Amino acid dipepetide frequency for Chitinophaga alhagiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.536AlaAla: 10.536 ± 0.163
0.884AlaCys: 0.884 ± 0.037
4.815AlaAsp: 4.815 ± 0.093
4.98AlaGlu: 4.98 ± 0.083
3.917AlaPhe: 3.917 ± 0.068
7.707AlaGly: 7.707 ± 0.114
1.66AlaHis: 1.66 ± 0.05
5.016AlaIle: 5.016 ± 0.096
3.945AlaLys: 3.945 ± 0.096
8.317AlaLeu: 8.317 ± 0.126
2.231AlaMet: 2.231 ± 0.06
3.43AlaAsn: 3.43 ± 0.07
3.655AlaPro: 3.655 ± 0.083
3.453AlaGln: 3.453 ± 0.076
4.33AlaArg: 4.33 ± 0.074
4.657AlaSer: 4.657 ± 0.088
4.796AlaThr: 4.796 ± 0.118
6.313AlaVal: 6.313 ± 0.099
1.155AlaTrp: 1.155 ± 0.039
3.207AlaTyr: 3.207 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.628CysAla: 0.628 ± 0.03
0.159CysCys: 0.159 ± 0.014
0.324CysAsp: 0.324 ± 0.02
0.385CysGlu: 0.385 ± 0.023
0.396CysPhe: 0.396 ± 0.024
0.706CysGly: 0.706 ± 0.031
0.204CysHis: 0.204 ± 0.018
0.584CysIle: 0.584 ± 0.03
0.406CysLys: 0.406 ± 0.022
0.817CysLeu: 0.817 ± 0.03
0.227CysMet: 0.227 ± 0.015
0.352CysAsn: 0.352 ± 0.022
0.299CysPro: 0.299 ± 0.019
0.244CysGln: 0.244 ± 0.019
0.463CysArg: 0.463 ± 0.026
0.507CysSer: 0.507 ± 0.024
0.479CysThr: 0.479 ± 0.027
0.479CysVal: 0.479 ± 0.025
0.124CysTrp: 0.124 ± 0.013
0.312CysTyr: 0.312 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.323AspAla: 4.323 ± 0.08
0.337AspCys: 0.337 ± 0.021
2.152AspAsp: 2.152 ± 0.077
3.145AspGlu: 3.145 ± 0.081
2.463AspPhe: 2.463 ± 0.052
3.7AspGly: 3.7 ± 0.089
1.057AspHis: 1.057 ± 0.04
3.179AspIle: 3.179 ± 0.074
2.967AspLys: 2.967 ± 0.07
4.463AspLeu: 4.463 ± 0.086
1.298AspMet: 1.298 ± 0.047
2.347AspAsn: 2.347 ± 0.056
2.237AspPro: 2.237 ± 0.055
1.514AspGln: 1.514 ± 0.042
2.394AspArg: 2.394 ± 0.057
2.664AspSer: 2.664 ± 0.069
2.652AspThr: 2.652 ± 0.073
3.601AspVal: 3.601 ± 0.075
0.739AspTrp: 0.739 ± 0.032
2.251AspTyr: 2.251 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
5.127GluAla: 5.127 ± 0.094
0.316GluCys: 0.316 ± 0.022
2.77GluAsp: 2.77 ± 0.077
4.047GluGlu: 4.047 ± 0.111
2.138GluPhe: 2.138 ± 0.055
3.792GluGly: 3.792 ± 0.073
1.289GluHis: 1.289 ± 0.043
3.569GluIle: 3.569 ± 0.067
4.744GluLys: 4.744 ± 0.1
5.678GluLeu: 5.678 ± 0.087
1.606GluMet: 1.606 ± 0.048
2.882GluAsn: 2.882 ± 0.061
1.871GluPro: 1.871 ± 0.052
2.795GluGln: 2.795 ± 0.072
2.875GluArg: 2.875 ± 0.063
2.403GluSer: 2.403 ± 0.056
2.89GluThr: 2.89 ± 0.06
3.946GluVal: 3.946 ± 0.089
0.723GluTrp: 0.723 ± 0.033
1.983GluTyr: 1.983 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.453PheAla: 3.453 ± 0.069
0.432PheCys: 0.432 ± 0.022
2.525PheAsp: 2.525 ± 0.064
2.514PheGlu: 2.514 ± 0.068
2.258PhePhe: 2.258 ± 0.058
3.187PheGly: 3.187 ± 0.066
0.951PheHis: 0.951 ± 0.033
2.796PheIle: 2.796 ± 0.06
2.227PheLys: 2.227 ± 0.057
4.085PheLeu: 4.085 ± 0.076
1.204PheMet: 1.204 ± 0.044
2.515PheAsn: 2.515 ± 0.067
1.863PhePro: 1.863 ± 0.049
1.319PheGln: 1.319 ± 0.04
2.615PheArg: 2.615 ± 0.068
3.51PheSer: 3.51 ± 0.076
3.095PheThr: 3.095 ± 0.072
2.673PheVal: 2.673 ± 0.058
0.585PheTrp: 0.585 ± 0.03
1.925PheTyr: 1.925 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
5.902GlyAla: 5.902 ± 0.1
0.656GlyCys: 0.656 ± 0.035
3.353GlyAsp: 3.353 ± 0.07
3.823GlyGlu: 3.823 ± 0.08
3.544GlyPhe: 3.544 ± 0.077
5.855GlyGly: 5.855 ± 0.119
1.513GlyHis: 1.513 ± 0.046
5.116GlyIle: 5.116 ± 0.091
5.17GlyLys: 5.17 ± 0.083
6.762GlyLeu: 6.762 ± 0.097
2.081GlyMet: 2.081 ± 0.055
3.907GlyAsn: 3.907 ± 0.077
2.119GlyPro: 2.119 ± 0.051
2.823GlyGln: 2.823 ± 0.064
3.689GlyArg: 3.689 ± 0.083
4.355GlySer: 4.355 ± 0.095
4.54GlyThr: 4.54 ± 0.087
4.835GlyVal: 4.835 ± 0.094
1.18GlyTrp: 1.18 ± 0.042
3.19GlyTyr: 3.19 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.741HisAla: 1.741 ± 0.048
0.256HisCys: 0.256 ± 0.018
0.813HisAsp: 0.813 ± 0.035
1.028HisGlu: 1.028 ± 0.034
1.265HisPhe: 1.265 ± 0.042
1.363HisGly: 1.363 ± 0.042
0.659HisHis: 0.659 ± 0.031
1.418HisIle: 1.418 ± 0.046
0.985HisLys: 0.985 ± 0.035
2.203HisLeu: 2.203 ± 0.065
0.447HisMet: 0.447 ± 0.025
0.98HisAsn: 0.98 ± 0.034
1.273HisPro: 1.273 ± 0.042
0.812HisGln: 0.812 ± 0.034
1.104HisArg: 1.104 ± 0.037
1.04HisSer: 1.04 ± 0.034
1.246HisThr: 1.246 ± 0.043
1.204HisVal: 1.204 ± 0.045
0.318HisTrp: 0.318 ± 0.022
0.962HisTyr: 0.962 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.396IleAla: 5.396 ± 0.095
0.651IleCys: 0.651 ± 0.033
3.263IleAsp: 3.263 ± 0.065
3.083IleGlu: 3.083 ± 0.081
2.651IlePhe: 2.651 ± 0.07
4.318IleGly: 4.318 ± 0.099
1.278IleHis: 1.278 ± 0.044
3.591IleIle: 3.591 ± 0.09
3.149IleLys: 3.149 ± 0.086
5.142IleLeu: 5.142 ± 0.093
1.32IleMet: 1.32 ± 0.043
2.936IleAsn: 2.936 ± 0.057
2.927IlePro: 2.927 ± 0.066
1.967IleGln: 1.967 ± 0.06
3.529IleArg: 3.529 ± 0.063
4.056IleSer: 4.056 ± 0.065
4.104IleThr: 4.104 ± 0.077
3.685IleVal: 3.685 ± 0.081
0.678IleTrp: 0.678 ± 0.032
2.19IleTyr: 2.19 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.114LysAla: 5.114 ± 0.104
0.277LysCys: 0.277 ± 0.019
3.546LysAsp: 3.546 ± 0.075
3.877LysGlu: 3.877 ± 0.094
1.929LysPhe: 1.929 ± 0.052
4.33LysGly: 4.33 ± 0.081
1.017LysHis: 1.017 ± 0.037
3.437LysIle: 3.437 ± 0.07
4.4LysLys: 4.4 ± 0.12
4.844LysLeu: 4.844 ± 0.087
1.761LysMet: 1.761 ± 0.045
2.817LysAsn: 2.817 ± 0.066
2.608LysPro: 2.608 ± 0.064
2.362LysGln: 2.362 ± 0.06
2.624LysArg: 2.624 ± 0.058
2.717LysSer: 2.717 ± 0.058
3.35LysThr: 3.35 ± 0.076
3.936LysVal: 3.936 ± 0.083
0.713LysTrp: 0.713 ± 0.034
2.151LysTyr: 2.151 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
8.399LeuAla: 8.399 ± 0.133
0.825LeuCys: 0.825 ± 0.037
4.493LeuAsp: 4.493 ± 0.093
5.484LeuGlu: 5.484 ± 0.092
4.3LeuPhe: 4.3 ± 0.076
6.569LeuGly: 6.569 ± 0.11
2.192LeuHis: 2.192 ± 0.06
4.856LeuIle: 4.856 ± 0.094
5.569LeuLys: 5.569 ± 0.101
10.541LeuLeu: 10.541 ± 0.167
2.337LeuMet: 2.337 ± 0.061
4.442LeuAsn: 4.442 ± 0.069
4.86LeuPro: 4.86 ± 0.083
5.119LeuGln: 5.119 ± 0.089
5.191LeuArg: 5.191 ± 0.082
5.861LeuSer: 5.861 ± 0.095
5.131LeuThr: 5.131 ± 0.076
6.008LeuVal: 6.008 ± 0.101
1.027LeuTrp: 1.027 ± 0.036
3.372LeuTyr: 3.372 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.312MetAla: 2.312 ± 0.066
0.125MetCys: 0.125 ± 0.012
1.288MetAsp: 1.288 ± 0.041
1.677MetGlu: 1.677 ± 0.053
0.859MetPhe: 0.859 ± 0.033
1.754MetGly: 1.754 ± 0.053
0.564MetHis: 0.564 ± 0.026
1.398MetIle: 1.398 ± 0.046
1.919MetLys: 1.919 ± 0.051
2.585MetLeu: 2.585 ± 0.06
0.69MetMet: 0.69 ± 0.03
1.263MetAsn: 1.263 ± 0.044
1.373MetPro: 1.373 ± 0.043
1.303MetGln: 1.303 ± 0.045
1.264MetArg: 1.264 ± 0.041
1.296MetSer: 1.296 ± 0.039
1.205MetThr: 1.205 ± 0.041
1.568MetVal: 1.568 ± 0.048
0.222MetTrp: 0.222 ± 0.015
0.734MetTyr: 0.734 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.876AsnAla: 3.876 ± 0.076
0.356AsnCys: 0.356 ± 0.024
2.161AsnAsp: 2.161 ± 0.057
2.537AsnGlu: 2.537 ± 0.055
2.106AsnPhe: 2.106 ± 0.057
4.011AsnGly: 4.011 ± 0.088
0.847AsnHis: 0.847 ± 0.033
3.451AsnIle: 3.451 ± 0.077
2.703AsnLys: 2.703 ± 0.061
4.131AsnLeu: 4.131 ± 0.077
1.219AsnMet: 1.219 ± 0.041
2.602AsnAsn: 2.602 ± 0.066
2.433AsnPro: 2.433 ± 0.055
1.483AsnGln: 1.483 ± 0.047
2.577AsnArg: 2.577 ± 0.059
2.458AsnSer: 2.458 ± 0.06
3.029AsnThr: 3.029 ± 0.069
2.976AsnVal: 2.976 ± 0.076
0.728AsnTrp: 0.728 ± 0.034
2.031AsnTyr: 2.031 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
5.092ProAla: 5.092 ± 0.103
0.246ProCys: 0.246 ± 0.021
2.793ProAsp: 2.793 ± 0.063
3.297ProGlu: 3.297 ± 0.068
2.01ProPhe: 2.01 ± 0.061
3.967ProGly: 3.967 ± 0.066
0.877ProHis: 0.877 ± 0.033
1.924ProIle: 1.924 ± 0.047
1.935ProLys: 1.935 ± 0.068
4.04ProLeu: 4.04 ± 0.073
0.917ProMet: 0.917 ± 0.034
1.632ProAsn: 1.632 ± 0.051
1.666ProPro: 1.666 ± 0.06
1.726ProGln: 1.726 ± 0.046
1.77ProArg: 1.77 ± 0.053
2.161ProSer: 2.161 ± 0.057
1.74ProThr: 1.74 ± 0.053
4.048ProVal: 4.048 ± 0.083
0.509ProTrp: 0.509 ± 0.033
1.652ProTyr: 1.652 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
3.546GlnAla: 3.546 ± 0.062
0.251GlnCys: 0.251 ± 0.02
1.645GlnAsp: 1.645 ± 0.044
2.527GlnGlu: 2.527 ± 0.061
1.785GlnPhe: 1.785 ± 0.046
2.488GlnGly: 2.488 ± 0.052
1.115GlnHis: 1.115 ± 0.033
1.908GlnIle: 1.908 ± 0.046
2.188GlnLys: 2.188 ± 0.047
4.649GlnLeu: 4.649 ± 0.079
1.042GlnMet: 1.042 ± 0.037
1.722GlnAsn: 1.722 ± 0.047
2.089GlnPro: 2.089 ± 0.056
2.95GlnGln: 2.95 ± 0.069
1.998GlnArg: 1.998 ± 0.059
1.844GlnSer: 1.844 ± 0.048
1.995GlnThr: 1.995 ± 0.053
2.838GlnVal: 2.838 ± 0.066
0.575GlnTrp: 0.575 ± 0.028
1.813GlnTyr: 1.813 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
3.495ArgAla: 3.495 ± 0.074
0.311ArgCys: 0.311 ± 0.02
2.22ArgAsp: 2.22 ± 0.055
3.332ArgGlu: 3.332 ± 0.077
2.636ArgPhe: 2.636 ± 0.056
2.848ArgGly: 2.848 ± 0.071
1.225ArgHis: 1.225 ± 0.05
3.412ArgIle: 3.412 ± 0.069
3.251ArgLys: 3.251 ± 0.063
5.326ArgLeu: 5.326 ± 0.086
1.42ArgMet: 1.42 ± 0.045
2.812ArgAsn: 2.812 ± 0.067
2.119ArgPro: 2.119 ± 0.054
2.59ArgGln: 2.59 ± 0.064
2.703ArgArg: 2.703 ± 0.075
2.734ArgSer: 2.734 ± 0.069
2.424ArgThr: 2.424 ± 0.05
3.03ArgVal: 3.03 ± 0.061
0.788ArgTrp: 0.788 ± 0.03
2.327ArgTyr: 2.327 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
4.759SerAla: 4.759 ± 0.091
0.487SerCys: 0.487 ± 0.026
2.398SerAsp: 2.398 ± 0.053
2.518SerGlu: 2.518 ± 0.055
3.095SerPhe: 3.095 ± 0.072
4.795SerGly: 4.795 ± 0.086
1.066SerHis: 1.066 ± 0.037
3.616SerIle: 3.616 ± 0.073
2.699SerLys: 2.699 ± 0.064
5.704SerLeu: 5.704 ± 0.096
1.333SerMet: 1.333 ± 0.045
2.441SerAsn: 2.441 ± 0.063
2.311SerPro: 2.311 ± 0.052
1.828SerGln: 1.828 ± 0.051
2.994SerArg: 2.994 ± 0.054
3.38SerSer: 3.38 ± 0.069
3.182SerThr: 3.182 ± 0.07
3.655SerVal: 3.655 ± 0.072
0.81SerTrp: 0.81 ± 0.035
2.322SerTyr: 2.322 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.785ThrAla: 5.785 ± 0.127
0.39ThrCys: 0.39 ± 0.023
3.081ThrAsp: 3.081 ± 0.071
2.691ThrGlu: 2.691 ± 0.073
2.574ThrPhe: 2.574 ± 0.064
5.475ThrGly: 5.475 ± 0.093
1.085ThrHis: 1.085 ± 0.04
3.497ThrIle: 3.497 ± 0.085
2.247ThrLys: 2.247 ± 0.055
5.463ThrLeu: 5.463 ± 0.093
1.137ThrMet: 1.137 ± 0.037
2.211ThrAsn: 2.211 ± 0.064
2.935ThrPro: 2.935 ± 0.073
1.876ThrGln: 1.876 ± 0.048
2.713ThrArg: 2.713 ± 0.067
2.945ThrSer: 2.945 ± 0.068
3.204ThrThr: 3.204 ± 0.099
4.434ThrVal: 4.434 ± 0.077
0.72ThrTrp: 0.72 ± 0.028
2.052ThrTyr: 2.052 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
5.405ValAla: 5.405 ± 0.099
0.669ValCys: 0.669 ± 0.033
3.071ValAsp: 3.071 ± 0.07
3.735ValGlu: 3.735 ± 0.087
3.0ValPhe: 3.0 ± 0.069
3.703ValGly: 3.703 ± 0.078
1.332ValHis: 1.332 ± 0.045
4.337ValIle: 4.337 ± 0.077
4.312ValLys: 4.312 ± 0.077
6.601ValLeu: 6.601 ± 0.104
1.825ValMet: 1.825 ± 0.052
3.537ValAsn: 3.537 ± 0.074
3.142ValPro: 3.142 ± 0.063
2.617ValGln: 2.617 ± 0.058
3.162ValArg: 3.162 ± 0.064
4.013ValSer: 4.013 ± 0.082
4.417ValThr: 4.417 ± 0.103
4.724ValVal: 4.724 ± 0.094
0.748ValTrp: 0.748 ± 0.033
2.557ValTyr: 2.557 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.97TrpAla: 0.97 ± 0.037
0.124TrpCys: 0.124 ± 0.014
0.683TrpAsp: 0.683 ± 0.025
0.807TrpGlu: 0.807 ± 0.031
0.605TrpPhe: 0.605 ± 0.028
0.983TrpGly: 0.983 ± 0.036
0.302TrpHis: 0.302 ± 0.021
0.671TrpIle: 0.671 ± 0.027
0.814TrpLys: 0.814 ± 0.038
1.457TrpLeu: 1.457 ± 0.05
0.428TrpMet: 0.428 ± 0.023
0.705TrpAsn: 0.705 ± 0.031
0.443TrpPro: 0.443 ± 0.026
0.668TrpGln: 0.668 ± 0.025
0.655TrpArg: 0.655 ± 0.03
0.611TrpSer: 0.611 ± 0.029
0.653TrpThr: 0.653 ± 0.031
0.757TrpVal: 0.757 ± 0.031
0.276TrpTrp: 0.276 ± 0.019
0.56TrpTyr: 0.56 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.147TyrAla: 3.147 ± 0.072
0.343TyrCys: 0.343 ± 0.022
2.091TyrAsp: 2.091 ± 0.06
1.955TyrGlu: 1.955 ± 0.057
2.203TyrPhe: 2.203 ± 0.06
2.862TyrGly: 2.862 ± 0.068
0.884TyrHis: 0.884 ± 0.035
2.137TyrIle: 2.137 ± 0.042
2.181TyrLys: 2.181 ± 0.065
3.769TyrLeu: 3.769 ± 0.076
0.874TyrMet: 0.874 ± 0.031
2.177TyrAsn: 2.177 ± 0.067
1.777TyrPro: 1.777 ± 0.055
1.517TyrGln: 1.517 ± 0.045
2.355TyrArg: 2.355 ± 0.064
2.181TyrSer: 2.181 ± 0.057
2.386TyrThr: 2.386 ± 0.061
2.195TyrVal: 2.195 ± 0.051
0.555TyrTrp: 0.555 ± 0.029
1.746TyrTyr: 1.746 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2126 proteins (798322 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski