Amino acid dipepetide frequency for Thermus phage G20c (Thermus thermophilus phage G20c)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.218AlaAla: 8.218 ± 1.041
0.116AlaCys: 0.116 ± 0.1
4.591AlaAsp: 4.591 ± 0.444
7.061AlaGlu: 7.061 ± 1.08
4.784AlaPhe: 4.784 ± 0.434
5.17AlaGly: 5.17 ± 0.919
1.582AlaHis: 1.582 ± 0.251
4.206AlaIle: 4.206 ± 0.389
6.675AlaLys: 6.675 ± 0.992
12.81AlaLeu: 12.81 ± 1.206
2.315AlaMet: 2.315 ± 0.322
2.778AlaAsn: 2.778 ± 0.318
3.55AlaPro: 3.55 ± 0.405
3.82AlaGln: 3.82 ± 0.482
5.865AlaArg: 5.865 ± 0.627
5.826AlaSer: 5.826 ± 0.587
4.244AlaThr: 4.244 ± 0.345
6.636AlaVal: 6.636 ± 0.797
1.273AlaTrp: 1.273 ± 0.216
4.437AlaTyr: 4.437 ± 0.413
0.0AlaXaa: 0.0 ± 0.0
Cys
0.502CysAla: 0.502 ± 0.189
0.039CysCys: 0.039 ± 0.041
0.077CysAsp: 0.077 ± 0.063
0.231CysGlu: 0.231 ± 0.106
0.231CysPhe: 0.231 ± 0.101
0.386CysGly: 0.386 ± 0.147
0.077CysHis: 0.077 ± 0.05
0.116CysIle: 0.116 ± 0.07
0.116CysLys: 0.116 ± 0.067
0.309CysLeu: 0.309 ± 0.138
0.154CysMet: 0.154 ± 0.084
0.154CysAsn: 0.154 ± 0.086
0.463CysPro: 0.463 ± 0.175
0.116CysGln: 0.116 ± 0.067
0.193CysArg: 0.193 ± 0.091
0.193CysSer: 0.193 ± 0.11
0.193CysThr: 0.193 ± 0.09
0.347CysVal: 0.347 ± 0.157
0.116CysTrp: 0.116 ± 0.067
0.193CysTyr: 0.193 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
4.167AspAla: 4.167 ± 0.481
0.27AspCys: 0.27 ± 0.128
2.469AspAsp: 2.469 ± 0.478
4.244AspGlu: 4.244 ± 0.434
2.971AspPhe: 2.971 ± 0.386
4.784AspGly: 4.784 ± 0.7
0.772AspHis: 0.772 ± 0.241
1.891AspIle: 1.891 ± 0.261
2.508AspLys: 2.508 ± 0.347
7.601AspLeu: 7.601 ± 0.483
0.617AspMet: 0.617 ± 0.127
1.389AspAsn: 1.389 ± 0.225
3.434AspPro: 3.434 ± 0.398
1.659AspGln: 1.659 ± 0.221
3.009AspArg: 3.009 ± 0.331
1.929AspSer: 1.929 ± 0.395
2.778AspThr: 2.778 ± 0.268
2.701AspVal: 2.701 ± 0.41
1.003AspTrp: 1.003 ± 0.284
2.238AspTyr: 2.238 ± 0.347
0.0AspXaa: 0.0 ± 0.0
Glu
9.183GluAla: 9.183 ± 1.142
0.154GluCys: 0.154 ± 0.075
3.704GluAsp: 3.704 ± 0.366
7.91GluGlu: 7.91 ± 0.837
2.701GluPhe: 2.701 ± 0.359
4.977GluGly: 4.977 ± 0.601
1.235GluHis: 1.235 ± 0.27
2.894GluIle: 2.894 ± 0.316
2.701GluLys: 2.701 ± 0.63
10.495GluLeu: 10.495 ± 1.37
1.312GluMet: 1.312 ± 0.195
1.505GluAsn: 1.505 ± 0.209
3.087GluPro: 3.087 ± 0.535
2.122GluGln: 2.122 ± 0.41
5.672GluArg: 5.672 ± 0.855
3.087GluSer: 3.087 ± 0.375
2.739GluThr: 2.739 ± 0.278
7.639GluVal: 7.639 ± 0.547
0.887GluTrp: 0.887 ± 0.19
2.161GluTyr: 2.161 ± 0.268
0.0GluXaa: 0.0 ± 0.0
Phe
3.665PheAla: 3.665 ± 0.375
0.347PheCys: 0.347 ± 0.125
2.006PheAsp: 2.006 ± 0.366
1.659PheGlu: 1.659 ± 0.28
1.891PhePhe: 1.891 ± 0.339
3.202PheGly: 3.202 ± 0.324
0.849PheHis: 0.849 ± 0.227
1.312PheIle: 1.312 ± 0.306
2.083PheLys: 2.083 ± 0.265
4.36PheLeu: 4.36 ± 0.393
0.965PheMet: 0.965 ± 0.236
1.389PheAsn: 1.389 ± 0.258
1.929PhePro: 1.929 ± 0.401
1.466PheGln: 1.466 ± 0.304
2.431PheArg: 2.431 ± 0.248
3.087PheSer: 3.087 ± 0.426
2.354PheThr: 2.354 ± 0.306
3.241PheVal: 3.241 ± 0.48
0.386PheTrp: 0.386 ± 0.107
1.659PheTyr: 1.659 ± 0.37
0.0PheXaa: 0.0 ± 0.0
Gly
5.209GlyAla: 5.209 ± 0.574
0.116GlyCys: 0.116 ± 0.078
3.511GlyAsp: 3.511 ± 0.348
4.244GlyGlu: 4.244 ± 0.381
3.009GlyPhe: 3.009 ± 0.382
4.321GlyGly: 4.321 ± 0.453
1.196GlyHis: 1.196 ± 0.27
2.546GlyIle: 2.546 ± 0.329
3.858GlyLys: 3.858 ± 0.452
8.218GlyLeu: 8.218 ± 0.916
1.466GlyMet: 1.466 ± 0.251
2.392GlyAsn: 2.392 ± 0.326
2.546GlyPro: 2.546 ± 0.324
2.624GlyGln: 2.624 ± 0.29
3.743GlyArg: 3.743 ± 0.352
3.627GlySer: 3.627 ± 0.356
4.321GlyThr: 4.321 ± 0.376
6.096GlyVal: 6.096 ± 0.493
1.428GlyTrp: 1.428 ± 0.374
3.434GlyTyr: 3.434 ± 0.381
0.0GlyXaa: 0.0 ± 0.0
His
1.813HisAla: 1.813 ± 0.299
0.154HisCys: 0.154 ± 0.074
1.003HisAsp: 1.003 ± 0.232
0.733HisGlu: 0.733 ± 0.224
0.733HisPhe: 0.733 ± 0.246
1.08HisGly: 1.08 ± 0.228
0.231HisHis: 0.231 ± 0.132
0.424HisIle: 0.424 ± 0.13
0.502HisLys: 0.502 ± 0.149
2.199HisLeu: 2.199 ± 0.252
0.27HisMet: 0.27 ± 0.088
0.772HisAsn: 0.772 ± 0.216
1.35HisPro: 1.35 ± 0.305
0.463HisGln: 0.463 ± 0.106
1.312HisArg: 1.312 ± 0.266
0.386HisSer: 0.386 ± 0.138
0.579HisThr: 0.579 ± 0.143
1.736HisVal: 1.736 ± 0.434
0.193HisTrp: 0.193 ± 0.099
0.694HisTyr: 0.694 ± 0.162
0.0HisXaa: 0.0 ± 0.0
Ile
3.935IleAla: 3.935 ± 0.372
0.116IleCys: 0.116 ± 0.075
1.659IleAsp: 1.659 ± 0.357
2.585IleGlu: 2.585 ± 0.37
1.273IlePhe: 1.273 ± 0.28
2.585IleGly: 2.585 ± 0.303
0.617IleHis: 0.617 ± 0.179
1.273IleIle: 1.273 ± 0.201
2.045IleLys: 2.045 ± 0.271
4.398IleLeu: 4.398 ± 0.43
0.424IleMet: 0.424 ± 0.111
1.312IleAsn: 1.312 ± 0.321
2.122IlePro: 2.122 ± 0.457
1.428IleGln: 1.428 ± 0.222
2.431IleArg: 2.431 ± 0.266
2.354IleSer: 2.354 ± 0.447
1.813IleThr: 1.813 ± 0.207
2.276IleVal: 2.276 ± 0.338
0.463IleTrp: 0.463 ± 0.152
1.543IleTyr: 1.543 ± 0.281
0.0IleXaa: 0.0 ± 0.0
Lys
5.247LysAla: 5.247 ± 0.66
0.231LysCys: 0.231 ± 0.113
2.894LysAsp: 2.894 ± 0.446
4.861LysGlu: 4.861 ± 0.856
1.312LysPhe: 1.312 ± 0.222
3.511LysGly: 3.511 ± 0.404
0.694LysHis: 0.694 ± 0.142
1.119LysIle: 1.119 ± 0.254
1.775LysLys: 1.775 ± 0.335
6.366LysLeu: 6.366 ± 0.687
0.579LysMet: 0.579 ± 0.15
1.698LysAsn: 1.698 ± 0.282
3.202LysPro: 3.202 ± 0.357
1.62LysGln: 1.62 ± 0.317
4.36LysArg: 4.36 ± 0.451
1.891LysSer: 1.891 ± 0.254
2.431LysThr: 2.431 ± 0.226
4.939LysVal: 4.939 ± 0.555
0.424LysTrp: 0.424 ± 0.13
1.775LysTyr: 1.775 ± 0.321
0.0LysXaa: 0.0 ± 0.0
Leu
12.231LeuAla: 12.231 ± 1.096
0.347LeuCys: 0.347 ± 0.155
7.099LeuAsp: 7.099 ± 0.592
9.414LeuGlu: 9.414 ± 1.053
3.472LeuPhe: 3.472 ± 0.348
7.717LeuGly: 7.717 ± 0.898
2.045LeuHis: 2.045 ± 0.418
3.935LeuIle: 3.935 ± 0.526
7.524LeuLys: 7.524 ± 0.751
9.53LeuLeu: 9.53 ± 0.565
2.546LeuMet: 2.546 ± 0.269
4.283LeuAsn: 4.283 ± 0.55
6.675LeuPro: 6.675 ± 0.528
4.514LeuGln: 4.514 ± 0.505
6.945LeuArg: 6.945 ± 0.65
7.485LeuSer: 7.485 ± 0.696
6.328LeuThr: 6.328 ± 0.636
9.491LeuVal: 9.491 ± 0.664
1.235LeuTrp: 1.235 ± 0.278
4.321LeuTyr: 4.321 ± 0.467
0.0LeuXaa: 0.0 ± 0.0
Met
1.968MetAla: 1.968 ± 0.286
0.039MetCys: 0.039 ± 0.04
1.235MetAsp: 1.235 ± 0.21
1.736MetGlu: 1.736 ± 0.216
0.463MetPhe: 0.463 ± 0.125
1.389MetGly: 1.389 ± 0.189
0.386MetHis: 0.386 ± 0.141
0.424MetIle: 0.424 ± 0.119
0.54MetLys: 0.54 ± 0.144
1.698MetLeu: 1.698 ± 0.233
0.463MetMet: 0.463 ± 0.126
0.579MetAsn: 0.579 ± 0.138
1.157MetPro: 1.157 ± 0.241
0.579MetGln: 0.579 ± 0.145
1.582MetArg: 1.582 ± 0.341
1.042MetSer: 1.042 ± 0.208
1.119MetThr: 1.119 ± 0.226
1.312MetVal: 1.312 ± 0.238
0.27MetTrp: 0.27 ± 0.116
0.54MetTyr: 0.54 ± 0.156
0.0MetXaa: 0.0 ± 0.0
Asn
3.318AsnAla: 3.318 ± 0.422
0.193AsnCys: 0.193 ± 0.115
1.466AsnAsp: 1.466 ± 0.269
1.543AsnGlu: 1.543 ± 0.229
1.273AsnPhe: 1.273 ± 0.256
2.546AsnGly: 2.546 ± 0.467
0.733AsnHis: 0.733 ± 0.212
1.312AsnIle: 1.312 ± 0.213
1.119AsnLys: 1.119 ± 0.201
3.897AsnLeu: 3.897 ± 0.569
0.386AsnMet: 0.386 ± 0.142
0.81AsnAsn: 0.81 ± 0.168
2.469AsnPro: 2.469 ± 0.299
1.196AsnGln: 1.196 ± 0.242
2.354AsnArg: 2.354 ± 0.407
1.543AsnSer: 1.543 ± 0.385
1.968AsnThr: 1.968 ± 0.339
1.891AsnVal: 1.891 ± 0.332
0.502AsnTrp: 0.502 ± 0.141
1.042AsnTyr: 1.042 ± 0.263
0.0AsnXaa: 0.0 ± 0.0
Pro
3.164ProAla: 3.164 ± 0.375
0.154ProCys: 0.154 ± 0.081
3.665ProAsp: 3.665 ± 0.5
5.093ProGlu: 5.093 ± 0.534
2.585ProPhe: 2.585 ± 0.283
3.28ProGly: 3.28 ± 0.401
1.119ProHis: 1.119 ± 0.246
2.739ProIle: 2.739 ± 0.363
3.164ProLys: 3.164 ± 0.4
5.093ProLeu: 5.093 ± 0.68
0.733ProMet: 0.733 ± 0.223
1.813ProAsn: 1.813 ± 0.334
2.817ProPro: 2.817 ± 0.456
1.119ProGln: 1.119 ± 0.192
2.238ProArg: 2.238 ± 0.373
3.665ProSer: 3.665 ± 0.414
2.392ProThr: 2.392 ± 0.327
4.437ProVal: 4.437 ± 0.397
0.617ProTrp: 0.617 ± 0.207
2.122ProTyr: 2.122 ± 0.369
0.0ProXaa: 0.0 ± 0.0
Gln
5.363GlnAla: 5.363 ± 1.03
0.039GlnCys: 0.039 ± 0.037
1.659GlnAsp: 1.659 ± 0.278
2.546GlnGlu: 2.546 ± 0.584
1.042GlnPhe: 1.042 ± 0.166
3.125GlnGly: 3.125 ± 0.366
0.309GlnHis: 0.309 ± 0.102
1.35GlnIle: 1.35 ± 0.217
1.62GlnLys: 1.62 ± 0.267
3.009GlnLeu: 3.009 ± 0.363
0.579GlnMet: 0.579 ± 0.133
1.312GlnAsn: 1.312 ± 0.181
1.119GlnPro: 1.119 ± 0.309
0.965GlnGln: 0.965 ± 0.235
2.238GlnArg: 2.238 ± 0.373
1.891GlnSer: 1.891 ± 0.32
1.736GlnThr: 1.736 ± 0.259
3.357GlnVal: 3.357 ± 0.339
0.309GlnTrp: 0.309 ± 0.121
1.003GlnTyr: 1.003 ± 0.153
0.0GlnXaa: 0.0 ± 0.0
Arg
5.672ArgAla: 5.672 ± 0.692
0.193ArgCys: 0.193 ± 0.08
2.739ArgAsp: 2.739 ± 0.285
5.749ArgGlu: 5.749 ± 0.859
3.087ArgPhe: 3.087 ± 0.354
3.627ArgGly: 3.627 ± 0.472
1.08ArgHis: 1.08 ± 0.22
2.855ArgIle: 2.855 ± 0.286
3.588ArgLys: 3.588 ± 0.401
8.527ArgLeu: 8.527 ± 0.749
1.659ArgMet: 1.659 ± 0.266
1.543ArgAsn: 1.543 ± 0.223
2.932ArgPro: 2.932 ± 0.44
2.894ArgGln: 2.894 ± 0.47
5.132ArgArg: 5.132 ± 0.529
2.932ArgSer: 2.932 ± 0.365
2.701ArgThr: 2.701 ± 0.298
5.71ArgVal: 5.71 ± 0.345
0.81ArgTrp: 0.81 ± 0.221
2.894ArgTyr: 2.894 ± 0.321
0.0ArgXaa: 0.0 ± 0.0
Ser
5.093SerAla: 5.093 ± 0.477
0.386SerCys: 0.386 ± 0.164
2.469SerAsp: 2.469 ± 0.343
3.241SerGlu: 3.241 ± 0.349
2.315SerPhe: 2.315 ± 0.32
4.823SerGly: 4.823 ± 0.551
0.694SerHis: 0.694 ± 0.152
1.62SerIle: 1.62 ± 0.371
2.469SerLys: 2.469 ± 0.253
6.868SerLeu: 6.868 ± 0.622
1.003SerMet: 1.003 ± 0.194
1.543SerAsn: 1.543 ± 0.279
3.395SerPro: 3.395 ± 0.319
1.466SerGln: 1.466 ± 0.179
3.202SerArg: 3.202 ± 0.303
3.164SerSer: 3.164 ± 0.564
2.701SerThr: 2.701 ± 0.321
4.63SerVal: 4.63 ± 0.523
0.887SerTrp: 0.887 ± 0.21
2.392SerTyr: 2.392 ± 0.402
0.0SerXaa: 0.0 ± 0.0
Thr
4.206ThrAla: 4.206 ± 0.437
0.231ThrCys: 0.231 ± 0.122
2.431ThrAsp: 2.431 ± 0.296
2.817ThrGlu: 2.817 ± 0.341
2.122ThrPhe: 2.122 ± 0.404
3.55ThrGly: 3.55 ± 0.452
0.656ThrHis: 0.656 ± 0.21
2.354ThrIle: 2.354 ± 0.464
1.968ThrLys: 1.968 ± 0.246
5.787ThrLeu: 5.787 ± 0.402
0.772ThrMet: 0.772 ± 0.192
1.389ThrAsn: 1.389 ± 0.251
3.395ThrPro: 3.395 ± 0.453
1.389ThrGln: 1.389 ± 0.254
3.241ThrArg: 3.241 ± 0.411
2.739ThrSer: 2.739 ± 0.511
2.392ThrThr: 2.392 ± 0.41
3.82ThrVal: 3.82 ± 0.389
1.042ThrTrp: 1.042 ± 0.307
2.161ThrTyr: 2.161 ± 0.28
0.0ThrXaa: 0.0 ± 0.0
Val
7.485ValAla: 7.485 ± 0.815
0.54ValCys: 0.54 ± 0.183
4.09ValAsp: 4.09 ± 0.381
6.945ValGlu: 6.945 ± 0.426
3.125ValPhe: 3.125 ± 0.377
4.283ValGly: 4.283 ± 0.484
1.273ValHis: 1.273 ± 0.294
2.469ValIle: 2.469 ± 0.433
4.669ValLys: 4.669 ± 0.58
9.453ValLeu: 9.453 ± 0.717
1.389ValMet: 1.389 ± 0.236
2.971ValAsn: 2.971 ± 0.428
3.897ValPro: 3.897 ± 0.545
3.704ValGln: 3.704 ± 0.454
5.556ValArg: 5.556 ± 0.403
4.9ValSer: 4.9 ± 0.63
2.431ValThr: 2.431 ± 0.412
6.135ValVal: 6.135 ± 0.545
1.466ValTrp: 1.466 ± 0.363
3.82ValTyr: 3.82 ± 0.438
0.0ValXaa: 0.0 ± 0.0
Trp
1.119TrpAla: 1.119 ± 0.295
0.154TrpCys: 0.154 ± 0.078
0.81TrpAsp: 0.81 ± 0.239
1.196TrpGlu: 1.196 ± 0.215
0.54TrpPhe: 0.54 ± 0.189
0.656TrpGly: 0.656 ± 0.194
0.463TrpHis: 0.463 ± 0.173
0.386TrpIle: 0.386 ± 0.142
0.617TrpLys: 0.617 ± 0.183
1.62TrpLeu: 1.62 ± 0.362
0.27TrpMet: 0.27 ± 0.121
0.617TrpAsn: 0.617 ± 0.158
0.656TrpPro: 0.656 ± 0.154
0.347TrpGln: 0.347 ± 0.128
1.08TrpArg: 1.08 ± 0.228
0.849TrpSer: 0.849 ± 0.177
0.617TrpThr: 0.617 ± 0.203
1.119TrpVal: 1.119 ± 0.315
0.386TrpTrp: 0.386 ± 0.145
0.772TrpTyr: 0.772 ± 0.224
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.437TyrAla: 4.437 ± 0.458
0.386TyrCys: 0.386 ± 0.142
2.855TyrAsp: 2.855 ± 0.334
2.354TyrGlu: 2.354 ± 0.315
1.35TyrPhe: 1.35 ± 0.273
2.894TyrGly: 2.894 ± 0.418
0.617TyrHis: 0.617 ± 0.211
1.428TyrIle: 1.428 ± 0.285
1.389TyrLys: 1.389 ± 0.23
4.9TyrLeu: 4.9 ± 0.617
0.579TyrMet: 0.579 ± 0.147
1.312TyrAsn: 1.312 ± 0.22
1.813TyrPro: 1.813 ± 0.333
1.08TyrGln: 1.08 ± 0.185
3.743TyrArg: 3.743 ± 0.39
1.775TyrSer: 1.775 ± 0.253
2.624TyrThr: 2.624 ± 0.446
3.087TyrVal: 3.087 ± 0.44
0.579TyrTrp: 0.579 ± 0.146
1.813TyrTyr: 1.813 ± 0.317
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 111 proteins (25919 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski