Amino acid dipepetide frequency for Amycolatopsis pithecelloba

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.067AlaAla: 19.067 ± 0.129	0.979AlaCys: 0.979 ± 0.025	8.006AlaAsp: 8.006 ± 0.079	8.534AlaGlu: 8.534 ± 0.068	3.489AlaPhe: 3.489 ± 0.042	13.262AlaGly: 13.262 ± 0.09	2.612AlaHis: 2.612 ± 0.035	4.729AlaIle: 4.729 ± 0.056	3.092AlaLys: 3.092 ± 0.043	13.269AlaLeu: 13.269 ± 0.112	2.556AlaMet: 2.556 ± 0.032	2.356AlaAsn: 2.356 ± 0.039	6.007AlaPro: 6.007 ± 0.067	3.878AlaGln: 3.878 ± 0.044	9.645AlaArg: 9.645 ± 0.071	5.815AlaSer: 5.815 ± 0.058	6.997AlaThr: 6.997 ± 0.059	11.3AlaVal: 11.3 ± 0.084	1.778AlaTrp: 1.778 ± 0.029	2.32AlaTyr: 2.32 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.991CysAla: 0.991 ± 0.024	0.1CysCys: 0.1 ± 0.006	0.457CysAsp: 0.457 ± 0.016	0.408CysGlu: 0.408 ± 0.015	0.255CysPhe: 0.255 ± 0.012	0.884CysGly: 0.884 ± 0.022	0.204CysHis: 0.204 ± 0.01	0.208CysIle: 0.208 ± 0.01	0.105CysLys: 0.105 ± 0.007	0.74CysLeu: 0.74 ± 0.019	0.099CysMet: 0.099 ± 0.007	0.14CysAsn: 0.14 ± 0.009	0.448CysPro: 0.448 ± 0.014	0.191CysGln: 0.191 ± 0.01	0.577CysArg: 0.577 ± 0.017	0.445CysSer: 0.445 ± 0.017	0.471CysThr: 0.471 ± 0.017	0.666CysVal: 0.666 ± 0.018	0.137CysTrp: 0.137 ± 0.008	0.172CysTyr: 0.172 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.228AspAla: 7.228 ± 0.068	0.386AspCys: 0.386 ± 0.015	3.475AspAsp: 3.475 ± 0.05	4.165AspGlu: 4.165 ± 0.047	1.734AspPhe: 1.734 ± 0.032	5.738AspGly: 5.738 ± 0.059	1.391AspHis: 1.391 ± 0.027	2.201AspIle: 2.201 ± 0.033	1.154AspLys: 1.154 ± 0.026	6.268AspLeu: 6.268 ± 0.057	0.799AspMet: 0.799 ± 0.018	1.068AspAsn: 1.068 ± 0.023	4.226AspPro: 4.226 ± 0.062	1.683AspGln: 1.683 ± 0.028	4.702AspArg: 4.702 ± 0.053	2.599AspSer: 2.599 ± 0.032	2.936AspThr: 2.936 ± 0.036	5.246AspVal: 5.246 ± 0.042	0.915AspTrp: 0.915 ± 0.018	1.243AspTyr: 1.243 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.508GluAla: 6.508 ± 0.054	0.34GluCys: 0.34 ± 0.013	2.648GluAsp: 2.648 ± 0.035	2.957GluGlu: 2.957 ± 0.039	1.874GluPhe: 1.874 ± 0.032	3.566GluGly: 3.566 ± 0.043	1.715GluHis: 1.715 ± 0.029	2.786GluIle: 2.786 ± 0.035	1.388GluLys: 1.388 ± 0.024	7.636GluLeu: 7.636 ± 0.067	1.005GluMet: 1.005 ± 0.022	1.241GluAsn: 1.241 ± 0.022	3.435GluPro: 3.435 ± 0.043	2.355GluGln: 2.355 ± 0.034	5.08GluArg: 5.08 ± 0.053	2.763GluSer: 2.763 ± 0.032	2.919GluThr: 2.919 ± 0.038	4.85GluVal: 4.85 ± 0.048	0.826GluTrp: 0.826 ± 0.016	1.118GluTyr: 1.118 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.1PheAla: 4.1 ± 0.044	0.292PheCys: 0.292 ± 0.011	2.264PheAsp: 2.264 ± 0.035	1.565PheGlu: 1.565 ± 0.028	0.941PhePhe: 0.941 ± 0.026	3.485PheGly: 3.485 ± 0.039	0.691PheHis: 0.691 ± 0.018	0.872PheIle: 0.872 ± 0.021	0.45PheLys: 0.45 ± 0.014	2.776PheLeu: 2.776 ± 0.035	0.366PheMet: 0.366 ± 0.013	0.562PheAsn: 0.562 ± 0.016	1.533PhePro: 1.533 ± 0.028	0.705PheGln: 0.705 ± 0.017	2.016PheArg: 2.016 ± 0.035	1.694PheSer: 1.694 ± 0.027	2.122PheThr: 2.122 ± 0.029	2.559PheVal: 2.559 ± 0.039	0.395PheTrp: 0.395 ± 0.014	0.624PheTyr: 0.624 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.247GlyAla: 10.247 ± 0.067	0.806GlyCys: 0.806 ± 0.023	4.806GlyAsp: 4.806 ± 0.054	5.26GlyGlu: 5.26 ± 0.051	3.072GlyPhe: 3.072 ± 0.039	7.969GlyGly: 7.969 ± 0.084	2.218GlyHis: 2.218 ± 0.036	4.055GlyIle: 4.055 ± 0.048	2.616GlyLys: 2.616 ± 0.032	9.312GlyLeu: 9.312 ± 0.068	2.037GlyMet: 2.037 ± 0.029	1.957GlyAsn: 1.957 ± 0.037	4.589GlyPro: 4.589 ± 0.044	2.906GlyGln: 2.906 ± 0.039	6.987GlyArg: 6.987 ± 0.06	5.09GlySer: 5.09 ± 0.05	5.563GlyThr: 5.563 ± 0.055	7.805GlyVal: 7.805 ± 0.06	1.691GlyTrp: 1.691 ± 0.027	2.411GlyTyr: 2.411 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.646HisAla: 2.646 ± 0.03	0.211HisCys: 0.211 ± 0.01	1.42HisAsp: 1.42 ± 0.026	1.325HisGlu: 1.325 ± 0.027	0.704HisPhe: 0.704 ± 0.017	2.384HisGly: 2.384 ± 0.037	0.692HisHis: 0.692 ± 0.019	0.755HisIle: 0.755 ± 0.017	0.359HisLys: 0.359 ± 0.01	2.358HisLeu: 2.358 ± 0.035	0.313HisMet: 0.313 ± 0.013	0.492HisAsn: 0.492 ± 0.017	1.682HisPro: 1.682 ± 0.029	0.669HisGln: 0.669 ± 0.017	2.044HisArg: 2.044 ± 0.027	1.075HisSer: 1.075 ± 0.022	1.241HisThr: 1.241 ± 0.024	1.757HisVal: 1.757 ± 0.032	0.372HisTrp: 0.372 ± 0.012	0.513HisTyr: 0.513 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.686IleAla: 5.686 ± 0.055	0.336IleCys: 0.336 ± 0.014	2.72IleAsp: 2.72 ± 0.037	2.484IleGlu: 2.484 ± 0.038	0.952IlePhe: 0.952 ± 0.02	4.204IleGly: 4.204 ± 0.048	0.704IleHis: 0.704 ± 0.018	1.214IleIle: 1.214 ± 0.025	0.733IleLys: 0.733 ± 0.019	2.89IleLeu: 2.89 ± 0.034	0.515IleMet: 0.515 ± 0.017	0.864IleAsn: 0.864 ± 0.021	2.149IlePro: 2.149 ± 0.034	0.872IleGln: 0.872 ± 0.02	2.691IleArg: 2.691 ± 0.029	2.151IleSer: 2.151 ± 0.031	2.553IleThr: 2.553 ± 0.037	3.568IleVal: 3.568 ± 0.05	0.421IleTrp: 0.421 ± 0.015	0.662IleTyr: 0.662 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.714LysAla: 2.714 ± 0.046	0.096LysCys: 0.096 ± 0.008	1.084LysAsp: 1.084 ± 0.024	1.028LysGlu: 1.028 ± 0.023	0.58LysPhe: 0.58 ± 0.018	1.484LysGly: 1.484 ± 0.027	0.486LysHis: 0.486 ± 0.014	1.053LysIle: 1.053 ± 0.02	0.579LysLys: 0.579 ± 0.017	2.347LysLeu: 2.347 ± 0.035	0.402LysMet: 0.402 ± 0.014	0.469LysAsn: 0.469 ± 0.015	1.498LysPro: 1.498 ± 0.026	0.751LysGln: 0.751 ± 0.019	1.578LysArg: 1.578 ± 0.03	1.136LysSer: 1.136 ± 0.024	1.295LysThr: 1.295 ± 0.023	1.879LysVal: 1.879 ± 0.029	0.298LysTrp: 0.298 ± 0.012	0.449LysTyr: 0.449 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.346LeuAla: 15.346 ± 0.098	0.816LeuCys: 0.816 ± 0.022	6.974LeuAsp: 6.974 ± 0.063	4.921LeuGlu: 4.921 ± 0.057	2.739LeuPhe: 2.739 ± 0.037	9.492LeuGly: 9.492 ± 0.079	2.261LeuHis: 2.261 ± 0.033	3.739LeuIle: 3.739 ± 0.045	1.739LeuLys: 1.739 ± 0.03	10.638LeuLeu: 10.638 ± 0.103	1.49LeuMet: 1.49 ± 0.027	1.968LeuAsn: 1.968 ± 0.028	6.247LeuPro: 6.247 ± 0.061	2.232LeuGln: 2.232 ± 0.031	8.775LeuArg: 8.775 ± 0.088	5.93LeuSer: 5.93 ± 0.061	6.492LeuThr: 6.492 ± 0.044	9.212LeuVal: 9.212 ± 0.078	1.216LeuTrp: 1.216 ± 0.027	1.692LeuTyr: 1.692 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.171MetAla: 2.171 ± 0.031	0.131MetCys: 0.131 ± 0.007	0.828MetAsp: 0.828 ± 0.022	0.633MetGlu: 0.633 ± 0.016	0.556MetPhe: 0.556 ± 0.017	1.198MetGly: 1.198 ± 0.022	0.384MetHis: 0.384 ± 0.014	0.778MetIle: 0.778 ± 0.018	0.425MetLys: 0.425 ± 0.015	1.788MetLeu: 1.788 ± 0.027	0.305MetMet: 0.305 ± 0.011	0.466MetAsn: 0.466 ± 0.013	1.136MetPro: 1.136 ± 0.021	0.429MetGln: 0.429 ± 0.013	1.519MetArg: 1.519 ± 0.024	1.421MetSer: 1.421 ± 0.023	1.598MetThr: 1.598 ± 0.026	1.373MetVal: 1.373 ± 0.027	0.21MetTrp: 0.21 ± 0.008	0.272MetTyr: 0.272 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.541AsnAla: 2.541 ± 0.034	0.173AsnCys: 0.173 ± 0.008	1.061AsnAsp: 1.061 ± 0.021	0.904AsnGlu: 0.904 ± 0.017	0.603AsnPhe: 0.603 ± 0.017	1.991AsnGly: 1.991 ± 0.034	0.463AsnHis: 0.463 ± 0.016	0.76AsnIle: 0.76 ± 0.02	0.382AsnLys: 0.382 ± 0.015	2.057AsnLeu: 2.057 ± 0.03	0.299AsnMet: 0.299 ± 0.012	0.497AsnAsn: 0.497 ± 0.016	1.617AsnPro: 1.617 ± 0.029	0.629AsnGln: 0.629 ± 0.017	1.447AsnArg: 1.447 ± 0.028	1.07AsnSer: 1.07 ± 0.024	1.177AsnThr: 1.177 ± 0.024	1.63AsnVal: 1.63 ± 0.03	0.337AsnTrp: 0.337 ± 0.012	0.48AsnTyr: 0.48 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.933ProAla: 7.933 ± 0.078	0.319ProCys: 0.319 ± 0.012	4.337ProAsp: 4.337 ± 0.056	4.084ProGlu: 4.084 ± 0.053	1.629ProPhe: 1.629 ± 0.028	6.292ProGly: 6.292 ± 0.061	1.269ProHis: 1.269 ± 0.024	1.807ProIle: 1.807 ± 0.028	1.184ProLys: 1.184 ± 0.023	5.094ProLeu: 5.094 ± 0.044	1.037ProMet: 1.037 ± 0.022	1.074ProAsn: 1.074 ± 0.026	3.302ProPro: 3.302 ± 0.052	1.685ProGln: 1.685 ± 0.033	3.882ProArg: 3.882 ± 0.046	3.043ProSer: 3.043 ± 0.036	2.872ProThr: 2.872 ± 0.037	5.328ProVal: 5.328 ± 0.044	0.885ProTrp: 0.885 ± 0.021	1.199ProTyr: 1.199 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.868GlnAla: 3.868 ± 0.047	0.193GlnCys: 0.193 ± 0.009	1.293GlnAsp: 1.293 ± 0.021	1.297GlnGlu: 1.297 ± 0.026	0.828GlnPhe: 0.828 ± 0.017	2.14GlnGly: 2.14 ± 0.028	0.719GlnHis: 0.719 ± 0.018	1.266GlnIle: 1.266 ± 0.025	0.583GlnLys: 0.583 ± 0.016	3.585GlnLeu: 3.585 ± 0.046	0.503GlnMet: 0.503 ± 0.014	0.596GlnAsn: 0.596 ± 0.02	1.854GlnPro: 1.854 ± 0.035	1.397GlnGln: 1.397 ± 0.049	2.59GlnArg: 2.59 ± 0.041	1.337GlnSer: 1.337 ± 0.025	1.404GlnThr: 1.404 ± 0.024	2.639GlnVal: 2.639 ± 0.031	0.494GlnTrp: 0.494 ± 0.015	0.61GlnTyr: 0.61 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.31ArgAla: 9.31 ± 0.079	0.62ArgCys: 0.62 ± 0.018	4.28ArgAsp: 4.28 ± 0.052	4.768ArgGlu: 4.768 ± 0.047	2.598ArgPhe: 2.598 ± 0.039	5.608ArgGly: 5.608 ± 0.043	2.02ArgHis: 2.02 ± 0.033	3.428ArgIle: 3.428 ± 0.041	1.853ArgLys: 1.853 ± 0.033	8.53ArgLeu: 8.53 ± 0.082	1.818ArgMet: 1.818 ± 0.026	1.581ArgAsn: 1.581 ± 0.029	4.497ArgPro: 4.497 ± 0.058	2.495ArgGln: 2.495 ± 0.043	7.532ArgArg: 7.532 ± 0.077	3.963ArgSer: 3.963 ± 0.05	4.613ArgThr: 4.613 ± 0.046	6.039ArgVal: 6.039 ± 0.054	1.371ArgTrp: 1.371 ± 0.027	1.954ArgTyr: 1.954 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.641SerAla: 6.641 ± 0.062	0.44SerCys: 0.44 ± 0.017	2.798SerAsp: 2.798 ± 0.04	2.56SerGlu: 2.56 ± 0.033	1.729SerPhe: 1.729 ± 0.03	5.82SerGly: 5.82 ± 0.052	1.043SerHis: 1.043 ± 0.021	1.939SerIle: 1.939 ± 0.032	1.06SerLys: 1.06 ± 0.021	4.987SerLeu: 4.987 ± 0.05	1.178SerMet: 1.178 ± 0.025	0.978SerAsn: 0.978 ± 0.019	3.154SerPro: 3.154 ± 0.04	1.388SerGln: 1.388 ± 0.025	3.833SerArg: 3.833 ± 0.048	3.114SerSer: 3.114 ± 0.048	3.283SerThr: 3.283 ± 0.042	4.53SerVal: 4.53 ± 0.046	0.969SerTrp: 0.969 ± 0.023	1.199SerTyr: 1.199 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	7.571ThrAla: 7.571 ± 0.057	0.402ThrCys: 0.402 ± 0.013	3.329ThrAsp: 3.329 ± 0.036	3.465ThrGlu: 3.465 ± 0.036	1.756ThrPhe: 1.756 ± 0.029	6.288ThrGly: 6.288 ± 0.055	1.169ThrHis: 1.169 ± 0.023	2.274ThrIle: 2.274 ± 0.036	1.287ThrLys: 1.287 ± 0.025	5.395ThrLeu: 5.395 ± 0.057	1.093ThrMet: 1.093 ± 0.023	1.128ThrAsn: 1.128 ± 0.022	3.695ThrPro: 3.695 ± 0.04	1.432ThrGln: 1.432 ± 0.028	3.79ThrArg: 3.79 ± 0.048	3.274ThrSer: 3.274 ± 0.039	3.842ThrThr: 3.842 ± 0.047	5.818ThrVal: 5.818 ± 0.059	0.859ThrTrp: 0.859 ± 0.018	1.211ThrTyr: 1.211 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.156ValAla: 11.156 ± 0.089	0.726ValCys: 0.726 ± 0.017	5.345ValAsp: 5.345 ± 0.055	4.864ValGlu: 4.864 ± 0.048	2.689ValPhe: 2.689 ± 0.04	6.521ValGly: 6.521 ± 0.058	2.072ValHis: 2.072 ± 0.03	3.402ValIle: 3.402 ± 0.044	1.614ValLys: 1.614 ± 0.028	10.026ValLeu: 10.026 ± 0.076	1.317ValMet: 1.317 ± 0.027	1.913ValAsn: 1.913 ± 0.033	5.191ValPro: 5.191 ± 0.053	2.176ValGln: 2.176 ± 0.034	6.976ValArg: 6.976 ± 0.065	4.713ValSer: 4.713 ± 0.048	5.639ValThr: 5.639 ± 0.049	8.541ValVal: 8.541 ± 0.078	1.05ValTrp: 1.05 ± 0.024	1.49ValTyr: 1.49 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.599TrpAla: 1.599 ± 0.029	0.153TrpCys: 0.153 ± 0.007	0.715TrpAsp: 0.715 ± 0.017	0.665TrpGlu: 0.665 ± 0.017	0.548TrpPhe: 0.548 ± 0.018	1.019TrpGly: 1.019 ± 0.023	0.414TrpHis: 0.414 ± 0.013	0.587TrpIle: 0.587 ± 0.015	0.305TrpLys: 0.305 ± 0.012	1.893TrpLeu: 1.893 ± 0.034	0.281TrpMet: 0.281 ± 0.012	0.347TrpAsn: 0.347 ± 0.013	0.817TrpPro: 0.817 ± 0.018	0.626TrpGln: 0.626 ± 0.016	1.355TrpArg: 1.355 ± 0.025	0.939TrpSer: 0.939 ± 0.022	0.927TrpThr: 0.927 ± 0.02	1.051TrpVal: 1.051 ± 0.021	0.319TrpTrp: 0.319 ± 0.013	0.32TrpTyr: 0.32 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.368TyrAla: 2.368 ± 0.033	0.182TyrCys: 0.182 ± 0.009	1.315TyrAsp: 1.315 ± 0.025	1.125TyrGlu: 1.125 ± 0.026	0.736TyrPhe: 0.736 ± 0.017	2.054TyrGly: 2.054 ± 0.033	0.487TyrHis: 0.487 ± 0.015	0.517TyrIle: 0.517 ± 0.017	0.295TyrLys: 0.295 ± 0.011	2.329TyrLeu: 2.329 ± 0.03	0.206TyrMet: 0.206 ± 0.01	0.421TyrAsn: 0.421 ± 0.014	1.176TyrPro: 1.176 ± 0.02	0.695TyrGln: 0.695 ± 0.018	1.859TyrArg: 1.859 ± 0.031	1.073TyrSer: 1.073 ± 0.022	1.135TyrThr: 1.135 ± 0.026	1.63TyrVal: 1.63 ± 0.023	0.338TyrTrp: 0.338 ± 0.013	0.493TyrTyr: 0.493 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7322 proteins (2356100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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