Amino acid dipepetide frequency for Kirkovirus Equ1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.885AlaAla: 2.885 ± 1.657
0.0AlaCys: 0.0 ± 0.0
1.923AlaAsp: 1.923 ± 0.987
1.923AlaGlu: 1.923 ± 0.963
2.885AlaPhe: 2.885 ± 1.427
3.846AlaGly: 3.846 ± 0.925
0.0AlaHis: 0.0 ± 0.0
3.846AlaIle: 3.846 ± 1.634
4.808AlaLys: 4.808 ± 2.463
0.0AlaLeu: 0.0 ± 0.0
1.923AlaMet: 1.923 ± 1.205
1.923AlaAsn: 1.923 ± 1.485
0.0AlaPro: 0.0 ± 0.0
0.962AlaGln: 0.962 ± 0.849
6.731AlaArg: 6.731 ± 2.982
0.962AlaSer: 0.962 ± 0.743
0.962AlaThr: 0.962 ± 0.859
2.885AlaVal: 2.885 ± 1.774
0.962AlaTrp: 0.962 ± 0.849
4.808AlaTyr: 4.808 ± 0.537
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.962CysGlu: 0.962 ± 0.849
0.962CysPhe: 0.962 ± 0.743
0.0CysGly: 0.0 ± 0.0
0.962CysHis: 0.962 ± 0.743
0.962CysIle: 0.962 ± 0.935
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.962CysGln: 0.962 ± 0.935
0.962CysArg: 0.962 ± 0.743
0.962CysSer: 0.962 ± 0.743
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.846AspAla: 3.846 ± 2.408
0.0AspCys: 0.0 ± 0.0
2.885AspAsp: 2.885 ± 0.972
3.846AspGlu: 3.846 ± 2.155
2.885AspPhe: 2.885 ± 0.914
1.923AspGly: 1.923 ± 0.909
1.923AspHis: 1.923 ± 0.909
3.846AspIle: 3.846 ± 1.381
4.808AspLys: 4.808 ± 2.092
4.808AspLeu: 4.808 ± 1.793
0.962AspMet: 0.962 ± 1.012
1.923AspAsn: 1.923 ± 1.148
4.808AspPro: 4.808 ± 2.706
0.962AspGln: 0.962 ± 1.012
3.846AspArg: 3.846 ± 1.381
1.923AspSer: 1.923 ± 0.987
2.885AspThr: 2.885 ± 1.145
5.769AspVal: 5.769 ± 3.119
0.0AspTrp: 0.0 ± 0.0
3.846AspTyr: 3.846 ± 0.941
0.0AspXaa: 0.0 ± 0.0
Glu
4.808GluAla: 4.808 ± 1.47
0.962GluCys: 0.962 ± 0.743
0.962GluAsp: 0.962 ± 0.743
9.615GluGlu: 9.615 ± 4.569
0.962GluPhe: 0.962 ± 1.012
4.808GluGly: 4.808 ± 1.556
1.923GluHis: 1.923 ± 0.989
4.808GluIle: 4.808 ± 1.905
1.923GluLys: 1.923 ± 0.987
3.846GluLeu: 3.846 ± 1.322
2.885GluMet: 2.885 ± 1.177
4.808GluAsn: 4.808 ± 1.905
4.808GluPro: 4.808 ± 1.887
3.846GluGln: 3.846 ± 1.923
0.962GluArg: 0.962 ± 0.849
4.808GluSer: 4.808 ± 2.051
0.962GluThr: 0.962 ± 0.849
3.846GluVal: 3.846 ± 2.408
0.962GluTrp: 0.962 ± 0.743
0.962GluTyr: 0.962 ± 0.849
0.0GluXaa: 0.0 ± 0.0
Phe
3.846PheAla: 3.846 ± 1.462
0.0PheCys: 0.0 ± 0.0
0.962PheAsp: 0.962 ± 1.012
2.885PheGlu: 2.885 ± 1.42
1.923PhePhe: 1.923 ± 1.148
1.923PheGly: 1.923 ± 1.344
0.962PheHis: 0.962 ± 0.743
1.923PheIle: 1.923 ± 1.485
4.808PheLys: 4.808 ± 2.391
2.885PheLeu: 2.885 ± 1.657
1.923PheMet: 1.923 ± 1.076
6.731PheAsn: 6.731 ± 1.901
2.885PhePro: 2.885 ± 1.03
1.923PheGln: 1.923 ± 0.987
2.885PheArg: 2.885 ± 1.03
3.846PheSer: 3.846 ± 1.925
3.846PheThr: 3.846 ± 2.048
2.885PheVal: 2.885 ± 2.228
0.962PheTrp: 0.962 ± 1.012
2.885PheTyr: 2.885 ± 1.605
0.0PheXaa: 0.0 ± 0.0
Gly
0.0GlyAla: 0.0 ± 0.0
0.0GlyCys: 0.0 ± 0.0
5.769GlyAsp: 5.769 ± 1.337
1.923GlyGlu: 1.923 ± 1.485
1.923GlyPhe: 1.923 ± 1.485
3.846GlyGly: 3.846 ± 1.975
0.962GlyHis: 0.962 ± 0.743
1.923GlyIle: 1.923 ± 1.205
2.885GlyLys: 2.885 ± 1.858
0.0GlyLeu: 0.0 ± 0.0
0.0GlyMet: 0.0 ± 0.0
1.923GlyAsn: 1.923 ± 1.039
0.962GlyPro: 0.962 ± 0.743
2.885GlyGln: 2.885 ± 1.785
1.923GlyArg: 1.923 ± 0.909
3.846GlySer: 3.846 ± 2.658
3.846GlyThr: 3.846 ± 1.578
5.769GlyVal: 5.769 ± 1.7
1.923GlyTrp: 1.923 ± 1.205
2.885GlyTyr: 2.885 ± 1.652
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.962HisCys: 0.962 ± 0.935
1.923HisAsp: 1.923 ± 1.205
1.923HisGlu: 1.923 ± 1.195
0.962HisPhe: 0.962 ± 1.012
0.962HisGly: 0.962 ± 0.935
0.0HisHis: 0.0 ± 0.0
2.885HisIle: 2.885 ± 1.657
1.923HisLys: 1.923 ± 1.717
3.846HisLeu: 3.846 ± 1.301
0.962HisMet: 0.962 ± 0.743
0.962HisAsn: 0.962 ± 0.859
2.885HisPro: 2.885 ± 1.857
0.962HisGln: 0.962 ± 0.743
3.846HisArg: 3.846 ± 1.634
5.769HisSer: 5.769 ± 2.136
0.0HisThr: 0.0 ± 0.0
0.962HisVal: 0.962 ± 0.935
0.0HisTrp: 0.0 ± 0.0
0.962HisTyr: 0.962 ± 0.859
0.0HisXaa: 0.0 ± 0.0
Ile
1.923IleAla: 1.923 ± 1.104
0.962IleCys: 0.962 ± 0.743
5.769IleAsp: 5.769 ± 2.136
2.885IleGlu: 2.885 ± 1.03
2.885IlePhe: 2.885 ± 1.133
1.923IleGly: 1.923 ± 0.963
2.885IleHis: 2.885 ± 1.133
6.731IleIle: 6.731 ± 1.339
5.769IleLys: 5.769 ± 2.345
2.885IleLeu: 2.885 ± 1.828
1.923IleMet: 1.923 ± 0.909
8.654IleAsn: 8.654 ± 3.004
4.808IlePro: 4.808 ± 1.793
0.962IleGln: 0.962 ± 0.743
2.885IleArg: 2.885 ± 1.605
2.885IleSer: 2.885 ± 1.133
2.885IleThr: 2.885 ± 1.476
3.846IleVal: 3.846 ± 1.265
0.962IleTrp: 0.962 ± 0.743
7.692IleTyr: 7.692 ± 2.23
0.0IleXaa: 0.0 ± 0.0
Lys
3.846LysAla: 3.846 ± 2.048
0.0LysCys: 0.0 ± 0.0
0.962LysAsp: 0.962 ± 1.012
3.846LysGlu: 3.846 ± 2.048
3.846LysPhe: 3.846 ± 1.488
2.885LysGly: 2.885 ± 0.914
0.962LysHis: 0.962 ± 1.012
2.885LysIle: 2.885 ± 1.427
8.654LysLys: 8.654 ± 1.635
0.962LysLeu: 0.962 ± 0.743
0.962LysMet: 0.962 ± 0.859
9.615LysAsn: 9.615 ± 2.081
1.923LysPro: 1.923 ± 1.195
0.0LysGln: 0.0 ± 0.0
2.885LysArg: 2.885 ± 1.743
6.731LysSer: 6.731 ± 2.634
2.885LysThr: 2.885 ± 0.926
0.962LysVal: 0.962 ± 0.935
0.962LysTrp: 0.962 ± 0.743
6.731LysTyr: 6.731 ± 2.592
0.0LysXaa: 0.0 ± 0.0
Leu
6.731LeuAla: 6.731 ± 1.901
0.0LeuCys: 0.0 ± 0.0
5.769LeuAsp: 5.769 ± 2.2
4.808LeuGlu: 4.808 ± 3.713
1.923LeuPhe: 1.923 ± 0.987
0.962LeuGly: 0.962 ± 0.743
0.962LeuHis: 0.962 ± 0.849
5.769LeuIle: 5.769 ± 0.297
3.846LeuLys: 3.846 ± 1.385
1.923LeuLeu: 1.923 ± 0.963
1.923LeuMet: 1.923 ± 1.195
1.923LeuAsn: 1.923 ± 0.909
2.885LeuPro: 2.885 ± 1.31
0.962LeuGln: 0.962 ± 1.012
1.923LeuArg: 1.923 ± 0.989
5.769LeuSer: 5.769 ± 2.789
3.846LeuThr: 3.846 ± 2.078
2.885LeuVal: 2.885 ± 1.657
0.962LeuTrp: 0.962 ± 0.743
1.923LeuTyr: 1.923 ± 1.195
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
2.885MetAsp: 2.885 ± 1.31
1.923MetGlu: 1.923 ± 0.989
0.962MetPhe: 0.962 ± 0.859
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.923MetIle: 1.923 ± 1.205
0.962MetLys: 0.962 ± 0.743
0.962MetLeu: 0.962 ± 0.935
0.0MetMet: 0.0 ± 0.0
1.923MetAsn: 1.923 ± 1.485
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.962MetArg: 0.962 ± 0.935
4.808MetSer: 4.808 ± 1.793
1.923MetThr: 1.923 ± 1.344
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
2.885MetTyr: 2.885 ± 1.831
0.0MetXaa: 0.0 ± 0.0
Asn
2.885AsnAla: 2.885 ± 0.914
0.0AsnCys: 0.0 ± 0.0
4.808AsnAsp: 4.808 ± 2.092
4.808AsnGlu: 4.808 ± 2.385
6.731AsnPhe: 6.731 ± 2.653
4.808AsnGly: 4.808 ± 0.537
2.885AsnHis: 2.885 ± 1.841
7.692AsnIle: 7.692 ± 1.958
4.808AsnLys: 4.808 ± 1.799
5.769AsnLeu: 5.769 ± 2.457
4.808AsnMet: 4.808 ± 1.238
1.923AsnAsn: 1.923 ± 0.963
2.885AsnPro: 2.885 ± 1.828
1.923AsnGln: 1.923 ± 0.909
0.962AsnArg: 0.962 ± 1.012
1.923AsnSer: 1.923 ± 0.963
2.885AsnThr: 2.885 ± 0.926
0.962AsnVal: 0.962 ± 1.012
0.0AsnTrp: 0.0 ± 0.0
3.846AsnTyr: 3.846 ± 0.928
0.0AsnXaa: 0.0 ± 0.0
Pro
2.885ProAla: 2.885 ± 0.972
0.0ProCys: 0.0 ± 0.0
2.885ProAsp: 2.885 ± 1.31
6.731ProGlu: 6.731 ± 2.786
2.885ProPhe: 2.885 ± 1.858
0.0ProGly: 0.0 ± 0.0
2.885ProHis: 2.885 ± 1.145
3.846ProIle: 3.846 ± 2.609
0.0ProLys: 0.0 ± 0.0
4.808ProLeu: 4.808 ± 2.128
0.962ProMet: 0.962 ± 0.859
4.808ProAsn: 4.808 ± 1.054
0.0ProPro: 0.0 ± 0.0
4.808ProGln: 4.808 ± 1.763
1.923ProArg: 1.923 ± 1.148
7.692ProSer: 7.692 ± 0.945
1.923ProThr: 1.923 ± 1.205
1.923ProVal: 1.923 ± 1.869
0.0ProTrp: 0.0 ± 0.0
0.962ProTyr: 0.962 ± 0.849
0.0ProXaa: 0.0 ± 0.0
Gln
0.962GlnAla: 0.962 ± 0.849
0.962GlnCys: 0.962 ± 0.935
1.923GlnAsp: 1.923 ± 0.989
1.923GlnGlu: 1.923 ± 0.989
3.846GlnPhe: 3.846 ± 0.925
2.885GlnGly: 2.885 ± 1.476
2.885GlnHis: 2.885 ± 1.018
2.885GlnIle: 2.885 ± 1.785
0.0GlnLys: 0.0 ± 0.0
0.0GlnLeu: 0.0 ± 0.0
0.962GlnMet: 0.962 ± 1.012
0.962GlnAsn: 0.962 ± 0.935
0.0GlnPro: 0.0 ± 0.0
1.923GlnGln: 1.923 ± 1.344
3.846GlnArg: 3.846 ± 2.118
2.885GlnSer: 2.885 ± 1.358
0.0GlnThr: 0.0 ± 0.0
2.885GlnVal: 2.885 ± 1.145
1.923GlnTrp: 1.923 ± 1.717
2.885GlnTyr: 2.885 ± 1.358
0.0GlnXaa: 0.0 ± 0.0
Arg
2.885ArgAla: 2.885 ± 1.605
0.0ArgCys: 0.0 ± 0.0
3.846ArgAsp: 3.846 ± 1.818
3.846ArgGlu: 3.846 ± 0.941
2.885ArgPhe: 2.885 ± 2.228
1.923ArgGly: 1.923 ± 0.909
1.923ArgHis: 1.923 ± 1.717
2.885ArgIle: 2.885 ± 1.841
5.769ArgLys: 5.769 ± 1.507
0.0ArgLeu: 0.0 ± 0.0
0.962ArgMet: 0.962 ± 0.935
4.808ArgAsn: 4.808 ± 1.721
0.962ArgPro: 0.962 ± 0.849
0.962ArgGln: 0.962 ± 0.935
5.769ArgArg: 5.769 ± 2.229
6.731ArgSer: 6.731 ± 3.514
0.962ArgThr: 0.962 ± 0.743
3.846ArgVal: 3.846 ± 1.634
0.0ArgTrp: 0.0 ± 0.0
5.769ArgTyr: 5.769 ± 2.229
0.0ArgXaa: 0.0 ± 0.0
Ser
2.885SerAla: 2.885 ± 1.42
0.962SerCys: 0.962 ± 0.743
4.808SerAsp: 4.808 ± 1.391
0.962SerGlu: 0.962 ± 0.859
4.808SerPhe: 4.808 ± 1.319
5.769SerGly: 5.769 ± 3.569
3.846SerHis: 3.846 ± 2.653
9.615SerIle: 9.615 ± 4.029
1.923SerLys: 1.923 ± 1.485
5.769SerLeu: 5.769 ± 2.127
0.0SerMet: 0.0 ± 0.0
4.808SerAsn: 4.808 ± 2.059
5.769SerPro: 5.769 ± 1.065
1.923SerGln: 1.923 ± 1.344
6.731SerArg: 6.731 ± 1.774
5.769SerSer: 5.769 ± 1.7
6.731SerThr: 6.731 ± 2.636
3.846SerVal: 3.846 ± 2.45
0.0SerTrp: 0.0 ± 0.0
5.769SerTyr: 5.769 ± 2.535
0.0SerXaa: 0.0 ± 0.0
Thr
0.0ThrAla: 0.0 ± 0.0
0.0ThrCys: 0.0 ± 0.0
0.0ThrAsp: 0.0 ± 0.0
0.962ThrGlu: 0.962 ± 0.935
4.808ThrPhe: 4.808 ± 2.42
0.962ThrGly: 0.962 ± 0.859
0.962ThrHis: 0.962 ± 0.935
1.923ThrIle: 1.923 ± 1.485
3.846ThrLys: 3.846 ± 1.265
6.731ThrLeu: 6.731 ± 1.535
0.0ThrMet: 0.0 ± 0.0
0.0ThrAsn: 0.0 ± 0.0
5.769ThrPro: 5.769 ± 1.21
4.808ThrGln: 4.808 ± 1.357
3.846ThrArg: 3.846 ± 0.928
5.769ThrSer: 5.769 ± 2.451
5.769ThrThr: 5.769 ± 3.577
0.962ThrVal: 0.962 ± 0.935
1.923ThrTrp: 1.923 ± 0.909
1.923ThrTyr: 1.923 ± 1.205
0.0ThrXaa: 0.0 ± 0.0
Val
2.885ValAla: 2.885 ± 1.42
0.0ValCys: 0.0 ± 0.0
0.962ValAsp: 0.962 ± 0.743
1.923ValGlu: 1.923 ± 0.987
2.885ValPhe: 2.885 ± 1.495
3.846ValGly: 3.846 ± 0.925
0.0ValHis: 0.0 ± 0.0
2.885ValIle: 2.885 ± 0.972
2.885ValLys: 2.885 ± 0.926
5.769ValLeu: 5.769 ± 1.494
0.0ValMet: 0.0 ± 0.0
3.846ValAsn: 3.846 ± 0.928
4.808ValPro: 4.808 ± 1.987
2.885ValGln: 2.885 ± 1.145
0.962ValArg: 0.962 ± 0.859
3.846ValSer: 3.846 ± 1.996
4.808ValThr: 4.808 ± 2.081
4.808ValVal: 4.808 ± 1.925
0.0ValTrp: 0.0 ± 0.0
6.731ValTyr: 6.731 ± 2.727
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.962TrpAsp: 0.962 ± 0.743
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.962TrpGly: 0.962 ± 0.743
0.962TrpHis: 0.962 ± 1.012
0.962TrpIle: 0.962 ± 0.743
1.923TrpLys: 1.923 ± 1.148
0.962TrpLeu: 0.962 ± 0.743
0.0TrpMet: 0.0 ± 0.0
0.962TrpAsn: 0.962 ± 0.743
0.0TrpPro: 0.0 ± 0.0
0.962TrpGln: 0.962 ± 0.859
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
1.923TrpThr: 1.923 ± 1.717
0.962TrpVal: 0.962 ± 1.012
0.962TrpTrp: 0.962 ± 0.743
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.962TyrAla: 0.962 ± 0.859
1.923TyrCys: 1.923 ± 0.963
7.692TyrAsp: 7.692 ± 2.636
5.769TyrGlu: 5.769 ± 4.09
1.923TyrPhe: 1.923 ± 1.148
0.962TyrGly: 0.962 ± 0.743
4.808TyrHis: 4.808 ± 2.789
1.923TyrIle: 1.923 ± 1.717
0.962TyrLys: 0.962 ± 0.849
5.769TyrLeu: 5.769 ± 1.537
0.0TyrMet: 0.0 ± 0.825
4.808TyrAsn: 4.808 ± 2.356
5.769TyrPro: 5.769 ± 3.211
1.923TyrGln: 1.923 ± 0.963
2.885TyrArg: 2.885 ± 0.926
5.769TyrSer: 5.769 ± 3.323
1.923TyrThr: 1.923 ± 1.698
6.731TyrVal: 6.731 ± 2.908
0.0TyrTrp: 0.0 ± 0.0
4.808TyrTyr: 4.808 ± 2.081
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski