Amino acid dipepetide frequency for Gemmata sp. SH-PL17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.443AlaAla: 14.443 ± 0.111
1.226AlaCys: 1.226 ± 0.025
7.065AlaAsp: 7.065 ± 0.053
7.013AlaGlu: 7.013 ± 0.055
4.139AlaPhe: 4.139 ± 0.045
9.558AlaGly: 9.558 ± 0.088
2.135AlaHis: 2.135 ± 0.032
4.551AlaIle: 4.551 ± 0.05
5.227AlaLys: 5.227 ± 0.063
12.117AlaLeu: 12.117 ± 0.092
2.002AlaMet: 2.002 ± 0.029
3.19AlaAsn: 3.19 ± 0.04
6.813AlaPro: 6.813 ± 0.066
3.259AlaGln: 3.259 ± 0.041
8.145AlaArg: 8.145 ± 0.073
5.229AlaSer: 5.229 ± 0.062
6.645AlaThr: 6.645 ± 0.072
9.589AlaVal: 9.589 ± 0.071
1.547AlaTrp: 1.547 ± 0.026
2.19AlaTyr: 2.19 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.143CysAla: 1.143 ± 0.024
0.209CysCys: 0.209 ± 0.01
0.649CysAsp: 0.649 ± 0.018
0.587CysGlu: 0.587 ± 0.017
0.37CysPhe: 0.37 ± 0.013
1.102CysGly: 1.102 ± 0.023
0.382CysHis: 0.382 ± 0.016
0.312CysIle: 0.312 ± 0.01
0.33CysLys: 0.33 ± 0.011
0.942CysLeu: 0.942 ± 0.018
0.168CysMet: 0.168 ± 0.008
0.241CysAsn: 0.241 ± 0.01
0.698CysPro: 0.698 ± 0.017
0.318CysGln: 0.318 ± 0.011
0.861CysArg: 0.861 ± 0.022
0.542CysSer: 0.542 ± 0.016
0.517CysThr: 0.517 ± 0.014
0.9CysVal: 0.9 ± 0.022
0.204CysTrp: 0.204 ± 0.01
0.269CysTyr: 0.269 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.811AspAla: 6.811 ± 0.052
0.471AspCys: 0.471 ± 0.014
3.193AspAsp: 3.193 ± 0.045
3.564AspGlu: 3.564 ± 0.043
2.007AspPhe: 2.007 ± 0.033
5.386AspGly: 5.386 ± 0.058
1.17AspHis: 1.17 ± 0.024
1.958AspIle: 1.958 ± 0.029
2.348AspLys: 2.348 ± 0.041
5.651AspLeu: 5.651 ± 0.047
0.818AspMet: 0.818 ± 0.019
1.273AspAsn: 1.273 ± 0.026
4.182AspPro: 4.182 ± 0.049
1.664AspGln: 1.664 ± 0.024
4.422AspArg: 4.422 ± 0.046
2.398AspSer: 2.398 ± 0.034
2.967AspThr: 2.967 ± 0.041
4.385AspVal: 4.385 ± 0.049
0.983AspTrp: 0.983 ± 0.017
1.342AspTyr: 1.342 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
6.051GluAla: 6.051 ± 0.058
0.529GluCys: 0.529 ± 0.015
2.403GluAsp: 2.403 ± 0.038
2.991GluGlu: 2.991 ± 0.047
2.277GluPhe: 2.277 ± 0.031
3.639GluGly: 3.639 ± 0.042
1.309GluHis: 1.309 ± 0.027
2.481GluIle: 2.481 ± 0.037
3.032GluLys: 3.032 ± 0.043
6.593GluLeu: 6.593 ± 0.062
1.247GluMet: 1.247 ± 0.023
1.41GluAsn: 1.41 ± 0.023
3.384GluPro: 3.384 ± 0.045
2.258GluGln: 2.258 ± 0.033
4.582GluArg: 4.582 ± 0.052
2.799GluSer: 2.799 ± 0.036
2.908GluThr: 2.908 ± 0.035
4.345GluVal: 4.345 ± 0.047
0.999GluTrp: 0.999 ± 0.021
