Amino acid dipepetide frequency for Wenling picorna-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.457AlaAla: 8.457 ± 2.691
0.677AlaCys: 0.677 ± 0.345
3.383AlaAsp: 3.383 ± 0.974
4.736AlaGlu: 4.736 ± 1.334
1.691AlaPhe: 1.691 ± 0.322
3.383AlaGly: 3.383 ± 0.645
2.706AlaHis: 2.706 ± 0.3
4.398AlaIle: 4.398 ± 1.162
3.721AlaLys: 3.721 ± 1.357
9.472AlaLeu: 9.472 ± 0.029
1.353AlaMet: 1.353 ± 0.15
2.03AlaAsn: 2.03 ± 0.495
2.706AlaPro: 2.706 ± 0.3
6.766AlaGln: 6.766 ± 0.868
3.045AlaArg: 3.045 ± 0.472
8.119AlaSer: 8.119 ± 0.179
4.398AlaThr: 4.398 ± 0.622
4.06AlaVal: 4.06 ± 1.529
1.353AlaTrp: 1.353 ± 0.389
2.706AlaTyr: 2.706 ± 0.239
0.0AlaXaa: 0.0 ± 0.0
Cys
1.015CysAla: 1.015 ± 0.022
0.338CysCys: 0.338 ± 0.367
1.691CysAsp: 1.691 ± 0.322
0.677CysGlu: 0.677 ± 0.345
0.0CysPhe: 0.0 ± 0.0
1.353CysGly: 1.353 ± 0.689
0.677CysHis: 0.677 ± 0.345
1.015CysIle: 1.015 ± 0.517
0.677CysLys: 0.677 ± 0.345
0.677CysLeu: 0.677 ± 0.195
0.0CysMet: 0.0 ± 0.0
1.015CysAsn: 1.015 ± 0.022
2.03CysPro: 2.03 ± 0.045
0.677CysGln: 0.677 ± 0.345
0.338CysArg: 0.338 ± 0.172
1.691CysSer: 1.691 ± 0.862
0.677CysThr: 0.677 ± 0.345
1.015CysVal: 1.015 ± 0.562
0.0CysTrp: 0.0 ± 0.0
0.677CysTyr: 0.677 ± 0.195
0.0CysXaa: 0.0 ± 0.0
Asp
3.721AspAla: 3.721 ± 1.357
0.677AspCys: 0.677 ± 0.345
3.045AspAsp: 3.045 ± 0.472
4.398AspGlu: 4.398 ± 0.457
3.721AspPhe: 3.721 ± 0.262
3.383AspGly: 3.383 ± 0.105
1.015AspHis: 1.015 ± 0.562
2.368AspIle: 2.368 ± 0.412
2.706AspLys: 2.706 ± 0.3
4.06AspLeu: 4.06 ± 0.089
1.353AspMet: 1.353 ± 0.689
2.706AspAsn: 2.706 ± 0.239
3.721AspPro: 3.721 ± 0.817
2.03AspGln: 2.03 ± 0.045
1.691AspArg: 1.691 ± 0.217
3.045AspSer: 3.045 ± 1.146
3.045AspThr: 3.045 ± 0.607
4.736AspVal: 4.736 ± 1.902
1.353AspTrp: 1.353 ± 0.15
2.368AspTyr: 2.368 ± 0.412
0.0AspXaa: 0.0 ± 0.0
Glu
3.721GluAla: 3.721 ± 1.357
1.353GluCys: 1.353 ± 0.15
2.368GluAsp: 2.368 ± 0.951
6.089GluGlu: 6.089 ± 1.484
1.691GluPhe: 1.691 ± 0.217
3.045GluGly: 3.045 ± 0.067
1.353GluHis: 1.353 ± 0.689
5.751GluIle: 5.751 ± 0.772
3.383GluLys: 3.383 ± 1.184
5.751GluLeu: 5.751 ± 1.312
0.677GluMet: 0.677 ± 0.734
2.03GluAsn: 2.03 ± 0.045
1.691GluPro: 1.691 ± 0.862
2.706GluGln: 2.706 ± 0.3
1.353GluArg: 1.353 ± 0.15
3.383GluSer: 3.383 ± 0.974
4.736GluThr: 4.736 ± 2.442
3.045GluVal: 3.045 ± 1.146
0.677GluTrp: 0.677 ± 0.345
4.398GluTyr: 4.398 ± 0.622
0.0GluXaa: 0.0 ± 0.0
Phe
2.03PheAla: 2.03 ± 0.584
1.353PheCys: 1.353 ± 0.689
2.368PheAsp: 2.368 ± 0.951
3.045PheGlu: 3.045 ± 0.067
1.015PhePhe: 1.015 ± 0.562
3.045PheGly: 3.045 ± 0.607
2.03PheHis: 2.03 ± 0.495
3.721PheIle: 3.721 ± 0.278
1.353PheLys: 1.353 ± 0.15
5.074PheLeu: 5.074 ± 1.191
1.015PheMet: 1.015 ± 0.517
2.706PheAsn: 2.706 ± 0.839
1.015PhePro: 1.015 ± 0.562
1.353PheGln: 1.353 ± 0.15
2.03PheArg: 2.03 ± 0.584
4.398PheSer: 4.398 ± 0.083
2.368PheThr: 2.368 ± 0.951
1.015PheVal: 1.015 ± 0.562
0.338PheTrp: 0.338 ± 0.172
1.015PheTyr: 1.015 ± 1.101
0.0PheXaa: 0.0 ± 0.0
Gly
2.368GlyAla: 2.368 ± 0.412
1.015GlyCys: 1.015 ± 0.022
4.398GlyAsp: 4.398 ± 1.162
3.383GlyGlu: 3.383 ± 0.974
2.03GlyPhe: 2.03 ± 0.045
3.383GlyGly: 3.383 ± 0.434
0.338GlyHis: 0.338 ± 0.367
4.398GlyIle: 4.398 ± 1.162
3.383GlyLys: 3.383 ± 1.724
4.06GlyLeu: 4.06 ± 0.989
1.353GlyMet: 1.353 ± 0.689
3.045GlyAsn: 3.045 ± 0.067
2.706GlyPro: 2.706 ± 0.779
1.015GlyGln: 1.015 ± 0.022
4.06GlyArg: 4.06 ± 0.089
4.398GlySer: 4.398 ± 0.996
5.074GlyThr: 5.074 ± 2.27
6.089GlyVal: 6.089 ± 0.945
1.015GlyTrp: 1.015 ± 0.022
3.045GlyTyr: 3.045 ± 0.472
0.0GlyXaa: 0.0 ± 0.0
His
1.691HisAla: 1.691 ± 0.862
0.0HisCys: 0.0 ± 0.0
2.03HisAsp: 2.03 ± 0.045
1.353HisGlu: 1.353 ± 0.389
1.015HisPhe: 1.015 ± 0.022
0.338HisGly: 0.338 ± 0.367
0.0HisHis: 0.0 ± 0.0
2.706HisIle: 2.706 ± 0.839
1.015HisLys: 1.015 ± 1.101
2.368HisLeu: 2.368 ± 0.128
0.338HisMet: 0.338 ± 0.367
0.677HisAsn: 0.677 ± 0.345
1.015HisPro: 1.015 ± 0.022
1.691HisGln: 1.691 ± 0.322
0.677HisArg: 0.677 ± 0.345
1.691HisSer: 1.691 ± 0.322
2.706HisThr: 2.706 ± 0.239
1.691HisVal: 1.691 ± 0.862
0.0HisTrp: 0.0 ± 0.0
1.015HisTyr: 1.015 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
3.721IleAla: 3.721 ± 0.278
2.03IleCys: 2.03 ± 0.495
3.045IleAsp: 3.045 ± 1.012
3.045IleGlu: 3.045 ± 0.067
3.721IlePhe: 3.721 ± 1.357
4.736IleGly: 4.736 ± 0.795
2.368IleHis: 2.368 ± 0.128
3.045IleIle: 3.045 ± 0.472
4.736IleLys: 4.736 ± 0.255
4.398IleLeu: 4.398 ± 1.701
2.03IleMet: 2.03 ± 1.034
2.706IleAsn: 2.706 ± 0.3
2.368IlePro: 2.368 ± 0.412
1.353IleGln: 1.353 ± 0.15
3.721IleArg: 3.721 ± 0.817
4.736IleSer: 4.736 ± 0.284
3.721IleThr: 3.721 ± 0.817
2.706IleVal: 2.706 ± 0.239
0.338IleTrp: 0.338 ± 0.172
3.045IleTyr: 3.045 ± 0.472
