Amino acid dipepetide frequency for Human papillomavirus type 18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.913AlaAla: 4.913 ± 0.684
1.134AlaCys: 1.134 ± 0.852
3.779AlaAsp: 3.779 ± 0.819
2.646AlaGlu: 2.646 ± 0.733
3.779AlaPhe: 3.779 ± 1.368
5.291AlaGly: 5.291 ± 1.075
0.756AlaHis: 0.756 ± 0.405
3.779AlaIle: 3.779 ± 0.986
3.023AlaLys: 3.023 ± 1.0
3.401AlaLeu: 3.401 ± 1.402
1.512AlaMet: 1.512 ± 0.414
0.756AlaAsn: 0.756 ± 0.389
3.023AlaPro: 3.023 ± 1.399
2.646AlaGln: 2.646 ± 1.276
4.157AlaArg: 4.157 ± 1.461
2.646AlaSer: 2.646 ± 1.294
7.181AlaThr: 7.181 ± 1.141
1.89AlaVal: 1.89 ± 0.809
0.756AlaTrp: 0.756 ± 0.616
1.89AlaTyr: 1.89 ± 0.832
0.0AlaXaa: 0.0 ± 0.0
Cys
2.268CysAla: 2.268 ± 1.015
1.134CysCys: 1.134 ± 0.835
0.0CysAsp: 0.0 ± 0.0
1.89CysGlu: 1.89 ± 0.751
1.512CysPhe: 1.512 ± 1.073
2.646CysGly: 2.646 ± 0.806
1.512CysHis: 1.512 ± 1.212
0.756CysIle: 0.756 ± 0.595
2.646CysLys: 2.646 ± 0.676
2.646CysLeu: 2.646 ± 0.723
1.89CysMet: 1.89 ± 1.103
1.134CysAsn: 1.134 ± 0.534
1.89CysPro: 1.89 ± 0.667
1.512CysGln: 1.512 ± 0.791
0.0CysArg: 0.0 ± 0.0
2.268CysSer: 2.268 ± 0.953
1.512CysThr: 1.512 ± 0.677
1.89CysVal: 1.89 ± 0.856
0.756CysTrp: 0.756 ± 0.361
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.268AspAla: 2.268 ± 0.816
1.512AspCys: 1.512 ± 0.533
3.401AspAsp: 3.401 ± 0.621
1.89AspGlu: 1.89 ± 1.204
1.512AspPhe: 1.512 ± 0.477
3.023AspGly: 3.023 ± 0.788
1.134AspHis: 1.134 ± 0.667
4.913AspIle: 4.913 ± 1.966
3.023AspLys: 3.023 ± 0.955
5.669AspLeu: 5.669 ± 1.568
1.512AspMet: 1.512 ± 0.403
3.401AspAsn: 3.401 ± 0.725
3.779AspPro: 3.779 ± 1.235
0.378AspGln: 0.378 ± 0.357
1.134AspArg: 1.134 ± 0.443
6.425AspSer: 6.425 ± 1.243
7.937AspThr: 7.937 ± 1.97
2.646AspVal: 2.646 ± 1.21
1.512AspTrp: 1.512 ± 0.533
1.134AspTyr: 1.134 ± 1.07
0.0AspXaa: 0.0 ± 0.0
Glu
1.134GluAla: 1.134 ± 0.715
0.378GluCys: 0.378 ± 0.332
3.401GluAsp: 3.401 ± 0.605
3.401GluGlu: 3.401 ± 0.954
1.89GluPhe: 1.89 ± 0.646
3.023GluGly: 3.023 ± 1.575
1.134GluHis: 1.134 ± 0.386
2.646GluIle: 2.646 ± 0.946
3.401GluLys: 3.401 ± 1.508
3.779GluLeu: 3.779 ± 1.321
0.378GluMet: 0.378 ± 0.28
2.646GluAsn: 2.646 ± 0.97
2.646GluPro: 2.646 ± 1.272
1.134GluGln: 1.134 ± 0.546
1.512GluArg: 1.512 ± 0.682
1.512GluSer: 1.512 ± 0.677
2.646GluThr: 2.646 ± 0.653
3.779GluVal: 3.779 ± 0.813
0.378GluTrp: 0.378 ± 0.28
1.134GluTyr: 1.134 ± 0.276
0.0GluXaa: 0.0 ± 0.0
Phe
2.646PheAla: 2.646 ± 0.913
2.268PheCys: 2.268 ± 1.487
3.023PheAsp: 3.023 ± 1.302
2.268PheGlu: 2.268 ± 1.142
1.89PhePhe: 1.89 ± 0.575
2.268PheGly: 2.268 ± 0.816
0.756PheHis: 0.756 ± 0.534
2.646PheIle: 2.646 ± 1.166
3.401PheLys: 3.401 ± 0.897
5.291PheLeu: 5.291 ± 0.862
0.378PheMet: 0.378 ± 0.382
0.378PheAsn: 0.378 ± 0.357
1.134PhePro: 1.134 ± 0.539
0.756PheGln: 0.756 ± 0.542
1.134PheArg: 1.134 ± 0.661
2.268PheSer: 2.268 ± 0.931
2.268PheThr: 2.268 ± 1.228
3.023PheVal: 3.023 ± 0.782
1.134PheTrp: 1.134 ± 0.661
2.268PheTyr: 2.268 ± 0.513
0.0PheXaa: 0.0 ± 0.0
Gly
3.779GlyAla: 3.779 ± 0.848
1.134GlyCys: 1.134 ± 0.539
3.779GlyAsp: 3.779 ± 1.274
2.268GlyGlu: 2.268 ± 0.705
1.134GlyPhe: 1.134 ± 0.718
4.157GlyGly: 4.157 ± 1.009
2.268GlyHis: 2.268 ± 1.118
3.023GlyIle: 3.023 ± 1.205
0.756GlyLys: 0.756 ± 0.559
4.157GlyLeu: 4.157 ± 0.774
0.756GlyMet: 0.756 ± 0.361
6.803GlyAsn: 6.803 ± 1.75
3.779GlyPro: 3.779 ± 1.135
3.401GlyGln: 3.401 ± 0.466
1.512GlyArg: 1.512 ± 0.764
2.646GlySer: 2.646 ± 0.848
9.826GlyThr: 9.826 ± 3.639
2.646GlyVal: 2.646 ± 1.351
0.378GlyTrp: 0.378 ± 0.28
2.646GlyTyr: 2.646 ± 0.736
0.0GlyXaa: 0.0 ± 0.0
His
1.89HisAla: 1.89 ± 0.863
1.89HisCys: 1.89 ± 1.062
0.756HisAsp: 0.756 ± 0.615
0.756HisGlu: 0.756 ± 0.525
2.268HisPhe: 2.268 ± 0.47
2.268HisGly: 2.268 ± 0.848
0.0HisHis: 0.0 ± 0.0
1.134HisIle: 1.134 ± 0.527
1.512HisLys: 1.512 ± 0.511
2.646HisLeu: 2.646 ± 1.263
0.0HisMet: 0.0 ± 0.0
1.512HisAsn: 1.512 ± 0.791
1.134HisPro: 1.134 ± 0.661
0.756HisGln: 0.756 ± 0.558
2.268HisArg: 2.268 ± 0.881
2.646HisSer: 2.646 ± 0.99
1.134HisThr: 1.134 ± 0.608
1.512HisVal: 1.512 ± 0.627
1.134HisTrp: 1.134 ± 0.494
3.401HisTyr: 3.401 ± 0.859
0.0HisXaa: 0.0 ± 0.0
Ile
1.512IleAla: 1.512 ± 0.666
1.512IleCys: 1.512 ± 1.426
3.779IleAsp: 3.779 ± 1.622
3.401IleGlu: 3.401 ± 1.491
2.646IlePhe: 2.646 ± 0.784
2.268IleGly: 2.268 ± 1.146
2.646IleHis: 2.646 ± 0.546
3.401IleIle: 3.401 ± 0.808
0.756IleLys: 0.756 ± 0.542
5.291IleLeu: 5.291 ± 1.266
0.0IleMet: 0.0 ± 0.0
0.378IleAsn: 0.378 ± 0.28
3.401IlePro: 3.401 ± 1.177
3.779IleGln: 3.779 ± 2.247
1.89IleArg: 1.89 ± 0.927
5.291IleSer: 5.291 ± 1.993
3.779IleThr: 3.779 ± 1.221
3.023IleVal: 3.023 ± 0.916
0.0IleTrp: 0.0 ± 0.0
0.756IleTyr: 0.756 ± 0.382
0.0IleXaa: 0.0 ± 0.0
Lys
1.89LysAla: 1.89 ± 0.751
3.023LysCys: 3.023 ± 0.876
3.779LysAsp: 3.779 ± 0.999
1.134LysGlu: 1.134 ± 0.659
3.023LysPhe: 3.023 ± 1.649
2.646LysGly: 2.646 ± 0.748
1.512LysHis: 1.512 ± 0.613
1.134LysIle: 1.134 ± 0.486
1.89LysLys: 1.89 ± 0.816
3.779LysLeu: 3.779 ± 1.49
0.378LysMet: 0.378 ± 0.313
1.512LysAsn: 1.512 ± 0.779
1.89LysPro: 1.89 ± 1.085
3.779LysGln: 3.779 ± 1.187
4.157LysArg: 4.157 ± 0.643
3.023LysSer: 3.023 ± 1.33
4.157LysThr: 4.157 ± 1.277
1.512LysVal: 1.512 ± 0.403
0.756LysTrp: 0.756 ± 0.413
1.512LysTyr: 1.512 ± 0.307
0.0LysXaa: 0.0 ± 0.0
Leu
2.646LeuAla: 2.646 ± 0.909
2.646LeuCys: 2.646 ± 1.172
3.779LeuAsp: 3.779 ± 1.145
3.779LeuGlu: 3.779 ± 1.512
3.779LeuPhe: 3.779 ± 1.118
4.535LeuGly: 4.535 ± 1.371
4.157LeuHis: 4.157 ± 1.285
3.779LeuIle: 3.779 ± 0.924
6.047LeuLys: 6.047 ± 2.025
6.803LeuLeu: 6.803 ± 2.807
0.756LeuMet: 0.756 ± 0.508
3.401LeuAsn: 3.401 ± 1.576
4.157LeuPro: 4.157 ± 1.72
6.803LeuGln: 6.803 ± 1.349
6.047LeuArg: 6.047 ± 1.64
5.291LeuSer: 5.291 ± 1.859
6.047LeuThr: 6.047 ± 1.015
4.913LeuVal: 4.913 ± 1.035
1.134LeuTrp: 1.134 ± 0.435
4.157LeuTyr: 4.157 ± 0.897
0.0LeuXaa: 0.0 ± 0.0
Met
2.646MetAla: 2.646 ± 0.691
1.89MetCys: 1.89 ± 0.633
1.134MetAsp: 1.134 ± 0.676
0.0MetGlu: 0.0 ± 0.0
0.756MetPhe: 0.756 ± 0.382
0.756MetGly: 0.756 ± 0.361
0.378MetHis: 0.378 ± 0.444
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
2.268MetLeu: 2.268 ± 1.255
0.378MetMet: 0.378 ± 0.427
0.756MetAsn: 0.756 ± 0.361
0.378MetPro: 0.378 ± 0.357
0.378MetGln: 0.378 ± 0.332
0.378MetArg: 0.378 ± 0.28
1.512MetSer: 1.512 ± 0.723
1.512MetThr: 1.512 ± 0.968
1.89MetVal: 1.89 ± 0.517
0.0MetTrp: 0.0 ± 0.0
0.378MetTyr: 0.378 ± 0.518
0.0MetXaa: 0.0 ± 0.0
Asn
1.89AsnAla: 1.89 ± 1.124
1.134AsnCys: 1.134 ± 0.611
2.268AsnAsp: 2.268 ± 0.887
1.89AsnGlu: 1.89 ± 0.711
1.512AsnPhe: 1.512 ± 0.403
1.89AsnGly: 1.89 ± 1.039
1.134AsnHis: 1.134 ± 0.604
1.89AsnIle: 1.89 ± 0.895
3.401AsnLys: 3.401 ± 1.622
0.756AsnLeu: 0.756 ± 0.595
0.378AsnMet: 0.378 ± 0.28
2.268AsnAsn: 2.268 ± 0.672
4.913AsnPro: 4.913 ± 0.868
0.378AsnGln: 0.378 ± 0.357
1.134AsnArg: 1.134 ± 0.573
4.157AsnSer: 4.157 ± 1.618
5.669AsnThr: 5.669 ± 1.439
3.779AsnVal: 3.779 ± 1.22
0.378AsnTrp: 0.378 ± 0.28
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
6.803ProAla: 6.803 ± 1.606
0.378ProCys: 0.378 ± 0.503
3.401ProAsp: 3.401 ± 1.123
2.646ProGlu: 2.646 ± 0.725
1.512ProPhe: 1.512 ± 0.779
1.512ProGly: 1.512 ± 0.754
0.756ProHis: 0.756 ± 0.71
3.401ProIle: 3.401 ± 0.901
2.646ProLys: 2.646 ± 0.588
9.07ProLeu: 9.07 ± 1.996
0.378ProMet: 0.378 ± 0.518
0.756ProAsn: 0.756 ± 0.361
4.157ProPro: 4.157 ± 1.621
2.268ProGln: 2.268 ± 1.031
2.268ProArg: 2.268 ± 0.877
6.047ProSer: 6.047 ± 2.51
6.047ProThr: 6.047 ± 2.12
4.157ProVal: 4.157 ± 1.672
0.756ProTrp: 0.756 ± 0.762
3.401ProTyr: 3.401 ± 1.131
0.0ProXaa: 0.0 ± 0.0
Gln
2.268GlnAla: 2.268 ± 1.05
1.134GlnCys: 1.134 ± 0.7
2.268GlnAsp: 2.268 ± 0.943
1.134GlnGlu: 1.134 ± 0.7
0.756GlnPhe: 0.756 ± 0.361
2.268GlnGly: 2.268 ± 0.816
2.646GlnHis: 2.646 ± 1.148
2.268GlnIle: 2.268 ± 0.768
1.512GlnLys: 1.512 ± 0.677
6.047GlnLeu: 6.047 ± 2.078
2.268GlnMet: 2.268 ± 0.734
0.756GlnAsn: 0.756 ± 0.525
1.512GlnPro: 1.512 ± 0.403
1.512GlnGln: 1.512 ± 0.892
3.023GlnArg: 3.023 ± 0.749
2.268GlnSer: 2.268 ± 1.231
3.023GlnThr: 3.023 ± 1.354
2.268GlnVal: 2.268 ± 0.783
1.134GlnTrp: 1.134 ± 0.559
2.268GlnTyr: 2.268 ± 1.231
0.0GlnXaa: 0.0 ± 0.0
Arg
4.157ArgAla: 4.157 ± 1.159
1.134ArgCys: 1.134 ± 0.982
1.512ArgAsp: 1.512 ± 0.603
1.512ArgGlu: 1.512 ± 0.963
2.268ArgPhe: 2.268 ± 0.951
1.512ArgGly: 1.512 ± 0.533
1.89ArgHis: 1.89 ± 1.257
1.512ArgIle: 1.512 ± 0.92
4.535ArgLys: 4.535 ± 1.008
6.425ArgLeu: 6.425 ± 1.078
0.0ArgMet: 0.0 ± 0.0
1.89ArgAsn: 1.89 ± 0.544
4.913ArgPro: 4.913 ± 0.956
0.756ArgGln: 0.756 ± 0.534
6.425ArgArg: 6.425 ± 2.264
2.646ArgSer: 2.646 ± 1.322
1.89ArgThr: 1.89 ± 0.607
3.779ArgVal: 3.779 ± 2.208
0.756ArgTrp: 0.756 ± 0.405
1.89ArgTyr: 1.89 ± 0.723
0.0ArgXaa: 0.0 ± 0.0
Ser
4.913SerAla: 4.913 ± 1.432
1.134SerCys: 1.134 ± 0.559
6.425SerAsp: 6.425 ± 1.019
3.401SerGlu: 3.401 ± 1.101
2.268SerPhe: 2.268 ± 1.109
5.291SerGly: 5.291 ± 2.11
1.512SerHis: 1.512 ± 0.307
4.535SerIle: 4.535 ± 1.714
1.89SerLys: 1.89 ± 0.921
4.535SerLeu: 4.535 ± 1.314
1.134SerMet: 1.134 ± 0.697
3.401SerAsn: 3.401 ± 1.394
4.913SerPro: 4.913 ± 1.149
1.89SerGln: 1.89 ± 0.728
4.535SerArg: 4.535 ± 0.98
7.937SerSer: 7.937 ± 2.632
7.937SerThr: 7.937 ± 1.748
7.181SerVal: 7.181 ± 1.643
0.378SerTrp: 0.378 ± 0.382
1.512SerTyr: 1.512 ± 0.469
0.0SerXaa: 0.0 ± 0.0
Thr
3.779ThrAla: 3.779 ± 0.725
3.401ThrCys: 3.401 ± 0.726
3.779ThrAsp: 3.779 ± 1.355
4.157ThrGlu: 4.157 ± 1.271
2.646ThrPhe: 2.646 ± 1.18
8.314ThrGly: 8.314 ± 2.111
1.512ThrHis: 1.512 ± 0.935
3.023ThrIle: 3.023 ± 0.984
2.268ThrLys: 2.268 ± 0.745
5.669ThrLeu: 5.669 ± 1.312
2.268ThrMet: 2.268 ± 0.474
2.268ThrAsn: 2.268 ± 0.634
6.047ThrPro: 6.047 ± 1.552
4.535ThrGln: 4.535 ± 0.697
3.023ThrArg: 3.023 ± 1.138
8.692ThrSer: 8.692 ± 2.64
7.181ThrThr: 7.181 ± 1.888
8.692ThrVal: 8.692 ± 1.671
1.89ThrTrp: 1.89 ± 0.954
3.779ThrTyr: 3.779 ± 0.965
0.0ThrXaa: 0.0 ± 0.0
Val
4.535ValAla: 4.535 ± 1.064
2.268ValCys: 2.268 ± 1.466
5.291ValAsp: 5.291 ± 1.401
1.89ValGlu: 1.89 ± 0.565
3.401ValPhe: 3.401 ± 1.1
3.401ValGly: 3.401 ± 1.221
1.512ValHis: 1.512 ± 0.307
1.89ValIle: 1.89 ± 0.774
1.134ValLys: 1.134 ± 0.667
3.779ValLeu: 3.779 ± 0.781
1.134ValMet: 1.134 ± 0.539
3.401ValAsn: 3.401 ± 1.066
6.425ValPro: 6.425 ± 2.545
4.157ValGln: 4.157 ± 1.067
2.268ValArg: 2.268 ± 0.82
4.913ValSer: 4.913 ± 1.847
4.913ValThr: 4.913 ± 1.221
4.535ValVal: 4.535 ± 1.767
0.756ValTrp: 0.756 ± 0.382
4.535ValTyr: 4.535 ± 1.702
0.0ValXaa: 0.0 ± 0.0
Trp
1.512TrpAla: 1.512 ± 0.749
0.378TrpCys: 0.378 ± 0.444
1.134TrpAsp: 1.134 ± 0.766
0.756TrpGlu: 0.756 ± 0.664
0.378TrpPhe: 0.378 ± 0.28
0.378TrpGly: 0.378 ± 0.28
1.134TrpHis: 1.134 ± 0.494
0.756TrpIle: 0.756 ± 0.559
0.756TrpLys: 0.756 ± 0.413
0.756TrpLeu: 0.756 ± 0.361
0.0TrpMet: 0.0 ± 0.0
1.512TrpAsn: 1.512 ± 1.027
1.134TrpPro: 1.134 ± 0.718
0.378TrpGln: 0.378 ± 0.332
0.756TrpArg: 0.756 ± 0.361
0.756TrpSer: 0.756 ± 0.389
1.512TrpThr: 1.512 ± 0.666
0.756TrpVal: 0.756 ± 0.55
0.0TrpTrp: 0.0 ± 0.0
0.378TrpTyr: 0.378 ± 0.28
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.512TyrAla: 1.512 ± 0.734
0.378TyrCys: 0.378 ± 0.486
1.512TyrAsp: 1.512 ± 0.953
1.134TyrGlu: 1.134 ± 0.486
2.268TyrPhe: 2.268 ± 0.565
3.401TyrGly: 3.401 ± 0.937
2.268TyrHis: 2.268 ± 0.952
3.023TyrIle: 3.023 ± 1.183
1.89TyrLys: 1.89 ± 0.4
1.89TyrLeu: 1.89 ± 0.517
1.89TyrMet: 1.89 ± 0.61
1.89TyrAsn: 1.89 ± 0.854
1.134TyrPro: 1.134 ± 0.825
1.134TyrGln: 1.134 ± 0.276
3.779TyrArg: 3.779 ± 1.062
3.779TyrSer: 3.779 ± 1.283
0.756TyrThr: 0.756 ± 0.382
2.268TyrVal: 2.268 ± 1.106
1.134TyrTrp: 1.134 ± 0.386
1.512TyrTyr: 1.512 ± 1.012
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (2647 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski