Amino acid dipepetide frequency for Solemya pervernicosa gill symbiont

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.922AlaAla: 9.922 ± 0.157	0.941AlaCys: 0.941 ± 0.033	5.247AlaAsp: 5.247 ± 0.124	7.02AlaGlu: 7.02 ± 0.121	3.006AlaPhe: 3.006 ± 0.054	6.732AlaGly: 6.732 ± 0.101	1.855AlaHis: 1.855 ± 0.047	5.814AlaIle: 5.814 ± 0.078	3.745AlaLys: 3.745 ± 0.067	10.339AlaLeu: 10.339 ± 0.118	2.603AlaMet: 2.603 ± 0.052	3.005AlaAsn: 3.005 ± 0.058	3.197AlaPro: 3.197 ± 0.07	3.302AlaGln: 3.302 ± 0.06	4.965AlaArg: 4.965 ± 0.07	5.382AlaSer: 5.382 ± 0.111	4.818AlaThr: 4.818 ± 0.068	6.662AlaVal: 6.662 ± 0.089	1.058AlaTrp: 1.058 ± 0.04	2.312AlaTyr: 2.312 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	0.747CysAla: 0.747 ± 0.028	0.14CysCys: 0.14 ± 0.013	0.653CysAsp: 0.653 ± 0.03	0.636CysGlu: 0.636 ± 0.026	0.363CysPhe: 0.363 ± 0.021	0.976CysGly: 0.976 ± 0.037	0.466CysHis: 0.466 ± 0.077	0.432CysIle: 0.432 ± 0.023	0.365CysLys: 0.365 ± 0.019	0.704CysLeu: 0.704 ± 0.027	0.207CysMet: 0.207 ± 0.015	0.388CysAsn: 0.388 ± 0.021	0.555CysPro: 0.555 ± 0.026	0.306CysGln: 0.306 ± 0.016	0.613CysArg: 0.613 ± 0.028	0.665CysSer: 0.665 ± 0.046	0.434CysThr: 0.434 ± 0.024	0.564CysVal: 0.564 ± 0.026	0.095CysTrp: 0.095 ± 0.009	0.273CysTyr: 0.273 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.271AspAla: 5.271 ± 0.102	0.541AspCys: 0.541 ± 0.031	3.549AspAsp: 3.549 ± 0.068	4.89AspGlu: 4.89 ± 0.076	2.217AspPhe: 2.217 ± 0.048	4.669AspGly: 4.669 ± 0.109	1.459AspHis: 1.459 ± 0.047	3.552AspIle: 3.552 ± 0.065	2.188AspLys: 2.188 ± 0.053	5.792AspLeu: 5.792 ± 0.09	1.341AspMet: 1.341 ± 0.042	2.053AspAsn: 2.053 ± 0.051	2.48AspPro: 2.48 ± 0.053	2.245AspGln: 2.245 ± 0.047	3.524AspArg: 3.524 ± 0.064	3.499AspSer: 3.499 ± 0.06	2.693AspThr: 2.693 ± 0.059	3.759AspVal: 3.759 ± 0.076	0.802AspTrp: 0.802 ± 0.029	2.076AspTyr: 2.076 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.857GluAla: 6.857 ± 0.102	0.542GluCys: 0.542 ± 0.025	2.877GluAsp: 2.877 ± 0.053	4.523GluGlu: 4.523 ± 0.081	2.235GluPhe: 2.235 ± 0.049	4.816GluGly: 4.816 ± 0.082	1.748GluHis: 1.748 ± 0.041	4.561GluIle: 4.561 ± 0.065	3.16GluLys: 3.16 ± 0.064	7.644GluLeu: 7.644 ± 0.103	2.242GluMet: 2.242 ± 0.046	2.2GluAsn: 2.2 ± 0.047	2.48GluPro: 2.48 ± 0.056	4.333GluGln: 4.333 ± 0.084	5.081GluArg: 5.081 ± 0.088	4.729GluSer: 4.729 ± 0.082	3.365GluThr: 3.365 ± 0.063	4.902GluVal: 4.902 ± 0.078	0.884GluTrp: 0.884 ± 0.035	1.577GluTyr: 1.577 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.083PheAla: 3.083 ± 0.058	0.376PheCys: 0.376 ± 0.02	2.667PheAsp: 2.667 ± 0.058	2.582PheGlu: 2.582 ± 0.047	1.382PhePhe: 1.382 ± 0.045	2.903PheGly: 2.903 ± 0.059	0.853PheHis: 0.853 ± 0.031	2.085PheIle: 2.085 ± 0.048	1.522PheLys: 1.522 ± 0.043	2.972PheLeu: 2.972 ± 0.07	0.884PheMet: 0.884 ± 0.028	1.538PheAsn: 1.538 ± 0.04	1.376PhePro: 1.376 ± 0.043	0.988PheGln: 0.988 ± 0.029	1.754PheArg: 1.754 ± 0.043	2.853PheSer: 2.853 ± 0.054	2.058PheThr: 2.058 ± 0.054	2.362PheVal: 2.362 ± 0.059	0.463PheTrp: 0.463 ± 0.021	1.11PheTyr: 1.11 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.11GlyAla: 6.11 ± 0.112	0.969GlyCys: 0.969 ± 0.036	4.584GlyAsp: 4.584 ± 0.109	5.744GlyGlu: 5.744 ± 0.088	3.014GlyPhe: 3.014 ± 0.056	6.316GlyGly: 6.316 ± 0.335	1.741GlyHis: 1.741 ± 0.046	4.598GlyIle: 4.598 ± 0.068	3.559GlyLys: 3.559 ± 0.07	7.292GlyLeu: 7.292 ± 0.092	2.294GlyMet: 2.294 ± 0.057	2.589GlyAsn: 2.589 ± 0.075	1.959GlyPro: 1.959 ± 0.047	2.331GlyGln: 2.331 ± 0.047	4.415GlyArg: 4.415 ± 0.07	5.034GlySer: 5.034 ± 0.137	3.737GlyThr: 3.737 ± 0.08	5.919GlyVal: 5.919 ± 0.086	1.152GlyTrp: 1.152 ± 0.036	2.584GlyTyr: 2.584 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.067HisAla: 2.067 ± 0.044	0.281HisCys: 0.281 ± 0.019	1.399HisAsp: 1.399 ± 0.04	1.397HisGlu: 1.397 ± 0.039	0.982HisPhe: 0.982 ± 0.031	1.817HisGly: 1.817 ± 0.044	0.85HisHis: 0.85 ± 0.033	1.372HisIle: 1.372 ± 0.046	0.861HisLys: 0.861 ± 0.033	2.501HisLeu: 2.501 ± 0.056	0.529HisMet: 0.529 ± 0.025	0.928HisAsn: 0.928 ± 0.045	1.378HisPro: 1.378 ± 0.034	0.995HisGln: 0.995 ± 0.037	1.464HisArg: 1.464 ± 0.039	1.385HisSer: 1.385 ± 0.049	1.215HisThr: 1.215 ± 0.036	1.209HisVal: 1.209 ± 0.038	0.319HisTrp: 0.319 ± 0.021	0.871HisTyr: 0.871 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.954IleAla: 5.954 ± 0.077	0.565IleCys: 0.565 ± 0.024	4.825IleAsp: 4.825 ± 0.072	5.328IleGlu: 5.328 ± 0.079	2.0IlePhe: 2.0 ± 0.056	4.907IleGly: 4.907 ± 0.079	1.353IleHis: 1.353 ± 0.036	3.032IleIle: 3.032 ± 0.058	2.75IleLys: 2.75 ± 0.058	4.612IleLeu: 4.612 ± 0.074	1.147IleMet: 1.147 ± 0.041	2.703IleAsn: 2.703 ± 0.059	2.579IlePro: 2.579 ± 0.059	1.592IleGln: 1.592 ± 0.041	3.148IleArg: 3.148 ± 0.055	4.173IleSer: 4.173 ± 0.074	3.715IleThr: 3.715 ± 0.069	3.66IleVal: 3.66 ± 0.069	0.541IleTrp: 0.541 ± 0.023	1.622IleTyr: 1.622 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	3.724LysAla: 3.724 ± 0.08	0.288LysCys: 0.288 ± 0.015	1.785LysAsp: 1.785 ± 0.047	2.57LysGlu: 2.57 ± 0.063	1.063LysPhe: 1.063 ± 0.032	3.061LysGly: 3.061 ± 0.06	1.02LysHis: 1.02 ± 0.032	2.425LysIle: 2.425 ± 0.053	2.255LysLys: 2.255 ± 0.08	4.274LysLeu: 4.274 ± 0.064	1.128LysMet: 1.128 ± 0.031	1.379LysAsn: 1.379 ± 0.038	2.051LysPro: 2.051 ± 0.057	2.253LysGln: 2.253 ± 0.046	3.274LysArg: 3.274 ± 0.063	2.731LysSer: 2.731 ± 0.059	1.964LysThr: 1.964 ± 0.041	2.971LysVal: 2.971 ± 0.066	0.414LysTrp: 0.414 ± 0.019	0.92LysTyr: 0.92 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	9.611LeuAla: 9.611 ± 0.105	0.893LeuCys: 0.893 ± 0.033	6.252LeuAsp: 6.252 ± 0.081	6.826LeuGlu: 6.826 ± 0.101	4.296LeuPhe: 4.296 ± 0.075	7.096LeuGly: 7.096 ± 0.109	2.38LeuHis: 2.38 ± 0.053	6.335LeuIle: 6.335 ± 0.09	4.781LeuLys: 4.781 ± 0.095	12.239LeuLeu: 12.239 ± 0.189	2.616LeuMet: 2.616 ± 0.056	3.934LeuAsn: 3.934 ± 0.064	4.865LeuPro: 4.865 ± 0.086	3.938LeuGln: 3.938 ± 0.076	6.022LeuArg: 6.022 ± 0.083	7.406LeuSer: 7.406 ± 0.092	5.397LeuThr: 5.397 ± 0.072	6.376LeuVal: 6.376 ± 0.099	1.089LeuTrp: 1.089 ± 0.035	2.709LeuTyr: 2.709 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.691MetAla: 2.691 ± 0.054	0.153MetCys: 0.153 ± 0.013	1.314MetAsp: 1.314 ± 0.038	1.558MetGlu: 1.558 ± 0.043	0.707MetPhe: 0.707 ± 0.027	1.97MetGly: 1.97 ± 0.045	0.516MetHis: 0.516 ± 0.025	1.468MetIle: 1.468 ± 0.04	1.249MetLys: 1.249 ± 0.035	2.819MetLeu: 2.819 ± 0.059	0.783MetMet: 0.783 ± 0.032	0.956MetAsn: 0.956 ± 0.029	1.274MetPro: 1.274 ± 0.038	1.09MetGln: 1.09 ± 0.033	1.565MetArg: 1.565 ± 0.039	1.948MetSer: 1.948 ± 0.042	1.291MetThr: 1.291 ± 0.037	2.156MetVal: 2.156 ± 0.053	0.216MetTrp: 0.216 ± 0.015	0.372MetTyr: 0.372 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.031AsnAla: 3.031 ± 0.068	0.39AsnCys: 0.39 ± 0.02	2.14AsnAsp: 2.14 ± 0.055	2.301AsnGlu: 2.301 ± 0.058	1.21AsnPhe: 1.21 ± 0.039	2.933AsnGly: 2.933 ± 0.077	0.904AsnHis: 0.904 ± 0.031	2.138AsnIle: 2.138 ± 0.044	1.449AsnLys: 1.449 ± 0.044	3.393AsnLeu: 3.393 ± 0.058	0.792AsnMet: 0.792 ± 0.028	1.518AsnAsn: 1.518 ± 0.047	1.889AsnPro: 1.889 ± 0.046	1.291AsnGln: 1.291 ± 0.037	2.423AsnArg: 2.423 ± 0.052	2.39AsnSer: 2.39 ± 0.07	1.789AsnThr: 1.789 ± 0.05	2.074AsnVal: 2.074 ± 0.05	0.447AsnTrp: 0.447 ± 0.02	1.17AsnTyr: 1.17 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.468ProAla: 3.468 ± 0.064	0.334ProCys: 0.334 ± 0.017	2.756ProAsp: 2.756 ± 0.049	3.419ProGlu: 3.419 ± 0.068	1.69ProPhe: 1.69 ± 0.043	3.027ProGly: 3.027 ± 0.066	0.941ProHis: 0.941 ± 0.035	2.456ProIle: 2.456 ± 0.053	1.669ProLys: 1.669 ± 0.045	4.512ProLeu: 4.512 ± 0.085	1.062ProMet: 1.062 ± 0.032	1.318ProAsn: 1.318 ± 0.036	1.603ProPro: 1.603 ± 0.05	1.531ProGln: 1.531 ± 0.038	1.811ProArg: 1.811 ± 0.044	2.313ProSer: 2.313 ± 0.05	2.165ProThr: 2.165 ± 0.05	3.261ProVal: 3.261 ± 0.061	0.516ProTrp: 0.516 ± 0.025	1.292ProTyr: 1.292 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.663GlnAla: 3.663 ± 0.075	0.31GlnCys: 0.31 ± 0.016	1.375GlnAsp: 1.375 ± 0.037	2.02GlnGlu: 2.02 ± 0.053	1.358GlnPhe: 1.358 ± 0.035	2.636GlnGly: 2.636 ± 0.054	1.093GlnHis: 1.093 ± 0.04	2.398GlnIle: 2.398 ± 0.051	1.428GlnLys: 1.428 ± 0.04	4.908GlnLeu: 4.908 ± 0.087	1.065GlnMet: 1.065 ± 0.034	1.045GlnAsn: 1.045 ± 0.039	1.732GlnPro: 1.732 ± 0.041	2.507GlnGln: 2.507 ± 0.069	3.099GlnArg: 3.099 ± 0.057	2.426GlnSer: 2.426 ± 0.062	1.734GlnThr: 1.734 ± 0.042	2.528GlnVal: 2.528 ± 0.052	0.498GlnTrp: 0.498 ± 0.023	0.806GlnTyr: 0.806 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	4.75ArgAla: 4.75 ± 0.075	0.638ArgCys: 0.638 ± 0.029	3.502ArgAsp: 3.502 ± 0.069	4.413ArgGlu: 4.413 ± 0.076	2.677ArgPhe: 2.677 ± 0.06	3.801ArgGly: 3.801 ± 0.063	1.612ArgHis: 1.612 ± 0.04	3.722ArgIle: 3.722 ± 0.06	2.361ArgLys: 2.361 ± 0.05	6.817ArgLeu: 6.817 ± 0.104	1.701ArgMet: 1.701 ± 0.038	2.184ArgAsn: 2.184 ± 0.046	2.24ArgPro: 2.24 ± 0.054	2.273ArgGln: 2.273 ± 0.047	3.899ArgArg: 3.899 ± 0.077	3.675ArgSer: 3.675 ± 0.071	2.571ArgThr: 2.571 ± 0.054	4.11ArgVal: 4.11 ± 0.069	0.817ArgTrp: 0.817 ± 0.033	2.217ArgTyr: 2.217 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.833SerAla: 5.833 ± 0.123	0.766SerCys: 0.766 ± 0.088	4.121SerAsp: 4.121 ± 0.063	4.646SerGlu: 4.646 ± 0.067	2.315SerPhe: 2.315 ± 0.046	6.237SerGly: 6.237 ± 0.125	1.603SerHis: 1.603 ± 0.045	3.764SerIle: 3.764 ± 0.063	2.399SerLys: 2.399 ± 0.047	6.477SerLeu: 6.477 ± 0.077	1.706SerMet: 1.706 ± 0.037	2.404SerAsn: 2.404 ± 0.067	2.335SerPro: 2.335 ± 0.059	2.155SerGln: 2.155 ± 0.051	3.721SerArg: 3.721 ± 0.067	4.536SerSer: 4.536 ± 0.108	3.198SerThr: 3.198 ± 0.067	4.49SerVal: 4.49 ± 0.09	0.804SerTrp: 0.804 ± 0.033	1.864SerTyr: 1.864 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.955ThrAla: 4.955 ± 0.09	0.389ThrCys: 0.389 ± 0.025	2.82ThrAsp: 2.82 ± 0.052	3.051ThrGlu: 3.051 ± 0.049	1.648ThrPhe: 1.648 ± 0.043	4.097ThrGly: 4.097 ± 0.083	1.111ThrHis: 1.111 ± 0.038	3.547ThrIle: 3.547 ± 0.062	1.559ThrLys: 1.559 ± 0.044	6.423ThrLeu: 6.423 ± 0.084	1.118ThrMet: 1.118 ± 0.04	1.683ThrAsn: 1.683 ± 0.046	2.895ThrPro: 2.895 ± 0.057	1.646ThrGln: 1.646 ± 0.052	2.656ThrArg: 2.656 ± 0.051	3.009ThrSer: 3.009 ± 0.072	3.167ThrThr: 3.167 ± 0.078	3.773ThrVal: 3.773 ± 0.068	0.423ThrTrp: 0.423 ± 0.018	1.216ThrTyr: 1.216 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.094ValAla: 7.094 ± 0.107	0.605ValCys: 0.605 ± 0.026	4.61ValAsp: 4.61 ± 0.073	5.597ValGlu: 5.597 ± 0.088	2.032ValPhe: 2.032 ± 0.043	4.941ValGly: 4.941 ± 0.082	1.243ValHis: 1.243 ± 0.037	4.489ValIle: 4.489 ± 0.072	2.814ValLys: 2.814 ± 0.067	6.456ValLeu: 6.456 ± 0.093	1.973ValMet: 1.973 ± 0.05	2.364ValAsn: 2.364 ± 0.051	2.511ValPro: 2.511 ± 0.055	1.916ValGln: 1.916 ± 0.049	3.649ValArg: 3.649 ± 0.064	4.625ValSer: 4.625 ± 0.078	4.133ValThr: 4.133 ± 0.079	6.171ValVal: 6.171 ± 0.095	0.661ValTrp: 0.661 ± 0.028	1.432ValTyr: 1.432 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.791TrpAla: 0.791 ± 0.03	0.146TrpCys: 0.146 ± 0.011	0.566TrpAsp: 0.566 ± 0.025	0.618TrpGlu: 0.618 ± 0.027	0.518TrpPhe: 0.518 ± 0.027	0.768TrpGly: 0.768 ± 0.027	0.333TrpHis: 0.333 ± 0.019	0.617TrpIle: 0.617 ± 0.027	0.47TrpLys: 0.47 ± 0.024	1.622TrpLeu: 1.622 ± 0.054	0.345TrpMet: 0.345 ± 0.017	0.445TrpAsn: 0.445 ± 0.02	0.472TrpPro: 0.472 ± 0.023	0.671TrpGln: 0.671 ± 0.027	0.839TrpArg: 0.839 ± 0.034	0.836TrpSer: 0.836 ± 0.04	0.397TrpThr: 0.397 ± 0.02	0.787TrpVal: 0.787 ± 0.03	0.184TrpTrp: 0.184 ± 0.015	0.318TrpTyr: 0.318 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.305TyrAla: 2.305 ± 0.044	0.315TyrCys: 0.315 ± 0.016	1.558TyrAsp: 1.558 ± 0.043	1.617TyrGlu: 1.617 ± 0.04	1.099TyrPhe: 1.099 ± 0.035	2.236TyrGly: 2.236 ± 0.118	0.74TyrHis: 0.74 ± 0.026	1.402TyrIle: 1.402 ± 0.04	0.968TyrLys: 0.968 ± 0.032	3.263TyrLeu: 3.263 ± 0.058	0.558TyrMet: 0.558 ± 0.02	1.039TyrAsn: 1.039 ± 0.038	1.271TyrPro: 1.271 ± 0.032	1.265TyrGln: 1.265 ± 0.034	2.059TyrArg: 2.059 ± 0.047	1.761TyrSer: 1.761 ± 0.038	1.343TyrThr: 1.343 ± 0.038	1.582TyrVal: 1.582 ± 0.036	0.361TyrTrp: 0.361 ± 0.021	0.863TyrTyr: 0.863 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3236 proteins (1026818 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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