Amino acid dipepetide frequency for Microlunatus soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.888AlaAla: 18.888 ± 0.134	0.771AlaCys: 0.771 ± 0.019	9.574AlaAsp: 9.574 ± 0.076	7.973AlaGlu: 7.973 ± 0.076	3.248AlaPhe: 3.248 ± 0.044	12.475AlaGly: 12.475 ± 0.088	1.996AlaHis: 1.996 ± 0.034	5.554AlaIle: 5.554 ± 0.061	2.528AlaLys: 2.528 ± 0.052	11.424AlaLeu: 11.424 ± 0.094	2.591AlaMet: 2.591 ± 0.041	1.999AlaAsn: 1.999 ± 0.03	5.436AlaPro: 5.436 ± 0.064	3.33AlaGln: 3.33 ± 0.043	8.042AlaArg: 8.042 ± 0.072	5.689AlaSer: 5.689 ± 0.06	7.041AlaThr: 7.041 ± 0.061	10.866AlaVal: 10.866 ± 0.096	1.59AlaTrp: 1.59 ± 0.029	2.194AlaTyr: 2.194 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.768CysAla: 0.768 ± 0.023	0.111CysCys: 0.111 ± 0.008	0.435CysAsp: 0.435 ± 0.014	0.312CysGlu: 0.312 ± 0.012	0.206CysPhe: 0.206 ± 0.009	0.774CysGly: 0.774 ± 0.028	0.199CysHis: 0.199 ± 0.011	0.228CysIle: 0.228 ± 0.011	0.094CysLys: 0.094 ± 0.008	0.679CysLeu: 0.679 ± 0.019	0.107CysMet: 0.107 ± 0.008	0.151CysAsn: 0.151 ± 0.008	0.398CysPro: 0.398 ± 0.014	0.191CysGln: 0.191 ± 0.01	0.565CysArg: 0.565 ± 0.016	0.446CysSer: 0.446 ± 0.014	0.446CysThr: 0.446 ± 0.015	0.546CysVal: 0.546 ± 0.018	0.149CysTrp: 0.149 ± 0.009	0.196CysTyr: 0.196 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.323AspAla: 7.323 ± 0.061	0.408AspCys: 0.408 ± 0.015	5.066AspAsp: 5.066 ± 0.064	3.673AspGlu: 3.673 ± 0.051	1.871AspPhe: 1.871 ± 0.032	6.662AspGly: 6.662 ± 0.083	2.144AspHis: 2.144 ± 0.04	2.116AspIle: 2.116 ± 0.035	1.267AspLys: 1.267 ± 0.034	7.337AspLeu: 7.337 ± 0.07	0.684AspMet: 0.684 ± 0.018	1.341AspAsn: 1.341 ± 0.026	5.038AspPro: 5.038 ± 0.049	2.866AspGln: 2.866 ± 0.043	6.314AspArg: 6.314 ± 0.061	3.156AspSer: 3.156 ± 0.053	2.998AspThr: 2.998 ± 0.045	4.824AspVal: 4.824 ± 0.051	1.22AspTrp: 1.22 ± 0.031	1.504AspTyr: 1.504 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	5.391GluAla: 5.391 ± 0.065	0.26GluCys: 0.26 ± 0.012	2.454GluAsp: 2.454 ± 0.041	2.263GluGlu: 2.263 ± 0.054	1.467GluPhe: 1.467 ± 0.029	2.852GluGly: 2.852 ± 0.047	1.411GluHis: 1.411 ± 0.027	2.557GluIle: 2.557 ± 0.04	0.985GluLys: 0.985 ± 0.026	6.738GluLeu: 6.738 ± 0.074	0.854GluMet: 0.854 ± 0.022	0.854GluAsn: 0.854 ± 0.021	3.334GluPro: 3.334 ± 0.06	2.661GluGln: 2.661 ± 0.039	4.437GluArg: 4.437 ± 0.051	2.748GluSer: 2.748 ± 0.04	2.523GluThr: 2.523 ± 0.034	4.051GluVal: 4.051 ± 0.047	0.654GluTrp: 0.654 ± 0.021	0.984GluTyr: 0.984 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.878PheAla: 3.878 ± 0.05	0.287PheCys: 0.287 ± 0.012	2.332PheAsp: 2.332 ± 0.035	1.28PheGlu: 1.28 ± 0.025	1.013PhePhe: 1.013 ± 0.029	3.518PheGly: 3.518 ± 0.044	0.572PheHis: 0.572 ± 0.018	1.073PheIle: 1.073 ± 0.024	0.439PheLys: 0.439 ± 0.016	2.633PheLeu: 2.633 ± 0.039	0.414PheMet: 0.414 ± 0.016	0.717PheAsn: 0.717 ± 0.02	1.361PhePro: 1.361 ± 0.029	0.691PheGln: 0.691 ± 0.02	1.816PheArg: 1.816 ± 0.032	1.717PheSer: 1.717 ± 0.026	1.994PheThr: 1.994 ± 0.035	2.525PheVal: 2.525 ± 0.041	0.486PheTrp: 0.486 ± 0.014	0.67PheTyr: 0.67 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	9.413GlyAla: 9.413 ± 0.066	0.902GlyCys: 0.902 ± 0.025	5.262GlyAsp: 5.262 ± 0.06	4.215GlyGlu: 4.215 ± 0.055	3.034GlyPhe: 3.034 ± 0.046	7.716GlyGly: 7.716 ± 0.095	1.966GlyHis: 1.966 ± 0.034	4.239GlyIle: 4.239 ± 0.049	2.251GlyLys: 2.251 ± 0.046	9.42GlyLeu: 9.42 ± 0.084	2.01GlyMet: 2.01 ± 0.038	1.962GlyAsn: 1.962 ± 0.037	4.667GlyPro: 4.667 ± 0.055	2.874GlyGln: 2.874 ± 0.043	7.489GlyArg: 7.489 ± 0.072	6.232GlySer: 6.232 ± 0.068	5.422GlyThr: 5.422 ± 0.062	7.229GlyVal: 7.229 ± 0.063	2.012GlyTrp: 2.012 ± 0.036	2.627GlyTyr: 2.627 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.107HisAla: 2.107 ± 0.032	0.19HisCys: 0.19 ± 0.009	1.58HisAsp: 1.58 ± 0.029	0.91HisGlu: 0.91 ± 0.017	0.602HisPhe: 0.602 ± 0.02	2.189HisGly: 2.189 ± 0.034	0.598HisHis: 0.598 ± 0.02	0.597HisIle: 0.597 ± 0.018	0.297HisLys: 0.297 ± 0.013	2.163HisLeu: 2.163 ± 0.033	0.233HisMet: 0.233 ± 0.011	0.424HisAsn: 0.424 ± 0.016	1.68HisPro: 1.68 ± 0.033	0.834HisGln: 0.834 ± 0.021	2.18HisArg: 2.18 ± 0.032	0.963HisSer: 0.963 ± 0.021	1.063HisThr: 1.063 ± 0.022	1.381HisVal: 1.381 ± 0.026	0.398HisTrp: 0.398 ± 0.014	0.515HisTyr: 0.515 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.556IleAla: 6.556 ± 0.057	0.416IleCys: 0.416 ± 0.014	3.755IleAsp: 3.755 ± 0.043	2.473IleGlu: 2.473 ± 0.041	1.477IlePhe: 1.477 ± 0.027	5.457IleGly: 5.457 ± 0.063	0.665IleHis: 0.665 ± 0.017	2.249IleIle: 2.249 ± 0.04	1.113IleLys: 1.113 ± 0.027	3.294IleLeu: 3.294 ± 0.042	0.872IleMet: 0.872 ± 0.022	1.336IleAsn: 1.336 ± 0.027	2.255IlePro: 2.255 ± 0.041	0.885IleGln: 0.885 ± 0.022	2.927IleArg: 2.927 ± 0.04	2.791IleSer: 2.791 ± 0.036	3.458IleThr: 3.458 ± 0.042	3.78IleVal: 3.78 ± 0.052	0.614IleTrp: 0.614 ± 0.019	0.896IleTyr: 0.896 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.296LysAla: 2.296 ± 0.048	0.082LysCys: 0.082 ± 0.007	1.124LysAsp: 1.124 ± 0.025	0.861LysGlu: 0.861 ± 0.025	0.495LysPhe: 0.495 ± 0.016	1.435LysGly: 1.435 ± 0.035	0.428LysHis: 0.428 ± 0.013	1.489LysIle: 1.489 ± 0.033	0.848LysLys: 0.848 ± 0.034	2.02LysLeu: 2.02 ± 0.037	0.376LysMet: 0.376 ± 0.014	0.538LysAsn: 0.538 ± 0.017	1.372LysPro: 1.372 ± 0.029	0.814LysGln: 0.814 ± 0.023	1.241LysArg: 1.241 ± 0.026	1.227LysSer: 1.227 ± 0.034	1.227LysThr: 1.227 ± 0.032	1.602LysVal: 1.602 ± 0.037	0.228LysTrp: 0.228 ± 0.012	0.448LysTyr: 0.448 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.608LeuAla: 13.608 ± 0.101	0.684LeuCys: 0.684 ± 0.019	6.927LeuAsp: 6.927 ± 0.073	4.148LeuGlu: 4.148 ± 0.049	2.759LeuPhe: 2.759 ± 0.042	8.884LeuGly: 8.884 ± 0.083	1.986LeuHis: 1.986 ± 0.033	5.627LeuIle: 5.627 ± 0.06	1.709LeuLys: 1.709 ± 0.037	10.606LeuLeu: 10.606 ± 0.103	1.664LeuMet: 1.664 ± 0.032	1.876LeuAsn: 1.876 ± 0.031	5.959LeuPro: 5.959 ± 0.065	3.17LeuGln: 3.17 ± 0.044	7.554LeuArg: 7.554 ± 0.066	5.841LeuSer: 5.841 ± 0.051	6.592LeuThr: 6.592 ± 0.06	8.107LeuVal: 8.107 ± 0.08	1.253LeuTrp: 1.253 ± 0.028	1.784LeuTyr: 1.784 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.19MetAla: 2.19 ± 0.033	0.097MetCys: 0.097 ± 0.007	0.799MetAsp: 0.799 ± 0.021	0.603MetGlu: 0.603 ± 0.018	0.516MetPhe: 0.516 ± 0.018	1.095MetGly: 1.095 ± 0.024	0.327MetHis: 0.327 ± 0.013	1.771MetIle: 1.771 ± 0.03	0.407MetLys: 0.407 ± 0.015	1.877MetLeu: 1.877 ± 0.034	0.385MetMet: 0.385 ± 0.013	0.461MetAsn: 0.461 ± 0.013	1.181MetPro: 1.181 ± 0.025	0.521MetGln: 0.521 ± 0.021	1.232MetArg: 1.232 ± 0.025	1.38MetSer: 1.38 ± 0.023	1.691MetThr: 1.691 ± 0.028	1.369MetVal: 1.369 ± 0.029	0.193MetTrp: 0.193 ± 0.01	0.322MetTyr: 0.322 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.32AsnAla: 2.32 ± 0.031	0.15AsnCys: 0.15 ± 0.009	1.258AsnAsp: 1.258 ± 0.027	0.844AsnGlu: 0.844 ± 0.02	0.654AsnPhe: 0.654 ± 0.019	2.069AsnGly: 2.069 ± 0.044	0.419AsnHis: 0.419 ± 0.015	0.755AsnIle: 0.755 ± 0.02	0.486AsnLys: 0.486 ± 0.019	1.927AsnLeu: 1.927 ± 0.029	0.309AsnMet: 0.309 ± 0.013	0.54AsnAsn: 0.54 ± 0.018	1.487AsnPro: 1.487 ± 0.03	0.628AsnGln: 0.628 ± 0.019	1.49AsnArg: 1.49 ± 0.03	1.194AsnSer: 1.194 ± 0.027	1.274AsnThr: 1.274 ± 0.039	1.452AsnVal: 1.452 ± 0.035	0.384AsnTrp: 0.384 ± 0.013	0.575AsnTyr: 0.575 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.186ProAla: 7.186 ± 0.07	0.273ProCys: 0.273 ± 0.02	4.927ProAsp: 4.927 ± 0.059	3.577ProGlu: 3.577 ± 0.045	1.576ProPhe: 1.576 ± 0.029	5.521ProGly: 5.521 ± 0.057	1.12ProHis: 1.12 ± 0.024	2.425ProIle: 2.425 ± 0.035	1.122ProLys: 1.122 ± 0.026	4.631ProLeu: 4.631 ± 0.054	1.062ProMet: 1.062 ± 0.023	1.124ProAsn: 1.124 ± 0.025	2.763ProPro: 2.763 ± 0.038	1.934ProGln: 1.934 ± 0.032	3.478ProArg: 3.478 ± 0.046	3.392ProSer: 3.392 ± 0.045	3.996ProThr: 3.996 ± 0.048	4.701ProVal: 4.701 ± 0.055	0.92ProTrp: 0.92 ± 0.025	1.386ProTyr: 1.386 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.891GlnAla: 3.891 ± 0.05	0.161GlnCys: 0.161 ± 0.009	1.601GlnAsp: 1.601 ± 0.03	1.202GlnGlu: 1.202 ± 0.028	0.893GlnPhe: 0.893 ± 0.022	2.156GlnGly: 2.156 ± 0.035	0.871GlnHis: 0.871 ± 0.021	1.579GlnIle: 1.579 ± 0.029	0.593GlnLys: 0.593 ± 0.02	4.225GlnLeu: 4.225 ± 0.046	0.549GlnMet: 0.549 ± 0.018	0.625GlnAsn: 0.625 ± 0.024	2.271GlnPro: 2.271 ± 0.039	2.097GlnGln: 2.097 ± 0.059	3.02GlnArg: 3.02 ± 0.04	1.657GlnSer: 1.657 ± 0.03	1.905GlnThr: 1.905 ± 0.032	2.77GlnVal: 2.77 ± 0.036	0.547GlnTrp: 0.547 ± 0.016	0.633GlnTyr: 0.633 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.992ArgAla: 7.992 ± 0.065	0.518ArgCys: 0.518 ± 0.013	4.293ArgAsp: 4.293 ± 0.052	3.441ArgGlu: 3.441 ± 0.041	2.448ArgPhe: 2.448 ± 0.037	5.086ArgGly: 5.086 ± 0.058	1.849ArgHis: 1.849 ± 0.032	3.789ArgIle: 3.789 ± 0.046	1.38ArgLys: 1.38 ± 0.025	8.418ArgLeu: 8.418 ± 0.078	1.852ArgMet: 1.852 ± 0.031	1.484ArgAsn: 1.484 ± 0.027	4.793ArgPro: 4.793 ± 0.052	2.851ArgGln: 2.851 ± 0.039	7.863ArgArg: 7.863 ± 0.084	5.076ArgSer: 5.076 ± 0.054	4.808ArgThr: 4.808 ± 0.048	5.437ArgVal: 5.437 ± 0.057	1.483ArgTrp: 1.483 ± 0.027	1.859ArgTyr: 1.859 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.012SerAla: 7.012 ± 0.059	0.404SerCys: 0.404 ± 0.015	3.722SerAsp: 3.722 ± 0.052	2.698SerGlu: 2.698 ± 0.041	1.819SerPhe: 1.819 ± 0.029	6.132SerGly: 6.132 ± 0.059	1.004SerHis: 1.004 ± 0.023	2.443SerIle: 2.443 ± 0.039	1.205SerLys: 1.205 ± 0.03	4.859SerLeu: 4.859 ± 0.047	1.364SerMet: 1.364 ± 0.027	1.159SerAsn: 1.159 ± 0.025	3.033SerPro: 3.033 ± 0.043	1.568SerGln: 1.568 ± 0.035	4.125SerArg: 4.125 ± 0.045	3.669SerSer: 3.669 ± 0.052	3.987SerThr: 3.987 ± 0.046	4.511SerVal: 4.511 ± 0.046	1.114SerTrp: 1.114 ± 0.024	1.605SerTyr: 1.605 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.181ThrAla: 8.181 ± 0.075	0.374ThrCys: 0.374 ± 0.022	4.584ThrAsp: 4.584 ± 0.053	3.427ThrGlu: 3.427 ± 0.048	1.788ThrPhe: 1.788 ± 0.029	6.275ThrGly: 6.275 ± 0.066	0.992ThrHis: 0.992 ± 0.023	2.841ThrIle: 2.841 ± 0.041	1.305ThrLys: 1.305 ± 0.034	5.371ThrLeu: 5.371 ± 0.053	1.2ThrMet: 1.2 ± 0.023	1.076ThrAsn: 1.076 ± 0.027	3.67ThrPro: 3.67 ± 0.045	1.396ThrGln: 1.396 ± 0.027	3.728ThrArg: 3.728 ± 0.043	3.581ThrSer: 3.581 ± 0.042	3.852ThrThr: 3.852 ± 0.056	5.926ThrVal: 5.926 ± 0.059	0.875ThrTrp: 0.875 ± 0.021	1.105ThrTyr: 1.105 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.012ValAla: 10.012 ± 0.085	0.605ValCys: 0.605 ± 0.016	5.757ValAsp: 5.757 ± 0.058	4.055ValGlu: 4.055 ± 0.049	2.254ValPhe: 2.254 ± 0.036	7.382ValGly: 7.382 ± 0.076	1.533ValHis: 1.533 ± 0.027	4.587ValIle: 4.587 ± 0.056	1.399ValLys: 1.399 ± 0.033	8.717ValLeu: 8.717 ± 0.084	1.353ValMet: 1.353 ± 0.029	1.592ValAsn: 1.592 ± 0.034	4.345ValPro: 4.345 ± 0.048	2.287ValGln: 2.287 ± 0.035	5.888ValArg: 5.888 ± 0.057	4.503ValSer: 4.503 ± 0.047	5.108ValThr: 5.108 ± 0.061	7.128ValVal: 7.128 ± 0.07	1.039ValTrp: 1.039 ± 0.027	1.371ValTyr: 1.371 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.565TrpAla: 1.565 ± 0.033	0.141TrpCys: 0.141 ± 0.008	0.857TrpAsp: 0.857 ± 0.024	0.579TrpGlu: 0.579 ± 0.017	0.555TrpPhe: 0.555 ± 0.017	1.085TrpGly: 1.085 ± 0.023	0.393TrpHis: 0.393 ± 0.013	0.741TrpIle: 0.741 ± 0.022	0.386TrpLys: 0.386 ± 0.014	1.927TrpLeu: 1.927 ± 0.033	0.335TrpMet: 0.335 ± 0.013	0.463TrpAsn: 0.463 ± 0.015	0.828TrpPro: 0.828 ± 0.023	0.827TrpGln: 0.827 ± 0.021	1.283TrpArg: 1.283 ± 0.026	1.066TrpSer: 1.066 ± 0.026	1.033TrpThr: 1.033 ± 0.024	1.09TrpVal: 1.09 ± 0.025	0.364TrpTrp: 0.364 ± 0.013	0.376TrpTyr: 0.376 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.63TyrAla: 2.63 ± 0.038	0.165TyrCys: 0.165 ± 0.009	1.504TyrAsp: 1.504 ± 0.037	0.945TyrGlu: 0.945 ± 0.022	0.742TyrPhe: 0.742 ± 0.015	2.178TyrGly: 2.178 ± 0.042	0.43TyrHis: 0.43 ± 0.016	0.609TyrIle: 0.609 ± 0.019	0.338TyrLys: 0.338 ± 0.013	2.473TyrLeu: 2.473 ± 0.036	0.206TyrMet: 0.206 ± 0.011	0.495TyrAsn: 0.495 ± 0.017	1.243TyrPro: 1.243 ± 0.024	0.822TyrGln: 0.822 ± 0.02	2.047TyrArg: 2.047 ± 0.033	1.103TyrSer: 1.103 ± 0.025	1.131TyrThr: 1.131 ± 0.025	1.621TyrVal: 1.621 ± 0.029	0.37TyrTrp: 0.37 ± 0.014	0.531TyrTyr: 0.531 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6014 proteins (2026290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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