Amino acid dipepetide frequency for Hungateiclostridium straminisolvens JCM 21531

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.902AlaAla: 4.902 ± 0.079	0.796AlaCys: 0.796 ± 0.03	3.343AlaAsp: 3.343 ± 0.057	4.317AlaGlu: 4.317 ± 0.064	2.643AlaPhe: 2.643 ± 0.052	4.667AlaGly: 4.667 ± 0.073	0.849AlaHis: 0.849 ± 0.029	5.242AlaIle: 5.242 ± 0.079	4.892AlaLys: 4.892 ± 0.061	6.041AlaLeu: 6.041 ± 0.087	1.654AlaMet: 1.654 ± 0.036	2.803AlaAsn: 2.803 ± 0.048	1.71AlaPro: 1.71 ± 0.042	1.829AlaGln: 1.829 ± 0.041	2.57AlaArg: 2.57 ± 0.055	3.769AlaSer: 3.769 ± 0.064	2.742AlaThr: 2.742 ± 0.06	5.193AlaVal: 5.193 ± 0.074	0.57AlaTrp: 0.57 ± 0.025	2.416AlaTyr: 2.416 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.673CysAla: 0.673 ± 0.022	0.209CysCys: 0.209 ± 0.014	0.641CysAsp: 0.641 ± 0.026	0.772CysGlu: 0.772 ± 0.031	0.596CysPhe: 0.596 ± 0.025	1.021CysGly: 1.021 ± 0.028	0.235CysHis: 0.235 ± 0.018	1.016CysIle: 1.016 ± 0.03	0.817CysLys: 0.817 ± 0.03	0.987CysLeu: 0.987 ± 0.025	0.32CysMet: 0.32 ± 0.016	0.615CysAsn: 0.615 ± 0.026	0.514CysPro: 0.514 ± 0.025	0.291CysGln: 0.291 ± 0.017	0.558CysArg: 0.558 ± 0.021	0.834CysSer: 0.834 ± 0.027	0.528CysThr: 0.528 ± 0.022	0.724CysVal: 0.724 ± 0.03	0.132CysTrp: 0.132 ± 0.009	0.437CysTyr: 0.437 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.311AspAla: 3.311 ± 0.062	0.658AspCys: 0.658 ± 0.029	2.931AspAsp: 2.931 ± 0.062	4.704AspGlu: 4.704 ± 0.069	2.891AspPhe: 2.891 ± 0.054	4.113AspGly: 4.113 ± 0.086	0.599AspHis: 0.599 ± 0.022	5.952AspIle: 5.952 ± 0.081	4.426AspLys: 4.426 ± 0.069	4.432AspLeu: 4.432 ± 0.068	1.626AspMet: 1.626 ± 0.041	3.019AspAsn: 3.019 ± 0.057	1.767AspPro: 1.767 ± 0.045	0.836AspGln: 0.836 ± 0.026	2.356AspArg: 2.356 ± 0.045	3.575AspSer: 3.575 ± 0.063	2.783AspThr: 2.783 ± 0.053	4.044AspVal: 4.044 ± 0.065	0.625AspTrp: 0.625 ± 0.026	2.798AspTyr: 2.798 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.712GluAla: 4.712 ± 0.072	0.715GluCys: 0.715 ± 0.028	4.019GluAsp: 4.019 ± 0.064	6.266GluGlu: 6.266 ± 0.086	3.024GluPhe: 3.024 ± 0.053	4.33GluGly: 4.33 ± 0.064	1.094GluHis: 1.094 ± 0.035	6.809GluIle: 6.809 ± 0.088	6.841GluLys: 6.841 ± 0.096	6.845GluLeu: 6.845 ± 0.083	2.033GluMet: 2.033 ± 0.047	4.715GluAsn: 4.715 ± 0.068	1.954GluPro: 1.954 ± 0.049	2.123GluGln: 2.123 ± 0.045	3.156GluArg: 3.156 ± 0.06	3.794GluSer: 3.794 ± 0.065	3.118GluThr: 3.118 ± 0.058	4.808GluVal: 4.808 ± 0.07	0.63GluTrp: 0.63 ± 0.025	3.309GluTyr: 3.309 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	2.674PheAla: 2.674 ± 0.049	0.634PheCys: 0.634 ± 0.025	2.954PheAsp: 2.954 ± 0.05	3.287PheGlu: 3.287 ± 0.054	1.897PhePhe: 1.897 ± 0.048	3.007PheGly: 3.007 ± 0.051	0.592PheHis: 0.592 ± 0.024	3.547PheIle: 3.547 ± 0.068	3.035PheLys: 3.035 ± 0.05	3.661PheLeu: 3.661 ± 0.065	1.136PheMet: 1.136 ± 0.032	2.23PheAsn: 2.23 ± 0.046	1.383PhePro: 1.383 ± 0.036	0.94PheGln: 0.94 ± 0.033	1.702PheArg: 1.702 ± 0.035	3.06PheSer: 3.06 ± 0.061	2.264PheThr: 2.264 ± 0.045	3.005PheVal: 3.005 ± 0.056	0.431PheTrp: 0.431 ± 0.021	1.765PheTyr: 1.765 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.069GlyAla: 4.069 ± 0.078	0.937GlyCys: 0.937 ± 0.035	3.58GlyAsp: 3.58 ± 0.059	4.428GlyGlu: 4.428 ± 0.064	3.184GlyPhe: 3.184 ± 0.061	4.329GlyGly: 4.329 ± 0.086	1.1GlyHis: 1.1 ± 0.036	6.386GlyIle: 6.386 ± 0.076	5.696GlyLys: 5.696 ± 0.076	5.451GlyLeu: 5.451 ± 0.076	1.868GlyMet: 1.868 ± 0.042	3.484GlyAsn: 3.484 ± 0.071	1.403GlyPro: 1.403 ± 0.039	1.785GlyGln: 1.785 ± 0.044	2.796GlyArg: 2.796 ± 0.053	3.899GlySer: 3.899 ± 0.07	3.807GlyThr: 3.807 ± 0.069	4.481GlyVal: 4.481 ± 0.073	0.667GlyTrp: 0.667 ± 0.023	3.209GlyTyr: 3.209 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	0.754HisAla: 0.754 ± 0.025	0.218HisCys: 0.218 ± 0.014	0.742HisAsp: 0.742 ± 0.025	0.873HisGlu: 0.873 ± 0.028	0.671HisPhe: 0.671 ± 0.024	1.036HisGly: 1.036 ± 0.034	0.34HisHis: 0.34 ± 0.022	1.282HisIle: 1.282 ± 0.035	0.929HisLys: 0.929 ± 0.032	1.203HisLeu: 1.203 ± 0.031	0.371HisMet: 0.371 ± 0.019	0.791HisAsn: 0.791 ± 0.027	0.744HisPro: 0.744 ± 0.025	0.373HisGln: 0.373 ± 0.017	0.731HisArg: 0.731 ± 0.03	0.971HisSer: 0.971 ± 0.035	0.718HisThr: 0.718 ± 0.027	0.847HisVal: 0.847 ± 0.028	0.19HisTrp: 0.19 ± 0.015	0.632HisTyr: 0.632 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.602IleAla: 5.602 ± 0.073	1.068IleCys: 1.068 ± 0.033	5.64IleAsp: 5.64 ± 0.078	6.538IleGlu: 6.538 ± 0.079	3.305IlePhe: 3.305 ± 0.058	5.296IleGly: 5.296 ± 0.07	1.155IleHis: 1.155 ± 0.03	6.986IleIle: 6.986 ± 0.104	6.964IleLys: 6.964 ± 0.083	7.599IleLeu: 7.599 ± 0.09	2.111IleMet: 2.111 ± 0.039	5.001IleAsn: 5.001 ± 0.063	3.347IlePro: 3.347 ± 0.055	2.024IleGln: 2.024 ± 0.044	3.6IleArg: 3.6 ± 0.052	6.195IleSer: 6.195 ± 0.077	4.449IleThr: 4.449 ± 0.06	5.602IleVal: 5.602 ± 0.081	0.615IleTrp: 0.615 ± 0.023	3.183IleTyr: 3.183 ± 0.071	0.0IleXaa: 0.0 ± 0.0
Lys	5.165LysAla: 5.165 ± 0.073	0.745LysCys: 0.745 ± 0.027	5.014LysAsp: 5.014 ± 0.068	6.998LysGlu: 6.998 ± 0.095	2.652LysPhe: 2.652 ± 0.047	4.834LysGly: 4.834 ± 0.076	1.153LysHis: 1.153 ± 0.034	6.556LysIle: 6.556 ± 0.086	6.751LysLys: 6.751 ± 0.087	6.457LysLeu: 6.457 ± 0.071	2.209LysMet: 2.209 ± 0.046	4.762LysAsn: 4.762 ± 0.073	2.442LysPro: 2.442 ± 0.05	1.998LysGln: 1.998 ± 0.042	3.492LysArg: 3.492 ± 0.06	4.637LysSer: 4.637 ± 0.064	4.015LysThr: 4.015 ± 0.059	5.491LysVal: 5.491 ± 0.069	0.682LysTrp: 0.682 ± 0.027	3.522LysTyr: 3.522 ± 0.071	0.0LysXaa: 0.0 ± 0.0
Leu	5.627LeuAla: 5.627 ± 0.083	1.102LeuCys: 1.102 ± 0.033	4.927LeuAsp: 4.927 ± 0.063	6.318LeuGlu: 6.318 ± 0.078	3.726LeuPhe: 3.726 ± 0.069	5.636LeuGly: 5.636 ± 0.076	1.186LeuHis: 1.186 ± 0.036	6.777LeuIle: 6.777 ± 0.099	7.793LeuLys: 7.793 ± 0.088	7.917LeuLeu: 7.917 ± 0.112	2.395LeuMet: 2.395 ± 0.045	4.789LeuAsn: 4.789 ± 0.07	3.275LeuPro: 3.275 ± 0.058	2.248LeuGln: 2.248 ± 0.049	3.759LeuArg: 3.759 ± 0.064	6.25LeuSer: 6.25 ± 0.072	4.318LeuThr: 4.318 ± 0.07	5.399LeuVal: 5.399 ± 0.078	0.747LeuTrp: 0.747 ± 0.025	3.287LeuTyr: 3.287 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.891MetAla: 1.891 ± 0.047	0.256MetCys: 0.256 ± 0.017	1.565MetAsp: 1.565 ± 0.038	1.991MetGlu: 1.991 ± 0.043	0.997MetPhe: 0.997 ± 0.032	1.81MetGly: 1.81 ± 0.046	0.403MetHis: 0.403 ± 0.019	1.935MetIle: 1.935 ± 0.043	2.281MetLys: 2.281 ± 0.052	2.445MetLeu: 2.445 ± 0.044	0.703MetMet: 0.703 ± 0.026	1.448MetAsn: 1.448 ± 0.036	1.061MetPro: 1.061 ± 0.033	0.763MetGln: 0.763 ± 0.029	1.018MetArg: 1.018 ± 0.031	1.741MetSer: 1.741 ± 0.036	1.366MetThr: 1.366 ± 0.037	1.812MetVal: 1.812 ± 0.037	0.207MetTrp: 0.207 ± 0.015	0.857MetTyr: 0.857 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.234AsnAla: 3.234 ± 0.057	0.647AsnCys: 0.647 ± 0.027	2.714AsnAsp: 2.714 ± 0.06	3.881AsnGlu: 3.881 ± 0.059	2.177AsnPhe: 2.177 ± 0.041	3.88AsnGly: 3.88 ± 0.073	0.707AsnHis: 0.707 ± 0.028	5.446AsnIle: 5.446 ± 0.075	3.814AsnLys: 3.814 ± 0.065	4.607AsnLeu: 4.607 ± 0.072	1.466AsnMet: 1.466 ± 0.035	3.066AsnAsn: 3.066 ± 0.058	2.38AsnPro: 2.38 ± 0.054	1.355AsnGln: 1.355 ± 0.031	2.267AsnArg: 2.267 ± 0.049	3.68AsnSer: 3.68 ± 0.067	2.743AsnThr: 2.743 ± 0.054	3.57AsnVal: 3.57 ± 0.058	0.534AsnTrp: 0.534 ± 0.023	2.219AsnTyr: 2.219 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.023ProAla: 2.023 ± 0.042	0.346ProCys: 0.346 ± 0.017	2.205ProAsp: 2.205 ± 0.048	2.989ProGlu: 2.989 ± 0.056	1.57ProPhe: 1.57 ± 0.037	2.364ProGly: 2.364 ± 0.048	0.581ProHis: 0.581 ± 0.025	2.371ProIle: 2.371 ± 0.047	2.273ProLys: 2.273 ± 0.051	2.751ProLeu: 2.751 ± 0.056	0.755ProMet: 0.755 ± 0.028	1.498ProAsn: 1.498 ± 0.036	0.938ProPro: 0.938 ± 0.034	1.078ProGln: 1.078 ± 0.033	1.057ProArg: 1.057 ± 0.032	2.163ProSer: 2.163 ± 0.051	1.799ProThr: 1.799 ± 0.063	2.937ProVal: 2.937 ± 0.049	0.34ProTrp: 0.34 ± 0.02	1.414ProTyr: 1.414 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.648GlnAla: 1.648 ± 0.037	0.268GlnCys: 0.268 ± 0.017	1.252GlnAsp: 1.252 ± 0.033	1.824GlnGlu: 1.824 ± 0.044	1.023GlnPhe: 1.023 ± 0.028	1.476GlnGly: 1.476 ± 0.035	0.351GlnHis: 0.351 ± 0.018	2.221GlnIle: 2.221 ± 0.048	2.39GlnLys: 2.39 ± 0.049	2.269GlnLeu: 2.269 ± 0.05	0.794GlnMet: 0.794 ± 0.028	1.552GlnAsn: 1.552 ± 0.034	0.738GlnPro: 0.738 ± 0.029	0.852GlnGln: 0.852 ± 0.032	1.238GlnArg: 1.238 ± 0.032	1.479GlnSer: 1.479 ± 0.037	1.208GlnThr: 1.208 ± 0.032	1.671GlnVal: 1.671 ± 0.039	0.279GlnTrp: 0.279 ± 0.017	1.157GlnTyr: 1.157 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.43ArgAla: 2.43 ± 0.048	0.453ArgCys: 0.453 ± 0.02	2.195ArgAsp: 2.195 ± 0.048	3.286ArgGlu: 3.286 ± 0.062	1.845ArgPhe: 1.845 ± 0.044	2.316ArgGly: 2.316 ± 0.05	0.675ArgHis: 0.675 ± 0.029	3.98ArgIle: 3.98 ± 0.062	3.547ArgLys: 3.547 ± 0.062	3.829ArgLeu: 3.829 ± 0.062	1.245ArgMet: 1.245 ± 0.031	2.295ArgAsn: 2.295 ± 0.049	1.251ArgPro: 1.251 ± 0.035	1.306ArgGln: 1.306 ± 0.033	1.892ArgArg: 1.892 ± 0.047	2.035ArgSer: 2.035 ± 0.047	2.014ArgThr: 2.014 ± 0.039	2.805ArgVal: 2.805 ± 0.056	0.369ArgTrp: 0.369 ± 0.022	1.891ArgTyr: 1.891 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.641SerAla: 3.641 ± 0.057	0.714SerCys: 0.714 ± 0.029	3.573SerAsp: 3.573 ± 0.067	4.329SerGlu: 4.329 ± 0.062	3.039SerPhe: 3.039 ± 0.052	4.831SerGly: 4.831 ± 0.086	0.888SerHis: 0.888 ± 0.03	5.641SerIle: 5.641 ± 0.078	5.041SerLys: 5.041 ± 0.068	5.635SerLeu: 5.635 ± 0.077	1.662SerMet: 1.662 ± 0.039	3.299SerAsn: 3.299 ± 0.061	2.043SerPro: 2.043 ± 0.045	1.673SerGln: 1.673 ± 0.036	2.507SerArg: 2.507 ± 0.047	4.331SerSer: 4.331 ± 0.08	3.346SerThr: 3.346 ± 0.062	4.314SerVal: 4.314 ± 0.065	0.59SerTrp: 0.59 ± 0.022	2.597SerTyr: 2.597 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.557ThrAla: 3.557 ± 0.072	0.57ThrCys: 0.57 ± 0.024	2.892ThrAsp: 2.892 ± 0.053	3.208ThrGlu: 3.208 ± 0.058	2.183ThrPhe: 2.183 ± 0.048	4.23ThrGly: 4.23 ± 0.069	0.737ThrHis: 0.737 ± 0.027	3.986ThrIle: 3.986 ± 0.072	3.048ThrLys: 3.048 ± 0.048	4.396ThrLeu: 4.396 ± 0.061	1.154ThrMet: 1.154 ± 0.034	2.246ThrAsn: 2.246 ± 0.052	2.281ThrPro: 2.281 ± 0.054	1.264ThrGln: 1.264 ± 0.033	1.915ThrArg: 1.915 ± 0.046	3.088ThrSer: 3.088 ± 0.057	2.555ThrThr: 2.555 ± 0.061	4.361ThrVal: 4.361 ± 0.078	0.429ThrTrp: 0.429 ± 0.022	2.061ThrTyr: 2.061 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.2ValAla: 4.2 ± 0.06	0.897ValCys: 0.897 ± 0.031	4.076ValAsp: 4.076 ± 0.06	4.864ValGlu: 4.864 ± 0.068	3.352ValPhe: 3.352 ± 0.063	3.979ValGly: 3.979 ± 0.069	0.96ValHis: 0.96 ± 0.032	5.768ValIle: 5.768 ± 0.066	5.337ValLys: 5.337 ± 0.074	6.6ValLeu: 6.6 ± 0.091	1.735ValMet: 1.735 ± 0.042	3.636ValAsn: 3.636 ± 0.06	2.496ValPro: 2.496 ± 0.05	1.637ValGln: 1.637 ± 0.041	2.76ValArg: 2.76 ± 0.053	4.796ValSer: 4.796 ± 0.063	3.625ValThr: 3.625 ± 0.072	4.937ValVal: 4.937 ± 0.086	0.619ValTrp: 0.619 ± 0.029	2.809ValTyr: 2.809 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.591TrpAla: 0.591 ± 0.023	0.115TrpCys: 0.115 ± 0.013	0.588TrpAsp: 0.588 ± 0.026	0.621TrpGlu: 0.621 ± 0.024	0.409TrpPhe: 0.409 ± 0.019	0.661TrpGly: 0.661 ± 0.031	0.164TrpHis: 0.164 ± 0.012	0.742TrpIle: 0.742 ± 0.031	0.667TrpLys: 0.667 ± 0.027	0.756TrpLeu: 0.756 ± 0.029	0.298TrpMet: 0.298 ± 0.016	0.571TrpAsn: 0.571 ± 0.025	0.233TrpPro: 0.233 ± 0.013	0.339TrpGln: 0.339 ± 0.02	0.374TrpArg: 0.374 ± 0.021	0.516TrpSer: 0.516 ± 0.021	0.472TrpThr: 0.472 ± 0.024	0.563TrpVal: 0.563 ± 0.023	0.13TrpTrp: 0.13 ± 0.012	0.387TrpTyr: 0.387 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.244TyrAla: 2.244 ± 0.046	0.574TyrCys: 0.574 ± 0.027	2.594TyrAsp: 2.594 ± 0.075	2.799TyrGlu: 2.799 ± 0.056	2.021TyrPhe: 2.021 ± 0.047	2.742TyrGly: 2.742 ± 0.048	0.649TyrHis: 0.649 ± 0.02	3.639TyrIle: 3.639 ± 0.059	3.033TyrLys: 3.033 ± 0.058	3.594TyrLeu: 3.594 ± 0.056	1.016TyrMet: 1.016 ± 0.031	2.567TyrAsn: 2.567 ± 0.055	1.49TyrPro: 1.49 ± 0.036	0.979TyrGln: 0.979 ± 0.034	1.909TyrArg: 1.909 ± 0.046	2.882TyrSer: 2.882 ± 0.058	2.288TyrThr: 2.288 ± 0.047	2.517TyrVal: 2.517 ± 0.056	0.412TyrTrp: 0.412 ± 0.023	2.062TyrTyr: 2.062 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4383 proteins (1081527 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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