Amino acid dipepetide frequency for Martelella mediterranea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.61AlaAla: 13.61 ± 0.124	0.99AlaCys: 0.99 ± 0.027	6.622AlaAsp: 6.622 ± 0.07	7.682AlaGlu: 7.682 ± 0.095	4.756AlaPhe: 4.756 ± 0.068	9.48AlaGly: 9.48 ± 0.095	2.026AlaHis: 2.026 ± 0.043	6.47AlaIle: 6.47 ± 0.064	3.972AlaLys: 3.972 ± 0.061	12.241AlaLeu: 12.241 ± 0.116	3.446AlaMet: 3.446 ± 0.054	2.957AlaAsn: 2.957 ± 0.051	4.367AlaPro: 4.367 ± 0.068	3.232AlaGln: 3.232 ± 0.057	7.266AlaArg: 7.266 ± 0.098	6.311AlaSer: 6.311 ± 0.08	5.193AlaThr: 5.193 ± 0.062	7.995AlaVal: 7.995 ± 0.095	1.256AlaTrp: 1.256 ± 0.033	2.606AlaTyr: 2.606 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.868CysAla: 0.868 ± 0.026	0.137CysCys: 0.137 ± 0.011	0.547CysAsp: 0.547 ± 0.024	0.479CysGlu: 0.479 ± 0.023	0.353CysPhe: 0.353 ± 0.015	0.936CysGly: 0.936 ± 0.032	0.239CysHis: 0.239 ± 0.013	0.389CysIle: 0.389 ± 0.014	0.232CysLys: 0.232 ± 0.011	0.8CysLeu: 0.8 ± 0.028	0.17CysMet: 0.17 ± 0.011	0.228CysAsn: 0.228 ± 0.014	0.42CysPro: 0.42 ± 0.019	0.231CysGln: 0.231 ± 0.013	0.548CysArg: 0.548 ± 0.021	0.491CysSer: 0.491 ± 0.021	0.384CysThr: 0.384 ± 0.02	0.583CysVal: 0.583 ± 0.022	0.11CysTrp: 0.11 ± 0.009	0.206CysTyr: 0.206 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.447AspAla: 6.447 ± 0.084	0.514AspCys: 0.514 ± 0.02	3.786AspAsp: 3.786 ± 0.064	4.017AspGlu: 4.017 ± 0.067	2.529AspPhe: 2.529 ± 0.045	5.347AspGly: 5.347 ± 0.067	1.36AspHis: 1.36 ± 0.035	3.702AspIle: 3.702 ± 0.056	2.026AspLys: 2.026 ± 0.04	5.692AspLeu: 5.692 ± 0.061	1.705AspMet: 1.705 ± 0.04	1.762AspAsn: 1.762 ± 0.037	3.223AspPro: 3.223 ± 0.055	1.957AspGln: 1.957 ± 0.035	3.982AspArg: 3.982 ± 0.063	2.285AspSer: 2.285 ± 0.037	2.871AspThr: 2.871 ± 0.049	4.082AspVal: 4.082 ± 0.065	0.952AspTrp: 0.952 ± 0.026	1.701AspTyr: 1.701 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.718GluAla: 7.718 ± 0.091	0.4GluCys: 0.4 ± 0.019	3.531GluAsp: 3.531 ± 0.061	3.798GluGlu: 3.798 ± 0.067	1.801GluPhe: 1.801 ± 0.034	4.467GluGly: 4.467 ± 0.062	1.282GluHis: 1.282 ± 0.037	3.969GluIle: 3.969 ± 0.055	3.277GluLys: 3.277 ± 0.06	5.091GluLeu: 5.091 ± 0.072	1.751GluMet: 1.751 ± 0.035	2.649GluAsn: 2.649 ± 0.045	2.723GluPro: 2.723 ± 0.054	2.22GluGln: 2.22 ± 0.044	4.833GluArg: 4.833 ± 0.073	2.641GluSer: 2.641 ± 0.046	4.246GluThr: 4.246 ± 0.067	3.724GluVal: 3.724 ± 0.053	0.761GluTrp: 0.761 ± 0.025	1.195GluTyr: 1.195 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.288PheAla: 4.288 ± 0.064	0.413PheCys: 0.413 ± 0.016	2.893PheAsp: 2.893 ± 0.051	2.52PheGlu: 2.52 ± 0.052	1.74PhePhe: 1.74 ± 0.043	3.746PheGly: 3.746 ± 0.061	0.76PheHis: 0.76 ± 0.024	2.182PheIle: 2.182 ± 0.046	1.233PheLys: 1.233 ± 0.031	3.67PheLeu: 3.67 ± 0.06	0.99PheMet: 0.99 ± 0.029	1.324PheAsn: 1.324 ± 0.035	1.69PhePro: 1.69 ± 0.036	1.171PheGln: 1.171 ± 0.031	2.232PheArg: 2.232 ± 0.043	3.066PheSer: 3.066 ± 0.046	2.06PheThr: 2.06 ± 0.046	2.844PheVal: 2.844 ± 0.051	0.596PheTrp: 0.596 ± 0.024	1.095PheTyr: 1.095 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.927GlyAla: 7.927 ± 0.086	0.803GlyCys: 0.803 ± 0.027	4.481GlyAsp: 4.481 ± 0.071	4.983GlyGlu: 4.983 ± 0.067	3.728GlyPhe: 3.728 ± 0.05	6.757GlyGly: 6.757 ± 0.148	1.89GlyHis: 1.89 ± 0.038	4.834GlyIle: 4.834 ± 0.066	3.708GlyLys: 3.708 ± 0.061	8.55GlyLeu: 8.55 ± 0.097	2.363GlyMet: 2.363 ± 0.043	2.474GlyAsn: 2.474 ± 0.049	3.114GlyPro: 3.114 ± 0.043	2.736GlyGln: 2.736 ± 0.05	5.332GlyArg: 5.332 ± 0.071	4.578GlySer: 4.578 ± 0.071	4.262GlyThr: 4.262 ± 0.068	5.771GlyVal: 5.771 ± 0.073	1.285GlyTrp: 1.285 ± 0.033	2.359GlyTyr: 2.359 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.088HisAla: 2.088 ± 0.042	0.245HisCys: 0.245 ± 0.013	1.329HisAsp: 1.329 ± 0.035	1.194HisGlu: 1.194 ± 0.032	0.99HisPhe: 0.99 ± 0.026	1.743HisGly: 1.743 ± 0.04	0.548HisHis: 0.548 ± 0.027	1.091HisIle: 1.091 ± 0.03	0.627HisLys: 0.627 ± 0.022	1.886HisLeu: 1.886 ± 0.039	0.569HisMet: 0.569 ± 0.021	0.567HisAsn: 0.567 ± 0.019	1.211HisPro: 1.211 ± 0.036	0.644HisGln: 0.644 ± 0.026	1.276HisArg: 1.276 ± 0.032	1.027HisSer: 1.027 ± 0.03	0.837HisThr: 0.837 ± 0.029	1.376HisVal: 1.376 ± 0.03	0.28HisTrp: 0.28 ± 0.016	0.589HisTyr: 0.589 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.509IleAla: 7.509 ± 0.071	0.572IleCys: 0.572 ± 0.022	3.994IleAsp: 3.994 ± 0.061	3.85IleGlu: 3.85 ± 0.053	2.113IlePhe: 2.113 ± 0.05	5.218IleGly: 5.218 ± 0.071	0.922IleHis: 0.922 ± 0.026	2.939IleIle: 2.939 ± 0.06	1.696IleLys: 1.696 ± 0.036	4.885IleLeu: 4.885 ± 0.074	1.303IleMet: 1.303 ± 0.035	1.749IleAsn: 1.749 ± 0.041	2.447IlePro: 2.447 ± 0.045	1.25IleGln: 1.25 ± 0.032	3.349IleArg: 3.349 ± 0.052	3.718IleSer: 3.718 ± 0.058	2.976IleThr: 2.976 ± 0.057	4.366IleVal: 4.366 ± 0.062	0.694IleTrp: 0.694 ± 0.025	1.35IleTyr: 1.35 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.917LysAla: 4.917 ± 0.07	0.202LysCys: 0.202 ± 0.014	2.031LysAsp: 2.031 ± 0.046	1.955LysGlu: 1.955 ± 0.046	0.964LysPhe: 0.964 ± 0.029	2.913LysGly: 2.913 ± 0.057	0.702LysHis: 0.702 ± 0.021	2.161LysIle: 2.161 ± 0.045	1.776LysLys: 1.776 ± 0.046	3.644LysLeu: 3.644 ± 0.058	0.964LysMet: 0.964 ± 0.027	1.334LysAsn: 1.334 ± 0.033	2.328LysPro: 2.328 ± 0.049	1.296LysGln: 1.296 ± 0.03	2.786LysArg: 2.786 ± 0.055	2.309LysSer: 2.309 ± 0.047	2.618LysThr: 2.618 ± 0.051	2.633LysVal: 2.633 ± 0.048	0.43LysTrp: 0.43 ± 0.02	0.705LysTyr: 0.705 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.354LeuAla: 11.354 ± 0.111	0.809LeuCys: 0.809 ± 0.025	5.649LeuAsp: 5.649 ± 0.069	5.694LeuGlu: 5.694 ± 0.078	3.925LeuPhe: 3.925 ± 0.064	7.259LeuGly: 7.259 ± 0.091	1.679LeuHis: 1.679 ± 0.041	5.385LeuIle: 5.385 ± 0.07	4.522LeuLys: 4.522 ± 0.056	8.605LeuLeu: 8.605 ± 0.106	2.578LeuMet: 2.578 ± 0.047	3.022LeuAsn: 3.022 ± 0.053	5.117LeuPro: 5.117 ± 0.071	2.82LeuGln: 2.82 ± 0.049	5.554LeuArg: 5.554 ± 0.077	7.545LeuSer: 7.545 ± 0.093	5.608LeuThr: 5.608 ± 0.077	6.584LeuVal: 6.584 ± 0.073	1.011LeuTrp: 1.011 ± 0.033	2.273LeuTyr: 2.273 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.199MetAla: 3.199 ± 0.06	0.157MetCys: 0.157 ± 0.011	1.304MetAsp: 1.304 ± 0.033	1.304MetGlu: 1.304 ± 0.036	0.809MetPhe: 0.809 ± 0.025	1.806MetGly: 1.806 ± 0.037	0.485MetHis: 0.485 ± 0.019	1.708MetIle: 1.708 ± 0.037	1.257MetLys: 1.257 ± 0.032	2.62MetLeu: 2.62 ± 0.049	0.834MetMet: 0.834 ± 0.03	1.035MetAsn: 1.035 ± 0.027	1.538MetPro: 1.538 ± 0.038	0.944MetGln: 0.944 ± 0.028	1.922MetArg: 1.922 ± 0.039	1.873MetSer: 1.873 ± 0.039	2.028MetThr: 2.028 ± 0.036	1.877MetVal: 1.877 ± 0.037	0.219MetTrp: 0.219 ± 0.013	0.346MetTyr: 0.346 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.621AsnAla: 3.621 ± 0.055	0.245AsnCys: 0.245 ± 0.014	1.848AsnAsp: 1.848 ± 0.04	1.668AsnGlu: 1.668 ± 0.042	1.195AsnPhe: 1.195 ± 0.035	2.962AsnGly: 2.962 ± 0.053	0.625AsnHis: 0.625 ± 0.021	1.734AsnIle: 1.734 ± 0.039	0.943AsnLys: 0.943 ± 0.029	2.785AsnLeu: 2.785 ± 0.043	0.851AsnMet: 0.851 ± 0.024	0.907AsnAsn: 0.907 ± 0.029	2.002AsnPro: 2.002 ± 0.036	1.009AsnGln: 1.009 ± 0.032	2.127AsnArg: 2.127 ± 0.044	1.423AsnSer: 1.423 ± 0.039	1.532AsnThr: 1.532 ± 0.037	2.12AsnVal: 2.12 ± 0.041	0.53AsnTrp: 0.53 ± 0.022	0.8AsnTyr: 0.8 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.025ProAla: 5.025 ± 0.068	0.298ProCys: 0.298 ± 0.015	3.699ProAsp: 3.699 ± 0.056	4.248ProGlu: 4.248 ± 0.065	1.989ProPhe: 1.989 ± 0.044	3.918ProGly: 3.918 ± 0.057	1.01ProHis: 1.01 ± 0.03	2.11ProIle: 2.11 ± 0.037	1.711ProLys: 1.711 ± 0.038	4.405ProLeu: 4.405 ± 0.066	1.132ProMet: 1.132 ± 0.032	1.315ProAsn: 1.315 ± 0.031	1.996ProPro: 1.996 ± 0.047	1.591ProGln: 1.591 ± 0.039	2.288ProArg: 2.288 ± 0.041	2.685ProSer: 2.685 ± 0.051	2.077ProThr: 2.077 ± 0.045	4.226ProVal: 4.226 ± 0.056	0.599ProTrp: 0.599 ± 0.023	1.289ProTyr: 1.289 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.714GlnAla: 3.714 ± 0.062	0.197GlnCys: 0.197 ± 0.011	1.511GlnAsp: 1.511 ± 0.038	1.59GlnGlu: 1.59 ± 0.038	1.202GlnPhe: 1.202 ± 0.032	2.038GlnGly: 2.038 ± 0.043	0.627GlnHis: 0.627 ± 0.021	1.961GlnIle: 1.961 ± 0.037	1.521GlnLys: 1.521 ± 0.039	2.885GlnLeu: 2.885 ± 0.051	0.986GlnMet: 0.986 ± 0.027	1.123GlnAsn: 1.123 ± 0.033	1.643GlnPro: 1.643 ± 0.036	1.267GlnGln: 1.267 ± 0.035	2.181GlnArg: 2.181 ± 0.042	2.014GlnSer: 2.014 ± 0.042	1.926GlnThr: 1.926 ± 0.039	2.056GlnVal: 2.056 ± 0.039	0.402GlnTrp: 0.402 ± 0.018	0.72GlnTyr: 0.72 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.477ArgAla: 6.477 ± 0.086	0.468ArgCys: 0.468 ± 0.021	3.747ArgAsp: 3.747 ± 0.056	3.971ArgGlu: 3.971 ± 0.058	2.977ArgPhe: 2.977 ± 0.055	4.051ArgGly: 4.051 ± 0.064	1.559ArgHis: 1.559 ± 0.038	3.907ArgIle: 3.907 ± 0.058	2.724ArgLys: 2.724 ± 0.045	6.921ArgLeu: 6.921 ± 0.09	1.826ArgMet: 1.826 ± 0.039	2.004ArgAsn: 2.004 ± 0.037	2.95ArgPro: 2.95 ± 0.054	2.65ArgGln: 2.65 ± 0.049	4.657ArgArg: 4.657 ± 0.07	3.665ArgSer: 3.665 ± 0.061	2.964ArgThr: 2.964 ± 0.049	3.944ArgVal: 3.944 ± 0.061	0.837ArgTrp: 0.837 ± 0.029	1.817ArgTyr: 1.817 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.678SerAla: 6.678 ± 0.078	0.421SerCys: 0.421 ± 0.018	3.713SerAsp: 3.713 ± 0.053	3.843SerGlu: 3.843 ± 0.065	2.6SerPhe: 2.6 ± 0.048	6.239SerGly: 6.239 ± 0.091	1.204SerHis: 1.204 ± 0.033	3.1SerIle: 3.1 ± 0.056	2.005SerLys: 2.005 ± 0.037	5.672SerLeu: 5.672 ± 0.076	1.536SerMet: 1.536 ± 0.036	1.577SerAsn: 1.577 ± 0.037	2.557SerPro: 2.557 ± 0.048	1.806SerGln: 1.806 ± 0.042	3.575SerArg: 3.575 ± 0.058	3.318SerSer: 3.318 ± 0.065	2.739SerThr: 2.739 ± 0.047	4.532SerVal: 4.532 ± 0.061	0.771SerTrp: 0.771 ± 0.023	1.428SerTyr: 1.428 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.729ThrAla: 5.729 ± 0.084	0.423ThrCys: 0.423 ± 0.02	2.966ThrAsp: 2.966 ± 0.051	2.853ThrGlu: 2.853 ± 0.051	2.158ThrPhe: 2.158 ± 0.037	5.144ThrGly: 5.144 ± 0.07	1.007ThrHis: 1.007 ± 0.029	3.161ThrIle: 3.161 ± 0.047	1.663ThrLys: 1.663 ± 0.04	5.735ThrLeu: 5.735 ± 0.079	1.348ThrMet: 1.348 ± 0.03	1.462ThrAsn: 1.462 ± 0.035	3.013ThrPro: 3.013 ± 0.048	1.373ThrGln: 1.373 ± 0.035	3.063ThrArg: 3.063 ± 0.051	3.058ThrSer: 3.058 ± 0.057	2.783ThrThr: 2.783 ± 0.059	4.405ThrVal: 4.405 ± 0.067	0.604ThrTrp: 0.604 ± 0.023	1.326ThrTyr: 1.326 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.754ValAla: 7.754 ± 0.083	0.652ValCys: 0.652 ± 0.025	4.053ValAsp: 4.053 ± 0.061	4.46ValGlu: 4.46 ± 0.067	3.071ValPhe: 3.071 ± 0.051	4.905ValGly: 4.905 ± 0.06	1.33ValHis: 1.33 ± 0.035	4.277ValIle: 4.277 ± 0.068	2.502ValLys: 2.502 ± 0.051	6.948ValLeu: 6.948 ± 0.097	2.008ValMet: 2.008 ± 0.048	2.16ValAsn: 2.16 ± 0.042	3.372ValPro: 3.372 ± 0.052	1.877ValGln: 1.877 ± 0.036	4.28ValArg: 4.28 ± 0.048	5.125ValSer: 5.125 ± 0.065	4.227ValThr: 4.227 ± 0.061	5.215ValVal: 5.215 ± 0.081	0.863ValTrp: 0.863 ± 0.023	1.629ValTyr: 1.629 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.071TrpAla: 1.071 ± 0.03	0.119TrpCys: 0.119 ± 0.009	0.613TrpAsp: 0.613 ± 0.023	0.556TrpGlu: 0.556 ± 0.021	0.566TrpPhe: 0.566 ± 0.022	0.784TrpGly: 0.784 ± 0.026	0.329TrpHis: 0.329 ± 0.018	0.688TrpIle: 0.688 ± 0.025	0.546TrpLys: 0.546 ± 0.021	1.562TrpLeu: 1.562 ± 0.035	0.376TrpMet: 0.376 ± 0.018	0.499TrpAsn: 0.499 ± 0.022	0.674TrpPro: 0.674 ± 0.026	0.622TrpGln: 0.622 ± 0.023	1.014TrpArg: 1.014 ± 0.026	0.84TrpSer: 0.84 ± 0.025	0.688TrpThr: 0.688 ± 0.026	0.729TrpVal: 0.729 ± 0.024	0.235TrpTrp: 0.235 ± 0.014	0.3TrpTyr: 0.3 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.483TyrAla: 2.483 ± 0.046	0.286TyrCys: 0.286 ± 0.017	1.622TyrAsp: 1.622 ± 0.036	1.412TyrGlu: 1.412 ± 0.032	1.049TyrPhe: 1.049 ± 0.029	2.223TyrGly: 2.223 ± 0.044	0.532TyrHis: 0.532 ± 0.02	1.132TyrIle: 1.132 ± 0.032	0.725TyrLys: 0.725 ± 0.023	2.396TyrLeu: 2.396 ± 0.042	0.529TyrMet: 0.529 ± 0.02	0.777TyrAsn: 0.777 ± 0.029	1.226TyrPro: 1.226 ± 0.03	0.869TyrGln: 0.869 ± 0.028	1.851TyrArg: 1.851 ± 0.039	1.346TyrSer: 1.346 ± 0.034	1.256TyrThr: 1.256 ± 0.037	1.647TyrVal: 1.647 ± 0.033	0.375TyrTrp: 0.375 ± 0.019	0.694TyrTyr: 0.694 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4157 proteins (1267225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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