0.0IleXaa: 0.0 ± 0.0
Lys
3.383LysAla: 3.383 ± 0.105
0.677LysCys: 0.677 ± 0.345
3.383LysAsp: 3.383 ± 0.974
3.383LysGlu: 3.383 ± 0.645
2.03LysPhe: 2.03 ± 0.584
2.03LysGly: 2.03 ± 0.495
2.03LysHis: 2.03 ± 1.034
3.383LysIle: 3.383 ± 0.105
2.706LysLys: 2.706 ± 0.839
3.721LysLeu: 3.721 ± 0.801
0.677LysMet: 0.677 ± 0.345
1.353LysAsn: 1.353 ± 0.15
2.368LysPro: 2.368 ± 0.951
2.706LysGln: 2.706 ± 0.3
5.074LysArg: 5.074 ± 1.507
3.045LysSer: 3.045 ± 1.012
3.383LysThr: 3.383 ± 0.645
3.721LysVal: 3.721 ± 1.357
0.0LysTrp: 0.0 ± 0.0
1.353LysTyr: 1.353 ± 0.689
0.0LysXaa: 0.0 ± 0.0
Leu
9.472LeuAla: 9.472 ± 3.208
0.677LeuCys: 0.677 ± 0.195
5.751LeuAsp: 5.751 ± 1.851
6.089LeuGlu: 6.089 ± 0.674
2.368LeuPhe: 2.368 ± 0.412
3.721LeuGly: 3.721 ± 0.262
1.353LeuHis: 1.353 ± 0.689
6.089LeuIle: 6.089 ± 0.405
7.442LeuLys: 7.442 ± 0.524
7.104LeuLeu: 7.104 ± 0.922
2.03LeuMet: 2.03 ± 0.045
3.721LeuAsn: 3.721 ± 0.262
6.089LeuPro: 6.089 ± 0.405
3.045LeuGln: 3.045 ± 0.607
2.03LeuArg: 2.03 ± 1.124
6.766LeuSer: 6.766 ± 0.329
5.074LeuThr: 5.074 ± 0.967
4.398LeuVal: 4.398 ± 0.457
1.691LeuTrp: 1.691 ± 0.322
1.691LeuTyr: 1.691 ± 0.217
0.0LeuXaa: 0.0 ± 0.0
Met
2.03MetAla: 2.03 ± 0.495
1.015MetCys: 1.015 ± 0.517
1.015MetAsp: 1.015 ± 0.022
1.353MetGlu: 1.353 ± 0.15
0.677MetPhe: 0.677 ± 0.195
1.353MetGly: 1.353 ± 0.389
0.0MetHis: 0.0 ± 0.0
1.015MetIle: 1.015 ± 0.517
1.353MetLys: 1.353 ± 0.929
0.338MetLeu: 0.338 ± 0.367
1.015MetMet: 1.015 ± 1.101
1.015MetAsn: 1.015 ± 0.517
0.677MetPro: 0.677 ± 0.195
0.677MetGln: 0.677 ± 0.345
1.353MetArg: 1.353 ± 0.689
1.353MetSer: 1.353 ± 0.389
1.691MetThr: 1.691 ± 0.757
2.706MetVal: 2.706 ± 0.839
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.06AsnAla: 4.06 ± 0.45
1.353AsnCys: 1.353 ± 0.689
3.383AsnAsp: 3.383 ± 0.974
1.353AsnGlu: 1.353 ± 0.15
1.691AsnPhe: 1.691 ± 0.862
3.383AsnGly: 3.383 ± 0.105
1.015AsnHis: 1.015 ± 0.517
2.03AsnIle: 2.03 ± 0.045
1.353AsnLys: 1.353 ± 0.689
4.398AsnLeu: 4.398 ± 0.996
0.338AsnMet: 0.338 ± 0.172
2.03AsnAsn: 2.03 ± 0.584
2.706AsnPro: 2.706 ± 0.239
0.677AsnGln: 0.677 ± 0.195
1.015AsnArg: 1.015 ± 0.517
3.045AsnSer: 3.045 ± 0.472
2.706AsnThr: 2.706 ± 1.858
2.368AsnVal: 2.368 ± 0.667
0.677AsnTrp: 0.677 ± 0.345
4.06AsnTyr: 4.06 ± 1.168
0.0AsnXaa: 0.0 ± 0.0
Pro
4.06ProAla: 4.06 ± 0.989
1.015ProCys: 1.015 ± 0.517
1.353ProAsp: 1.353 ± 0.689
3.383ProGlu: 3.383 ± 1.513
2.03ProPhe: 2.03 ± 0.584
3.383ProGly: 3.383 ± 0.105
2.03ProHis: 2.03 ± 0.495
3.721ProIle: 3.721 ± 0.817
0.338ProLys: 0.338 ± 0.172
3.045ProLeu: 3.045 ± 1.146
1.691ProMet: 1.691 ± 0.217
1.015ProAsn: 1.015 ± 1.101
2.03ProPro: 2.03 ± 0.584
2.706ProGln: 2.706 ± 0.3
1.691ProArg: 1.691 ± 0.862
4.06ProSer: 4.06 ± 1.168
2.368ProThr: 2.368 ± 0.412
6.766ProVal: 6.766 ± 2.487
0.677ProTrp: 0.677 ± 0.195
5.074ProTyr: 5.074 ± 1.73
0.0ProXaa: 0.0 ± 0.0
Gln
2.706GlnAla: 2.706 ± 1.379
0.338GlnCys: 0.338 ± 0.172
2.368GlnAsp: 2.368 ± 0.951
1.353GlnGlu: 1.353 ± 0.689
2.03GlnPhe: 2.03 ± 0.045
2.706GlnGly: 2.706 ± 0.239
0.677GlnHis: 0.677 ± 0.345
1.691GlnIle: 1.691 ± 0.217
1.353GlnLys: 1.353 ± 0.689
3.721GlnLeu: 3.721 ± 1.357
0.338GlnMet: 0.338 ± 0.367
2.368GlnAsn: 2.368 ± 0.667
2.368GlnPro: 2.368 ± 0.128
1.691GlnGln: 1.691 ± 0.322
2.368GlnArg: 2.368 ± 0.667
2.368GlnSer: 2.368 ± 0.951
4.06GlnThr: 4.06 ± 0.629
3.721GlnVal: 3.721 ± 0.801
0.0GlnTrp: 0.0 ± 0.0
1.691GlnTyr: 1.691 ± 0.217
0.0GlnXaa: 0.0 ± 0.0
Arg
3.721ArgAla: 3.721 ± 0.262
0.677ArgCys: 0.677 ± 0.195
1.691ArgAsp: 1.691 ± 0.322
2.03ArgGlu: 2.03 ± 0.045
2.03ArgPhe: 2.03 ± 1.124
5.074ArgGly: 5.074 ± 0.112
1.353ArgHis: 1.353 ± 0.389
3.045ArgIle: 3.045 ± 1.012
3.721ArgLys: 3.721 ± 0.817
2.03ArgLeu: 2.03 ± 0.495
0.677ArgMet: 0.677 ± 0.195
1.691ArgAsn: 1.691 ± 0.862
3.383ArgPro: 3.383 ± 0.105
2.368ArgGln: 2.368 ± 0.667
1.353ArgArg: 1.353 ± 0.389
1.691ArgSer: 1.691 ± 0.862
3.721ArgThr: 3.721 ± 0.262
2.706ArgVal: 2.706 ± 0.3
0.0ArgTrp: 0.0 ± 0.0
2.03ArgTyr: 2.03 ± 0.495
0.0ArgXaa: 0.0 ± 0.0
Ser
4.398SerAla: 4.398 ± 2.075
1.353SerCys: 1.353 ± 0.389
2.706SerAsp: 2.706 ± 0.779
4.398SerGlu: 4.398 ± 0.622
4.398SerPhe: 4.398 ± 0.083
2.706SerGly: 2.706 ± 0.239
0.677SerHis: 0.677 ± 0.734
4.06SerIle: 4.06 ± 0.989
4.736SerLys: 4.736 ± 0.255
9.472SerLeu: 9.472 ± 1.589
1.353SerMet: 1.353 ± 0.389
5.413SerAsn: 5.413 ± 1.018
3.045SerPro: 3.045 ± 0.607
1.691SerGln: 1.691 ± 0.217
3.721SerArg: 3.721 ± 0.817
4.398SerSer: 4.398 ± 2.614
4.736SerThr: 4.736 ± 2.442
6.428SerVal: 6.428 ± 0.578
0.677SerTrp: 0.677 ± 0.195
2.03SerTyr: 2.03 ± 1.124
0.0SerXaa: 0.0 ± 0.0
Thr
5.751ThrAla: 5.751 ± 0.306
1.353ThrCys: 1.353 ± 0.389
3.045ThrAsp: 3.045 ± 0.067
3.383ThrGlu: 3.383 ± 0.105
3.045ThrPhe: 3.045 ± 0.607
4.398ThrGly: 4.398 ± 0.996
2.706ThrHis: 2.706 ± 0.239
3.721ThrIle: 3.721 ± 0.278
1.691ThrLys: 1.691 ± 0.322
6.089ThrLeu: 6.089 ± 1.213
1.015ThrMet: 1.015 ± 0.562
3.383ThrAsn: 3.383 ± 0.974
3.721ThrPro: 3.721 ± 2.42
2.368ThrGln: 2.368 ± 0.667
2.368ThrArg: 2.368 ± 0.412
4.398ThrSer: 4.398 ± 0.996
6.766ThrThr: 6.766 ± 3.566
4.736ThrVal: 4.736 ± 1.902
0.677ThrTrp: 0.677 ± 0.345
2.03ThrTyr: 2.03 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
7.442ValAla: 7.442 ± 0.016
0.0ValCys: 0.0 ± 0.0
5.074ValAsp: 5.074 ± 0.651
2.368ValGlu: 2.368 ± 0.667
4.736ValPhe: 4.736 ± 2.442
5.413ValGly: 5.413 ± 1.139
1.353ValHis: 1.353 ± 0.929
2.03ValIle: 2.03 ± 0.495
2.368ValLys: 2.368 ± 0.412
5.413ValLeu: 5.413 ± 0.061
1.353ValMet: 1.353 ± 0.128
2.706ValAsn: 2.706 ± 0.239
5.074ValPro: 5.074 ± 1.73
2.368ValGln: 2.368 ± 0.667
4.06ValArg: 4.06 ± 0.45
6.766ValSer: 6.766 ± 1.408
3.383ValThr: 3.383 ± 0.434
4.398ValVal: 4.398 ± 0.457
0.677ValTrp: 0.677 ± 0.345
2.706ValTyr: 2.706 ± 0.3
0.0ValXaa: 0.0 ± 0.0
Trp
0.677TrpAla: 0.677 ± 0.345
0.338TrpCys: 0.338 ± 0.172
0.0TrpAsp: 0.0 ± 0.0
1.691TrpGlu: 1.691 ± 0.322
0.677TrpPhe: 0.677 ± 0.345
0.338TrpGly: 0.338 ± 0.172
0.0TrpHis: 0.0 ± 0.0
1.015TrpIle: 1.015 ± 0.517
0.0TrpLys: 0.0 ± 0.0
0.338TrpLeu: 0.338 ± 0.172
0.338TrpMet: 0.338 ± 0.151
0.677TrpAsn: 0.677 ± 0.345
0.0TrpPro: 0.0 ± 0.0
0.338TrpGln: 0.338 ± 0.172
0.677TrpArg: 0.677 ± 0.734
0.338TrpSer: 0.338 ± 0.367
1.353TrpThr: 1.353 ± 0.15
1.353TrpVal: 1.353 ± 0.15
0.338TrpTrp: 0.338 ± 0.172
0.677TrpTyr: 0.677 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.736TyrAla: 4.736 ± 0.824
0.0TyrCys: 0.0 ± 0.0
3.045TyrAsp: 3.045 ± 0.607
1.691TyrGlu: 1.691 ± 0.322
1.691TyrPhe: 1.691 ± 0.217
3.383TyrGly: 3.383 ± 0.105
0.338TyrHis: 0.338 ± 0.367
2.368TyrIle: 2.368 ± 0.412
2.368TyrLys: 2.368 ± 0.128
5.074TyrLeu: 5.074 ± 0.967
1.353TyrMet: 1.353 ± 0.15
1.353TyrAsn: 1.353 ± 0.389
3.721TyrPro: 3.721 ± 0.262
1.691TyrGln: 1.691 ± 0.757
2.368TyrArg: 2.368 ± 0.951
2.706TyrSer: 2.706 ± 0.3
0.677TyrThr: 0.677 ± 0.345
2.368TyrVal: 2.368 ± 1.491
0.677TyrTrp: 0.677 ± 0.345
1.691TyrTyr: 1.691 ± 0.217
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2957 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski