Amino acid dipepetide frequency for Rhodobacter maris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.299AlaAla: 21.299 ± 0.252	1.233AlaCys: 1.233 ± 0.042	6.572AlaAsp: 6.572 ± 0.089	10.079AlaGlu: 10.079 ± 0.118	4.515AlaPhe: 4.515 ± 0.073	11.821AlaGly: 11.821 ± 0.129	2.569AlaHis: 2.569 ± 0.051	5.66AlaIle: 5.66 ± 0.074	4.149AlaLys: 4.149 ± 0.07	16.828AlaLeu: 16.828 ± 0.204	3.92AlaMet: 3.92 ± 0.055	2.521AlaAsn: 2.521 ± 0.047	7.702AlaPro: 7.702 ± 0.12	5.078AlaGln: 5.078 ± 0.08	10.845AlaArg: 10.845 ± 0.143	5.662AlaSer: 5.662 ± 0.082	6.301AlaThr: 6.301 ± 0.083	8.866AlaVal: 8.866 ± 0.101	1.457AlaTrp: 1.457 ± 0.04	2.455AlaTyr: 2.455 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.241CysAla: 1.241 ± 0.035	0.104CysCys: 0.104 ± 0.01	0.607CysAsp: 0.607 ± 0.026	0.451CysGlu: 0.451 ± 0.018	0.282CysPhe: 0.282 ± 0.013	0.955CysGly: 0.955 ± 0.03	0.271CysHis: 0.271 ± 0.015	0.391CysIle: 0.391 ± 0.017	0.212CysLys: 0.212 ± 0.013	0.929CysLeu: 0.929 ± 0.032	0.183CysMet: 0.183 ± 0.011	0.221CysAsn: 0.221 ± 0.012	0.603CysPro: 0.603 ± 0.023	0.209CysGln: 0.209 ± 0.013	0.607CysArg: 0.607 ± 0.027	0.426CysSer: 0.426 ± 0.019	0.503CysThr: 0.503 ± 0.023	0.553CysVal: 0.553 ± 0.022	0.117CysTrp: 0.117 ± 0.01	0.192CysTyr: 0.192 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.729AspAla: 6.729 ± 0.088	0.494AspCys: 0.494 ± 0.02	2.66AspAsp: 2.66 ± 0.073	2.93AspGlu: 2.93 ± 0.053	2.334AspPhe: 2.334 ± 0.048	4.619AspGly: 4.619 ± 0.087	1.207AspHis: 1.207 ± 0.03	2.489AspIle: 2.489 ± 0.046	1.326AspLys: 1.326 ± 0.042	6.611AspLeu: 6.611 ± 0.079	1.361AspMet: 1.361 ± 0.032	0.935AspAsn: 0.935 ± 0.029	3.581AspPro: 3.581 ± 0.057	1.562AspGln: 1.562 ± 0.05	3.838AspArg: 3.838 ± 0.064	1.765AspSer: 1.765 ± 0.051	2.685AspThr: 2.685 ± 0.072	3.541AspVal: 3.541 ± 0.056	1.166AspTrp: 1.166 ± 0.036	1.521AspTyr: 1.521 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	9.689GluAla: 9.689 ± 0.127	0.371GluCys: 0.371 ± 0.018	3.186GluAsp: 3.186 ± 0.062	3.741GluGlu: 3.741 ± 0.065	1.662GluPhe: 1.662 ± 0.038	5.443GluGly: 5.443 ± 0.078	1.068GluHis: 1.068 ± 0.032	3.907GluIle: 3.907 ± 0.058	2.234GluLys: 2.234 ± 0.047	5.12GluLeu: 5.12 ± 0.077	1.967GluMet: 1.967 ± 0.042	1.535GluAsn: 1.535 ± 0.04	2.838GluPro: 2.838 ± 0.097	1.656GluGln: 1.656 ± 0.041	4.726GluArg: 4.726 ± 0.069	2.383GluSer: 2.383 ± 0.053	4.017GluThr: 4.017 ± 0.068	4.415GluVal: 4.415 ± 0.066	0.559GluTrp: 0.559 ± 0.023	0.858GluTyr: 0.858 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.737PheAla: 4.737 ± 0.067	0.445PheCys: 0.445 ± 0.019	2.549PheAsp: 2.549 ± 0.048	2.338PheGlu: 2.338 ± 0.051	1.337PhePhe: 1.337 ± 0.035	3.694PheGly: 3.694 ± 0.056	0.684PheHis: 0.684 ± 0.023	1.438PheIle: 1.438 ± 0.045	0.82PheLys: 0.82 ± 0.025	3.575PheLeu: 3.575 ± 0.075	0.754PheMet: 0.754 ± 0.024	0.902PheAsn: 0.902 ± 0.028	1.549PhePro: 1.549 ± 0.039	0.868PheGln: 0.868 ± 0.028	2.197PheArg: 2.197 ± 0.051	2.09PheSer: 2.09 ± 0.043	2.05PheThr: 2.05 ± 0.039	2.575PheVal: 2.575 ± 0.049	0.58PheTrp: 0.58 ± 0.029	0.837PheTyr: 0.837 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.812GlyAla: 11.812 ± 0.124	0.974GlyCys: 0.974 ± 0.03	4.059GlyAsp: 4.059 ± 0.104	4.786GlyGlu: 4.786 ± 0.064	3.642GlyPhe: 3.642 ± 0.057	7.513GlyGly: 7.513 ± 0.139	1.941GlyHis: 1.941 ± 0.047	4.217GlyIle: 4.217 ± 0.067	3.178GlyLys: 3.178 ± 0.066	10.011GlyLeu: 10.011 ± 0.11	2.497GlyMet: 2.497 ± 0.049	1.938GlyAsn: 1.938 ± 0.063	4.065GlyPro: 4.065 ± 0.077	2.96GlyGln: 2.96 ± 0.057	6.256GlyArg: 6.256 ± 0.074	3.867GlySer: 3.867 ± 0.069	4.821GlyThr: 4.821 ± 0.087	6.19GlyVal: 6.19 ± 0.075	1.516GlyTrp: 1.516 ± 0.041	2.184GlyTyr: 2.184 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.466HisAla: 2.466 ± 0.049	0.204HisCys: 0.204 ± 0.014	1.221HisAsp: 1.221 ± 0.034	1.095HisGlu: 1.095 ± 0.034	0.818HisPhe: 0.818 ± 0.025	1.876HisGly: 1.876 ± 0.042	0.513HisHis: 0.513 ± 0.026	0.868HisIle: 0.868 ± 0.028	0.411HisLys: 0.411 ± 0.022	2.172HisLeu: 2.172 ± 0.05	0.499HisMet: 0.499 ± 0.023	0.39HisAsn: 0.39 ± 0.019	1.425HisPro: 1.425 ± 0.036	0.533HisGln: 0.533 ± 0.022	1.476HisArg: 1.476 ± 0.04	0.818HisSer: 0.818 ± 0.026	0.713HisThr: 0.713 ± 0.026	1.382HisVal: 1.382 ± 0.033	0.363HisTrp: 0.363 ± 0.018	0.556HisTyr: 0.556 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.241IleAla: 7.241 ± 0.084	0.585IleCys: 0.585 ± 0.022	3.256IleAsp: 3.256 ± 0.063	3.539IleGlu: 3.539 ± 0.062	1.648IlePhe: 1.648 ± 0.039	4.632IleGly: 4.632 ± 0.069	0.897IleHis: 0.897 ± 0.029	1.749IleIle: 1.749 ± 0.045	1.185IleLys: 1.185 ± 0.04	4.39IleLeu: 4.39 ± 0.068	0.865IleMet: 0.865 ± 0.027	1.124IleAsn: 1.124 ± 0.029	2.124IlePro: 2.124 ± 0.044	0.886IleGln: 0.886 ± 0.026	3.199IleArg: 3.199 ± 0.049	2.755IleSer: 2.755 ± 0.06	2.793IleThr: 2.793 ± 0.046	3.466IleVal: 3.466 ± 0.065	0.704IleTrp: 0.704 ± 0.026	1.031IleTyr: 1.031 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.136LysAla: 4.136 ± 0.077	0.174LysCys: 0.174 ± 0.013	1.489LysAsp: 1.489 ± 0.044	1.508LysGlu: 1.508 ± 0.044	0.888LysPhe: 0.888 ± 0.028	2.688LysGly: 2.688 ± 0.056	0.551LysHis: 0.551 ± 0.025	1.698LysIle: 1.698 ± 0.043	1.108LysLys: 1.108 ± 0.045	3.092LysLeu: 3.092 ± 0.059	0.868LysMet: 0.868 ± 0.033	0.681LysAsn: 0.681 ± 0.026	1.847LysPro: 1.847 ± 0.053	0.756LysGln: 0.756 ± 0.032	2.163LysArg: 2.163 ± 0.042	1.568LysSer: 1.568 ± 0.04	1.765LysThr: 1.765 ± 0.042	2.38LysVal: 2.38 ± 0.057	0.331LysTrp: 0.331 ± 0.018	0.615LysTyr: 0.615 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.845LeuAla: 15.845 ± 0.162	1.029LeuCys: 1.029 ± 0.027	5.82LeuAsp: 5.82 ± 0.082	5.789LeuGlu: 5.789 ± 0.076	3.602LeuPhe: 3.602 ± 0.068	9.449LeuGly: 9.449 ± 0.133	1.991LeuHis: 1.991 ± 0.036	5.147LeuIle: 5.147 ± 0.065	3.282LeuLys: 3.282 ± 0.061	9.043LeuLeu: 9.043 ± 0.128	2.736LeuMet: 2.736 ± 0.057	2.251LeuAsn: 2.251 ± 0.043	6.164LeuPro: 6.164 ± 0.085	2.503LeuGln: 2.503 ± 0.056	7.768LeuArg: 7.768 ± 0.101	6.611LeuSer: 6.611 ± 0.088	5.92LeuThr: 5.92 ± 0.087	7.22LeuVal: 7.22 ± 0.108	1.506LeuTrp: 1.506 ± 0.041	1.976LeuTyr: 1.976 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.536MetAla: 3.536 ± 0.058	0.169MetCys: 0.169 ± 0.011	1.156MetAsp: 1.156 ± 0.034	1.294MetGlu: 1.294 ± 0.033	0.723MetPhe: 0.723 ± 0.026	2.238MetGly: 2.238 ± 0.05	0.468MetHis: 0.468 ± 0.02	1.404MetIle: 1.404 ± 0.036	1.037MetLys: 1.037 ± 0.031	2.659MetLeu: 2.659 ± 0.045	0.774MetMet: 0.774 ± 0.025	0.71MetAsn: 0.71 ± 0.028	1.479MetPro: 1.479 ± 0.036	0.95MetGln: 0.95 ± 0.029	2.05MetArg: 2.05 ± 0.041	1.589MetSer: 1.589 ± 0.035	1.956MetThr: 1.956 ± 0.04	1.904MetVal: 1.904 ± 0.046	0.197MetTrp: 0.197 ± 0.015	0.276MetTyr: 0.276 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.886AsnAla: 2.886 ± 0.049	0.254AsnCys: 0.254 ± 0.016	1.349AsnAsp: 1.349 ± 0.056	0.98AsnGlu: 0.98 ± 0.032	0.842AsnPhe: 0.842 ± 0.03	1.983AsnGly: 1.983 ± 0.045	0.419AsnHis: 0.419 ± 0.021	1.116AsnIle: 1.116 ± 0.035	0.512AsnLys: 0.512 ± 0.023	2.29AsnLeu: 2.29 ± 0.046	0.592AsnMet: 0.592 ± 0.022	0.474AsnAsn: 0.474 ± 0.021	1.651AsnPro: 1.651 ± 0.037	0.55AsnGln: 0.55 ± 0.022	1.607AsnArg: 1.607 ± 0.043	0.906AsnSer: 0.906 ± 0.029	1.124AsnThr: 1.124 ± 0.03	1.482AsnVal: 1.482 ± 0.036	0.361AsnTrp: 0.361 ± 0.018	0.539AsnTyr: 0.539 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.237ProAla: 7.237 ± 0.114	0.412ProCys: 0.412 ± 0.02	3.321ProAsp: 3.321 ± 0.06	5.041ProGlu: 5.041 ± 0.124	2.069ProPhe: 2.069 ± 0.041	5.339ProGly: 5.339 ± 0.067	1.028ProHis: 1.028 ± 0.033	2.002ProIle: 2.002 ± 0.043	1.734ProLys: 1.734 ± 0.043	5.069ProLeu: 5.069 ± 0.084	1.393ProMet: 1.393 ± 0.036	1.079ProAsn: 1.079 ± 0.029	2.753ProPro: 2.753 ± 0.075	1.668ProGln: 1.668 ± 0.04	3.289ProArg: 3.289 ± 0.06	2.431ProSer: 2.431 ± 0.045	2.196ProThr: 2.196 ± 0.045	4.507ProVal: 4.507 ± 0.07	0.699ProTrp: 0.699 ± 0.026	1.042ProTyr: 1.042 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.014GlnAla: 4.014 ± 0.069	0.197GlnCys: 0.197 ± 0.013	1.276GlnAsp: 1.276 ± 0.033	1.443GlnGlu: 1.443 ± 0.034	0.984GlnPhe: 0.984 ± 0.033	2.576GlnGly: 2.576 ± 0.047	0.491GlnHis: 0.491 ± 0.023	2.035GlnIle: 2.035 ± 0.055	0.977GlnLys: 0.977 ± 0.03	2.682GlnLeu: 2.682 ± 0.054	1.049GlnMet: 1.049 ± 0.035	0.811GlnAsn: 0.811 ± 0.028	1.502GlnPro: 1.502 ± 0.04	0.866GlnGln: 0.866 ± 0.033	1.921GlnArg: 1.921 ± 0.05	1.656GlnSer: 1.656 ± 0.039	1.618GlnThr: 1.618 ± 0.039	2.264GlnVal: 2.264 ± 0.048	0.368GlnTrp: 0.368 ± 0.017	0.478GlnTyr: 0.478 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.204ArgAla: 10.204 ± 0.12	0.532ArgCys: 0.532 ± 0.021	3.755ArgAsp: 3.755 ± 0.054	4.187ArgGlu: 4.187 ± 0.068	2.819ArgPhe: 2.819 ± 0.051	4.992ArgGly: 4.992 ± 0.067	1.616ArgHis: 1.616 ± 0.04	3.894ArgIle: 3.894 ± 0.061	2.213ArgLys: 2.213 ± 0.048	8.44ArgLeu: 8.44 ± 0.114	2.01ArgMet: 2.01 ± 0.049	1.608ArgAsn: 1.608 ± 0.036	3.741ArgPro: 3.741 ± 0.062	2.127ArgGln: 2.127 ± 0.049	5.423ArgArg: 5.423 ± 0.082	3.09ArgSer: 3.09 ± 0.06	2.879ArgThr: 2.879 ± 0.055	4.791ArgVal: 4.791 ± 0.072	0.987ArgTrp: 0.987 ± 0.035	1.472ArgTyr: 1.472 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.262SerAla: 6.262 ± 0.089	0.425SerCys: 0.425 ± 0.019	2.685SerAsp: 2.685 ± 0.05	2.824SerGlu: 2.824 ± 0.048	2.088SerPhe: 2.088 ± 0.046	5.3SerGly: 5.3 ± 0.092	0.971SerHis: 0.971 ± 0.028	2.023SerIle: 2.023 ± 0.042	1.319SerLys: 1.319 ± 0.041	4.816SerLeu: 4.816 ± 0.067	1.114SerMet: 1.114 ± 0.033	1.034SerAsn: 1.034 ± 0.032	2.548SerPro: 2.548 ± 0.049	1.357SerGln: 1.357 ± 0.036	3.134SerArg: 3.134 ± 0.055	2.372SerSer: 2.372 ± 0.053	2.36SerThr: 2.36 ± 0.062	3.512SerVal: 3.512 ± 0.056	0.677SerTrp: 0.677 ± 0.026	1.191SerTyr: 1.191 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.54ThrAla: 6.54 ± 0.085	0.486ThrCys: 0.486 ± 0.023	2.813ThrAsp: 2.813 ± 0.061	3.094ThrGlu: 3.094 ± 0.051	1.768ThrPhe: 1.768 ± 0.04	5.321ThrGly: 5.321 ± 0.084	1.04ThrHis: 1.04 ± 0.03	2.562ThrIle: 2.562 ± 0.046	1.465ThrLys: 1.465 ± 0.037	6.233ThrLeu: 6.233 ± 0.086	1.162ThrMet: 1.162 ± 0.03	1.133ThrAsn: 1.133 ± 0.033	3.421ThrPro: 3.421 ± 0.06	1.482ThrGln: 1.482 ± 0.04	3.502ThrArg: 3.502 ± 0.052	2.354ThrSer: 2.354 ± 0.059	2.746ThrThr: 2.746 ± 0.058	4.017ThrVal: 4.017 ± 0.065	0.612ThrTrp: 0.612 ± 0.022	1.051ThrTyr: 1.051 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.612ValAla: 9.612 ± 0.101	0.6ValCys: 0.6 ± 0.025	3.509ValAsp: 3.509 ± 0.068	4.373ValGlu: 4.373 ± 0.069	2.691ValPhe: 2.691 ± 0.051	5.019ValGly: 5.019 ± 0.074	1.257ValHis: 1.257 ± 0.034	3.976ValIle: 3.976 ± 0.06	2.179ValLys: 2.179 ± 0.051	7.911ValLeu: 7.911 ± 0.099	2.048ValMet: 2.048 ± 0.041	1.72ValAsn: 1.72 ± 0.044	3.677ValPro: 3.677 ± 0.064	1.996ValGln: 1.996 ± 0.038	4.11ValArg: 4.11 ± 0.065	3.95ValSer: 3.95 ± 0.064	4.626ValThr: 4.626 ± 0.066	5.511ValVal: 5.511 ± 0.093	0.89ValTrp: 0.89 ± 0.028	1.236ValTyr: 1.236 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.546TrpAla: 1.546 ± 0.043	0.135TrpCys: 0.135 ± 0.011	0.638TrpAsp: 0.638 ± 0.023	0.681TrpGlu: 0.681 ± 0.025	0.505TrpPhe: 0.505 ± 0.021	1.076TrpGly: 1.076 ± 0.034	0.369TrpHis: 0.369 ± 0.021	0.664TrpIle: 0.664 ± 0.025	0.448TrpLys: 0.448 ± 0.017	1.622TrpLeu: 1.622 ± 0.042	0.349TrpMet: 0.349 ± 0.017	0.336TrpAsn: 0.336 ± 0.018	0.668TrpPro: 0.668 ± 0.027	0.588TrpGln: 0.588 ± 0.024	1.156TrpArg: 1.156 ± 0.036	0.755TrpSer: 0.755 ± 0.025	0.652TrpThr: 0.652 ± 0.023	0.969TrpVal: 0.969 ± 0.033	0.208TrpTrp: 0.208 ± 0.015	0.25TrpTyr: 0.25 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.052	0.232TyrCys: 0.232 ± 0.014	1.43TyrAsp: 1.43 ± 0.04	1.201TyrGlu: 1.201 ± 0.036	0.803TyrPhe: 0.803 ± 0.027	1.896TyrGly: 1.896 ± 0.045	0.449TyrHis: 0.449 ± 0.023	0.828TyrIle: 0.828 ± 0.028	0.517TyrLys: 0.517 ± 0.027	2.158TyrLeu: 2.158 ± 0.045	0.428TyrMet: 0.428 ± 0.018	0.517TyrAsn: 0.517 ± 0.023	0.971TyrPro: 0.971 ± 0.029	0.614TyrGln: 0.614 ± 0.026	1.512TyrArg: 1.512 ± 0.037	0.962TyrSer: 0.962 ± 0.034	1.078TyrThr: 1.078 ± 0.034	1.347TyrVal: 1.347 ± 0.036	0.317TyrTrp: 0.317 ± 0.016	0.547TyrTyr: 0.547 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3687 proteins (1149499 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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