Amino acid dipepetide frequency for Oscillibacter sp. 1-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.468AlaAla: 13.468 ± 0.15	1.521AlaCys: 1.521 ± 0.041	5.456AlaAsp: 5.456 ± 0.072	7.55AlaGlu: 7.55 ± 0.095	3.377AlaPhe: 3.377 ± 0.062	8.462AlaGly: 8.462 ± 0.107	1.456AlaHis: 1.456 ± 0.032	4.457AlaIle: 4.457 ± 0.067	3.979AlaLys: 3.979 ± 0.072	10.374AlaLeu: 10.374 ± 0.123	2.703AlaMet: 2.703 ± 0.05	2.423AlaAsn: 2.423 ± 0.052	3.772AlaPro: 3.772 ± 0.069	3.395AlaGln: 3.395 ± 0.056	5.111AlaArg: 5.111 ± 0.079	4.539AlaSer: 4.539 ± 0.076	3.272AlaThr: 3.272 ± 0.066	8.491AlaVal: 8.491 ± 0.091	0.978AlaTrp: 0.978 ± 0.027	2.854AlaTyr: 2.854 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.618CysAla: 1.618 ± 0.038	0.387CysCys: 0.387 ± 0.019	0.849CysAsp: 0.849 ± 0.031	0.856CysGlu: 0.856 ± 0.028	0.675CysPhe: 0.675 ± 0.024	1.967CysGly: 1.967 ± 0.042	0.332CysHis: 0.332 ± 0.016	0.799CysIle: 0.799 ± 0.026	0.595CysLys: 0.595 ± 0.022	1.492CysLeu: 1.492 ± 0.041	0.4CysMet: 0.4 ± 0.018	0.427CysAsn: 0.427 ± 0.02	0.858CysPro: 0.858 ± 0.027	0.535CysGln: 0.535 ± 0.022	1.271CysArg: 1.271 ± 0.035	0.889CysSer: 0.889 ± 0.027	0.838CysThr: 0.838 ± 0.026	1.238CysVal: 1.238 ± 0.036	0.19CysTrp: 0.19 ± 0.013	0.532CysTyr: 0.532 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.941AspAla: 4.941 ± 0.065	0.986AspCys: 0.986 ± 0.031	2.48AspAsp: 2.48 ± 0.048	3.578AspGlu: 3.578 ± 0.062	2.513AspPhe: 2.513 ± 0.047	5.283AspGly: 5.283 ± 0.082	0.96AspHis: 0.96 ± 0.026	3.348AspIle: 3.348 ± 0.057	2.167AspLys: 2.167 ± 0.049	5.088AspLeu: 5.088 ± 0.071	1.579AspMet: 1.579 ± 0.04	1.58AspAsn: 1.58 ± 0.041	2.531AspPro: 2.531 ± 0.054	1.604AspGln: 1.604 ± 0.04	3.257AspArg: 3.257 ± 0.058	2.973AspSer: 2.973 ± 0.054	3.097AspThr: 3.097 ± 0.056	3.531AspVal: 3.531 ± 0.064	0.754AspTrp: 0.754 ± 0.025	2.321AspTyr: 2.321 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.859GluAla: 6.859 ± 0.098	0.788GluCys: 0.788 ± 0.024	3.932GluAsp: 3.932 ± 0.062	5.887GluGlu: 5.887 ± 0.092	2.175GluPhe: 2.175 ± 0.047	4.494GluGly: 4.494 ± 0.056	1.246GluHis: 1.246 ± 0.039	4.437GluIle: 4.437 ± 0.063	4.254GluLys: 4.254 ± 0.067	6.894GluLeu: 6.894 ± 0.084	1.985GluMet: 1.985 ± 0.045	3.178GluAsn: 3.178 ± 0.053	2.455GluPro: 2.455 ± 0.048	3.008GluGln: 3.008 ± 0.059	4.817GluArg: 4.817 ± 0.079	3.134GluSer: 3.134 ± 0.056	4.043GluThr: 4.043 ± 0.059	3.927GluVal: 3.927 ± 0.066	0.697GluTrp: 0.697 ± 0.027	2.343GluTyr: 2.343 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.316PheAla: 3.316 ± 0.059	0.829PheCys: 0.829 ± 0.025	2.266PheAsp: 2.266 ± 0.048	2.049PheGlu: 2.049 ± 0.039	1.654PhePhe: 1.654 ± 0.039	2.87PheGly: 2.87 ± 0.052	0.774PheHis: 0.774 ± 0.025	1.94PheIle: 1.94 ± 0.045	1.283PheLys: 1.283 ± 0.035	4.01PheLeu: 4.01 ± 0.072	0.801PheMet: 0.801 ± 0.029	1.165PheAsn: 1.165 ± 0.033	1.64PhePro: 1.64 ± 0.039	1.487PheGln: 1.487 ± 0.037	2.193PheArg: 2.193 ± 0.037	2.772PheSer: 2.772 ± 0.056	2.403PheThr: 2.403 ± 0.054	2.294PheVal: 2.294 ± 0.05	0.474PheTrp: 0.474 ± 0.021	1.405PheTyr: 1.405 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.911GlyAla: 6.911 ± 0.091	1.441GlyCys: 1.441 ± 0.038	3.985GlyAsp: 3.985 ± 0.059	5.306GlyGlu: 5.306 ± 0.061	2.988GlyPhe: 2.988 ± 0.051	7.051GlyGly: 7.051 ± 0.107	1.426GlyHis: 1.426 ± 0.035	4.691GlyIle: 4.691 ± 0.066	4.261GlyLys: 4.261 ± 0.061	7.132GlyLeu: 7.132 ± 0.088	2.387GlyMet: 2.387 ± 0.046	2.505GlyAsn: 2.505 ± 0.054	2.18GlyPro: 2.18 ± 0.051	2.684GlyGln: 2.684 ± 0.052	4.929GlyArg: 4.929 ± 0.073	4.339GlySer: 4.339 ± 0.075	4.887GlyThr: 4.887 ± 0.096	5.872GlyVal: 5.872 ± 0.074	0.986GlyTrp: 0.986 ± 0.03	3.178GlyTyr: 3.178 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.334HisAla: 1.334 ± 0.036	0.322HisCys: 0.322 ± 0.017	0.882HisAsp: 0.882 ± 0.031	0.962HisGlu: 0.962 ± 0.032	0.767HisPhe: 0.767 ± 0.025	1.415HisGly: 1.415 ± 0.036	0.405HisHis: 0.405 ± 0.024	1.203HisIle: 1.203 ± 0.034	0.659HisLys: 0.659 ± 0.025	1.649HisLeu: 1.649 ± 0.037	0.492HisMet: 0.492 ± 0.02	0.592HisAsn: 0.592 ± 0.023	0.999HisPro: 0.999 ± 0.028	0.569HisGln: 0.569 ± 0.024	1.061HisArg: 1.061 ± 0.028	0.984HisSer: 0.984 ± 0.031	1.074HisThr: 1.074 ± 0.031	1.101HisVal: 1.101 ± 0.033	0.209HisTrp: 0.209 ± 0.013	0.705HisTyr: 0.705 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.194IleAla: 5.194 ± 0.063	1.022IleCys: 1.022 ± 0.031	2.998IleAsp: 2.998 ± 0.059	3.133IleGlu: 3.133 ± 0.06	2.099IlePhe: 2.099 ± 0.052	4.03IleGly: 4.03 ± 0.066	1.079IleHis: 1.079 ± 0.035	2.981IleIle: 2.981 ± 0.062	2.179IleLys: 2.179 ± 0.053	5.595IleLeu: 5.595 ± 0.078	1.245IleMet: 1.245 ± 0.029	1.762IleAsn: 1.762 ± 0.041	2.917IlePro: 2.917 ± 0.053	2.071IleGln: 2.071 ± 0.041	3.523IleArg: 3.523 ± 0.054	3.608IleSer: 3.608 ± 0.059	3.498IleThr: 3.498 ± 0.059	3.65IleVal: 3.65 ± 0.057	0.567IleTrp: 0.567 ± 0.021	1.823IleTyr: 1.823 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.172LysAla: 4.172 ± 0.07	0.542LysCys: 0.542 ± 0.022	2.413LysAsp: 2.413 ± 0.055	3.31LysGlu: 3.31 ± 0.055	1.262LysPhe: 1.262 ± 0.034	3.063LysGly: 3.063 ± 0.05	0.669LysHis: 0.669 ± 0.027	2.747LysIle: 2.747 ± 0.053	3.233LysLys: 3.233 ± 0.059	4.192LysLeu: 4.192 ± 0.057	1.372LysMet: 1.372 ± 0.037	1.967LysAsn: 1.967 ± 0.042	1.9LysPro: 1.9 ± 0.041	1.602LysGln: 1.602 ± 0.04	2.979LysArg: 2.979 ± 0.057	2.346LysSer: 2.346 ± 0.046	2.906LysThr: 2.906 ± 0.061	2.784LysVal: 2.784 ± 0.058	0.487LysTrp: 0.487 ± 0.02	1.689LysTyr: 1.689 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	9.513LeuAla: 9.513 ± 0.106	2.052LeuCys: 2.052 ± 0.042	5.756LeuAsp: 5.756 ± 0.067	6.993LeuGlu: 6.993 ± 0.077	3.7LeuPhe: 3.7 ± 0.066	6.736LeuGly: 6.736 ± 0.09	1.638LeuHis: 1.638 ± 0.036	4.706LeuIle: 4.706 ± 0.071	4.188LeuLys: 4.188 ± 0.065	10.422LeuLeu: 10.422 ± 0.159	2.513LeuMet: 2.513 ± 0.051	3.182LeuAsn: 3.182 ± 0.051	4.917LeuPro: 4.917 ± 0.07	2.902LeuGln: 2.902 ± 0.052	6.662LeuArg: 6.662 ± 0.098	6.603LeuSer: 6.603 ± 0.082	6.318LeuThr: 6.318 ± 0.088	5.631LeuVal: 5.631 ± 0.076	1.089LeuTrp: 1.089 ± 0.033	3.228LeuTyr: 3.228 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.757MetAla: 2.757 ± 0.051	0.338MetCys: 0.338 ± 0.017	1.775MetAsp: 1.775 ± 0.045	2.35MetGlu: 2.35 ± 0.047	0.773MetPhe: 0.773 ± 0.028	2.077MetGly: 2.077 ± 0.044	0.32MetHis: 0.32 ± 0.019	1.35MetIle: 1.35 ± 0.033	1.736MetLys: 1.736 ± 0.035	2.514MetLeu: 2.514 ± 0.047	0.774MetMet: 0.774 ± 0.029	1.112MetAsn: 1.112 ± 0.03	1.152MetPro: 1.152 ± 0.03	0.786MetGln: 0.786 ± 0.024	1.506MetArg: 1.506 ± 0.03	1.568MetSer: 1.568 ± 0.038	1.63MetThr: 1.63 ± 0.041	1.668MetVal: 1.668 ± 0.039	0.216MetTrp: 0.216 ± 0.016	0.639MetTyr: 0.639 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.889AsnAla: 2.889 ± 0.044	0.558AsnCys: 0.558 ± 0.022	1.536AsnAsp: 1.536 ± 0.042	1.809AsnGlu: 1.809 ± 0.042	1.21AsnPhe: 1.21 ± 0.031	3.084AsnGly: 3.084 ± 0.071	0.663AsnHis: 0.663 ± 0.023	2.233AsnIle: 2.233 ± 0.043	1.242AsnLys: 1.242 ± 0.034	3.174AsnLeu: 3.174 ± 0.049	0.888AsnMet: 0.888 ± 0.027	1.085AsnAsn: 1.085 ± 0.039	1.87AsnPro: 1.87 ± 0.042	1.113AsnGln: 1.113 ± 0.034	2.018AsnArg: 2.018 ± 0.044	1.708AsnSer: 1.708 ± 0.042	1.943AsnThr: 1.943 ± 0.043	2.172AsnVal: 2.172 ± 0.044	0.41AsnTrp: 0.41 ± 0.018	1.244AsnTyr: 1.244 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.835ProAla: 4.835 ± 0.075	0.606ProCys: 0.606 ± 0.023	2.849ProAsp: 2.849 ± 0.054	4.335ProGlu: 4.335 ± 0.068	1.529ProPhe: 1.529 ± 0.03	3.507ProGly: 3.507 ± 0.063	0.738ProHis: 0.738 ± 0.023	1.973ProIle: 1.973 ± 0.039	1.724ProLys: 1.724 ± 0.043	3.757ProLeu: 3.757 ± 0.054	1.053ProMet: 1.053 ± 0.028	1.287ProAsn: 1.287 ± 0.039	1.917ProPro: 1.917 ± 0.055	1.519ProGln: 1.519 ± 0.038	1.979ProArg: 1.979 ± 0.044	2.199ProSer: 2.199 ± 0.047	1.876ProThr: 1.876 ± 0.046	3.41ProVal: 3.41 ± 0.057	0.471ProTrp: 0.471 ± 0.021	1.467ProTyr: 1.467 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.539GlnAla: 3.539 ± 0.052	0.425GlnCys: 0.425 ± 0.021	1.701GlnAsp: 1.701 ± 0.036	2.728GlnGlu: 2.728 ± 0.054	1.203GlnPhe: 1.203 ± 0.032	2.39GlnGly: 2.39 ± 0.048	0.551GlnHis: 0.551 ± 0.024	2.157GlnIle: 2.157 ± 0.04	1.948GlnLys: 1.948 ± 0.042	3.196GlnLeu: 3.196 ± 0.049	1.117GlnMet: 1.117 ± 0.031	1.329GlnAsn: 1.329 ± 0.036	1.296GlnPro: 1.296 ± 0.034	1.373GlnGln: 1.373 ± 0.038	2.303GlnArg: 2.303 ± 0.05	1.877GlnSer: 1.877 ± 0.038	2.022GlnThr: 2.022 ± 0.045	2.21GlnVal: 2.21 ± 0.048	0.413GlnTrp: 0.413 ± 0.017	1.329GlnTyr: 1.329 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.137ArgAla: 5.137 ± 0.074	0.992ArgCys: 0.992 ± 0.033	3.249ArgAsp: 3.249 ± 0.059	5.173ArgGlu: 5.173 ± 0.08	2.393ArgPhe: 2.393 ± 0.046	3.941ArgGly: 3.941 ± 0.066	1.136ArgHis: 1.136 ± 0.033	3.312ArgIle: 3.312 ± 0.053	3.031ArgLys: 3.031 ± 0.059	6.195ArgLeu: 6.195 ± 0.087	1.833ArgMet: 1.833 ± 0.036	1.959ArgAsn: 1.959 ± 0.043	2.565ArgPro: 2.565 ± 0.051	2.918ArgGln: 2.918 ± 0.06	5.036ArgArg: 5.036 ± 0.097	3.137ArgSer: 3.137 ± 0.052	3.178ArgThr: 3.178 ± 0.047	3.575ArgVal: 3.575 ± 0.06	0.786ArgTrp: 0.786 ± 0.028	2.373ArgTyr: 2.373 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.613SerAla: 5.613 ± 0.082	0.89SerCys: 0.89 ± 0.028	2.679SerAsp: 2.679 ± 0.052	3.249SerGlu: 3.249 ± 0.048	2.43SerPhe: 2.43 ± 0.049	5.657SerGly: 5.657 ± 0.098	0.989SerHis: 0.989 ± 0.027	3.11SerIle: 3.11 ± 0.047	2.175SerLys: 2.175 ± 0.045	5.411SerLeu: 5.411 ± 0.074	1.513SerMet: 1.513 ± 0.036	1.669SerAsn: 1.669 ± 0.042	2.334SerPro: 2.334 ± 0.047	1.908SerGln: 1.908 ± 0.04	3.459SerArg: 3.459 ± 0.054	3.183SerSer: 3.183 ± 0.057	2.731SerThr: 2.731 ± 0.053	4.145SerVal: 4.145 ± 0.059	0.676SerTrp: 0.676 ± 0.023	1.949SerTyr: 1.949 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.475ThrAla: 6.475 ± 0.096	0.732ThrCys: 0.732 ± 0.03	2.98ThrAsp: 2.98 ± 0.058	3.575ThrGlu: 3.575 ± 0.06	2.094ThrPhe: 2.094 ± 0.047	5.072ThrGly: 5.072 ± 0.087	0.956ThrHis: 0.956 ± 0.028	3.102ThrIle: 3.102 ± 0.073	1.968ThrLys: 1.968 ± 0.043	5.721ThrLeu: 5.721 ± 0.079	1.47ThrMet: 1.47 ± 0.036	1.572ThrAsn: 1.572 ± 0.044	2.886ThrPro: 2.886 ± 0.053	1.648ThrGln: 1.648 ± 0.045	2.639ThrArg: 2.639 ± 0.047	2.612ThrSer: 2.612 ± 0.062	2.722ThrThr: 2.722 ± 0.062	5.357ThrVal: 5.357 ± 0.093	0.634ThrTrp: 0.634 ± 0.028	1.886ThrTyr: 1.886 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.977ValAla: 4.977 ± 0.074	1.435ValCys: 1.435 ± 0.035	3.851ValAsp: 3.851 ± 0.057	4.605ValGlu: 4.605 ± 0.064	2.874ValPhe: 2.874 ± 0.047	4.374ValGly: 4.374 ± 0.059	1.097ValHis: 1.097 ± 0.028	3.957ValIle: 3.957 ± 0.064	3.116ValLys: 3.116 ± 0.049	7.328ValLeu: 7.328 ± 0.097	1.837ValMet: 1.837 ± 0.042	2.29ValAsn: 2.29 ± 0.048	3.121ValPro: 3.121 ± 0.049	2.111ValGln: 2.111 ± 0.043	4.152ValArg: 4.152 ± 0.064	4.8ValSer: 4.8 ± 0.066	4.751ValThr: 4.751 ± 0.101	4.749ValVal: 4.749 ± 0.081	0.801ValTrp: 0.801 ± 0.023	2.377ValTyr: 2.377 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.921TrpAla: 0.921 ± 0.031	0.202TrpCys: 0.202 ± 0.014	0.697TrpAsp: 0.697 ± 0.024	0.885TrpGlu: 0.885 ± 0.027	0.468TrpPhe: 0.468 ± 0.021	0.832TrpGly: 0.832 ± 0.028	0.201TrpHis: 0.201 ± 0.011	0.547TrpIle: 0.547 ± 0.022	0.571TrpLys: 0.571 ± 0.022	1.188TrpLeu: 1.188 ± 0.037	0.283TrpMet: 0.283 ± 0.015	0.514TrpAsn: 0.514 ± 0.021	0.355TrpPro: 0.355 ± 0.018	0.478TrpGln: 0.478 ± 0.022	0.755TrpArg: 0.755 ± 0.027	0.627TrpSer: 0.627 ± 0.024	0.616TrpThr: 0.616 ± 0.025	0.639TrpVal: 0.639 ± 0.022	0.14TrpTrp: 0.14 ± 0.011	0.464TrpTyr: 0.464 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.17TyrAla: 3.17 ± 0.049	0.681TyrCys: 0.681 ± 0.024	2.237TyrAsp: 2.237 ± 0.048	2.223TyrGlu: 2.223 ± 0.047	1.442TyrPhe: 1.442 ± 0.035	2.834TyrGly: 2.834 ± 0.046	0.745TyrHis: 0.745 ± 0.026	1.924TyrIle: 1.924 ± 0.043	1.325TyrLys: 1.325 ± 0.036	3.415TyrLeu: 3.415 ± 0.061	0.797TyrMet: 0.797 ± 0.026	1.25TyrAsn: 1.25 ± 0.032	1.366TyrPro: 1.366 ± 0.035	1.394TyrGln: 1.394 ± 0.034	2.272TyrArg: 2.272 ± 0.043	1.872TyrSer: 1.872 ± 0.036	2.293TyrThr: 2.293 ± 0.053	2.161TyrVal: 2.161 ± 0.047	0.404TyrTrp: 0.404 ± 0.018	1.377TyrTyr: 1.377 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4209 proteins (1246555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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