Amino acid dipepetide frequency for Thiohalorhabdus denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.501AlaAla: 14.501 ± 0.202	0.881AlaCys: 0.881 ± 0.037	6.384AlaAsp: 6.384 ± 0.104	9.761AlaGlu: 9.761 ± 0.137	3.982AlaPhe: 3.982 ± 0.075	11.519AlaGly: 11.519 ± 0.159	2.392AlaHis: 2.392 ± 0.057	3.906AlaIle: 3.906 ± 0.076	2.393AlaLys: 2.393 ± 0.055	13.149AlaLeu: 13.149 ± 0.172	2.61AlaMet: 2.61 ± 0.053	2.292AlaAsn: 2.292 ± 0.054	5.346AlaPro: 5.346 ± 0.088	3.331AlaGln: 3.331 ± 0.071	9.259AlaArg: 9.259 ± 0.144	4.664AlaSer: 4.664 ± 0.075	5.043AlaThr: 5.043 ± 0.085	9.192AlaVal: 9.192 ± 0.133	1.784AlaTrp: 1.784 ± 0.049	2.681AlaTyr: 2.681 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.727CysAla: 0.727 ± 0.024	0.096CysCys: 0.096 ± 0.011	0.387CysAsp: 0.387 ± 0.023	0.413CysGlu: 0.413 ± 0.022	0.248CysPhe: 0.248 ± 0.017	0.928CysGly: 0.928 ± 0.038	0.272CysHis: 0.272 ± 0.022	0.286CysIle: 0.286 ± 0.02	0.148CysLys: 0.148 ± 0.014	0.729CysLeu: 0.729 ± 0.03	0.133CysMet: 0.133 ± 0.012	0.189CysAsn: 0.189 ± 0.015	0.653CysPro: 0.653 ± 0.033	0.213CysGln: 0.213 ± 0.017	0.65CysArg: 0.65 ± 0.031	0.354CysSer: 0.354 ± 0.023	0.414CysThr: 0.414 ± 0.023	0.45CysVal: 0.45 ± 0.024	0.064CysTrp: 0.064 ± 0.009	0.183CysTyr: 0.183 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.671AspAla: 5.671 ± 0.096	0.427AspCys: 0.427 ± 0.024	2.496AspAsp: 2.496 ± 0.067	3.609AspGlu: 3.609 ± 0.073	2.163AspPhe: 2.163 ± 0.059	5.031AspGly: 5.031 ± 0.092	1.397AspHis: 1.397 ± 0.042	2.071AspIle: 2.071 ± 0.051	1.236AspLys: 1.236 ± 0.051	6.928AspLeu: 6.928 ± 0.102	1.125AspMet: 1.125 ± 0.037	1.244AspAsn: 1.244 ± 0.044	4.58AspPro: 4.58 ± 0.079	1.929AspGln: 1.929 ± 0.049	5.257AspArg: 5.257 ± 0.096	2.372AspSer: 2.372 ± 0.059	2.625AspThr: 2.625 ± 0.062	3.229AspVal: 3.229 ± 0.075	1.064AspTrp: 1.064 ± 0.036	1.669AspTyr: 1.669 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	10.667GluAla: 10.667 ± 0.144	0.426GluCys: 0.426 ± 0.024	4.36GluAsp: 4.36 ± 0.081	7.447GluGlu: 7.447 ± 0.137	1.697GluPhe: 1.697 ± 0.05	7.441GluGly: 7.441 ± 0.097	1.736GluHis: 1.736 ± 0.048	2.731GluIle: 2.731 ± 0.062	2.111GluLys: 2.111 ± 0.064	7.374GluLeu: 7.374 ± 0.111	1.612GluMet: 1.612 ± 0.048	1.579GluAsn: 1.579 ± 0.047	4.215GluPro: 4.215 ± 0.131	2.99GluGln: 2.99 ± 0.075	7.52GluArg: 7.52 ± 0.134	3.118GluSer: 3.118 ± 0.067	3.587GluThr: 3.587 ± 0.07	6.377GluVal: 6.377 ± 0.1	0.995GluTrp: 0.995 ± 0.034	1.479GluTyr: 1.479 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.331PheAla: 3.331 ± 0.065	0.312PheCys: 0.312 ± 0.018	1.972PheAsp: 1.972 ± 0.052	2.169PheGlu: 2.169 ± 0.049	1.43PhePhe: 1.43 ± 0.044	3.187PheGly: 3.187 ± 0.071	0.913PheHis: 0.913 ± 0.033	1.164PheIle: 1.164 ± 0.043	0.649PheLys: 0.649 ± 0.032	4.047PheLeu: 4.047 ± 0.084	0.714PheMet: 0.714 ± 0.029	0.83PheAsn: 0.83 ± 0.038	1.821PhePro: 1.821 ± 0.042	1.248PheGln: 1.248 ± 0.034	2.718PheArg: 2.718 ± 0.069	1.715PheSer: 1.715 ± 0.047	1.756PheThr: 1.756 ± 0.05	2.206PheVal: 2.206 ± 0.056	0.542PheTrp: 0.542 ± 0.027	0.97PheTyr: 0.97 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	9.493GlyAla: 9.493 ± 0.123	0.901GlyCys: 0.901 ± 0.037	5.078GlyAsp: 5.078 ± 0.087	7.534GlyGlu: 7.534 ± 0.114	3.225GlyPhe: 3.225 ± 0.065	8.94GlyGly: 8.94 ± 0.125	2.238GlyHis: 2.238 ± 0.053	3.846GlyIle: 3.846 ± 0.08	2.651GlyLys: 2.651 ± 0.07	10.235GlyLeu: 10.235 ± 0.133	2.553GlyMet: 2.553 ± 0.062	2.122GlyAsn: 2.122 ± 0.057	4.547GlyPro: 4.547 ± 0.082	3.06GlyGln: 3.06 ± 0.068	7.434GlyArg: 7.434 ± 0.086	4.592GlySer: 4.592 ± 0.086	4.826GlyThr: 4.826 ± 0.082	7.132GlyVal: 7.132 ± 0.104	1.645GlyTrp: 1.645 ± 0.048	2.487GlyTyr: 2.487 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.289HisAla: 2.289 ± 0.059	0.234HisCys: 0.234 ± 0.018	1.069HisAsp: 1.069 ± 0.037	1.123HisGlu: 1.123 ± 0.037	0.888HisPhe: 0.888 ± 0.034	2.218HisGly: 2.218 ± 0.056	0.682HisHis: 0.682 ± 0.027	0.79HisIle: 0.79 ± 0.03	0.52HisLys: 0.52 ± 0.028	2.728HisLeu: 2.728 ± 0.063	0.453HisMet: 0.453 ± 0.021	0.515HisAsn: 0.515 ± 0.025	1.851HisPro: 1.851 ± 0.047	0.766HisGln: 0.766 ± 0.03	2.029HisArg: 2.029 ± 0.048	0.926HisSer: 0.926 ± 0.032	1.077HisThr: 1.077 ± 0.036	1.385HisVal: 1.385 ± 0.042	0.405HisTrp: 0.405 ± 0.021	0.688HisTyr: 0.688 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	3.98IleAla: 3.98 ± 0.083	0.259IleCys: 0.259 ± 0.017	2.089IleAsp: 2.089 ± 0.059	2.491IleGlu: 2.491 ± 0.065	1.1IlePhe: 1.1 ± 0.04	3.369IleGly: 3.369 ± 0.068	1.022IleHis: 1.022 ± 0.044	1.277IleIle: 1.277 ± 0.042	1.021IleLys: 1.021 ± 0.043	4.139IleLeu: 4.139 ± 0.075	0.653IleMet: 0.653 ± 0.029	1.043IleAsn: 1.043 ± 0.041	2.312IlePro: 2.312 ± 0.055	1.377IleGln: 1.377 ± 0.038	3.2IleArg: 3.2 ± 0.065	1.728IleSer: 1.728 ± 0.053	1.959IleThr: 1.959 ± 0.047	2.225IleVal: 2.225 ± 0.058	0.392IleTrp: 0.392 ± 0.02	0.823IleTyr: 0.823 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	2.907LysAla: 2.907 ± 0.063	0.136LysCys: 0.136 ± 0.013	1.396LysAsp: 1.396 ± 0.046	1.942LysGlu: 1.942 ± 0.058	0.554LysPhe: 0.554 ± 0.027	2.283LysGly: 2.283 ± 0.059	0.441LysHis: 0.441 ± 0.025	0.9LysIle: 0.9 ± 0.041	0.946LysLys: 0.946 ± 0.036	2.053LysLeu: 2.053 ± 0.057	0.496LysMet: 0.496 ± 0.025	0.606LysAsn: 0.606 ± 0.031	1.321LysPro: 1.321 ± 0.044	0.813LysGln: 0.813 ± 0.037	2.056LysArg: 2.056 ± 0.05	1.085LysSer: 1.085 ± 0.039	1.175LysThr: 1.175 ± 0.045	1.985LysVal: 1.985 ± 0.061	0.27LysTrp: 0.27 ± 0.019	0.569LysTyr: 0.569 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.235LeuAla: 14.235 ± 0.183	0.674LeuCys: 0.674 ± 0.032	6.425LeuAsp: 6.425 ± 0.091	9.083LeuGlu: 9.083 ± 0.122	3.754LeuPhe: 3.754 ± 0.08	10.283LeuGly: 10.283 ± 0.135	2.279LeuHis: 2.279 ± 0.054	3.638LeuIle: 3.638 ± 0.067	2.514LeuLys: 2.514 ± 0.067	11.735LeuLeu: 11.735 ± 0.199	2.002LeuMet: 2.002 ± 0.046	2.209LeuAsn: 2.209 ± 0.055	6.221LeuPro: 6.221 ± 0.092	3.238LeuGln: 3.238 ± 0.069	8.444LeuArg: 8.444 ± 0.131	4.95LeuSer: 4.95 ± 0.079	5.159LeuThr: 5.159 ± 0.079	8.458LeuVal: 8.458 ± 0.118	1.434LeuTrp: 1.434 ± 0.055	2.286LeuTyr: 2.286 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.861MetAla: 2.861 ± 0.057	0.115MetCys: 0.115 ± 0.011	1.39MetAsp: 1.39 ± 0.042	1.757MetGlu: 1.757 ± 0.05	0.497MetPhe: 0.497 ± 0.026	1.978MetGly: 1.978 ± 0.053	0.407MetHis: 0.407 ± 0.022	0.78MetIle: 0.78 ± 0.032	0.617MetLys: 0.617 ± 0.026	1.808MetLeu: 1.808 ± 0.05	0.356MetMet: 0.356 ± 0.025	0.563MetAsn: 0.563 ± 0.027	1.123MetPro: 1.123 ± 0.035	0.69MetGln: 0.69 ± 0.026	1.562MetArg: 1.562 ± 0.044	1.15MetSer: 1.15 ± 0.039	1.191MetThr: 1.191 ± 0.036	1.808MetVal: 1.808 ± 0.047	0.188MetTrp: 0.188 ± 0.015	0.341MetTyr: 0.341 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.294AsnAla: 2.294 ± 0.055	0.205AsnCys: 0.205 ± 0.016	1.048AsnAsp: 1.048 ± 0.035	1.283AsnGlu: 1.283 ± 0.045	0.728AsnPhe: 0.728 ± 0.031	2.019AsnGly: 2.019 ± 0.065	0.532AsnHis: 0.532 ± 0.028	0.933AsnIle: 0.933 ± 0.032	0.545AsnLys: 0.545 ± 0.024	2.683AsnLeu: 2.683 ± 0.057	0.454AsnMet: 0.454 ± 0.025	0.619AsnAsn: 0.619 ± 0.031	1.691AsnPro: 1.691 ± 0.048	0.849AsnGln: 0.849 ± 0.032	2.053AsnArg: 2.053 ± 0.042	0.822AsnSer: 0.822 ± 0.032	1.0AsnThr: 1.0 ± 0.036	1.543AsnVal: 1.543 ± 0.047	0.32AsnTrp: 0.32 ± 0.02	0.542AsnTyr: 0.542 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.285ProAla: 6.285 ± 0.087	0.359ProCys: 0.359 ± 0.021	4.05ProAsp: 4.05 ± 0.074	6.519ProGlu: 6.519 ± 0.13	1.986ProPhe: 1.986 ± 0.05	5.934ProGly: 5.934 ± 0.087	1.228ProHis: 1.228 ± 0.046	1.65ProIle: 1.65 ± 0.046	1.169ProLys: 1.169 ± 0.039	5.32ProLeu: 5.32 ± 0.086	1.154ProMet: 1.154 ± 0.039	1.098ProAsn: 1.098 ± 0.036	2.855ProPro: 2.855 ± 0.066	1.565ProGln: 1.565 ± 0.045	3.621ProArg: 3.621 ± 0.069	2.324ProSer: 2.324 ± 0.056	2.303ProThr: 2.303 ± 0.048	4.869ProVal: 4.869 ± 0.091	0.827ProTrp: 0.827 ± 0.031	1.316ProTyr: 1.316 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.213GlnAla: 4.213 ± 0.082	0.216GlnCys: 0.216 ± 0.017	1.658GlnAsp: 1.658 ± 0.05	2.877GlnGlu: 2.877 ± 0.066	0.899GlnPhe: 0.899 ± 0.033	3.196GlnGly: 3.196 ± 0.063	0.597GlnHis: 0.597 ± 0.028	1.129GlnIle: 1.129 ± 0.041	0.834GlnLys: 0.834 ± 0.035	2.841GlnLeu: 2.841 ± 0.062	0.695GlnMet: 0.695 ± 0.03	0.681GlnAsn: 0.681 ± 0.029	1.768GlnPro: 1.768 ± 0.054	1.268GlnGln: 1.268 ± 0.049	2.772GlnArg: 2.772 ± 0.061	1.431GlnSer: 1.431 ± 0.042	1.338GlnThr: 1.338 ± 0.046	2.764GlnVal: 2.764 ± 0.068	0.535GlnTrp: 0.535 ± 0.026	0.688GlnTyr: 0.688 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	8.568ArgAla: 8.568 ± 0.124	0.58ArgCys: 0.58 ± 0.031	4.495ArgAsp: 4.495 ± 0.087	6.972ArgGlu: 6.972 ± 0.125	3.224ArgPhe: 3.224 ± 0.073	5.958ArgGly: 5.958 ± 0.081	1.96ArgHis: 1.96 ± 0.056	3.768ArgIle: 3.768 ± 0.069	2.092ArgLys: 2.092 ± 0.056	9.588ArgLeu: 9.588 ± 0.138	1.886ArgMet: 1.886 ± 0.051	1.746ArgAsn: 1.746 ± 0.044	4.227ArgPro: 4.227 ± 0.081	2.811ArgGln: 2.811 ± 0.066	6.845ArgArg: 6.845 ± 0.127	3.473ArgSer: 3.473 ± 0.07	3.65ArgThr: 3.65 ± 0.069	6.299ArgVal: 6.299 ± 0.095	1.298ArgTrp: 1.298 ± 0.041	2.286ArgTyr: 2.286 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.541SerAla: 4.541 ± 0.08	0.4SerCys: 0.4 ± 0.022	2.3SerAsp: 2.3 ± 0.06	2.835SerGlu: 2.835 ± 0.069	1.659SerPhe: 1.659 ± 0.053	5.302SerGly: 5.302 ± 0.085	0.964SerHis: 0.964 ± 0.037	1.604SerIle: 1.604 ± 0.048	1.009SerLys: 1.009 ± 0.037	4.958SerLeu: 4.958 ± 0.085	1.104SerMet: 1.104 ± 0.035	0.973SerAsn: 0.973 ± 0.03	2.78SerPro: 2.78 ± 0.061	1.381SerGln: 1.381 ± 0.047	3.4SerArg: 3.4 ± 0.063	2.133SerSer: 2.133 ± 0.057	2.006SerThr: 2.006 ± 0.056	3.014SerVal: 3.014 ± 0.068	0.666SerTrp: 0.666 ± 0.033	1.153SerTyr: 1.153 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.28ThrAla: 5.28 ± 0.085	0.362ThrCys: 0.362 ± 0.02	2.705ThrAsp: 2.705 ± 0.056	3.259ThrGlu: 3.259 ± 0.063	1.746ThrPhe: 1.746 ± 0.052	5.068ThrGly: 5.068 ± 0.09	1.009ThrHis: 1.009 ± 0.037	1.809ThrIle: 1.809 ± 0.046	0.969ThrLys: 0.969 ± 0.035	5.64ThrLeu: 5.64 ± 0.096	0.879ThrMet: 0.879 ± 0.032	1.049ThrAsn: 1.049 ± 0.042	2.892ThrPro: 2.892 ± 0.062	1.221ThrGln: 1.221 ± 0.042	3.286ThrArg: 3.286 ± 0.068	2.016ThrSer: 2.016 ± 0.055	2.347ThrThr: 2.347 ± 0.054	4.207ThrVal: 4.207 ± 0.083	0.644ThrTrp: 0.644 ± 0.029	1.257ThrTyr: 1.257 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	9.303ValAla: 9.303 ± 0.144	0.604ValCys: 0.604 ± 0.027	4.715ValAsp: 4.715 ± 0.083	5.934ValGlu: 5.934 ± 0.091	2.458ValPhe: 2.458 ± 0.052	6.433ValGly: 6.433 ± 0.09	1.668ValHis: 1.668 ± 0.04	2.795ValIle: 2.795 ± 0.065	1.581ValLys: 1.581 ± 0.049	8.313ValLeu: 8.313 ± 0.124	1.525ValMet: 1.525 ± 0.044	1.801ValAsn: 1.801 ± 0.051	4.134ValPro: 4.134 ± 0.076	2.199ValGln: 2.199 ± 0.057	6.068ValArg: 6.068 ± 0.092	3.523ValSer: 3.523 ± 0.069	4.287ValThr: 4.287 ± 0.088	6.989ValVal: 6.989 ± 0.131	0.895ValTrp: 0.895 ± 0.033	1.691ValTyr: 1.691 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.517TrpAla: 1.517 ± 0.044	0.129TrpCys: 0.129 ± 0.012	0.777TrpAsp: 0.777 ± 0.029	1.075TrpGlu: 1.075 ± 0.036	0.479TrpPhe: 0.479 ± 0.022	1.17TrpGly: 1.17 ± 0.041	0.289TrpHis: 0.289 ± 0.019	0.606TrpIle: 0.606 ± 0.027	0.358TrpLys: 0.358 ± 0.021	1.864TrpLeu: 1.864 ± 0.054	0.358TrpMet: 0.358 ± 0.024	0.328TrpAsn: 0.328 ± 0.02	0.69TrpPro: 0.69 ± 0.033	0.514TrpGln: 0.514 ± 0.028	1.237TrpArg: 1.237 ± 0.044	0.733TrpSer: 0.733 ± 0.03	0.669TrpThr: 0.669 ± 0.028	1.244TrpVal: 1.244 ± 0.043	0.282TrpTrp: 0.282 ± 0.019	0.354TrpTyr: 0.354 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.41TyrAla: 2.41 ± 0.05	0.221TyrCys: 0.221 ± 0.016	1.33TyrAsp: 1.33 ± 0.058	1.378TyrGlu: 1.378 ± 0.042	0.976TyrPhe: 0.976 ± 0.034	2.28TyrGly: 2.28 ± 0.049	0.609TyrHis: 0.609 ± 0.03	0.776TyrIle: 0.776 ± 0.032	0.572TyrLys: 0.572 ± 0.029	2.886TyrLeu: 2.886 ± 0.056	0.421TyrMet: 0.421 ± 0.023	0.674TyrAsn: 0.674 ± 0.03	1.407TyrPro: 1.407 ± 0.043	0.94TyrGln: 0.94 ± 0.032	2.316TyrArg: 2.316 ± 0.059	1.075TyrSer: 1.075 ± 0.043	1.231TyrThr: 1.231 ± 0.042	1.541TyrVal: 1.541 ± 0.05	0.423TyrTrp: 0.423 ± 0.026	0.743TyrTyr: 0.743 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2692 proteins (850307 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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