Amino acid dipepetide frequency for Dankookia rubra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	26.56AlaAla: 26.56 ± 0.202	1.397AlaCys: 1.397 ± 0.029	6.774AlaAsp: 6.774 ± 0.053	9.803AlaGlu: 9.803 ± 0.083	4.304AlaPhe: 4.304 ± 0.047	14.51AlaGly: 14.51 ± 0.099	2.364AlaHis: 2.364 ± 0.031	5.436AlaIle: 5.436 ± 0.052	3.063AlaLys: 3.063 ± 0.049	16.909AlaLeu: 16.909 ± 0.126	4.113AlaMet: 4.113 ± 0.042	2.448AlaAsn: 2.448 ± 0.038	8.217AlaPro: 8.217 ± 0.08	4.526AlaGln: 4.526 ± 0.052	12.054AlaArg: 12.054 ± 0.092	5.81AlaSer: 5.81 ± 0.058	6.802AlaThr: 6.802 ± 0.056	10.542AlaVal: 10.542 ± 0.081	2.332AlaTrp: 2.332 ± 0.045	2.278AlaTyr: 2.278 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.178CysAla: 1.178 ± 0.025	0.153CysCys: 0.153 ± 0.009	0.523CysAsp: 0.523 ± 0.016	0.388CysGlu: 0.388 ± 0.016	0.331CysPhe: 0.331 ± 0.012	1.059CysGly: 1.059 ± 0.023	0.248CysHis: 0.248 ± 0.014	0.376CysIle: 0.376 ± 0.014	0.136CysLys: 0.136 ± 0.008	0.865CysLeu: 0.865 ± 0.019	0.176CysMet: 0.176 ± 0.007	0.18CysAsn: 0.18 ± 0.009	0.524CysPro: 0.524 ± 0.016	0.235CysGln: 0.235 ± 0.01	0.833CysArg: 0.833 ± 0.022	0.434CysSer: 0.434 ± 0.014	0.481CysThr: 0.481 ± 0.015	0.618CysVal: 0.618 ± 0.018	0.155CysTrp: 0.155 ± 0.009	0.184CysTyr: 0.184 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.166AspAla: 7.166 ± 0.063	0.452AspCys: 0.452 ± 0.014	2.194AspAsp: 2.194 ± 0.034	2.293AspGlu: 2.293 ± 0.036	1.836AspPhe: 1.836 ± 0.027	5.174AspGly: 5.174 ± 0.059	1.124AspHis: 1.124 ± 0.028	2.114AspIle: 2.114 ± 0.034	0.873AspLys: 0.873 ± 0.02	5.691AspLeu: 5.691 ± 0.05	1.034AspMet: 1.034 ± 0.021	0.867AspAsn: 0.867 ± 0.022	3.963AspPro: 3.963 ± 0.046	1.48AspGln: 1.48 ± 0.029	4.634AspArg: 4.634 ± 0.049	1.78AspSer: 1.78 ± 0.026	2.273AspThr: 2.273 ± 0.043	3.26AspVal: 3.26 ± 0.04	1.06AspTrp: 1.06 ± 0.022	1.152AspTyr: 1.152 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	9.493GluAla: 9.493 ± 0.083	0.34GluCys: 0.34 ± 0.014	2.465GluAsp: 2.465 ± 0.036	2.864GluGlu: 2.864 ± 0.048	1.555GluPhe: 1.555 ± 0.025	4.639GluGly: 4.639 ± 0.044	1.1GluHis: 1.1 ± 0.022	2.46GluIle: 2.46 ± 0.037	1.23GluLys: 1.23 ± 0.026	4.785GluLeu: 4.785 ± 0.049	1.385GluMet: 1.385 ± 0.026	1.035GluAsn: 1.035 ± 0.023	2.788GluPro: 2.788 ± 0.038	1.855GluGln: 1.855 ± 0.028	4.942GluArg: 4.942 ± 0.05	1.82GluSer: 1.82 ± 0.029	2.85GluThr: 2.85 ± 0.037	4.203GluVal: 4.203 ± 0.048	0.731GluTrp: 0.731 ± 0.019	0.805GluTyr: 0.805 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	4.656PheAla: 4.656 ± 0.046	0.384PheCys: 0.384 ± 0.014	2.111PheAsp: 2.111 ± 0.036	1.683PheGlu: 1.683 ± 0.027	1.086PhePhe: 1.086 ± 0.026	3.617PheGly: 3.617 ± 0.048	0.713PheHis: 0.713 ± 0.02	1.095PheIle: 1.095 ± 0.026	0.524PheLys: 0.524 ± 0.016	3.235PheLeu: 3.235 ± 0.042	0.591PheMet: 0.591 ± 0.017	0.732PheAsn: 0.732 ± 0.019	1.623PhePro: 1.623 ± 0.029	0.835PheGln: 0.835 ± 0.019	2.456PheArg: 2.456 ± 0.032	1.59PheSer: 1.59 ± 0.031	1.721PheThr: 1.721 ± 0.028	2.292PheVal: 2.292 ± 0.033	0.533PheTrp: 0.533 ± 0.017	0.633PheTyr: 0.633 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	11.779GlyAla: 11.779 ± 0.094	0.985GlyCys: 0.985 ± 0.022	4.102GlyAsp: 4.102 ± 0.05	4.661GlyGlu: 4.661 ± 0.042	3.886GlyPhe: 3.886 ± 0.045	9.191GlyGly: 9.191 ± 0.103	2.066GlyHis: 2.066 ± 0.032	4.355GlyIle: 4.355 ± 0.043	2.242GlyLys: 2.242 ± 0.033	10.633GlyLeu: 10.633 ± 0.084	2.713GlyMet: 2.713 ± 0.031	2.059GlyAsn: 2.059 ± 0.042	4.953GlyPro: 4.953 ± 0.048	3.154GlyGln: 3.154 ± 0.037	8.232GlyArg: 8.232 ± 0.067	4.572GlySer: 4.572 ± 0.049	5.389GlyThr: 5.389 ± 0.057	6.24GlyVal: 6.24 ± 0.062	1.864GlyTrp: 1.864 ± 0.029	2.046GlyTyr: 2.046 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.837HisAla: 2.837 ± 0.039	0.265HisCys: 0.265 ± 0.012	1.106HisAsp: 1.106 ± 0.022	0.858HisGlu: 0.858 ± 0.022	0.697HisPhe: 0.697 ± 0.019	2.158HisGly: 2.158 ± 0.039	0.588HisHis: 0.588 ± 0.019	0.692HisIle: 0.692 ± 0.017	0.323HisLys: 0.323 ± 0.012	2.232HisLeu: 2.232 ± 0.031	0.429HisMet: 0.429 ± 0.014	0.385HisAsn: 0.385 ± 0.015	1.61HisPro: 1.61 ± 0.029	0.528HisGln: 0.528 ± 0.016	1.735HisArg: 1.735 ± 0.03	0.797HisSer: 0.797 ± 0.02	0.816HisThr: 0.816 ± 0.019	1.538HisVal: 1.538 ± 0.027	0.409HisTrp: 0.409 ± 0.016	0.468HisTyr: 0.468 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.159IleAla: 6.159 ± 0.059	0.4IleCys: 0.4 ± 0.012	2.253IleAsp: 2.253 ± 0.035	2.595IleGlu: 2.595 ± 0.034	1.106IlePhe: 1.106 ± 0.029	4.383IleGly: 4.383 ± 0.053	0.749IleHis: 0.749 ± 0.018	1.298IleIle: 1.298 ± 0.028	0.724IleLys: 0.724 ± 0.019	3.711IleLeu: 3.711 ± 0.045	0.648IleMet: 0.648 ± 0.016	0.828IleAsn: 0.828 ± 0.022	2.208IlePro: 2.208 ± 0.031	0.951IleGln: 0.951 ± 0.019	3.163IleArg: 3.163 ± 0.04	1.763IleSer: 1.763 ± 0.031	2.036IleThr: 2.036 ± 0.025	2.761IleVal: 2.761 ± 0.034	0.51IleTrp: 0.51 ± 0.016	0.681IleTyr: 0.681 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.919LysAla: 2.919 ± 0.047	0.106LysCys: 0.106 ± 0.006	0.996LysAsp: 0.996 ± 0.023	0.941LysGlu: 0.941 ± 0.025	0.472LysPhe: 0.472 ± 0.016	1.781LysGly: 1.781 ± 0.031	0.433LysHis: 0.433 ± 0.015	0.727LysIle: 0.727 ± 0.019	0.505LysLys: 0.505 ± 0.021	2.299LysLeu: 2.299 ± 0.034	0.388LysMet: 0.388 ± 0.013	0.402LysAsn: 0.402 ± 0.015	1.583LysPro: 1.583 ± 0.031	0.693LysGln: 0.693 ± 0.018	1.792LysArg: 1.792 ± 0.034	0.9LysSer: 0.9 ± 0.026	1.039LysThr: 1.039 ± 0.023	1.674LysVal: 1.674 ± 0.035	0.228LysTrp: 0.228 ± 0.011	0.357LysTyr: 0.357 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	18.033LeuAla: 18.033 ± 0.122	1.019LeuCys: 1.019 ± 0.023	5.939LeuAsp: 5.939 ± 0.057	5.077LeuGlu: 5.077 ± 0.056	2.99LeuPhe: 2.99 ± 0.039	10.162LeuGly: 10.162 ± 0.073	2.203LeuHis: 2.203 ± 0.032	3.482LeuIle: 3.482 ± 0.045	2.222LeuLys: 2.222 ± 0.043	12.136LeuLeu: 12.136 ± 0.097	1.95LeuMet: 1.95 ± 0.032	2.034LeuAsn: 2.034 ± 0.031	7.572LeuPro: 7.572 ± 0.069	3.051LeuGln: 3.051 ± 0.038	9.65LeuArg: 9.65 ± 0.09	5.152LeuSer: 5.152 ± 0.051	5.012LeuThr: 5.012 ± 0.048	8.299LeuVal: 8.299 ± 0.062	1.411LeuTrp: 1.411 ± 0.026	1.715LeuTyr: 1.715 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	3.481MetAla: 3.481 ± 0.042	0.149MetCys: 0.149 ± 0.008	1.06MetAsp: 1.06 ± 0.02	0.984MetGlu: 0.984 ± 0.02	0.532MetPhe: 0.532 ± 0.016	1.784MetGly: 1.784 ± 0.028	0.432MetHis: 0.432 ± 0.014	0.877MetIle: 0.877 ± 0.023	0.524MetLys: 0.524 ± 0.016	2.663MetLeu: 2.663 ± 0.038	0.491MetMet: 0.491 ± 0.017	0.517MetAsn: 0.517 ± 0.015	1.81MetPro: 1.81 ± 0.026	0.85MetGln: 0.85 ± 0.02	1.998MetArg: 1.998 ± 0.03	1.211MetSer: 1.211 ± 0.023	1.466MetThr: 1.466 ± 0.027	1.679MetVal: 1.679 ± 0.03	0.193MetTrp: 0.193 ± 0.01	0.242MetTyr: 0.242 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.673AsnAla: 2.673 ± 0.036	0.192AsnCys: 0.192 ± 0.01	0.982AsnAsp: 0.982 ± 0.027	0.817AsnGlu: 0.817 ± 0.019	0.658AsnPhe: 0.658 ± 0.018	1.892AsnGly: 1.892 ± 0.031	0.418AsnHis: 0.418 ± 0.015	0.88AsnIle: 0.88 ± 0.02	0.379AsnLys: 0.379 ± 0.014	2.184AsnLeu: 2.184 ± 0.032	0.427AsnMet: 0.427 ± 0.015	0.515AsnAsn: 0.515 ± 0.016	1.669AsnPro: 1.669 ± 0.031	0.558AsnGln: 0.558 ± 0.016	1.664AsnArg: 1.664 ± 0.028	0.843AsnSer: 0.843 ± 0.024	1.019AsnThr: 1.019 ± 0.024	1.297AsnVal: 1.297 ± 0.024	0.338AsnTrp: 0.338 ± 0.012	0.435AsnTyr: 0.435 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.735ProAla: 9.735 ± 0.094	0.448ProCys: 0.448 ± 0.016	4.057ProAsp: 4.057 ± 0.04	4.417ProGlu: 4.417 ± 0.042	2.002ProPhe: 2.002 ± 0.029	6.973ProGly: 6.973 ± 0.066	1.204ProHis: 1.204 ± 0.024	2.0ProIle: 2.0 ± 0.033	1.281ProLys: 1.281 ± 0.024	5.834ProLeu: 5.834 ± 0.057	1.369ProMet: 1.369 ± 0.025	1.232ProAsn: 1.232 ± 0.023	4.458ProPro: 4.458 ± 0.069	1.814ProGln: 1.814 ± 0.03	4.488ProArg: 4.488 ± 0.053	2.653ProSer: 2.653 ± 0.036	2.61ProThr: 2.61 ± 0.037	4.906ProVal: 4.906 ± 0.043	0.998ProTrp: 0.998 ± 0.024	1.16ProTyr: 1.16 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	5.164GlnAla: 5.164 ± 0.056	0.2GlnCys: 0.2 ± 0.01	1.499GlnAsp: 1.499 ± 0.026	1.441GlnGlu: 1.441 ± 0.025	0.806GlnPhe: 0.806 ± 0.021	2.841GlnGly: 2.841 ± 0.039	0.667GlnHis: 0.667 ± 0.018	1.17GlnIle: 1.17 ± 0.025	0.644GlnLys: 0.644 ± 0.018	2.687GlnLeu: 2.687 ± 0.032	0.712GlnMet: 0.712 ± 0.022	0.569GlnAsn: 0.569 ± 0.018	2.096GlnPro: 2.096 ± 0.034	1.298GlnGln: 1.298 ± 0.033	2.775GlnArg: 2.775 ± 0.036	1.268GlnSer: 1.268 ± 0.024	1.366GlnThr: 1.366 ± 0.024	2.614GlnVal: 2.614 ± 0.036	0.374GlnTrp: 0.374 ± 0.013	0.444GlnTyr: 0.444 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	11.134ArgAla: 11.134 ± 0.089	0.747ArgCys: 0.747 ± 0.02	4.468ArgAsp: 4.468 ± 0.044	4.279ArgGlu: 4.279 ± 0.045	3.085ArgPhe: 3.085 ± 0.045	6.578ArgGly: 6.578 ± 0.066	2.132ArgHis: 2.132 ± 0.035	3.953ArgIle: 3.953 ± 0.037	1.594ArgLys: 1.594 ± 0.028	10.137ArgLeu: 10.137 ± 0.085	2.121ArgMet: 2.121 ± 0.03	1.647ArgAsn: 1.647 ± 0.027	5.366ArgPro: 5.366 ± 0.056	2.888ArgGln: 2.888 ± 0.039	8.395ArgArg: 8.395 ± 0.075	3.601ArgSer: 3.601 ± 0.041	3.657ArgThr: 3.657 ± 0.045	5.643ArgVal: 5.643 ± 0.059	1.433ArgTrp: 1.433 ± 0.027	1.597ArgTyr: 1.597 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	5.55SerAla: 5.55 ± 0.061	0.407SerCys: 0.407 ± 0.013	2.051SerAsp: 2.051 ± 0.036	1.873SerGlu: 1.873 ± 0.032	1.763SerPhe: 1.763 ± 0.028	4.8SerGly: 4.8 ± 0.05	0.875SerHis: 0.875 ± 0.021	1.876SerIle: 1.876 ± 0.026	0.849SerLys: 0.849 ± 0.021	4.822SerLeu: 4.822 ± 0.051	0.994SerMet: 0.994 ± 0.022	0.959SerAsn: 0.959 ± 0.021	2.916SerPro: 2.916 ± 0.034	1.172SerGln: 1.172 ± 0.022	3.343SerArg: 3.343 ± 0.045	2.012SerSer: 2.012 ± 0.035	2.157SerThr: 2.157 ± 0.031	3.151SerVal: 3.151 ± 0.042	0.768SerTrp: 0.768 ± 0.019	0.979SerTyr: 0.979 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	6.68ThrAla: 6.68 ± 0.049	0.404ThrCys: 0.404 ± 0.014	2.512ThrAsp: 2.512 ± 0.035	2.529ThrGlu: 2.529 ± 0.038	1.428ThrPhe: 1.428 ± 0.026	5.227ThrGly: 5.227 ± 0.053	0.982ThrHis: 0.982 ± 0.024	2.131ThrIle: 2.131 ± 0.033	0.928ThrLys: 0.928 ± 0.02	5.845ThrLeu: 5.845 ± 0.055	1.087ThrMet: 1.087 ± 0.02	0.977ThrAsn: 0.977 ± 0.023	3.544ThrPro: 3.544 ± 0.041	1.299ThrGln: 1.299 ± 0.025	3.571ThrArg: 3.571 ± 0.045	2.167ThrSer: 2.167 ± 0.035	2.641ThrThr: 2.641 ± 0.041	3.819ThrVal: 3.819 ± 0.048	0.743ThrTrp: 0.743 ± 0.02	0.925ThrTyr: 0.925 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	10.831ValAla: 10.831 ± 0.076	0.631ValCys: 0.631 ± 0.018	3.39ValAsp: 3.39 ± 0.045	4.304ValGlu: 4.304 ± 0.048	2.427ValPhe: 2.427 ± 0.032	5.388ValGly: 5.388 ± 0.057	1.38ValHis: 1.38 ± 0.028	2.842ValIle: 2.842 ± 0.04	1.527ValLys: 1.527 ± 0.029	8.568ValLeu: 8.568 ± 0.07	1.622ValMet: 1.622 ± 0.026	1.65ValAsn: 1.65 ± 0.031	4.789ValPro: 4.789 ± 0.049	2.284ValGln: 2.284 ± 0.034	5.391ValArg: 5.391 ± 0.056	3.304ValSer: 3.304 ± 0.041	4.436ValThr: 4.436 ± 0.048	6.29ValVal: 6.29 ± 0.059	0.975ValTrp: 0.975 ± 0.022	1.07ValTyr: 1.07 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.689TrpAla: 1.689 ± 0.033	0.176TrpCys: 0.176 ± 0.009	0.764TrpAsp: 0.764 ± 0.019	0.662TrpGlu: 0.662 ± 0.018	0.549TrpPhe: 0.549 ± 0.015	1.153TrpGly: 1.153 ± 0.025	0.413TrpHis: 0.413 ± 0.014	0.599TrpIle: 0.599 ± 0.018	0.348TrpLys: 0.348 ± 0.013	2.029TrpLeu: 2.029 ± 0.031	0.388TrpMet: 0.388 ± 0.013	0.402TrpAsn: 0.402 ± 0.013	0.982TrpPro: 0.982 ± 0.021	0.644TrpGln: 0.644 ± 0.019	1.624TrpArg: 1.624 ± 0.027	0.806TrpSer: 0.806 ± 0.019	0.864TrpThr: 0.864 ± 0.019	0.978TrpVal: 0.978 ± 0.022	0.294TrpTrp: 0.294 ± 0.012	0.311TrpTyr: 0.311 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.527TyrAla: 2.527 ± 0.037	0.223TyrCys: 0.223 ± 0.009	1.175TyrAsp: 1.175 ± 0.023	0.876TyrGlu: 0.876 ± 0.02	0.593TyrPhe: 0.593 ± 0.021	1.81TyrGly: 1.81 ± 0.029	0.378TyrHis: 0.378 ± 0.013	0.568TyrIle: 0.568 ± 0.016	0.318TyrLys: 0.318 ± 0.015	1.843TyrLeu: 1.843 ± 0.032	0.306TyrMet: 0.306 ± 0.012	0.404TyrAsn: 0.404 ± 0.015	0.969TyrPro: 0.969 ± 0.023	0.521TyrGln: 0.521 ± 0.014	1.715TyrArg: 1.715 ± 0.029	0.833TyrSer: 0.833 ± 0.022	0.808TyrThr: 0.808 ± 0.019	1.291TyrVal: 1.291 ± 0.026	0.324TyrTrp: 0.324 ± 0.012	0.42TyrTyr: 0.42 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7087 proteins (2193505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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