Amino acid dipepetide frequency for Mycobacterium phage A6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.598AlaAla: 13.598 ± 1.535
0.533AlaCys: 0.533 ± 0.172
6.999AlaAsp: 6.999 ± 0.638
6.532AlaGlu: 6.532 ± 0.774
3.066AlaPhe: 3.066 ± 0.522
7.399AlaGly: 7.399 ± 0.736
1.333AlaHis: 1.333 ± 0.364
4.733AlaIle: 4.733 ± 0.618
3.999AlaLys: 3.999 ± 0.455
9.465AlaLeu: 9.465 ± 0.926
2.6AlaMet: 2.6 ± 0.453
2.8AlaAsn: 2.8 ± 0.42
4.933AlaPro: 4.933 ± 0.745
2.733AlaGln: 2.733 ± 0.432
5.866AlaArg: 5.866 ± 0.496
6.066AlaSer: 6.066 ± 0.792
5.666AlaThr: 5.666 ± 0.607
7.599AlaVal: 7.599 ± 0.615
1.933AlaTrp: 1.933 ± 0.347
2.8AlaTyr: 2.8 ± 0.448
0.0AlaXaa: 0.0 ± 0.0
Cys
0.6CysAla: 0.6 ± 0.215
0.0CysCys: 0.0 ± 0.0
0.467CysAsp: 0.467 ± 0.179
0.667CysGlu: 0.667 ± 0.212
0.2CysPhe: 0.2 ± 0.107
0.6CysGly: 0.6 ± 0.245
0.067CysHis: 0.067 ± 0.063
0.2CysIle: 0.2 ± 0.115
0.133CysLys: 0.133 ± 0.106
0.267CysLeu: 0.267 ± 0.105
0.067CysMet: 0.067 ± 0.063
0.267CysAsn: 0.267 ± 0.138
0.267CysPro: 0.267 ± 0.141
0.133CysGln: 0.133 ± 0.089
0.333CysArg: 0.333 ± 0.138
0.267CysSer: 0.267 ± 0.153
0.2CysThr: 0.2 ± 0.124
0.2CysVal: 0.2 ± 0.098
0.133CysTrp: 0.133 ± 0.088
0.133CysTyr: 0.133 ± 0.106
0.0CysXaa: 0.0 ± 0.0
Asp
6.666AspAla: 6.666 ± 0.645
0.467AspCys: 0.467 ± 0.188
4.266AspAsp: 4.266 ± 0.464
4.133AspGlu: 4.133 ± 0.469
2.133AspPhe: 2.133 ± 0.384
6.133AspGly: 6.133 ± 0.653
1.266AspHis: 1.266 ± 0.346
2.6AspIle: 2.6 ± 0.518
2.2AspLys: 2.2 ± 0.5
7.399AspLeu: 7.399 ± 0.835
1.333AspMet: 1.333 ± 0.252
1.733AspAsn: 1.733 ± 0.317
4.866AspPro: 4.866 ± 0.588
1.666AspGln: 1.666 ± 0.362
3.799AspArg: 3.799 ± 0.427
3.266AspSer: 3.266 ± 0.525
3.933AspThr: 3.933 ± 0.523
4.866AspVal: 4.866 ± 0.574
1.8AspTrp: 1.8 ± 0.35
2.0AspTyr: 2.0 ± 0.353
0.0AspXaa: 0.0 ± 0.0
Glu
6.133GluAla: 6.133 ± 0.836
0.2GluCys: 0.2 ± 0.149
4.533GluAsp: 4.533 ± 0.623
5.133GluGlu: 5.133 ± 0.7
2.466GluPhe: 2.466 ± 0.484
3.466GluGly: 3.466 ± 0.462
1.6GluHis: 1.6 ± 0.375
3.466GluIle: 3.466 ± 0.499
3.0GluLys: 3.0 ± 0.46
7.266GluLeu: 7.266 ± 0.661
1.866GluMet: 1.866 ± 0.313
1.866GluAsn: 1.866 ± 0.344
2.4GluPro: 2.4 ± 0.391
2.666GluGln: 2.666 ± 0.401
3.733GluArg: 3.733 ± 0.575
3.466GluSer: 3.466 ± 0.387
3.666GluThr: 3.666 ± 0.487
5.266GluVal: 5.266 ± 0.436
1.6GluTrp: 1.6 ± 0.339
2.4GluTyr: 2.4 ± 0.479
0.0GluXaa: 0.0 ± 0.0
Phe
2.533PheAla: 2.533 ± 0.333
0.4PheCys: 0.4 ± 0.162
3.2PheAsp: 3.2 ± 0.394
2.4PheGlu: 2.4 ± 0.394
0.4PhePhe: 0.4 ± 0.147
3.6PheGly: 3.6 ± 0.557
0.867PheHis: 0.867 ± 0.237
1.266PheIle: 1.266 ± 0.26
1.333PheLys: 1.333 ± 0.299
2.466PheLeu: 2.466 ± 0.479
0.6PheMet: 0.6 ± 0.205
1.133PheAsn: 1.133 ± 0.243
1.6PhePro: 1.6 ± 0.314
1.0PheGln: 1.0 ± 0.272
2.0PheArg: 2.0 ± 0.345
2.266PheSer: 2.266 ± 0.418
2.0PheThr: 2.0 ± 0.354
2.266PheVal: 2.266 ± 0.361
0.733PheTrp: 0.733 ± 0.189
0.933PheTyr: 0.933 ± 0.272
0.0PheXaa: 0.0 ± 0.0
Gly
6.799GlyAla: 6.799 ± 0.896
0.4GlyCys: 0.4 ± 0.164
5.466GlyAsp: 5.466 ± 0.532
4.733GlyGlu: 4.733 ± 0.512
2.8GlyPhe: 2.8 ± 0.492
6.999GlyGly: 6.999 ± 1.153
1.933GlyHis: 1.933 ± 0.383
4.399GlyIle: 4.399 ± 0.735
3.266GlyLys: 3.266 ± 0.447
7.932GlyLeu: 7.932 ± 1.001
2.066GlyMet: 2.066 ± 0.437
3.266GlyAsn: 3.266 ± 0.516
3.733GlyPro: 3.733 ± 0.577
2.333GlyGln: 2.333 ± 0.365
4.533GlyArg: 4.533 ± 0.516
5.599GlySer: 5.599 ± 0.737
5.266GlyThr: 5.266 ± 0.65
5.199GlyVal: 5.199 ± 0.706
2.333GlyTrp: 2.333 ± 0.405
2.866GlyTyr: 2.866 ± 0.342
0.0GlyXaa: 0.0 ± 0.0
His
1.733HisAla: 1.733 ± 0.383
0.067HisCys: 0.067 ± 0.057
1.333HisAsp: 1.333 ± 0.268
1.6HisGlu: 1.6 ± 0.335
0.667HisPhe: 0.667 ± 0.18
1.733HisGly: 1.733 ± 0.385
0.667HisHis: 0.667 ± 0.21
1.0HisIle: 1.0 ± 0.246
1.0HisLys: 1.0 ± 0.302
1.466HisLeu: 1.466 ± 0.353
0.133HisMet: 0.133 ± 0.095
0.267HisAsn: 0.267 ± 0.124
1.2HisPro: 1.2 ± 0.28
1.067HisGln: 1.067 ± 0.227
1.733HisArg: 1.733 ± 0.334
0.933HisSer: 0.933 ± 0.231
0.933HisThr: 0.933 ± 0.207
1.666HisVal: 1.666 ± 0.343
0.667HisTrp: 0.667 ± 0.207
0.667HisTyr: 0.667 ± 0.212
0.0HisXaa: 0.0 ± 0.0
Ile
5.999IleAla: 5.999 ± 0.808
0.2IleCys: 0.2 ± 0.122
3.133IleAsp: 3.133 ± 0.353
3.533IleGlu: 3.533 ± 0.443
1.067IlePhe: 1.067 ± 0.197
4.133IleGly: 4.133 ± 0.454
0.933IleHis: 0.933 ± 0.234
1.466IleIle: 1.466 ± 0.363
1.933IleLys: 1.933 ± 0.502
3.333IleLeu: 3.333 ± 0.45
0.867IleMet: 0.867 ± 0.202
2.0IleAsn: 2.0 ± 0.305
3.466IlePro: 3.466 ± 0.436
1.4IleGln: 1.4 ± 0.323
3.533IleArg: 3.533 ± 0.474
3.266IleSer: 3.266 ± 0.508
3.133IleThr: 3.133 ± 0.536
3.0IleVal: 3.0 ± 0.528
0.8IleTrp: 0.8 ± 0.202
1.6IleTyr: 1.6 ± 0.289
0.0IleXaa: 0.0 ± 0.0
Lys
3.666LysAla: 3.666 ± 0.496
0.267LysCys: 0.267 ± 0.15
2.4LysAsp: 2.4 ± 0.413
2.333LysGlu: 2.333 ± 0.381
1.666LysPhe: 1.666 ± 0.293
2.666LysGly: 2.666 ± 0.377
1.067LysHis: 1.067 ± 0.279
2.266LysIle: 2.266 ± 0.425
2.266LysLys: 2.266 ± 0.479
3.4LysLeu: 3.4 ± 0.498
0.867LysMet: 0.867 ± 0.209
1.4LysAsn: 1.4 ± 0.256
2.666LysPro: 2.666 ± 0.391
1.533LysGln: 1.533 ± 0.34
2.466LysArg: 2.466 ± 0.426
2.533LysSer: 2.533 ± 0.434
2.2LysThr: 2.2 ± 0.443
3.133LysVal: 3.133 ± 0.453
0.8LysTrp: 0.8 ± 0.206
0.933LysTyr: 0.933 ± 0.261
0.0LysXaa: 0.0 ± 0.0
Leu
9.532LeuAla: 9.532 ± 0.868
0.2LeuCys: 0.2 ± 0.116
6.199LeuAsp: 6.199 ± 0.679
5.533LeuGlu: 5.533 ± 0.608
2.2LeuPhe: 2.2 ± 0.462
7.266LeuGly: 7.266 ± 0.871
1.666LeuHis: 1.666 ± 0.328
4.733LeuIle: 4.733 ± 0.667
3.999LeuLys: 3.999 ± 0.499
5.666LeuLeu: 5.666 ± 0.663
1.8LeuMet: 1.8 ± 0.298
3.133LeuAsn: 3.133 ± 0.409
5.399LeuPro: 5.399 ± 0.605
2.666LeuGln: 2.666 ± 0.465
5.799LeuArg: 5.799 ± 0.585
5.866LeuSer: 5.866 ± 0.593
6.399LeuThr: 6.399 ± 0.498
4.999LeuVal: 4.999 ± 0.659
1.333LeuTrp: 1.333 ± 0.346
2.333LeuTyr: 2.333 ± 0.414
0.0LeuXaa: 0.0 ± 0.0
Met
2.6MetAla: 2.6 ± 0.39
0.0MetCys: 0.0 ± 0.0
1.4MetAsp: 1.4 ± 0.269
1.466MetGlu: 1.466 ± 0.312
0.733MetPhe: 0.733 ± 0.228
1.533MetGly: 1.533 ± 0.342
0.333MetHis: 0.333 ± 0.126
0.8MetIle: 0.8 ± 0.218
0.933MetLys: 0.933 ± 0.259
1.266MetLeu: 1.266 ± 0.302
0.067MetMet: 0.067 ± 0.069
0.933MetAsn: 0.933 ± 0.197
1.266MetPro: 1.266 ± 0.256
0.467MetGln: 0.467 ± 0.153
1.133MetArg: 1.133 ± 0.273
2.0MetSer: 2.0 ± 0.36
2.333MetThr: 2.333 ± 0.33
1.133MetVal: 1.133 ± 0.304
0.333MetTrp: 0.333 ± 0.135
0.467MetTyr: 0.467 ± 0.166
0.0MetXaa: 0.0 ± 0.0
Asn
2.866AsnAla: 2.866 ± 0.512
0.0AsnCys: 0.0 ± 0.0
2.266AsnAsp: 2.266 ± 0.394
2.0AsnGlu: 2.0 ± 0.419
1.0AsnPhe: 1.0 ± 0.283
3.333AsnGly: 3.333 ± 0.443
0.667AsnHis: 0.667 ± 0.2
1.533AsnIle: 1.533 ± 0.35
0.667AsnLys: 0.667 ± 0.202
2.533AsnLeu: 2.533 ± 0.341
0.6AsnMet: 0.6 ± 0.173
0.933AsnAsn: 0.933 ± 0.268
2.733AsnPro: 2.733 ± 0.399
1.0AsnGln: 1.0 ± 0.249
1.6AsnArg: 1.6 ± 0.342
2.333AsnSer: 2.333 ± 0.411
1.8AsnThr: 1.8 ± 0.272
2.6AsnVal: 2.6 ± 0.466
0.733AsnTrp: 0.733 ± 0.214
1.2AsnTyr: 1.2 ± 0.274
0.0AsnXaa: 0.0 ± 0.0
Pro
5.199ProAla: 5.199 ± 0.605
0.333ProCys: 0.333 ± 0.163
4.333ProAsp: 4.333 ± 0.491
3.999ProGlu: 3.999 ± 0.484
2.266ProPhe: 2.266 ± 0.423
4.466ProGly: 4.466 ± 0.652
1.0ProHis: 1.0 ± 0.234
2.466ProIle: 2.466 ± 0.408
2.2ProLys: 2.2 ± 0.28
4.533ProLeu: 4.533 ± 0.499
0.933ProMet: 0.933 ± 0.239
1.733ProAsn: 1.733 ± 0.348
2.6ProPro: 2.6 ± 0.394
1.666ProGln: 1.666 ± 0.359
2.6ProArg: 2.6 ± 0.453
3.733ProSer: 3.733 ± 0.466
4.133ProThr: 4.133 ± 0.579
3.866ProVal: 3.866 ± 0.409
0.667ProTrp: 0.667 ± 0.285
1.733ProTyr: 1.733 ± 0.337
0.0ProXaa: 0.0 ± 0.0
Gln
3.266GlnAla: 3.266 ± 0.484
0.067GlnCys: 0.067 ± 0.067
1.466GlnAsp: 1.466 ± 0.338
1.6GlnGlu: 1.6 ± 0.282
1.2GlnPhe: 1.2 ± 0.329
2.533GlnGly: 2.533 ± 0.363
0.667GlnHis: 0.667 ± 0.191
2.666GlnIle: 2.666 ± 0.525
1.133GlnLys: 1.133 ± 0.222
3.666GlnLeu: 3.666 ± 0.472
1.0GlnMet: 1.0 ± 0.277
0.6GlnAsn: 0.6 ± 0.173
1.866GlnPro: 1.866 ± 0.401
1.8GlnGln: 1.8 ± 0.365
1.733GlnArg: 1.733 ± 0.373
1.466GlnSer: 1.466 ± 0.295
1.8GlnThr: 1.8 ± 0.301
2.666GlnVal: 2.666 ± 0.357
0.733GlnTrp: 0.733 ± 0.192
0.667GlnTyr: 0.667 ± 0.201
0.0GlnXaa: 0.0 ± 0.0
Arg
5.466ArgAla: 5.466 ± 0.584
0.6ArgCys: 0.6 ± 0.258
3.133ArgAsp: 3.133 ± 0.353
4.533ArgGlu: 4.533 ± 0.62
1.933ArgPhe: 1.933 ± 0.374
4.733ArgGly: 4.733 ± 0.562
1.2ArgHis: 1.2 ± 0.274
3.0ArgIle: 3.0 ± 0.468
3.133ArgLys: 3.133 ± 0.554
5.733ArgLeu: 5.733 ± 0.691
1.866ArgMet: 1.866 ± 0.414
2.0ArgAsn: 2.0 ± 0.467
2.4ArgPro: 2.4 ± 0.432
1.933ArgGln: 1.933 ± 0.365
5.333ArgArg: 5.333 ± 0.753
3.666ArgSer: 3.666 ± 0.64
2.866ArgThr: 2.866 ± 0.531
5.466ArgVal: 5.466 ± 0.647
1.133ArgTrp: 1.133 ± 0.28
1.866ArgTyr: 1.866 ± 0.313
0.0ArgXaa: 0.0 ± 0.0
Ser
6.466SerAla: 6.466 ± 0.843
0.467SerCys: 0.467 ± 0.167
3.466SerAsp: 3.466 ± 0.491
3.799SerGlu: 3.799 ± 0.574
2.333SerPhe: 2.333 ± 0.488
6.332SerGly: 6.332 ± 0.849
1.533SerHis: 1.533 ± 0.326
3.0SerIle: 3.0 ± 0.511
2.466SerLys: 2.466 ± 0.376
4.866SerLeu: 4.866 ± 0.689
1.8SerMet: 1.8 ± 0.327
2.066SerAsn: 2.066 ± 0.332
3.0SerPro: 3.0 ± 0.473
2.2SerGln: 2.2 ± 0.329
2.733SerArg: 2.733 ± 0.421
3.266SerSer: 3.266 ± 0.555
3.666SerThr: 3.666 ± 0.541
4.333SerVal: 4.333 ± 0.52
1.266SerTrp: 1.266 ± 0.32
1.533SerTyr: 1.533 ± 0.376
0.0SerXaa: 0.0 ± 0.0
Thr
6.466ThrAla: 6.466 ± 0.855
0.333ThrCys: 0.333 ± 0.148
4.066ThrAsp: 4.066 ± 0.527
4.199ThrGlu: 4.199 ± 0.616
2.466ThrPhe: 2.466 ± 0.401
6.133ThrGly: 6.133 ± 0.688
1.133ThrHis: 1.133 ± 0.291
2.466ThrIle: 2.466 ± 0.569
2.6ThrLys: 2.6 ± 0.365
5.866ThrLeu: 5.866 ± 0.706
0.867ThrMet: 0.867 ± 0.224
1.866ThrAsn: 1.866 ± 0.321
4.066ThrPro: 4.066 ± 0.488
1.8ThrGln: 1.8 ± 0.366
3.533ThrArg: 3.533 ± 0.53
3.266ThrSer: 3.266 ± 0.494
4.199ThrThr: 4.199 ± 0.473
5.866ThrVal: 5.866 ± 0.647
1.133ThrTrp: 1.133 ± 0.304
1.933ThrTyr: 1.933 ± 0.336
0.0ThrXaa: 0.0 ± 0.0
Val
6.932ValAla: 6.932 ± 0.729
0.333ValCys: 0.333 ± 0.131
5.733ValAsp: 5.733 ± 0.6
4.799ValGlu: 4.799 ± 0.513
2.533ValPhe: 2.533 ± 0.37
4.533ValGly: 4.533 ± 0.668
1.466ValHis: 1.466 ± 0.23
3.866ValIle: 3.866 ± 0.459
3.0ValLys: 3.0 ± 0.397
5.133ValLeu: 5.133 ± 0.64
1.0ValMet: 1.0 ± 0.293
2.466ValAsn: 2.466 ± 0.35
3.866ValPro: 3.866 ± 0.483
2.4ValGln: 2.4 ± 0.421
5.266ValArg: 5.266 ± 0.768
4.933ValSer: 4.933 ± 0.534
5.866ValThr: 5.866 ± 0.585
4.799ValVal: 4.799 ± 0.642
1.333ValTrp: 1.333 ± 0.308
2.266ValTyr: 2.266 ± 0.409
0.0ValXaa: 0.0 ± 0.0
Trp
1.8TrpAla: 1.8 ± 0.32
0.2TrpCys: 0.2 ± 0.117
1.4TrpAsp: 1.4 ± 0.269
1.067TrpGlu: 1.067 ± 0.234
1.067TrpPhe: 1.067 ± 0.249
1.666TrpGly: 1.666 ± 0.289
0.333TrpHis: 0.333 ± 0.155
1.2TrpIle: 1.2 ± 0.243
0.267TrpLys: 0.267 ± 0.186
1.533TrpLeu: 1.533 ± 0.308
0.333TrpMet: 0.333 ± 0.171
0.533TrpAsn: 0.533 ± 0.147
0.8TrpPro: 0.8 ± 0.261
1.133TrpGln: 1.133 ± 0.289
1.333TrpArg: 1.333 ± 0.392
1.0TrpSer: 1.0 ± 0.259
2.066TrpThr: 2.066 ± 0.357
1.8TrpVal: 1.8 ± 0.294
0.8TrpTrp: 0.8 ± 0.342
0.333TrpTyr: 0.333 ± 0.151
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.4TyrAla: 2.4 ± 0.412
0.133TyrCys: 0.133 ± 0.099
1.266TyrAsp: 1.266 ± 0.289
2.133TyrGlu: 2.133 ± 0.362
0.8TyrPhe: 0.8 ± 0.21
2.666TyrGly: 2.666 ± 0.398
0.8TyrHis: 0.8 ± 0.237
1.666TyrIle: 1.666 ± 0.343
1.0TyrLys: 1.0 ± 0.198
2.933TyrLeu: 2.933 ± 0.461
0.467TyrMet: 0.467 ± 0.153
1.4TyrAsn: 1.4 ± 0.33
1.333TyrPro: 1.333 ± 0.286
1.0TyrGln: 1.0 ± 0.268
2.933TyrArg: 2.933 ± 0.435
1.4TyrSer: 1.4 ± 0.311
2.133TyrThr: 2.133 ± 0.36
1.8TyrVal: 1.8 ± 0.369
0.4TyrTrp: 0.4 ± 0.164
0.6TyrTyr: 0.6 ± 0.222
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 85 proteins (15003 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski