Amino acid dipepetide frequency for Longibacter salinarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.699AlaAla: 9.699 ± 0.127	0.738AlaCys: 0.738 ± 0.027	6.395AlaAsp: 6.395 ± 0.068	6.598AlaGlu: 6.598 ± 0.093	3.85AlaPhe: 3.85 ± 0.064	7.455AlaGly: 7.455 ± 0.079	1.868AlaHis: 1.868 ± 0.047	4.889AlaIle: 4.889 ± 0.079	2.358AlaLys: 2.358 ± 0.051	9.457AlaLeu: 9.457 ± 0.11	2.447AlaMet: 2.447 ± 0.054	2.602AlaAsn: 2.602 ± 0.054	4.47AlaPro: 4.47 ± 0.065	3.413AlaGln: 3.413 ± 0.061	6.553AlaArg: 6.553 ± 0.092	6.935AlaSer: 6.935 ± 0.086	5.843AlaThr: 5.843 ± 0.086	7.329AlaVal: 7.329 ± 0.095	1.2AlaTrp: 1.2 ± 0.037	2.714AlaTyr: 2.714 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.589CysAla: 0.589 ± 0.02	0.09CysCys: 0.09 ± 0.009	0.436CysAsp: 0.436 ± 0.018	0.349CysGlu: 0.349 ± 0.017	0.242CysPhe: 0.242 ± 0.014	0.6CysGly: 0.6 ± 0.024	0.167CysHis: 0.167 ± 0.014	0.334CysIle: 0.334 ± 0.019	0.116CysLys: 0.116 ± 0.01	0.556CysLeu: 0.556 ± 0.021	0.124CysMet: 0.124 ± 0.009	0.177CysAsn: 0.177 ± 0.013	0.354CysPro: 0.354 ± 0.017	0.167CysGln: 0.167 ± 0.013	0.444CysArg: 0.444 ± 0.019	0.445CysSer: 0.445 ± 0.02	0.422CysThr: 0.422 ± 0.02	0.479CysVal: 0.479 ± 0.02	0.07CysTrp: 0.07 ± 0.008	0.171CysTyr: 0.171 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.997AspAla: 7.997 ± 0.092	0.272AspCys: 0.272 ± 0.016	5.279AspAsp: 5.279 ± 0.09	5.269AspGlu: 5.269 ± 0.087	2.284AspPhe: 2.284 ± 0.051	6.323AspGly: 6.323 ± 0.097	1.409AspHis: 1.409 ± 0.037	3.265AspIle: 3.265 ± 0.057	1.32AspLys: 1.32 ± 0.037	6.757AspLeu: 6.757 ± 0.077	1.211AspMet: 1.211 ± 0.031	1.647AspAsn: 1.647 ± 0.037	3.772AspPro: 3.772 ± 0.054	1.99AspGln: 1.99 ± 0.042	5.414AspArg: 5.414 ± 0.069	3.705AspSer: 3.705 ± 0.081	3.867AspThr: 3.867 ± 0.071	6.535AspVal: 6.535 ± 0.071	0.949AspTrp: 0.949 ± 0.029	1.75AspTyr: 1.75 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.374GluAla: 7.374 ± 0.108	0.296GluCys: 0.296 ± 0.017	4.207GluAsp: 4.207 ± 0.07	5.301GluGlu: 5.301 ± 0.1	1.698GluPhe: 1.698 ± 0.042	4.422GluGly: 4.422 ± 0.054	1.639GluHis: 1.639 ± 0.041	3.516GluIle: 3.516 ± 0.052	2.507GluLys: 2.507 ± 0.059	5.397GluLeu: 5.397 ± 0.077	1.707GluMet: 1.707 ± 0.041	2.274GluAsn: 2.274 ± 0.043	3.167GluPro: 3.167 ± 0.057	2.804GluGln: 2.804 ± 0.051	5.646GluArg: 5.646 ± 0.083	4.135GluSer: 4.135 ± 0.065	4.405GluThr: 4.405 ± 0.057	4.751GluVal: 4.751 ± 0.062	0.872GluTrp: 0.872 ± 0.029	1.711GluTyr: 1.711 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.398PheAla: 3.398 ± 0.063	0.28PheCys: 0.28 ± 0.016	3.019PheAsp: 3.019 ± 0.051	2.549PheGlu: 2.549 ± 0.049	1.537PhePhe: 1.537 ± 0.044	3.309PheGly: 3.309 ± 0.063	0.675PheHis: 0.675 ± 0.026	1.636PheIle: 1.636 ± 0.042	0.754PheLys: 0.754 ± 0.026	3.194PheLeu: 3.194 ± 0.057	0.638PheMet: 0.638 ± 0.025	1.11PheAsn: 1.11 ± 0.033	1.515PhePro: 1.515 ± 0.033	1.213PheGln: 1.213 ± 0.032	2.443PheArg: 2.443 ± 0.047	2.58PheSer: 2.58 ± 0.054	2.151PheThr: 2.151 ± 0.047	3.063PheVal: 3.063 ± 0.06	0.508PheTrp: 0.508 ± 0.021	1.134PheTyr: 1.134 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.207GlyAla: 7.207 ± 0.091	0.675GlyCys: 0.675 ± 0.025	5.163GlyAsp: 5.163 ± 0.087	4.888GlyGlu: 4.888 ± 0.068	3.071GlyPhe: 3.071 ± 0.054	6.246GlyGly: 6.246 ± 0.095	1.616GlyHis: 1.616 ± 0.035	4.07GlyIle: 4.07 ± 0.066	2.116GlyLys: 2.116 ± 0.049	7.226GlyLeu: 7.226 ± 0.1	1.825GlyMet: 1.825 ± 0.037	2.207GlyAsn: 2.207 ± 0.055	3.192GlyPro: 3.192 ± 0.054	2.658GlyGln: 2.658 ± 0.061	5.34GlyArg: 5.34 ± 0.069	5.144GlySer: 5.144 ± 0.085	5.5GlyThr: 5.5 ± 0.101	5.99GlyVal: 5.99 ± 0.092	1.12GlyTrp: 1.12 ± 0.032	2.432GlyTyr: 2.432 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.068HisAla: 2.068 ± 0.047	0.185HisCys: 0.185 ± 0.013	1.48HisAsp: 1.48 ± 0.032	1.393HisGlu: 1.393 ± 0.035	0.831HisPhe: 0.831 ± 0.028	1.693HisGly: 1.693 ± 0.043	0.58HisHis: 0.58 ± 0.021	0.945HisIle: 0.945 ± 0.029	0.386HisLys: 0.386 ± 0.019	2.135HisLeu: 2.135 ± 0.041	0.378HisMet: 0.378 ± 0.02	0.509HisAsn: 0.509 ± 0.022	1.417HisPro: 1.417 ± 0.035	0.631HisGln: 0.631 ± 0.024	1.679HisArg: 1.679 ± 0.042	1.076HisSer: 1.076 ± 0.031	1.088HisThr: 1.088 ± 0.036	1.93HisVal: 1.93 ± 0.047	0.28HisTrp: 0.28 ± 0.016	0.584HisTyr: 0.584 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.01IleAla: 5.01 ± 0.073	0.35IleCys: 0.35 ± 0.016	4.145IleAsp: 4.145 ± 0.054	3.793IleGlu: 3.793 ± 0.065	1.609IlePhe: 1.609 ± 0.043	4.283IleGly: 4.283 ± 0.064	0.972IleHis: 0.972 ± 0.03	2.04IleIle: 2.04 ± 0.049	1.105IleLys: 1.105 ± 0.032	4.053IleLeu: 4.053 ± 0.07	0.781IleMet: 0.781 ± 0.029	1.382IleAsn: 1.382 ± 0.036	2.455IlePro: 2.455 ± 0.047	1.693IleGln: 1.693 ± 0.039	3.623IleArg: 3.623 ± 0.064	2.882IleSer: 2.882 ± 0.051	2.852IleThr: 2.852 ± 0.05	3.91IleVal: 3.91 ± 0.065	0.538IleTrp: 0.538 ± 0.022	1.25IleTyr: 1.25 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	2.5LysAla: 2.5 ± 0.056	0.116LysCys: 0.116 ± 0.01	1.544LysAsp: 1.544 ± 0.042	1.991LysGlu: 1.991 ± 0.053	0.59LysPhe: 0.59 ± 0.022	1.837LysGly: 1.837 ± 0.046	0.682LysHis: 0.682 ± 0.027	1.182LysIle: 1.182 ± 0.037	1.225LysLys: 1.225 ± 0.045	2.241LysLeu: 2.241 ± 0.051	0.68LysMet: 0.68 ± 0.024	0.859LysAsn: 0.859 ± 0.03	1.249LysPro: 1.249 ± 0.037	1.173LysGln: 1.173 ± 0.037	2.195LysArg: 2.195 ± 0.046	1.621LysSer: 1.621 ± 0.038	1.789LysThr: 1.789 ± 0.041	1.707LysVal: 1.707 ± 0.044	0.3LysTrp: 0.3 ± 0.015	0.715LysTyr: 0.715 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	8.781LeuAla: 8.781 ± 0.105	0.604LeuCys: 0.604 ± 0.023	6.726LeuAsp: 6.726 ± 0.076	5.604LeuGlu: 5.604 ± 0.074	3.522LeuPhe: 3.522 ± 0.057	6.752LeuGly: 6.752 ± 0.091	2.056LeuHis: 2.056 ± 0.042	4.191LeuIle: 4.191 ± 0.071	2.609LeuLys: 2.609 ± 0.046	8.959LeuLeu: 8.959 ± 0.124	1.859LeuMet: 1.859 ± 0.045	2.713LeuAsn: 2.713 ± 0.054	4.854LeuPro: 4.854 ± 0.072	3.427LeuGln: 3.427 ± 0.046	7.12LeuArg: 7.12 ± 0.099	6.507LeuSer: 6.507 ± 0.078	5.615LeuThr: 5.615 ± 0.073	6.854LeuVal: 6.854 ± 0.085	1.017LeuTrp: 1.017 ± 0.033	2.483LeuTyr: 2.483 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.088MetAla: 2.088 ± 0.041	0.122MetCys: 0.122 ± 0.009	1.342MetAsp: 1.342 ± 0.031	1.339MetGlu: 1.339 ± 0.035	0.588MetPhe: 0.588 ± 0.024	1.486MetGly: 1.486 ± 0.039	0.518MetHis: 0.518 ± 0.024	1.135MetIle: 1.135 ± 0.034	0.804MetLys: 0.804 ± 0.027	2.008MetLeu: 2.008 ± 0.043	0.553MetMet: 0.553 ± 0.023	0.768MetAsn: 0.768 ± 0.022	1.348MetPro: 1.348 ± 0.034	0.917MetGln: 0.917 ± 0.032	1.502MetArg: 1.502 ± 0.038	1.738MetSer: 1.738 ± 0.042	1.46MetThr: 1.46 ± 0.04	1.391MetVal: 1.391 ± 0.037	0.217MetTrp: 0.217 ± 0.014	0.522MetTyr: 0.522 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.021AsnAla: 3.021 ± 0.059	0.185AsnCys: 0.185 ± 0.014	2.039AsnAsp: 2.039 ± 0.046	1.836AsnGlu: 1.836 ± 0.039	0.922AsnPhe: 0.922 ± 0.031	2.755AsnGly: 2.755 ± 0.068	0.566AsnHis: 0.566 ± 0.025	1.325AsnIle: 1.325 ± 0.037	0.617AsnLys: 0.617 ± 0.027	2.665AsnLeu: 2.665 ± 0.049	0.565AsnMet: 0.565 ± 0.019	0.893AsnAsn: 0.893 ± 0.042	1.865AsnPro: 1.865 ± 0.04	0.957AsnGln: 0.957 ± 0.03	2.068AsnArg: 2.068 ± 0.04	1.334AsnSer: 1.334 ± 0.038	1.63AsnThr: 1.63 ± 0.044	2.628AsnVal: 2.628 ± 0.044	0.387AsnTrp: 0.387 ± 0.019	0.808AsnTyr: 0.808 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.398ProAla: 4.398 ± 0.06	0.229ProCys: 0.229 ± 0.014	4.672ProAsp: 4.672 ± 0.07	4.04ProGlu: 4.04 ± 0.069	1.967ProPhe: 1.967 ± 0.04	3.807ProGly: 3.807 ± 0.067	1.048ProHis: 1.048 ± 0.032	2.344ProIle: 2.344 ± 0.042	1.187ProLys: 1.187 ± 0.031	4.055ProLeu: 4.055 ± 0.06	1.033ProMet: 1.033 ± 0.03	1.663ProAsn: 1.663 ± 0.041	2.39ProPro: 2.39 ± 0.052	1.451ProGln: 1.451 ± 0.041	2.537ProArg: 2.537 ± 0.048	3.966ProSer: 3.966 ± 0.064	2.974ProThr: 2.974 ± 0.054	4.235ProVal: 4.235 ± 0.056	0.586ProTrp: 0.586 ± 0.025	1.352ProTyr: 1.352 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.342GlnAla: 3.342 ± 0.053	0.176GlnCys: 0.176 ± 0.012	1.986GlnAsp: 1.986 ± 0.041	2.269GlnGlu: 2.269 ± 0.044	1.293GlnPhe: 1.293 ± 0.028	2.193GlnGly: 2.193 ± 0.049	0.768GlnHis: 0.768 ± 0.029	1.813GlnIle: 1.813 ± 0.039	1.126GlnLys: 1.126 ± 0.035	2.94GlnLeu: 2.94 ± 0.053	0.916GlnMet: 0.916 ± 0.031	1.196GlnAsn: 1.196 ± 0.032	1.823GlnPro: 1.823 ± 0.045	1.604GlnGln: 1.604 ± 0.053	2.789GlnArg: 2.789 ± 0.057	2.347GlnSer: 2.347 ± 0.05	2.261GlnThr: 2.261 ± 0.047	2.372GlnVal: 2.372 ± 0.046	0.454GlnTrp: 0.454 ± 0.022	0.997GlnTyr: 0.997 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.237ArgAla: 6.237 ± 0.092	0.422ArgCys: 0.422 ± 0.02	4.653ArgAsp: 4.653 ± 0.076	4.836ArgGlu: 4.836 ± 0.075	3.038ArgPhe: 3.038 ± 0.052	4.497ArgGly: 4.497 ± 0.066	1.65ArgHis: 1.65 ± 0.04	3.808ArgIle: 3.808 ± 0.048	2.001ArgLys: 2.001 ± 0.045	7.145ArgLeu: 7.145 ± 0.093	1.797ArgMet: 1.797 ± 0.044	1.897ArgAsn: 1.897 ± 0.042	3.42ArgPro: 3.42 ± 0.06	2.578ArgGln: 2.578 ± 0.047	5.615ArgArg: 5.615 ± 0.093	5.048ArgSer: 5.048 ± 0.098	4.292ArgThr: 4.292 ± 0.066	5.547ArgVal: 5.547 ± 0.069	1.038ArgTrp: 1.038 ± 0.033	2.341ArgTyr: 2.341 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.069SerAla: 6.069 ± 0.081	0.362SerCys: 0.362 ± 0.018	4.76SerAsp: 4.76 ± 0.068	3.978SerGlu: 3.978 ± 0.059	2.646SerPhe: 2.646 ± 0.049	5.947SerGly: 5.947 ± 0.107	1.22SerHis: 1.22 ± 0.033	3.408SerIle: 3.408 ± 0.058	1.605SerLys: 1.605 ± 0.044	5.914SerLeu: 5.914 ± 0.081	1.593SerMet: 1.593 ± 0.031	2.021SerAsn: 2.021 ± 0.05	3.391SerPro: 3.391 ± 0.063	1.914SerGln: 1.914 ± 0.046	4.049SerArg: 4.049 ± 0.072	5.038SerSer: 5.038 ± 0.09	4.503SerThr: 4.503 ± 0.077	5.24SerVal: 5.24 ± 0.08	0.753SerTrp: 0.753 ± 0.024	1.79SerTyr: 1.79 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.871ThrAla: 5.871 ± 0.075	0.389ThrCys: 0.389 ± 0.019	4.167ThrAsp: 4.167 ± 0.067	3.627ThrGlu: 3.627 ± 0.06	2.607ThrPhe: 2.607 ± 0.05	5.316ThrGly: 5.316 ± 0.078	1.149ThrHis: 1.149 ± 0.032	3.236ThrIle: 3.236 ± 0.062	1.403ThrLys: 1.403 ± 0.037	6.159ThrLeu: 6.159 ± 0.08	1.134ThrMet: 1.134 ± 0.034	1.663ThrAsn: 1.663 ± 0.049	3.582ThrPro: 3.582 ± 0.064	1.814ThrGln: 1.814 ± 0.04	3.55ThrArg: 3.55 ± 0.056	4.295ThrSer: 4.295 ± 0.08	3.804ThrThr: 3.804 ± 0.076	5.408ThrVal: 5.408 ± 0.077	0.821ThrTrp: 0.821 ± 0.029	1.96ThrTyr: 1.96 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	7.434ValAla: 7.434 ± 0.099	0.56ValCys: 0.56 ± 0.021	6.043ValAsp: 6.043 ± 0.077	5.659ValGlu: 5.659 ± 0.068	2.778ValPhe: 2.778 ± 0.061	5.662ValGly: 5.662 ± 0.076	1.745ValHis: 1.745 ± 0.048	3.803ValIle: 3.803 ± 0.071	1.924ValLys: 1.924 ± 0.047	7.563ValLeu: 7.563 ± 0.095	1.686ValMet: 1.686 ± 0.038	2.198ValAsn: 2.198 ± 0.049	3.853ValPro: 3.853 ± 0.06	2.87ValGln: 2.87 ± 0.042	5.88ValArg: 5.88 ± 0.092	5.039ValSer: 5.039 ± 0.071	4.87ValThr: 4.87 ± 0.071	6.579ValVal: 6.579 ± 0.083	0.889ValTrp: 0.889 ± 0.034	2.086ValTyr: 2.086 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.054TrpAla: 1.054 ± 0.027	0.098TrpCys: 0.098 ± 0.01	0.741TrpAsp: 0.741 ± 0.03	0.609TrpGlu: 0.609 ± 0.024	0.477TrpPhe: 0.477 ± 0.024	0.835TrpGly: 0.835 ± 0.028	0.311TrpHis: 0.311 ± 0.018	0.708TrpIle: 0.708 ± 0.024	0.409TrpLys: 0.409 ± 0.019	1.264TrpLeu: 1.264 ± 0.038	0.448TrpMet: 0.448 ± 0.022	0.428TrpAsn: 0.428 ± 0.019	0.51TrpPro: 0.51 ± 0.025	0.469TrpGln: 0.469 ± 0.018	0.954TrpArg: 0.954 ± 0.027	0.891TrpSer: 0.891 ± 0.033	0.991TrpThr: 0.991 ± 0.031	0.84TrpVal: 0.84 ± 0.028	0.22TrpTrp: 0.22 ± 0.014	0.328TrpTyr: 0.328 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.675TyrAla: 2.675 ± 0.054	0.182TyrCys: 0.182 ± 0.012	2.218TyrAsp: 2.218 ± 0.052	1.904TyrGlu: 1.904 ± 0.037	1.154TyrPhe: 1.154 ± 0.032	2.267TyrGly: 2.267 ± 0.049	0.629TyrHis: 0.629 ± 0.021	1.079TyrIle: 1.079 ± 0.029	0.626TyrLys: 0.626 ± 0.024	2.564TyrLeu: 2.564 ± 0.054	0.473TyrMet: 0.473 ± 0.021	0.857TyrAsn: 0.857 ± 0.032	1.309TyrPro: 1.309 ± 0.038	0.921TyrGln: 0.921 ± 0.03	2.46TyrArg: 2.46 ± 0.051	1.473TyrSer: 1.473 ± 0.039	1.636TyrThr: 1.636 ± 0.039	2.332TyrVal: 2.332 ± 0.046	0.368TyrTrp: 0.368 ± 0.018	0.816TyrTyr: 0.816 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3409 proteins (1207722 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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