1.399GluTyr: 1.399 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
4.659PheAla: 4.659 ± 0.047
0.43PheCys: 0.43 ± 0.014
2.591PheAsp: 2.591 ± 0.034
2.002PheGlu: 2.002 ± 0.03
1.254PhePhe: 1.254 ± 0.026
3.518PheGly: 3.518 ± 0.039
0.777PheHis: 0.777 ± 0.018
1.139PheIle: 1.139 ± 0.024
1.231PheLys: 1.231 ± 0.026
3.311PheLeu: 3.311 ± 0.04
0.497PheMet: 0.497 ± 0.015
1.044PheAsn: 1.044 ± 0.024
1.934PhePro: 1.934 ± 0.029
1.03PheGln: 1.03 ± 0.02
2.649PheArg: 2.649 ± 0.031
1.874PheSer: 1.874 ± 0.026
2.386PheThr: 2.386 ± 0.033
3.198PheVal: 3.198 ± 0.041
0.536PheTrp: 0.536 ± 0.016
0.809PheTyr: 0.809 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
8.952GlyAla: 8.952 ± 0.087
1.118GlyCys: 1.118 ± 0.024
4.341GlyAsp: 4.341 ± 0.05
4.357GlyGlu: 4.357 ± 0.042
3.293GlyPhe: 3.293 ± 0.04
7.721GlyGly: 7.721 ± 0.107
1.777GlyHis: 1.777 ± 0.029
3.222GlyIle: 3.222 ± 0.043
4.35GlyLys: 4.35 ± 0.054
7.436GlyLeu: 7.436 ± 0.066
1.706GlyMet: 1.706 ± 0.028
2.397GlyAsn: 2.397 ± 0.035
4.117GlyPro: 4.117 ± 0.052
2.54GlyGln: 2.54 ± 0.043
5.818GlyArg: 5.818 ± 0.062
4.626GlySer: 4.626 ± 0.058
5.952GlyThr: 5.952 ± 0.094
6.097GlyVal: 6.097 ± 0.051
1.527GlyTrp: 1.527 ± 0.027
2.224GlyTyr: 2.224 ± 0.031
0.0GlyXaa: 0.0 ± 0.0
His
2.185HisAla: 2.185 ± 0.03
0.296HisCys: 0.296 ± 0.012
1.11HisAsp: 1.11 ± 0.019
1.108HisGlu: 1.108 ± 0.022
0.791HisPhe: 0.791 ± 0.018
1.731HisGly: 1.731 ± 0.03
0.539HisHis: 0.539 ± 0.017
0.763HisIle: 0.763 ± 0.019
0.682HisLys: 0.682 ± 0.017
2.07HisLeu: 2.07 ± 0.031
0.317HisMet: 0.317 ± 0.012
0.562HisAsn: 0.562 ± 0.017
1.548HisPro: 1.548 ± 0.029
0.532HisGln: 0.532 ± 0.014
1.507HisArg: 1.507 ± 0.026
0.939HisSer: 0.939 ± 0.02
1.221HisThr: 1.221 ± 0.023
1.544HisVal: 1.544 ± 0.026
0.378HisTrp: 0.378 ± 0.013
0.539HisTyr: 0.539 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.94IleAla: 4.94 ± 0.044
0.396IleCys: 0.396 ± 0.013
2.722IleAsp: 2.722 ± 0.032
2.749IleGlu: 2.749 ± 0.034
1.038IlePhe: 1.038 ± 0.022
3.647IleGly: 3.647 ± 0.045
0.758IleHis: 0.758 ± 0.016
1.288IleIle: 1.288 ± 0.025
1.441IleLys: 1.441 ± 0.024
3.089IleLeu: 3.089 ± 0.033
0.487IleMet: 0.487 ± 0.014
1.088IleAsn: 1.088 ± 0.024
2.146IlePro: 2.146 ± 0.029
1.041IleGln: 1.041 ± 0.02
2.785IleArg: 2.785 ± 0.032
1.819IleSer: 1.819 ± 0.028
2.475IleThr: 2.475 ± 0.038
3.078IleVal: 3.078 ± 0.037
0.445IleTrp: 0.445 ± 0.015
0.811IleTyr: 0.811 ± 0.019
0.0IleXaa: 0.0 ± 0.0
Lys
4.544LysAla: 4.544 ± 0.049
0.392LysCys: 0.392 ± 0.012
2.519LysAsp: 2.519 ± 0.04
2.535LysGlu: 2.535 ± 0.041
1.431LysPhe: 1.431 ± 0.027
3.055LysGly: 3.055 ± 0.039
0.879LysHis: 0.879 ± 0.021
1.678LysIle: 1.678 ± 0.026
2.671LysLys: 2.671 ± 0.046
4.621LysLeu: 4.621 ± 0.056
1.124LysMet: 1.124 ± 0.021
1.283LysAsn: 1.283 ± 0.026
3.151LysPro: 3.151 ± 0.039
1.562LysGln: 1.562 ± 0.028
2.667LysArg: 2.667 ± 0.035
2.194LysSer: 2.194 ± 0.032
2.438LysThr: 2.438 ± 0.036
3.328LysVal: 3.328 ± 0.044
0.705LysTrp: 0.705 ± 0.019
1.069LysTyr: 1.069 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
12.529LeuAla: 12.529 ± 0.091
1.026LeuCys: 1.026 ± 0.022
5.682LeuAsp: 5.682 ± 0.051
4.957LeuGlu: 4.957 ± 0.054
3.57LeuPhe: 3.57 ± 0.042
7.572LeuGly: 7.572 ± 0.064
1.813LeuHis: 1.813 ± 0.03
3.75LeuIle: 3.75 ± 0.044
4.345LeuLys: 4.345 ± 0.054
9.425LeuLeu: 9.425 ± 0.078
1.552LeuMet: 1.552 ± 0.028
2.777LeuAsn: 2.777 ± 0.031
5.929LeuPro: 5.929 ± 0.049
2.505LeuGln: 2.505 ± 0.032
6.876LeuArg: 6.876 ± 0.059
5.079LeuSer: 5.079 ± 0.05
6.447LeuThr: 6.447 ± 0.062
8.023LeuVal: 8.023 ± 0.067
1.246LeuTrp: 1.246 ± 0.025
1.972LeuTyr: 1.972 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
1.807MetAla: 1.807 ± 0.032
0.209MetCys: 0.209 ± 0.009
0.774MetAsp: 0.774 ± 0.018
0.75MetGlu: 0.75 ± 0.02
0.619MetPhe: 0.619 ± 0.016
1.251MetGly: 1.251 ± 0.021
0.346MetHis: 0.346 ± 0.012
0.75MetIle: 0.75 ± 0.016
0.865MetLys: 0.865 ± 0.018
1.673MetLeu: 1.673 ± 0.025
0.358MetMet: 0.358 ± 0.013
0.653MetAsn: 0.653 ± 0.015
1.353MetPro: 1.353 ± 0.022
0.479MetGln: 0.479 ± 0.013
1.33MetArg: 1.33 ± 0.021
1.313MetSer: 1.313 ± 0.025
1.261MetThr: 1.261 ± 0.023
1.187MetVal: 1.187 ± 0.02
0.234MetTrp: 0.234 ± 0.009
0.383MetTyr: 0.383 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.96AsnAla: 2.96 ± 0.038
0.312AsnCys: 0.312 ± 0.013
1.54AsnAsp: 1.54 ± 0.028
1.492AsnGlu: 1.492 ± 0.028
0.957AsnPhe: 0.957 ± 0.023
2.807AsnGly: 2.807 ± 0.041
0.587AsnHis: 0.587 ± 0.016
0.968AsnIle: 0.968 ± 0.022
1.059AsnLys: 1.059 ± 0.023
2.608AsnLeu: 2.608 ± 0.038
0.45AsnMet: 0.45 ± 0.012
0.957AsnAsn: 0.957 ± 0.023
2.299AsnPro: 2.299 ± 0.033
0.911AsnGln: 0.911 ± 0.027
2.037AsnArg: 2.037 ± 0.031
1.341AsnSer: 1.341 ± 0.025
1.627AsnThr: 1.627 ± 0.029
2.094AsnVal: 2.094 ± 0.03
0.494AsnTrp: 0.494 ± 0.012
0.721AsnTyr: 0.721 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.429ProAla: 7.429 ± 0.068
0.434ProCys: 0.434 ± 0.015
4.367ProAsp: 4.367 ± 0.047
4.112ProGlu: 4.112 ± 0.045
2.167ProPhe: 2.167 ± 0.031
5.43ProGly: 5.43 ± 0.063
1.266ProHis: 1.266 ± 0.023
2.202ProIle: 2.202 ± 0.031
2.961ProLys: 2.961 ± 0.048
4.985ProLeu: 4.985 ± 0.053
0.949ProMet: 0.949 ± 0.019
2.103ProAsn: 2.103 ± 0.032
4.419ProPro: 4.419 ± 0.067
1.677ProGln: 1.677 ± 0.032
3.432ProArg: 3.432 ± 0.042
3.126ProSer: 3.126 ± 0.043
3.929ProThr: 3.929 ± 0.043
5.257ProVal: 5.257 ± 0.057
0.757ProTrp: 0.757 ± 0.018
1.152ProTyr: 1.152 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
3.082GlnAla: 3.082 ± 0.038
0.299GlnCys: 0.299 ± 0.011
1.19GlnAsp: 1.19 ± 0.022
1.449GlnGlu: 1.449 ± 0.026
1.331GlnPhe: 1.331 ± 0.022
1.834GlnGly: 1.834 ± 0.032
0.64GlnHis: 0.64 ± 0.015
1.526GlnIle: 1.526 ± 0.023
1.53GlnLys: 1.53 ± 0.024
3.264GlnLeu: 3.264 ± 0.037
0.709GlnMet: 0.709 ± 0.017
0.857GlnAsn: 0.857 ± 0.018
1.921GlnPro: 1.921 ± 0.032
1.174GlnGln: 1.174 ± 0.025
2.119GlnArg: 2.119 ± 0.036
1.584GlnSer: 1.584 ± 0.03
1.738GlnThr: 1.738 ± 0.029
2.312GlnVal: 2.312 ± 0.036
0.468GlnTrp: 0.468 ± 0.014
0.667GlnTyr: 0.667 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
8.24ArgAla: 8.24 ± 0.079
0.743ArgCys: 0.743 ± 0.019
4.198ArgAsp: 4.198 ± 0.038
4.381ArgGlu: 4.381 ± 0.05
2.97ArgPhe: 2.97 ± 0.04
5.199ArgGly: 5.199 ± 0.048
1.414ArgHis: 1.414 ± 0.027
2.817ArgIle: 2.817 ± 0.036
2.811ArgLys: 2.811 ± 0.031
7.129ArgLeu: 7.129 ± 0.061
1.396ArgMet: 1.396 ± 0.021
1.831ArgAsn: 1.831 ± 0.025
3.935ArgPro: 3.935 ± 0.045
2.149ArgGln: 2.149 ± 0.029
5.19ArgArg: 5.19 ± 0.07
3.504ArgSer: 3.504 ± 0.044
4.311ArgThr: 4.311 ± 0.062
5.992ArgVal: 5.992 ± 0.056
1.171ArgTrp: 1.171 ± 0.021
1.795ArgTyr: 1.795 ± 0.024
0.0ArgXaa: 0.0 ± 0.0
Ser
6.263SerAla: 6.263 ± 0.055
0.519SerCys: 0.519 ± 0.017
2.971SerAsp: 2.971 ± 0.032
2.789SerGlu: 2.789 ± 0.038
1.777SerPhe: 1.777 ± 0.028
5.184SerGly: 5.184 ± 0.058
1.0SerHis: 1.0 ± 0.019
1.823SerIle: 1.823 ± 0.045
1.843SerLys: 1.843 ± 0.029
4.307SerLeu: 4.307 ± 0.043
0.874SerMet: 0.874 ± 0.022
1.433SerAsn: 1.433 ± 0.027
3.222SerPro: 3.222 ± 0.038
1.374SerGln: 1.374 ± 0.022
3.391SerArg: 3.391 ± 0.045
2.745SerSer: 2.745 ± 0.046
3.086SerThr: 3.086 ± 0.084
4.103SerVal: 4.103 ± 0.051
0.835SerTrp: 0.835 ± 0.019
1.139SerTyr: 1.139 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
7.136ThrAla: 7.136 ± 0.068
0.582ThrCys: 0.582 ± 0.016
3.794ThrAsp: 3.794 ± 0.048
3.398ThrGlu: 3.398 ± 0.038
2.351ThrPhe: 2.351 ± 0.035
6.107ThrGly: 6.107 ± 0.106
1.225ThrHis: 1.225 ± 0.021
2.475ThrIle: 2.475 ± 0.038
2.365ThrLys: 2.365 ± 0.035
5.5ThrLeu: 5.5 ± 0.06
0.85ThrMet: 0.85 ± 0.017
1.825ThrAsn: 1.825 ± 0.041
4.048ThrPro: 4.048 ± 0.041
1.619ThrGln: 1.619 ± 0.026
3.931ThrArg: 3.931 ± 0.039
3.084ThrSer: 3.084 ± 0.085
3.725ThrThr: 3.725 ± 0.089
5.345ThrVal: 5.345 ± 0.068
0.795ThrTrp: 0.795 ± 0.019
1.321ThrTyr: 1.321 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
9.151ValAla: 9.151 ± 0.074
1.052ValCys: 1.052 ± 0.023
3.636ValAsp: 3.636 ± 0.042
4.323ValGlu: 4.323 ± 0.047
2.974ValPhe: 2.974 ± 0.037
5.881ValGly: 5.881 ± 0.049
1.422ValHis: 1.422 ± 0.022
3.291ValIle: 3.291 ± 0.035
3.207ValLys: 3.207 ± 0.044
8.257ValLeu: 8.257 ± 0.07
1.415ValMet: 1.415 ± 0.026
2.183ValAsn: 2.183 ± 0.032
5.063ValPro: 5.063 ± 0.059
2.248ValGln: 2.248 ± 0.032
6.33ValArg: 6.33 ± 0.052
4.397ValSer: 4.397 ± 0.044
5.572ValThr: 5.572 ± 0.075
6.889ValVal: 6.889 ± 0.067
1.331ValTrp: 1.331 ± 0.025
1.887ValTyr: 1.887 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.551TrpAla: 1.551 ± 0.024
0.205TrpCys: 0.205 ± 0.009
0.926TrpAsp: 0.926 ± 0.02
0.766TrpGlu: 0.766 ± 0.019
0.592TrpPhe: 0.592 ± 0.015
1.047TrpGly: 1.047 ± 0.023
0.38TrpHis: 0.38 ± 0.013
0.541TrpIle: 0.541 ± 0.015
0.703TrpLys: 0.703 ± 0.018
1.768TrpLeu: 1.768 ± 0.027
0.32TrpMet: 0.32 ± 0.011
0.49TrpAsn: 0.49 ± 0.014
0.715TrpPro: 0.715 ± 0.017
0.517TrpGln: 0.517 ± 0.015
1.115TrpArg: 1.115 ± 0.024
0.863TrpSer: 0.863 ± 0.019
0.828TrpThr: 0.828 ± 0.019
1.33TrpVal: 1.33 ± 0.027
0.312TrpTrp: 0.312 ± 0.011
0.382TrpTyr: 0.382 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.207TyrAla: 2.207 ± 0.031
0.295TyrCys: 0.295 ± 0.01
1.323TyrAsp: 1.323 ± 0.049
1.317TyrGlu: 1.317 ± 0.023
0.959TyrPhe: 0.959 ± 0.019
1.899TyrGly: 1.899 ± 0.025
0.543TyrHis: 0.543 ± 0.014
0.707TyrIle: 0.707 ± 0.018
0.844TyrLys: 0.844 ± 0.018
2.328TyrLeu: 2.328 ± 0.031
0.36TyrMet: 0.36 ± 0.013
0.626TyrAsn: 0.626 ± 0.016
1.279TyrPro: 1.279 ± 0.025
0.837TyrGln: 0.837 ± 0.019
1.987TyrArg: 1.987 ± 0.03
1.222TyrSer: 1.222 ± 0.023
1.444TyrThr: 1.444 ± 0.028
1.513TyrVal: 1.513 ± 0.027
0.382TyrTrp: 0.382 ± 0.013
0.656TyrTyr: 0.656 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7589 proteins (2568544 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski