Amino acid dipepetide frequency for Hubei toti-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.627AlaAla: 6.627 ± 0.909
0.663AlaCys: 0.663 ± 0.458
1.988AlaAsp: 1.988 ± 0.459
8.615AlaGlu: 8.615 ± 0.465
0.663AlaPhe: 0.663 ± 0.457
6.627AlaGly: 6.627 ± 1.836
1.325AlaHis: 1.325 ± 0.001
4.639AlaIle: 4.639 ± 0.453
3.313AlaLys: 3.313 ± 1.369
5.964AlaLeu: 5.964 ± 1.378
5.302AlaMet: 5.302 ± 1.825
2.651AlaAsn: 2.651 ± 0.002
1.325AlaPro: 1.325 ± 0.916
3.313AlaGln: 3.313 ± 1.369
2.651AlaArg: 2.651 ± 1.827
2.651AlaSer: 2.651 ± 0.912
5.302AlaThr: 5.302 ± 0.91
7.29AlaVal: 7.29 ± 1.379
1.988AlaTrp: 1.988 ± 0.459
3.313AlaTyr: 3.313 ± 0.454
0.0AlaXaa: 0.0 ± 0.0
Cys
0.663CysAla: 0.663 ± 0.458
0.0CysCys: 0.0 ± 0.0
1.325CysAsp: 1.325 ± 0.914
2.651CysGlu: 2.651 ± 1.827
0.663CysPhe: 0.663 ± 0.458
1.325CysGly: 1.325 ± 0.001
0.0CysHis: 0.0 ± 0.0
0.663CysIle: 0.663 ± 0.458
0.0CysLys: 0.0 ± 0.0
0.663CysLeu: 0.663 ± 0.457
1.325CysMet: 1.325 ± 0.001
1.325CysAsn: 1.325 ± 0.914
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.663CysArg: 0.663 ± 0.458
1.325CysSer: 1.325 ± 0.001
0.0CysThr: 0.0 ± 0.0
1.325CysVal: 1.325 ± 0.916
0.0CysTrp: 0.0 ± 0.0
0.663CysTyr: 0.663 ± 0.457
0.0CysXaa: 0.0 ± 0.0
Asp
1.988AspAla: 1.988 ± 0.456
1.325AspCys: 1.325 ± 0.001
3.313AspAsp: 3.313 ± 0.46
1.325AspGlu: 1.325 ± 0.001
3.313AspPhe: 3.313 ± 1.369
5.302AspGly: 5.302 ± 0.92
0.0AspHis: 0.0 ± 0.0
1.988AspIle: 1.988 ± 0.459
2.651AspLys: 2.651 ± 0.912
3.976AspLeu: 3.976 ± 0.919
2.651AspMet: 2.651 ± 0.33
0.663AspAsn: 0.663 ± 0.458
1.325AspPro: 1.325 ± 0.916
2.651AspGln: 2.651 ± 1.832
2.651AspArg: 2.651 ± 0.912
3.976AspSer: 3.976 ± 1.826
3.313AspThr: 3.313 ± 0.46
4.639AspVal: 4.639 ± 1.368
0.663AspTrp: 0.663 ± 0.458
1.988AspTyr: 1.988 ± 0.456
0.0AspXaa: 0.0 ± 0.0
Glu
8.615GluAla: 8.615 ± 0.465
0.0GluCys: 0.0 ± 0.0
3.313GluAsp: 3.313 ± 1.369
6.627GluGlu: 6.627 ± 0.909
5.302GluPhe: 5.302 ± 0.005
5.302GluGly: 5.302 ± 0.005
2.651GluHis: 2.651 ± 0.912
5.964GluIle: 5.964 ± 0.452
5.302GluLys: 5.302 ± 0.005
3.313GluLeu: 3.313 ± 0.454
2.651GluMet: 2.651 ± 0.002
1.988GluAsn: 1.988 ± 0.459
2.651GluPro: 2.651 ± 0.002
1.988GluGln: 1.988 ± 0.459
5.302GluArg: 5.302 ± 0.91
3.976GluSer: 3.976 ± 0.004
3.976GluThr: 3.976 ± 2.748
3.976GluVal: 3.976 ± 0.911
1.988GluTrp: 1.988 ± 0.456
3.976GluTyr: 3.976 ± 0.919
0.0GluXaa: 0.0 ± 0.0
Phe
1.988PheAla: 1.988 ± 0.456
0.0PheCys: 0.0 ± 0.0
3.313PheAsp: 3.313 ± 0.46
2.651PheGlu: 2.651 ± 1.827
0.663PhePhe: 0.663 ± 0.458
1.988PheGly: 1.988 ± 0.456
0.663PheHis: 0.663 ± 0.458
1.325PheIle: 1.325 ± 0.001
4.639PheLys: 4.639 ± 0.453
1.988PheLeu: 1.988 ± 0.456
1.325PheMet: 1.325 ± 0.001
0.663PheAsn: 0.663 ± 0.457
1.988PhePro: 1.988 ± 0.459
1.325PheGln: 1.325 ± 0.916
1.988PheArg: 1.988 ± 0.456
4.639PheSer: 4.639 ± 0.462
0.663PheThr: 0.663 ± 0.458
5.302PheVal: 5.302 ± 0.005
0.0PheTrp: 0.0 ± 0.0
1.988PheTyr: 1.988 ± 0.459
0.0PheXaa: 0.0 ± 0.0
Gly
2.651GlyAla: 2.651 ± 0.002
0.663GlyCys: 0.663 ± 0.458
1.988GlyAsp: 1.988 ± 0.456
7.29GlyGlu: 7.29 ± 0.464
2.651GlyPhe: 2.651 ± 1.832
3.313GlyGly: 3.313 ± 1.375
1.325GlyHis: 1.325 ± 0.916
5.302GlyIle: 5.302 ± 1.825
3.976GlyLys: 3.976 ± 0.004
4.639GlyLeu: 4.639 ± 2.291
2.651GlyMet: 2.651 ± 0.917
0.663GlyAsn: 0.663 ± 0.458
1.325GlyPro: 1.325 ± 0.001
0.663GlyGln: 0.663 ± 0.458
2.651GlyArg: 2.651 ± 0.912
3.313GlySer: 3.313 ± 0.46
3.976GlyThr: 3.976 ± 0.919
8.615GlyVal: 8.615 ± 0.465
1.325GlyTrp: 1.325 ± 0.001
3.313GlyTyr: 3.313 ± 0.46
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
1.325HisAsp: 1.325 ± 0.001
1.325HisGlu: 1.325 ± 0.001
0.0HisPhe: 0.0 ± 0.0
1.988HisGly: 1.988 ± 0.459
0.663HisHis: 0.663 ± 0.457
0.663HisIle: 0.663 ± 0.457
1.988HisLys: 1.988 ± 0.456
0.663HisLeu: 0.663 ± 0.458
0.0HisMet: 0.0 ± 0.0
2.651HisAsn: 2.651 ± 0.912
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
2.651HisArg: 2.651 ± 0.912
2.651HisSer: 2.651 ± 0.912
0.663HisThr: 0.663 ± 0.457
3.976HisVal: 3.976 ± 0.919
0.663HisTrp: 0.663 ± 0.458
1.325HisTyr: 1.325 ± 0.001
0.0HisXaa: 0.0 ± 0.0
Ile
5.302IleAla: 5.302 ± 0.005
0.663IleCys: 0.663 ± 0.457
2.651IleAsp: 2.651 ± 0.912
3.313IleGlu: 3.313 ± 0.46
1.988IlePhe: 1.988 ± 1.371
0.663IleGly: 0.663 ± 0.457
1.325IleHis: 1.325 ± 0.001
1.988IleIle: 1.988 ± 0.456
3.976IleLys: 3.976 ± 0.911
4.639IleLeu: 4.639 ± 0.462
1.325IleMet: 1.325 ± 0.001
5.964IleAsn: 5.964 ± 1.378
0.663IlePro: 0.663 ± 0.458
1.988IleGln: 1.988 ± 0.456
1.325IleArg: 1.325 ± 0.001
4.639IleSer: 4.639 ± 1.368
3.976IleThr: 3.976 ± 0.919
2.651IleVal: 2.651 ± 0.002
0.663IleTrp: 0.663 ± 0.457
3.313IleTyr: 3.313 ± 0.454
0.0IleXaa: 0.0 ± 0.0
Lys
3.976LysAla: 3.976 ± 0.911
1.325LysCys: 1.325 ± 0.001
1.325LysAsp: 1.325 ± 0.001
3.976LysGlu: 3.976 ± 0.919
2.651LysPhe: 2.651 ± 0.002
3.313LysGly: 3.313 ± 1.375
0.663LysHis: 0.663 ± 0.457
5.964LysIle: 5.964 ± 2.282
1.325LysLys: 1.325 ± 0.001
4.639LysLeu: 4.639 ± 1.377
3.976LysMet: 3.976 ± 0.911
1.325LysAsn: 1.325 ± 0.914
1.325LysPro: 1.325 ± 0.914
4.639LysGln: 4.639 ± 1.377
2.651LysArg: 2.651 ± 0.912
3.313LysSer: 3.313 ± 0.46
1.988LysThr: 1.988 ± 0.456
2.651LysVal: 2.651 ± 0.002
0.663LysTrp: 0.663 ± 0.457
3.976LysTyr: 3.976 ± 0.004
0.0LysXaa: 0.0 ± 0.0
Leu
5.302LeuAla: 5.302 ± 0.92
1.325LeuCys: 1.325 ± 0.001
5.302LeuAsp: 5.302 ± 0.005
5.964LeuGlu: 5.964 ± 1.378
2.651LeuPhe: 2.651 ± 0.002
2.651LeuGly: 2.651 ± 0.912
0.0LeuHis: 0.0 ± 0.0
3.313LeuIle: 3.313 ± 0.454
7.952LeuLys: 7.952 ± 0.007
6.627LeuLeu: 6.627 ± 0.909
1.988LeuMet: 1.988 ± 1.172
5.302LeuAsn: 5.302 ± 0.91
1.988LeuPro: 1.988 ± 0.459
1.325LeuGln: 1.325 ± 0.916
7.29LeuArg: 7.29 ± 1.379
5.302LeuSer: 5.302 ± 0.005
5.964LeuThr: 5.964 ± 1.378
4.639LeuVal: 4.639 ± 0.453
0.663LeuTrp: 0.663 ± 0.457
3.976LeuTyr: 3.976 ± 0.919
0.0LeuXaa: 0.0 ± 0.0
Met
1.988MetAla: 1.988 ± 0.459
0.663MetCys: 0.663 ± 0.458
2.651MetAsp: 2.651 ± 1.832
0.663MetGlu: 0.663 ± 0.458
1.325MetPhe: 1.325 ± 0.914
1.325MetGly: 1.325 ± 0.916
0.663MetHis: 0.663 ± 0.457
0.663MetIle: 0.663 ± 0.457
1.325MetLys: 1.325 ± 0.001
1.988MetLeu: 1.988 ± 0.459
0.663MetMet: 0.663 ± 0.458
0.663MetAsn: 0.663 ± 0.457
3.313MetPro: 3.313 ± 1.375
1.325MetGln: 1.325 ± 0.001
3.976MetArg: 3.976 ± 1.826
2.651MetSer: 2.651 ± 0.912
3.976MetThr: 3.976 ± 0.919
1.988MetVal: 1.988 ± 0.459
0.663MetTrp: 0.663 ± 0.457
1.988MetTyr: 1.988 ± 1.371
0.0MetXaa: 0.0 ± 0.0
Asn
1.988AsnAla: 1.988 ± 0.456
0.0AsnCys: 0.0 ± 0.0
0.663AsnAsp: 0.663 ± 0.458
1.325AsnGlu: 1.325 ± 0.001
1.988AsnPhe: 1.988 ± 0.456
3.313AsnGly: 3.313 ± 0.454
1.988AsnHis: 1.988 ± 0.459
2.651AsnIle: 2.651 ± 0.002
3.313AsnLys: 3.313 ± 0.454
2.651AsnLeu: 2.651 ± 1.832
0.663AsnMet: 0.663 ± 0.458
2.651AsnAsn: 2.651 ± 0.912
1.325AsnPro: 1.325 ± 0.001
0.663AsnGln: 0.663 ± 0.458
3.313AsnArg: 3.313 ± 0.46
1.325AsnSer: 1.325 ± 0.001
3.313AsnThr: 3.313 ± 0.454
4.639AsnVal: 4.639 ± 0.453
1.325AsnTrp: 1.325 ± 0.001
1.325AsnTyr: 1.325 ± 0.001
0.0AsnXaa: 0.0 ± 0.0
Pro
3.313ProAla: 3.313 ± 0.46
0.0ProCys: 0.0 ± 0.0
0.663ProAsp: 0.663 ± 0.458
4.639ProGlu: 4.639 ± 0.462
1.325ProPhe: 1.325 ± 0.001
3.313ProGly: 3.313 ± 0.46
0.663ProHis: 0.663 ± 0.458
3.313ProIle: 3.313 ± 0.46
0.663ProLys: 0.663 ± 0.458
2.651ProLeu: 2.651 ± 0.002
1.325ProMet: 1.325 ± 0.916
1.988ProAsn: 1.988 ± 0.459
1.325ProPro: 1.325 ± 0.916
1.325ProGln: 1.325 ± 0.001
1.988ProArg: 1.988 ± 0.456
1.325ProSer: 1.325 ± 0.001
1.325ProThr: 1.325 ± 0.001
1.988ProVal: 1.988 ± 0.459
0.0ProTrp: 0.0 ± 0.0
1.325ProTyr: 1.325 ± 0.001
0.0ProXaa: 0.0 ± 0.0
Gln
3.976GlnAla: 3.976 ± 0.911
0.663GlnCys: 0.663 ± 0.458
0.663GlnAsp: 0.663 ± 0.458
3.313GlnGlu: 3.313 ± 0.46
1.325GlnPhe: 1.325 ± 0.916
1.325GlnGly: 1.325 ± 0.916
1.988GlnHis: 1.988 ± 0.459
2.651GlnIle: 2.651 ± 1.832
0.663GlnLys: 0.663 ± 0.458
1.988GlnLeu: 1.988 ± 0.456
0.663GlnMet: 0.663 ± 0.458
0.663GlnAsn: 0.663 ± 0.458
0.663GlnPro: 0.663 ± 0.457
0.663GlnGln: 0.663 ± 0.458
1.988GlnArg: 1.988 ± 0.456
1.325GlnSer: 1.325 ± 0.916
1.325GlnThr: 1.325 ± 0.916
1.988GlnVal: 1.988 ± 0.459
0.663GlnTrp: 0.663 ± 0.458
3.313GlnTyr: 3.313 ± 1.369
0.0GlnXaa: 0.0 ± 0.0
Arg
7.952ArgAla: 7.952 ± 2.737
3.976ArgCys: 3.976 ± 1.826
0.663ArgAsp: 0.663 ± 0.458
5.302ArgGlu: 5.302 ± 2.74
3.976ArgPhe: 3.976 ± 0.919
5.302ArgGly: 5.302 ± 0.005
1.325ArgHis: 1.325 ± 0.001
0.0ArgIle: 0.0 ± 0.0
3.976ArgLys: 3.976 ± 0.919
8.615ArgLeu: 8.615 ± 0.45
3.313ArgMet: 3.313 ± 1.369
0.663ArgAsn: 0.663 ± 0.458
1.325ArgPro: 1.325 ± 0.914
1.325ArgGln: 1.325 ± 0.914
3.313ArgArg: 3.313 ± 2.284
2.651ArgSer: 2.651 ± 0.002
2.651ArgThr: 2.651 ± 0.002
3.976ArgVal: 3.976 ± 1.826
0.663ArgTrp: 0.663 ± 0.457
3.313ArgTyr: 3.313 ± 1.369
0.0ArgXaa: 0.0 ± 0.0
Ser
5.302SerAla: 5.302 ± 0.92
0.0SerCys: 0.0 ± 0.0
3.313SerAsp: 3.313 ± 0.46
5.302SerGlu: 5.302 ± 0.92
1.988SerPhe: 1.988 ± 1.374
1.988SerGly: 1.988 ± 1.371
1.988SerHis: 1.988 ± 0.456
2.651SerIle: 2.651 ± 0.002
1.988SerLys: 1.988 ± 0.456
6.627SerLeu: 6.627 ± 0.006
1.988SerMet: 1.988 ± 0.456
2.651SerAsn: 2.651 ± 0.917
2.651SerPro: 2.651 ± 0.002
1.988SerGln: 1.988 ± 1.371
5.964SerArg: 5.964 ± 0.452
5.964SerSer: 5.964 ± 1.378
7.29SerThr: 7.29 ± 2.294
5.302SerVal: 5.302 ± 3.655
0.663SerTrp: 0.663 ± 0.458
0.663SerTyr: 0.663 ± 0.458
0.0SerXaa: 0.0 ± 0.0
Thr
5.302ThrAla: 5.302 ± 0.005
0.663ThrCys: 0.663 ± 0.457
2.651ThrAsp: 2.651 ± 1.832
5.964ThrGlu: 5.964 ± 1.378
1.325ThrPhe: 1.325 ± 0.914
5.302ThrGly: 5.302 ± 3.664
1.325ThrHis: 1.325 ± 0.001
2.651ThrIle: 2.651 ± 0.917
1.988ThrLys: 1.988 ± 0.459
5.964ThrLeu: 5.964 ± 1.367
0.663ThrMet: 0.663 ± 0.458
1.325ThrAsn: 1.325 ± 0.914
2.651ThrPro: 2.651 ± 0.917
1.325ThrGln: 1.325 ± 0.916
7.29ThrArg: 7.29 ± 2.281
2.651ThrSer: 2.651 ± 0.917
3.313ThrThr: 3.313 ± 0.454
2.651ThrVal: 2.651 ± 0.917
1.325ThrTrp: 1.325 ± 0.001
0.663ThrTyr: 0.663 ± 0.458
0.0ThrXaa: 0.0 ± 0.0
Val
4.639ValAla: 4.639 ± 1.368
1.325ValCys: 1.325 ± 0.001
5.964ValAsp: 5.964 ± 3.197
5.302ValGlu: 5.302 ± 0.005
3.313ValPhe: 3.313 ± 0.454
3.976ValGly: 3.976 ± 0.911
4.639ValHis: 4.639 ± 2.283
3.313ValIle: 3.313 ± 0.454
3.313ValLys: 3.313 ± 0.46
5.964ValLeu: 5.964 ± 0.452
0.663ValMet: 0.663 ± 0.458
4.639ValAsn: 4.639 ± 2.291
4.639ValPro: 4.639 ± 0.453
3.313ValGln: 3.313 ± 1.375
2.651ValArg: 2.651 ± 0.002
7.29ValSer: 7.29 ± 0.464
3.313ValThr: 3.313 ± 1.369
3.313ValVal: 3.313 ± 0.454
3.313ValTrp: 3.313 ± 2.29
1.325ValTyr: 1.325 ± 0.001
0.0ValXaa: 0.0 ± 0.0
Trp
1.988TrpAla: 1.988 ± 0.456
0.0TrpCys: 0.0 ± 0.0
1.325TrpAsp: 1.325 ± 0.914
1.325TrpGlu: 1.325 ± 0.914
0.0TrpPhe: 0.0 ± 0.0
1.325TrpGly: 1.325 ± 0.916
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.663TrpLys: 0.663 ± 0.458
3.313TrpLeu: 3.313 ± 0.46
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
1.325TrpPro: 1.325 ± 0.916
0.663TrpGln: 0.663 ± 0.458
0.663TrpArg: 0.663 ± 0.457
2.651TrpSer: 2.651 ± 1.832
0.0TrpThr: 0.0 ± 0.0
1.988TrpVal: 1.988 ± 0.456
0.663TrpTrp: 0.663 ± 0.458
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.651TyrAla: 2.651 ± 1.832
1.325TyrCys: 1.325 ± 0.914
5.302TyrAsp: 5.302 ± 0.005
1.988TyrGlu: 1.988 ± 0.456
1.988TyrPhe: 1.988 ± 0.456
2.651TyrGly: 2.651 ± 0.002
0.0TyrHis: 0.0 ± 0.0
3.313TyrIle: 3.313 ± 0.454
2.651TyrLys: 2.651 ± 0.912
3.313TyrLeu: 3.313 ± 0.454
0.663TyrMet: 0.663 ± 0.458
1.988TyrAsn: 1.988 ± 0.456
2.651TyrPro: 2.651 ± 0.917
1.325TyrGln: 1.325 ± 0.916
3.313TyrArg: 3.313 ± 1.369
2.651TyrSer: 2.651 ± 0.002
0.663TyrThr: 0.663 ± 0.457
3.313TyrVal: 3.313 ± 0.454
0.0TyrTrp: 0.0 ± 0.0
3.313TyrTyr: 3.313 ± 0.46
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1510 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski