: 3.42 ± 0.644
4.702AspVal: 4.702 ± 0.801
0.427AspTrp: 0.427 ± 0.28
1.496AspTyr: 1.496 ± 0.225
0.0AspXaa: 0.0 ± 0.0
Glu
2.992GluAla: 2.992 ± 0.582
1.71GluCys: 1.71 ± 0.784
2.992GluAsp: 2.992 ± 0.593
3.42GluGlu: 3.42 ± 1.255
1.71GluPhe: 1.71 ± 0.697
3.633GluGly: 3.633 ± 1.19
1.069GluHis: 1.069 ± 0.661
5.129GluIle: 5.129 ± 1.007
3.206GluLys: 3.206 ± 0.76
5.984GluLeu: 5.984 ± 1.06
0.427GluMet: 0.427 ± 0.308
1.282GluAsn: 1.282 ± 0.303
2.565GluPro: 2.565 ± 0.716
1.923GluGln: 1.923 ± 0.449
1.496GluArg: 1.496 ± 0.41
5.129GluSer: 5.129 ± 0.996
5.129GluThr: 5.129 ± 1.251
2.992GluVal: 2.992 ± 0.461
1.496GluTrp: 1.496 ± 0.361
0.641GluTyr: 0.641 ± 0.281
0.0GluXaa: 0.0 ± 0.0
Phe
1.069PheAla: 1.069 ± 0.374
0.427PheCys: 0.427 ± 0.21
1.282PheAsp: 1.282 ± 0.458
0.855PheGlu: 0.855 ± 0.314
1.282PhePhe: 1.282 ± 0.783
1.496PheGly: 1.496 ± 0.405
0.855PheHis: 0.855 ± 0.262
3.42PheIle: 3.42 ± 1.262
1.71PheLys: 1.71 ± 0.604
2.992PheLeu: 2.992 ± 0.929
1.282PheMet: 1.282 ± 0.771
1.71PheAsn: 1.71 ± 0.618
0.855PhePro: 0.855 ± 0.319
1.069PheGln: 1.069 ± 0.442
2.778PheArg: 2.778 ± 1.135
1.496PheSer: 1.496 ± 0.418
1.71PheThr: 1.71 ± 0.628
2.565PheVal: 2.565 ± 1.064
0.855PheTrp: 0.855 ± 0.522
0.855PheTyr: 0.855 ± 0.523
0.0PheXaa: 0.0 ± 0.0
Gly
2.137GlyAla: 2.137 ± 0.902
0.427GlyCys: 0.427 ± 0.261
4.274GlyAsp: 4.274 ± 0.597
4.061GlyGlu: 4.061 ± 1.643
2.992GlyPhe: 2.992 ± 0.744
4.702GlyGly: 4.702 ± 1.125
1.923GlyHis: 1.923 ± 0.51
3.42GlyIle: 3.42 ± 0.946
2.565GlyLys: 2.565 ± 1.029
8.976GlyLeu: 8.976 ± 1.034
2.565GlyMet: 2.565 ± 0.721
3.206GlyAsn: 3.206 ± 0.639
2.778GlyPro: 2.778 ± 0.882
2.992GlyGln: 2.992 ± 0.968
3.847GlyArg: 3.847 ± 1.092
7.267GlySer: 7.267 ± 0.659
3.633GlyThr: 3.633 ± 1.081
5.557GlyVal: 5.557 ± 1.938
0.214GlyTrp: 0.214 ± 0.13
2.565GlyTyr: 2.565 ± 0.306
0.0GlyXaa: 0.0 ± 0.0
His
1.923HisAla: 1.923 ± 0.499
0.855HisCys: 0.855 ± 0.4
1.496HisAsp: 1.496 ± 0.913
1.496HisGlu: 1.496 ± 0.545
0.427HisPhe: 0.427 ± 0.21
1.069HisGly: 1.069 ± 0.511
0.427HisHis: 0.427 ± 0.261
2.137HisIle: 2.137 ± 0.761
0.641HisLys: 0.641 ± 0.281
2.137HisLeu: 2.137 ± 0.609
0.641HisMet: 0.641 ± 0.233
0.641HisAsn: 0.641 ± 0.305
1.069HisPro: 1.069 ± 0.42
1.496HisGln: 1.496 ± 0.478
2.565HisArg: 2.565 ± 0.632
1.71HisSer: 1.71 ± 0.412
1.069HisThr: 1.069 ± 0.652
1.069HisVal: 1.069 ± 0.308
0.427HisTrp: 0.427 ± 0.403
0.641HisTyr: 0.641 ± 0.391
0.0HisXaa: 0.0 ± 0.0
Ile
4.702IleAla: 4.702 ± 1.262
0.427IleCys: 0.427 ± 0.243
3.42IleAsp: 3.42 ± 0.965
3.633IleGlu: 3.633 ± 0.746
1.496IlePhe: 1.496 ± 0.753
6.412IleGly: 6.412 ± 1.18
2.565IleHis: 2.565 ± 0.518
3.633IleIle: 3.633 ± 0.932
5.984IleLys: 5.984 ± 0.812
5.343IleLeu: 5.343 ± 2.165
1.71IleMet: 1.71 ± 0.728
4.916IleAsn: 4.916 ± 0.584
4.061IlePro: 4.061 ± 0.657
2.565IleGln: 2.565 ± 0.566
4.702IleArg: 4.702 ± 0.586
6.625IleSer: 6.625 ± 1.324
4.274IleThr: 4.274 ± 0.476
3.847IleVal: 3.847 ± 0.935
0.427IleTrp: 0.427 ± 0.501
2.137IleTyr: 2.137 ± 0.761
0.0IleXaa: 0.0 ± 0.0
Lys
2.992LysAla: 2.992 ± 0.593
0.641LysCys: 0.641 ± 0.304
3.206LysAsp: 3.206 ± 0.815
4.274LysGlu: 4.274 ± 1.404
1.71LysPhe: 1.71 ± 0.464
5.129LysGly: 5.129 ± 0.874
0.641LysHis: 0.641 ± 0.391
4.061LysIle: 4.061 ± 1.166
2.992LysLys: 2.992 ± 0.988
6.839LysLeu: 6.839 ± 1.064
1.71LysMet: 1.71 ± 1.062
1.282LysAsn: 1.282 ± 0.303
1.71LysPro: 1.71 ± 1.202
1.069LysGln: 1.069 ± 0.471
2.351LysArg: 2.351 ± 0.545
3.42LysSer: 3.42 ± 0.473
1.923LysThr: 1.923 ± 0.997
3.633LysVal: 3.633 ± 0.878
0.214LysTrp: 0.214 ± 0.261
1.71LysTyr: 1.71 ± 0.7
0.0LysXaa: 0.0 ± 0.0
Leu
7.908LeuAla: 7.908 ± 1.262
1.923LeuCys: 1.923 ± 0.394
4.702LeuAsp: 4.702 ± 0.54
6.839LeuGlu: 6.839 ± 1.243
3.42LeuPhe: 3.42 ± 0.684
7.908LeuGly: 7.908 ± 1.804
3.206LeuHis: 3.206 ± 0.944
8.335LeuIle: 8.335 ± 2.071
8.121LeuLys: 8.121 ± 1.164
10.045LeuLeu: 10.045 ± 1.085
3.42LeuMet: 3.42 ± 0.468
3.847LeuAsn: 3.847 ± 0.713
2.565LeuPro: 2.565 ± 0.761
3.206LeuGln: 3.206 ± 1.36
5.984LeuArg: 5.984 ± 1.412
9.831LeuSer: 9.831 ± 2.459
5.343LeuThr: 5.343 ± 0.802
5.77LeuVal: 5.77 ± 1.311
1.282LeuTrp: 1.282 ± 1.002
2.992LeuTyr: 2.992 ± 0.974
0.0LeuXaa: 0.0 ± 0.0
Met
1.923MetAla: 1.923 ± 0.578
0.214MetCys: 0.214 ± 0.25
0.641MetAsp: 0.641 ± 0.233
0.427MetGlu: 0.427 ± 0.21
0.855MetPhe: 0.855 ± 0.477
1.71MetGly: 1.71 ± 0.252
0.214MetHis: 0.214 ± 0.13
1.71MetIle: 1.71 ± 0.277
1.496MetLys: 1.496 ± 0.486
2.351MetLeu: 2.351 ± 0.817
0.0MetMet: 0.0 ± 0.0
1.496MetAsn: 1.496 ± 0.41
1.069MetPro: 1.069 ± 0.534
0.214MetGln: 0.214 ± 0.261
0.855MetArg: 0.855 ± 0.522
2.565MetSer: 2.565 ± 0.79
3.42MetThr: 3.42 ± 0.29
1.71MetVal: 1.71 ± 0.65
0.641MetTrp: 0.641 ± 0.315
1.282MetTyr: 1.282 ± 0.427
0.0MetXaa: 0.0 ± 0.0
Asn
2.778AsnAla: 2.778 ± 1.002
1.282AsnCys: 1.282 ± 0.561
1.71AsnAsp: 1.71 ± 0.494
2.351AsnGlu: 2.351 ± 0.643
1.496AsnPhe: 1.496 ± 0.336
2.778AsnGly: 2.778 ± 0.642
0.641AsnHis: 0.641 ± 0.363
3.206AsnIle: 3.206 ± 1.289
1.282AsnLys: 1.282 ± 0.608
5.984AsnLeu: 5.984 ± 0.695
1.069AsnMet: 1.069 ± 0.42
2.137AsnAsn: 2.137 ± 0.473
3.206AsnPro: 3.206 ± 1.075
2.992AsnGln: 2.992 ± 0.48
1.71AsnArg: 1.71 ± 0.675
2.778AsnSer: 2.778 ± 0.555
1.069AsnThr: 1.069 ± 0.579
3.206AsnVal: 3.206 ± 0.542
0.641AsnTrp: 0.641 ± 0.391
1.069AsnTyr: 1.069 ± 0.42
0.0AsnXaa: 0.0 ± 0.0
Pro
2.137ProAla: 2.137 ± 0.442
0.427ProCys: 0.427 ± 0.382
2.778ProAsp: 2.778 ± 1.047
3.206ProGlu: 3.206 ± 0.561
0.641ProPhe: 0.641 ± 0.233
4.061ProGly: 4.061 ± 1.428
0.855ProHis: 0.855 ± 0.314
5.343ProIle: 5.343 ± 0.976
2.351ProLys: 2.351 ± 0.531
3.847ProLeu: 3.847 ± 1.368
1.282ProMet: 1.282 ± 0.306
1.496ProAsn: 1.496 ± 0.286
3.847ProPro: 3.847 ± 1.244
1.71ProGln: 1.71 ± 1.032
2.992ProArg: 2.992 ± 0.923
4.061ProSer: 4.061 ± 1.269
2.565ProThr: 2.565 ± 0.762
2.351ProVal: 2.351 ± 0.478
0.214ProTrp: 0.214 ± 0.322
2.137ProTyr: 2.137 ± 0.767
0.0ProXaa: 0.0 ± 0.0
Gln
3.847GlnAla: 3.847 ± 1.465
1.496GlnCys: 1.496 ± 0.633
2.351GlnAsp: 2.351 ± 0.445
1.923GlnGlu: 1.923 ± 1.127
0.641GlnPhe: 0.641 ± 0.456
2.778GlnGly: 2.778 ± 0.56
0.427GlnHis: 0.427 ± 0.28
2.351GlnIle: 2.351 ± 0.877
1.282GlnLys: 1.282 ± 0.667
3.206GlnLeu: 3.206 ± 0.859
0.641GlnMet: 0.641 ± 0.28
1.923GlnAsn: 1.923 ± 0.591
1.496GlnPro: 1.496 ± 0.575
1.496GlnGln: 1.496 ± 0.507
2.137GlnArg: 2.137 ± 0.639
2.351GlnSer: 2.351 ± 0.739
0.855GlnThr: 0.855 ± 0.368
2.351GlnVal: 2.351 ± 0.539
0.427GlnTrp: 0.427 ± 0.261
0.427GlnTyr: 0.427 ± 0.522
0.0GlnXaa: 0.0 ± 0.0
Arg
5.129ArgAla: 5.129 ± 1.339
1.069ArgCys: 1.069 ± 0.344
3.206ArgAsp: 3.206 ± 0.647
3.633ArgGlu: 3.633 ± 0.775
1.71ArgPhe: 1.71 ± 0.477
4.488ArgGly: 4.488 ± 0.899
2.137ArgHis: 2.137 ± 0.303
3.633ArgIle: 3.633 ± 1.012
2.778ArgLys: 2.778 ± 1.012
7.267ArgLeu: 7.267 ± 1.095
1.496ArgMet: 1.496 ± 0.437
1.496ArgAsn: 1.496 ± 0.337
1.923ArgPro: 1.923 ± 0.573
1.71ArgGln: 1.71 ± 0.443
3.633ArgArg: 3.633 ± 0.849
5.343ArgSer: 5.343 ± 0.949
2.137ArgThr: 2.137 ± 0.76
3.633ArgVal: 3.633 ± 0.642
0.214ArgTrp: 0.214 ± 0.25
2.137ArgTyr: 2.137 ± 0.79
0.0ArgXaa: 0.0 ± 0.0
Ser
4.274SerAla: 4.274 ± 1.053
1.496SerCys: 1.496 ± 0.673
4.702SerAsp: 4.702 ± 1.45
2.992SerGlu: 2.992 ± 0.805
2.778SerPhe: 2.778 ± 0.759
8.121SerGly: 8.121 ± 1.769
1.923SerHis: 1.923 ± 0.738
5.343SerIle: 5.343 ± 0.895
4.061SerLys: 4.061 ± 0.476
8.121SerLeu: 8.121 ± 0.655
2.565SerMet: 2.565 ± 0.585
3.633SerAsn: 3.633 ± 0.981
2.992SerPro: 2.992 ± 0.913
3.206SerGln: 3.206 ± 0.904
6.198SerArg: 6.198 ± 0.827
7.267SerSer: 7.267 ± 0.995
6.412SerThr: 6.412 ± 0.908
3.847SerVal: 3.847 ± 0.984
1.282SerTrp: 1.282 ± 0.418
2.351SerTyr: 2.351 ± 1.13
0.0SerXaa: 0.0 ± 0.0
Thr
3.206ThrAla: 3.206 ± 0.921
1.71ThrCys: 1.71 ± 0.472
3.633ThrAsp: 3.633 ± 0.809
3.42ThrGlu: 3.42 ± 0.991
0.855ThrPhe: 0.855 ± 0.322
4.061ThrGly: 4.061 ± 0.762
1.069ThrHis: 1.069 ± 0.432
4.061ThrIle: 4.061 ± 0.905
1.282ThrLys: 1.282 ± 0.63
6.412ThrLeu: 6.412 ± 1.503
1.069ThrMet: 1.069 ± 0.355
2.992ThrAsn: 2.992 ± 0.944
2.778ThrPro: 2.778 ± 0.889
1.496ThrGln: 1.496 ± 0.465
3.42ThrArg: 3.42 ± 0.619
4.061ThrSer: 4.061 ± 0.311
3.847ThrThr: 3.847 ± 0.738
2.778ThrVal: 2.778 ± 0.667
1.069ThrTrp: 1.069 ± 0.425
2.565ThrTyr: 2.565 ± 0.588
0.0ThrXaa: 0.0 ± 0.0
Val
2.778ValAla: 2.778 ± 0.468
1.282ValCys: 1.282 ± 0.482
2.778ValAsp: 2.778 ± 0.5
4.061ValGlu: 4.061 ± 0.579
2.565ValPhe: 2.565 ± 0.825
3.633ValGly: 3.633 ± 0.699
1.282ValHis: 1.282 ± 0.424
6.412ValIle: 6.412 ± 1.133
3.206ValLys: 3.206 ± 0.889
6.839ValLeu: 6.839 ± 1.136
0.855ValMet: 0.855 ± 0.267
2.137ValAsn: 2.137 ± 0.559
4.488ValPro: 4.488 ± 0.85
2.137ValGln: 2.137 ± 0.663
3.206ValArg: 3.206 ± 1.131
4.916ValSer: 4.916 ± 1.058
3.42ValThr: 3.42 ± 0.735
2.137ValVal: 2.137 ± 0.912
0.214ValTrp: 0.214 ± 0.261
3.633ValTyr: 3.633 ± 0.375
0.0ValXaa: 0.0 ± 0.0
Trp
1.282TrpAla: 1.282 ± 0.466
0.641TrpCys: 0.641 ± 0.599
0.641TrpAsp: 0.641 ± 0.336
0.214TrpGlu: 0.214 ± 0.302
0.855TrpPhe: 0.855 ± 0.393
0.641TrpGly: 0.641 ± 0.363
0.214TrpHis: 0.214 ± 0.13
0.427TrpIle: 0.427 ± 0.431
0.427TrpLys: 0.427 ± 0.21
0.641TrpLeu: 0.641 ± 0.233
0.0TrpMet: 0.0 ± 0.0
0.855TrpAsn: 0.855 ± 0.367
0.641TrpPro: 0.641 ± 0.315
0.214TrpGln: 0.214 ± 0.302
0.855TrpArg: 0.855 ± 0.596
0.855TrpSer: 0.855 ± 0.319
0.427TrpThr: 0.427 ± 0.24
0.641TrpVal: 0.641 ± 0.233
0.0TrpTrp: 0.0 ± 0.0
0.641TrpTyr: 0.641 ± 0.308
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.855TyrAla: 0.855 ± 0.343
1.282TyrCys: 1.282 ± 0.387
2.992TyrAsp: 2.992 ± 0.716
1.282TyrGlu: 1.282 ± 0.783
0.855TyrPhe: 0.855 ± 0.267
1.282TyrGly: 1.282 ± 0.466
0.855TyrHis: 0.855 ± 0.372
1.069TyrIle: 1.069 ± 0.705
1.923TyrLys: 1.923 ± 0.577
4.702TyrLeu: 4.702 ± 1.212
1.282TyrMet: 1.282 ± 0.657
1.069TyrAsn: 1.069 ± 0.282
2.778TyrPro: 2.778 ± 0.826
1.069TyrGln: 1.069 ± 0.355
1.069TyrArg: 1.069 ± 0.313
3.847TyrSer: 3.847 ± 1.247
1.923TyrThr: 1.923 ± 0.605
2.137TyrVal: 2.137 ± 0.67
0.214TyrTrp: 0.214 ± 0.261
1.71TyrTyr: 1.71 ± 0.535
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski