Amino acid dipepetide frequency for Wobbly possum disease virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.83AlaAla: 7.83 ± 1.247
2.457AlaCys: 2.457 ± 0.765
2.303AlaAsp: 2.303 ± 0.632
2.303AlaGlu: 2.303 ± 0.637
3.531AlaPhe: 3.531 ± 1.179
4.913AlaGly: 4.913 ± 0.892
1.842AlaHis: 1.842 ± 1.2
3.992AlaIle: 3.992 ± 0.993
3.378AlaLys: 3.378 ± 1.002
9.366AlaLeu: 9.366 ± 1.143
1.382AlaMet: 1.382 ± 0.368
2.61AlaAsn: 2.61 ± 1.08
5.067AlaPro: 5.067 ± 0.732
2.303AlaGln: 2.303 ± 0.467
5.067AlaArg: 5.067 ± 1.643
7.063AlaSer: 7.063 ± 0.971
7.83AlaThr: 7.83 ± 1.166
8.598AlaVal: 8.598 ± 1.923
0.614AlaTrp: 0.614 ± 0.248
3.531AlaTyr: 3.531 ± 0.747
0.0AlaXaa: 0.0 ± 0.0
Cys
3.531CysAla: 3.531 ± 0.644
0.307CysCys: 0.307 ± 0.555
1.075CysAsp: 1.075 ± 0.406
0.614CysGlu: 0.614 ± 0.244
1.689CysPhe: 1.689 ± 0.571
3.531CysGly: 3.531 ± 0.97
0.921CysHis: 0.921 ± 0.662
1.075CysIle: 1.075 ± 0.89
0.307CysLys: 0.307 ± 0.434
2.61CysLeu: 2.61 ± 1.358
0.614CysMet: 0.614 ± 0.37
1.382CysAsn: 1.382 ± 0.786
0.921CysPro: 0.921 ± 0.371
0.461CysGln: 0.461 ± 0.361
1.689CysArg: 1.689 ± 0.566
2.15CysSer: 2.15 ± 0.997
0.768CysThr: 0.768 ± 0.778
2.61CysVal: 2.61 ± 0.605
0.614CysTrp: 0.614 ± 0.49
1.842CysTyr: 1.842 ± 0.668
0.0CysXaa: 0.0 ± 0.0
Asp
2.15AspAla: 2.15 ± 0.708
1.382AspCys: 1.382 ± 0.574
1.382AspAsp: 1.382 ± 0.574
2.61AspGlu: 2.61 ± 0.525
2.457AspPhe: 2.457 ± 0.36
4.146AspGly: 4.146 ± 1.194
1.228AspHis: 1.228 ± 0.397
2.457AspIle: 2.457 ± 0.766
1.382AspLys: 1.382 ± 0.412
5.067AspLeu: 5.067 ± 0.716
1.075AspMet: 1.075 ± 0.397
1.075AspAsn: 1.075 ± 0.397
2.15AspPro: 2.15 ± 0.587
1.382AspGln: 1.382 ± 0.516
2.61AspArg: 2.61 ± 0.613
2.15AspSer: 2.15 ± 0.53
3.685AspThr: 3.685 ± 1.779
2.917AspVal: 2.917 ± 1.046
0.768AspTrp: 0.768 ± 0.277
2.15AspTyr: 2.15 ± 0.795
0.0AspXaa: 0.0 ± 0.0
Glu
4.606GluAla: 4.606 ± 1.133
0.614GluCys: 0.614 ± 0.248
0.768GluAsp: 0.768 ± 0.359
1.535GluGlu: 1.535 ± 0.528
0.768GluPhe: 0.768 ± 0.332
2.917GluGly: 2.917 ± 1.067
0.921GluHis: 0.921 ± 0.378
3.378GluIle: 3.378 ± 0.697
1.382GluLys: 1.382 ± 0.501
2.917GluLeu: 2.917 ± 0.714
0.614GluMet: 0.614 ± 0.261
0.921GluAsn: 0.921 ± 0.337
1.689GluPro: 1.689 ± 0.47
1.842GluGln: 1.842 ± 0.477
1.075GluArg: 1.075 ± 0.738
1.842GluSer: 1.842 ± 0.529
2.457GluThr: 2.457 ± 0.613
2.917GluVal: 2.917 ± 0.633
0.461GluTrp: 0.461 ± 0.397
1.228GluTyr: 1.228 ± 0.441
0.0GluXaa: 0.0 ± 0.0
Phe
4.913PheAla: 4.913 ± 1.094
0.768PheCys: 0.768 ± 0.574
1.996PheAsp: 1.996 ± 0.766
1.382PheGlu: 1.382 ± 0.347
2.303PhePhe: 2.303 ± 0.466
2.61PheGly: 2.61 ± 0.808
0.768PheHis: 0.768 ± 0.277
2.457PheIle: 2.457 ± 0.888
1.842PheLys: 1.842 ± 0.64
3.224PheLeu: 3.224 ± 0.646
1.382PheMet: 1.382 ± 0.516
2.764PheAsn: 2.764 ± 0.792
1.996PhePro: 1.996 ± 0.717
0.921PheGln: 0.921 ± 0.553
1.228PheArg: 1.228 ± 0.854
3.378PheSer: 3.378 ± 1.098
2.61PheThr: 2.61 ± 0.743
3.685PheVal: 3.685 ± 0.696
0.461PheTrp: 0.461 ± 0.362
1.382PheTyr: 1.382 ± 0.486
0.0PheXaa: 0.0 ± 0.0
Gly
3.685GlyAla: 3.685 ± 1.336
2.303GlyCys: 2.303 ± 0.541
3.378GlyAsp: 3.378 ± 0.652
1.689GlyGlu: 1.689 ± 0.539
3.071GlyPhe: 3.071 ± 0.614
3.685GlyGly: 3.685 ± 1.344
1.842GlyHis: 1.842 ± 0.561
2.457GlyIle: 2.457 ± 1.048
4.146GlyLys: 4.146 ± 1.487
6.602GlyLeu: 6.602 ± 0.949
1.535GlyMet: 1.535 ± 0.482
2.15GlyAsn: 2.15 ± 0.759
4.146GlyPro: 4.146 ± 0.924
1.382GlyGln: 1.382 ± 0.347
2.303GlyArg: 2.303 ± 1.595
5.834GlySer: 5.834 ± 1.268
5.374GlyThr: 5.374 ± 1.301
8.138GlyVal: 8.138 ± 0.916
1.535GlyTrp: 1.535 ± 0.619
4.299GlyTyr: 4.299 ± 0.786
0.0GlyXaa: 0.0 ± 0.0
His
1.228HisAla: 1.228 ± 0.882
1.228HisCys: 1.228 ± 0.393
0.768HisAsp: 0.768 ± 0.282
0.768HisGlu: 0.768 ± 0.473
1.842HisPhe: 1.842 ± 1.207
1.228HisGly: 1.228 ± 0.986
0.614HisHis: 0.614 ± 0.321
1.382HisIle: 1.382 ± 0.565
1.075HisLys: 1.075 ± 0.468
1.842HisLeu: 1.842 ± 0.665
0.461HisMet: 0.461 ± 0.167
1.382HisAsn: 1.382 ± 0.887
1.689HisPro: 1.689 ± 0.872
0.768HisGln: 0.768 ± 1.001
1.075HisArg: 1.075 ± 0.517
1.996HisSer: 1.996 ± 0.375
1.996HisThr: 1.996 ± 1.591
3.378HisVal: 3.378 ± 0.506
0.768HisTrp: 0.768 ± 0.928
1.535HisTyr: 1.535 ± 0.358
0.0HisXaa: 0.0 ± 0.0
Ile
3.224IleAla: 3.224 ± 2.076
1.382IleCys: 1.382 ± 0.417
1.996IleAsp: 1.996 ± 0.49
1.842IleGlu: 1.842 ± 0.529
2.61IlePhe: 2.61 ± 0.846
4.299IleGly: 4.299 ± 1.248
1.535IleHis: 1.535 ± 0.872
1.842IleIle: 1.842 ± 1.843
2.15IleLys: 2.15 ± 0.359
3.224IleLeu: 3.224 ± 0.676
1.382IleMet: 1.382 ± 0.601
2.15IleAsn: 2.15 ± 0.71
1.689IlePro: 1.689 ± 0.509
1.535IleGln: 1.535 ± 0.426
1.228IleArg: 1.228 ± 0.93
4.299IleSer: 4.299 ± 0.466
4.299IleThr: 4.299 ± 1.962
5.067IleVal: 5.067 ± 0.998
0.614IleTrp: 0.614 ± 0.516
1.382IleTyr: 1.382 ± 0.409
0.0IleXaa: 0.0 ± 0.0
Lys
3.992LysAla: 3.992 ± 1.249
0.921LysCys: 0.921 ± 0.27
3.071LysAsp: 3.071 ± 0.921
0.921LysGlu: 0.921 ± 0.334
0.921LysPhe: 0.921 ± 0.424
1.996LysGly: 1.996 ± 0.485
1.689LysHis: 1.689 ± 0.686
1.075LysIle: 1.075 ± 0.299
2.15LysLys: 2.15 ± 0.866
6.142LysLeu: 6.142 ± 0.801
0.921LysMet: 0.921 ± 0.666
1.996LysAsn: 1.996 ± 0.717
1.996LysPro: 1.996 ± 0.478
1.382LysGln: 1.382 ± 0.476
2.917LysArg: 2.917 ± 0.922
1.996LysSer: 1.996 ± 0.398
1.075LysThr: 1.075 ± 0.355
1.996LysVal: 1.996 ± 0.485
0.461LysTrp: 0.461 ± 0.536
1.535LysTyr: 1.535 ± 0.453
0.0LysXaa: 0.0 ± 0.0
Leu
10.287LeuAla: 10.287 ± 1.347
2.303LeuCys: 2.303 ± 1.062
4.146LeuAsp: 4.146 ± 0.768
1.535LeuGlu: 1.535 ± 0.586
2.303LeuPhe: 2.303 ± 0.466
4.913LeuGly: 4.913 ± 1.004
2.764LeuHis: 2.764 ± 1.076
2.61LeuIle: 2.61 ± 1.383
4.453LeuLys: 4.453 ± 0.973
7.677LeuLeu: 7.677 ± 2.739
3.071LeuMet: 3.071 ± 0.891
5.374LeuAsn: 5.374 ± 1.117
7.984LeuPro: 7.984 ± 1.898
2.303LeuGln: 2.303 ± 0.346
4.606LeuArg: 4.606 ± 1.623
7.83LeuSer: 7.83 ± 1.137
7.063LeuThr: 7.063 ± 2.177
6.142LeuVal: 6.142 ± 1.058
1.689LeuTrp: 1.689 ± 0.606
2.764LeuTyr: 2.764 ± 2.23
0.0LeuXaa: 0.0 ± 0.0
Met
2.457MetAla: 2.457 ± 1.181
0.614MetCys: 0.614 ± 0.244
1.228MetAsp: 1.228 ± 0.441
0.921MetGlu: 0.921 ± 0.525
0.921MetPhe: 0.921 ± 0.367
0.614MetGly: 0.614 ± 0.248
0.461MetHis: 0.461 ± 0.167
2.15MetIle: 2.15 ± 0.791
0.921MetLys: 0.921 ± 0.486
2.764MetLeu: 2.764 ± 1.527
0.307MetMet: 0.307 ± 0.124
0.461MetAsn: 0.461 ± 0.167
2.457MetPro: 2.457 ± 0.525
0.154MetGln: 0.154 ± 0.584
1.228MetArg: 1.228 ± 0.806
1.535MetSer: 1.535 ± 0.614
1.535MetThr: 1.535 ± 0.35
1.842MetVal: 1.842 ± 0.671
0.0MetTrp: 0.0 ± 0.0
0.461MetTyr: 0.461 ± 0.336
0.0MetXaa: 0.0 ± 0.0
Asn
2.764AsnAla: 2.764 ± 0.794
1.075AsnCys: 1.075 ± 0.891
1.689AsnAsp: 1.689 ± 0.747
1.689AsnGlu: 1.689 ± 0.449
1.382AsnPhe: 1.382 ± 0.41
4.913AsnGly: 4.913 ± 0.829
0.461AsnHis: 0.461 ± 0.397
1.996AsnIle: 1.996 ± 0.424
0.768AsnLys: 0.768 ± 0.336
2.917AsnLeu: 2.917 ± 0.861
0.921AsnMet: 0.921 ± 0.371
1.382AsnAsn: 1.382 ± 0.342
1.842AsnPro: 1.842 ± 0.442
0.768AsnGln: 0.768 ± 0.422
1.996AsnArg: 1.996 ± 0.717
2.303AsnSer: 2.303 ± 0.574
2.15AsnThr: 2.15 ± 0.656
2.764AsnVal: 2.764 ± 0.911
0.461AsnTrp: 0.461 ± 0.277
2.457AsnTyr: 2.457 ± 0.735
0.0AsnXaa: 0.0 ± 0.0
Pro
5.988ProAla: 5.988 ± 1.485
1.382ProCys: 1.382 ± 0.618
3.224ProAsp: 3.224 ± 0.713
3.531ProGlu: 3.531 ± 0.746
2.15ProPhe: 2.15 ± 0.628
4.453ProGly: 4.453 ± 1.037
1.689ProHis: 1.689 ± 0.747
2.61ProIle: 2.61 ± 0.733
1.382ProLys: 1.382 ± 0.501
4.299ProLeu: 4.299 ± 1.129
1.075ProMet: 1.075 ± 0.791
0.921ProAsn: 0.921 ± 0.488
4.606ProPro: 4.606 ± 0.87
2.303ProGln: 2.303 ± 0.703
4.146ProArg: 4.146 ± 0.922
4.146ProSer: 4.146 ± 1.086
5.067ProThr: 5.067 ± 0.871
12.13ProVal: 12.13 ± 2.498
0.921ProTrp: 0.921 ± 0.599
1.382ProTyr: 1.382 ± 0.501
0.0ProXaa: 0.0 ± 0.0
Gln
1.689GlnAla: 1.689 ± 0.45
1.228GlnCys: 1.228 ± 0.495
1.535GlnAsp: 1.535 ± 0.407
1.842GlnGlu: 1.842 ± 0.668
1.075GlnPhe: 1.075 ± 0.339
1.075GlnGly: 1.075 ± 0.483
0.461GlnHis: 0.461 ± 0.167
1.228GlnIle: 1.228 ± 0.642
0.921GlnLys: 0.921 ± 0.371
1.996GlnLeu: 1.996 ± 0.551
0.307GlnMet: 0.307 ± 0.124
0.614GlnAsn: 0.614 ± 0.664
1.535GlnPro: 1.535 ± 0.402
0.307GlnGln: 0.307 ± 0.642
2.303GlnArg: 2.303 ± 1.104
1.075GlnSer: 1.075 ± 0.549
1.689GlnThr: 1.689 ± 0.511
0.921GlnVal: 0.921 ± 0.331
0.614GlnTrp: 0.614 ± 0.587
1.382GlnTyr: 1.382 ± 1.091
0.0GlnXaa: 0.0 ± 0.0
Arg
4.299ArgAla: 4.299 ± 0.913
1.228ArgCys: 1.228 ± 0.563
2.303ArgAsp: 2.303 ± 0.835
1.689ArgGlu: 1.689 ± 0.485
2.61ArgPhe: 2.61 ± 0.695
2.15ArgGly: 2.15 ± 0.588
0.768ArgHis: 0.768 ± 0.726
3.071ArgIle: 3.071 ± 0.563
2.303ArgLys: 2.303 ± 0.584
4.606ArgLeu: 4.606 ± 1.415
1.075ArgMet: 1.075 ± 1.064
1.075ArgAsn: 1.075 ± 1.33
3.071ArgPro: 3.071 ± 0.532
1.228ArgGln: 1.228 ± 1.035
2.303ArgArg: 2.303 ± 1.633
2.917ArgSer: 2.917 ± 2.121
3.992ArgThr: 3.992 ± 0.589
5.374ArgVal: 5.374 ± 1.589
0.461ArgTrp: 0.461 ± 0.425
2.917ArgTyr: 2.917 ± 0.645
0.0ArgXaa: 0.0 ± 0.0
Ser
7.063SerAla: 7.063 ± 1.034
2.457SerCys: 2.457 ± 0.638
1.996SerAsp: 1.996 ± 0.501
1.996SerGlu: 1.996 ± 0.497
3.378SerPhe: 3.378 ± 0.84
6.449SerGly: 6.449 ± 1.073
1.842SerHis: 1.842 ± 1.408
2.764SerIle: 2.764 ± 0.837
2.303SerLys: 2.303 ± 1.01
5.834SerLeu: 5.834 ± 1.475
1.842SerMet: 1.842 ± 0.667
3.685SerAsn: 3.685 ± 0.842
6.295SerPro: 6.295 ± 1.233
0.921SerGln: 0.921 ± 0.367
3.838SerArg: 3.838 ± 0.832
5.681SerSer: 5.681 ± 1.715
4.76SerThr: 4.76 ± 0.584
5.067SerVal: 5.067 ± 0.932
1.075SerTrp: 1.075 ± 0.327
2.457SerTyr: 2.457 ± 1.162
0.0SerXaa: 0.0 ± 0.0
Thr
4.606ThrAla: 4.606 ± 0.54
2.764ThrCys: 2.764 ± 0.689
3.071ThrAsp: 3.071 ± 0.639
2.457ThrGlu: 2.457 ± 0.646
2.917ThrPhe: 2.917 ± 0.625
7.216ThrGly: 7.216 ± 1.37
3.071ThrHis: 3.071 ± 1.536
4.453ThrIle: 4.453 ± 0.84
2.303ThrLys: 2.303 ± 0.508
6.756ThrLeu: 6.756 ± 3.284
1.535ThrMet: 1.535 ± 0.692
2.15ThrAsn: 2.15 ± 0.866
5.527ThrPro: 5.527 ± 0.786
1.382ThrGln: 1.382 ± 0.347
2.917ThrArg: 2.917 ± 0.933
5.067ThrSer: 5.067 ± 2.934
3.531ThrThr: 3.531 ± 0.768
5.374ThrVal: 5.374 ± 1.286
0.461ThrTrp: 0.461 ± 0.397
2.61ThrTyr: 2.61 ± 1.368
0.0ThrXaa: 0.0 ± 0.0
Val
7.984ValAla: 7.984 ± 2.196
1.996ValCys: 1.996 ± 1.018
4.913ValAsp: 4.913 ± 1.207
4.606ValGlu: 4.606 ± 0.828
5.067ValPhe: 5.067 ± 1.219
5.527ValGly: 5.527 ± 1.325
1.842ValHis: 1.842 ± 0.664
4.606ValIle: 4.606 ± 0.9
3.685ValLys: 3.685 ± 1.137
8.905ValLeu: 8.905 ± 0.842
1.535ValMet: 1.535 ± 0.391
2.61ValAsn: 2.61 ± 0.705
9.212ValPro: 9.212 ± 2.149
1.535ValGln: 1.535 ± 0.426
4.453ValArg: 4.453 ± 1.333
5.374ValSer: 5.374 ± 1.094
7.83ValThr: 7.83 ± 1.036
9.673ValVal: 9.673 ± 2.815
0.614ValTrp: 0.614 ± 0.244
2.303ValTyr: 2.303 ± 1.669
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.768TrpCys: 0.768 ± 0.516
0.921TrpAsp: 0.921 ± 0.462
0.154TrpGlu: 0.154 ± 0.098
0.614TrpPhe: 0.614 ± 0.321
0.307TrpGly: 0.307 ± 0.658
0.154TrpHis: 0.154 ± 0.582
0.154TrpIle: 0.154 ± 0.321
0.921TrpLys: 0.921 ± 0.313
2.303TrpLeu: 2.303 ± 0.608
0.154TrpMet: 0.154 ± 0.098
1.075TrpAsn: 1.075 ± 0.339
1.228TrpPro: 1.228 ± 0.673
0.0TrpGln: 0.0 ± 0.0
0.307TrpArg: 0.307 ± 0.303
1.689TrpSer: 1.689 ± 0.618
0.307TrpThr: 0.307 ± 0.124
1.382TrpVal: 1.382 ± 0.514
0.0TrpTrp: 0.0 ± 0.0
0.307TrpTyr: 0.307 ± 0.124
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.838TyrAla: 3.838 ± 1.304
1.535TyrCys: 1.535 ± 0.619
2.457TyrAsp: 2.457 ± 0.912
0.768TyrGlu: 0.768 ± 0.284
0.461TyrPhe: 0.461 ± 0.167
2.61TyrGly: 2.61 ± 1.146
2.15TyrHis: 2.15 ± 1.145
1.996TyrIle: 1.996 ± 0.791
1.382TyrLys: 1.382 ± 0.342
2.764TyrLeu: 2.764 ± 1.411
1.689TyrMet: 1.689 ± 1.104
0.921TyrAsn: 0.921 ± 0.313
2.303TyrPro: 2.303 ± 0.645
0.921TyrGln: 0.921 ± 0.445
2.15TyrArg: 2.15 ± 0.613
3.378TyrSer: 3.378 ± 0.644
2.15TyrThr: 2.15 ± 1.417
4.299TyrVal: 4.299 ± 0.88
0.154TyrTrp: 0.154 ± 0.582
1.689TyrTyr: 1.689 ± 0.798
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (6514 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski