Amino acid dipepetide frequency for Actinomyces virus Av1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.341AlaAla: 9.341 ± 1.8
0.549AlaCys: 0.549 ± 0.408
3.297AlaAsp: 3.297 ± 0.866
4.029AlaGlu: 4.029 ± 1.279
3.114AlaPhe: 3.114 ± 0.883
7.143AlaGly: 7.143 ± 1.04
1.099AlaHis: 1.099 ± 0.414
4.029AlaIle: 4.029 ± 0.668
6.227AlaLys: 6.227 ± 1.516
4.212AlaLeu: 4.212 ± 0.67
2.747AlaMet: 2.747 ± 0.81
4.396AlaAsn: 4.396 ± 1.094
2.381AlaPro: 2.381 ± 0.631
5.495AlaGln: 5.495 ± 1.25
4.579AlaArg: 4.579 ± 1.019
4.762AlaSer: 4.762 ± 1.009
4.945AlaThr: 4.945 ± 0.774
4.945AlaVal: 4.945 ± 0.911
1.465AlaTrp: 1.465 ± 0.549
2.93AlaTyr: 2.93 ± 0.685
0.0AlaXaa: 0.0 ± 0.0
Cys
0.733CysAla: 0.733 ± 0.332
0.183CysCys: 0.183 ± 0.183
0.366CysAsp: 0.366 ± 0.287
0.366CysGlu: 0.366 ± 0.244
0.0CysPhe: 0.0 ± 0.0
0.366CysGly: 0.366 ± 0.315
0.0CysHis: 0.0 ± 0.0
0.549CysIle: 0.549 ± 0.266
0.183CysLys: 0.183 ± 0.192
0.549CysLeu: 0.549 ± 0.336
0.183CysMet: 0.183 ± 0.179
0.183CysAsn: 0.183 ± 0.209
0.366CysPro: 0.366 ± 0.256
0.183CysGln: 0.183 ± 0.159
0.733CysArg: 0.733 ± 0.345
0.916CysSer: 0.916 ± 0.472
0.549CysThr: 0.549 ± 0.318
0.549CysVal: 0.549 ± 0.272
0.0CysTrp: 0.0 ± 0.0
0.183CysTyr: 0.183 ± 0.168
0.0CysXaa: 0.0 ± 0.0
Asp
3.846AspAla: 3.846 ± 0.823
0.549AspCys: 0.549 ± 0.256
4.396AspAsp: 4.396 ± 1.034
2.198AspGlu: 2.198 ± 0.679
3.114AspPhe: 3.114 ± 0.957
5.495AspGly: 5.495 ± 0.906
1.099AspHis: 1.099 ± 0.405
4.945AspIle: 4.945 ± 0.751
3.114AspLys: 3.114 ± 0.815
4.029AspLeu: 4.029 ± 0.856
1.832AspMet: 1.832 ± 0.52
4.029AspAsn: 4.029 ± 0.847
2.93AspPro: 2.93 ± 0.996
1.832AspGln: 1.832 ± 0.688
3.48AspArg: 3.48 ± 0.954
4.579AspSer: 4.579 ± 0.866
4.762AspThr: 4.762 ± 1.174
5.311AspVal: 5.311 ± 1.154
0.916AspTrp: 0.916 ± 0.338
3.48AspTyr: 3.48 ± 0.927
0.0AspXaa: 0.0 ± 0.0
Glu
4.579GluAla: 4.579 ± 1.477
0.183GluCys: 0.183 ± 0.168
1.832GluAsp: 1.832 ± 0.539
3.663GluGlu: 3.663 ± 1.336
2.93GluPhe: 2.93 ± 0.659
3.48GluGly: 3.48 ± 0.72
0.916GluHis: 0.916 ± 0.347
3.846GluIle: 3.846 ± 0.86
3.663GluLys: 3.663 ± 1.174
2.93GluLeu: 2.93 ± 0.63
1.648GluMet: 1.648 ± 0.48
2.564GluAsn: 2.564 ± 0.796
2.198GluPro: 2.198 ± 0.626
1.648GluGln: 1.648 ± 0.386
3.663GluArg: 3.663 ± 0.796
3.846GluSer: 3.846 ± 0.82
3.48GluThr: 3.48 ± 0.886
2.747GluVal: 2.747 ± 0.81
0.183GluTrp: 0.183 ± 0.192
1.282GluTyr: 1.282 ± 0.538
0.0GluXaa: 0.0 ± 0.0
Phe
3.48PheAla: 3.48 ± 1.174
0.183PheCys: 0.183 ± 0.157
2.015PheAsp: 2.015 ± 0.509
1.648PheGlu: 1.648 ± 0.517
1.282PhePhe: 1.282 ± 0.448
2.381PheGly: 2.381 ± 0.63
0.733PheHis: 0.733 ± 0.285
3.48PheIle: 3.48 ± 1.136
2.198PheLys: 2.198 ± 0.743
0.916PheLeu: 0.916 ± 0.475
2.198PheMet: 2.198 ± 0.513
2.564PheAsn: 2.564 ± 0.6
1.465PhePro: 1.465 ± 0.525
0.549PheGln: 0.549 ± 0.299
2.198PheArg: 2.198 ± 0.609
2.198PheSer: 2.198 ± 0.915
2.564PheThr: 2.564 ± 0.815
1.832PheVal: 1.832 ± 0.6
0.183PheTrp: 0.183 ± 0.168
1.465PheTyr: 1.465 ± 0.424
0.0PheXaa: 0.0 ± 0.0
Gly
4.762GlyAla: 4.762 ± 0.937
0.733GlyCys: 0.733 ± 0.493
6.044GlyAsp: 6.044 ± 1.363
4.029GlyGlu: 4.029 ± 0.748
2.015GlyPhe: 2.015 ± 0.59
8.974GlyGly: 8.974 ± 2.371
0.733GlyHis: 0.733 ± 0.41
5.495GlyIle: 5.495 ± 1.031
5.128GlyLys: 5.128 ± 1.275
4.579GlyLeu: 4.579 ± 0.744
2.564GlyMet: 2.564 ± 0.832
3.297GlyAsn: 3.297 ± 0.727
1.465GlyPro: 1.465 ± 0.53
3.297GlyGln: 3.297 ± 0.754
3.297GlyArg: 3.297 ± 0.763
5.311GlySer: 5.311 ± 1.102
5.861GlyThr: 5.861 ± 0.758
6.41GlyVal: 6.41 ± 1.764
1.465GlyTrp: 1.465 ± 0.629
3.846GlyTyr: 3.846 ± 0.936
0.0GlyXaa: 0.0 ± 0.0
His
0.916HisAla: 0.916 ± 0.393
0.0HisCys: 0.0 ± 0.0
0.549HisAsp: 0.549 ± 0.312
0.916HisGlu: 0.916 ± 0.401
0.549HisPhe: 0.549 ± 0.27
1.832HisGly: 1.832 ± 0.743
0.183HisHis: 0.183 ± 0.175
2.198HisIle: 2.198 ± 0.669
0.366HisLys: 0.366 ± 0.25
0.549HisLeu: 0.549 ± 0.417
0.916HisMet: 0.916 ± 0.394
1.282HisAsn: 1.282 ± 0.591
0.183HisPro: 0.183 ± 0.157
0.366HisGln: 0.366 ± 0.219
0.733HisArg: 0.733 ± 0.274
0.916HisSer: 0.916 ± 0.364
1.465HisThr: 1.465 ± 0.433
0.549HisVal: 0.549 ± 0.341
0.549HisTrp: 0.549 ± 0.291
1.282HisTyr: 1.282 ± 0.584
0.0HisXaa: 0.0 ± 0.0
Ile
4.212IleAla: 4.212 ± 0.823
0.0IleCys: 0.0 ± 0.0
6.227IleAsp: 6.227 ± 1.084
2.381IleGlu: 2.381 ± 0.466
1.648IlePhe: 1.648 ± 0.557
5.311IleGly: 5.311 ± 0.79
0.366IleHis: 0.366 ± 0.309
2.747IleIle: 2.747 ± 0.614
3.663IleLys: 3.663 ± 0.691
4.396IleLeu: 4.396 ± 0.988
2.381IleMet: 2.381 ± 0.833
2.93IleAsn: 2.93 ± 0.496
2.564IlePro: 2.564 ± 0.71
2.381IleGln: 2.381 ± 0.564
3.297IleArg: 3.297 ± 0.807
4.579IleSer: 4.579 ± 0.869
5.495IleThr: 5.495 ± 1.204
3.846IleVal: 3.846 ± 0.59
1.282IleTrp: 1.282 ± 0.524
2.381IleTyr: 2.381 ± 0.684
0.0IleXaa: 0.0 ± 0.0
Lys
5.678LysAla: 5.678 ± 2.152
0.366LysCys: 0.366 ± 0.244
3.663LysAsp: 3.663 ± 1.202
3.48LysGlu: 3.48 ± 0.97
1.648LysPhe: 1.648 ± 0.444
3.846LysGly: 3.846 ± 1.023
1.282LysHis: 1.282 ± 0.648
2.93LysIle: 2.93 ± 0.602
4.579LysLys: 4.579 ± 1.595
4.212LysLeu: 4.212 ± 1.66
1.832LysMet: 1.832 ± 0.51
3.114LysAsn: 3.114 ± 0.694
3.114LysPro: 3.114 ± 0.942
1.282LysGln: 1.282 ± 0.463
2.747LysArg: 2.747 ± 0.637
4.396LysSer: 4.396 ± 1.234
4.029LysThr: 4.029 ± 0.905
4.212LysVal: 4.212 ± 1.073
1.465LysTrp: 1.465 ± 0.474
0.916LysTyr: 0.916 ± 0.343
0.0LysXaa: 0.0 ± 0.0
Leu
5.128LeuAla: 5.128 ± 0.9
0.0LeuCys: 0.0 ± 0.0
3.846LeuAsp: 3.846 ± 1.022
4.212LeuGlu: 4.212 ± 0.592
1.648LeuPhe: 1.648 ± 0.537
4.762LeuGly: 4.762 ± 0.887
0.916LeuHis: 0.916 ± 0.632
3.663LeuIle: 3.663 ± 0.95
3.297LeuLys: 3.297 ± 0.913
2.747LeuLeu: 2.747 ± 0.613
1.465LeuMet: 1.465 ± 0.51
4.579LeuAsn: 4.579 ± 1.037
2.381LeuPro: 2.381 ± 0.769
1.648LeuGln: 1.648 ± 0.378
4.212LeuArg: 4.212 ± 1.11
6.593LeuSer: 6.593 ± 1.017
4.029LeuThr: 4.029 ± 0.811
2.747LeuVal: 2.747 ± 0.49
1.282LeuTrp: 1.282 ± 0.538
2.564LeuTyr: 2.564 ± 0.592
0.0LeuXaa: 0.0 ± 0.0
Met
3.663MetAla: 3.663 ± 0.779
0.366MetCys: 0.366 ± 0.249
1.099MetAsp: 1.099 ± 0.455
1.099MetGlu: 1.099 ± 0.571
0.733MetPhe: 0.733 ± 0.435
2.198MetGly: 2.198 ± 0.578
0.549MetHis: 0.549 ± 0.334
1.832MetIle: 1.832 ± 0.723
0.916MetLys: 0.916 ± 0.447
2.198MetLeu: 2.198 ± 0.488
0.549MetMet: 0.549 ± 0.287
1.832MetAsn: 1.832 ± 0.478
1.282MetPro: 1.282 ± 0.477
0.549MetGln: 0.549 ± 0.384
1.648MetArg: 1.648 ± 0.53
2.015MetSer: 2.015 ± 0.621
1.648MetThr: 1.648 ± 0.462
2.015MetVal: 2.015 ± 0.614
0.733MetTrp: 0.733 ± 0.314
1.648MetTyr: 1.648 ± 0.538
0.0MetXaa: 0.0 ± 0.0
Asn
4.579AsnAla: 4.579 ± 0.96
0.183AsnCys: 0.183 ± 0.172
3.297AsnAsp: 3.297 ± 0.797
2.198AsnGlu: 2.198 ± 0.672
1.465AsnPhe: 1.465 ± 0.51
4.945AsnGly: 4.945 ± 0.987
0.916AsnHis: 0.916 ± 0.393
2.93AsnIle: 2.93 ± 0.866
3.48AsnLys: 3.48 ± 1.175
2.381AsnLeu: 2.381 ± 0.868
0.916AsnMet: 0.916 ± 0.431
3.663AsnAsn: 3.663 ± 0.925
3.663AsnPro: 3.663 ± 0.569
1.648AsnGln: 1.648 ± 0.662
2.747AsnArg: 2.747 ± 0.985
4.762AsnSer: 4.762 ± 0.528
4.579AsnThr: 4.579 ± 1.274
3.48AsnVal: 3.48 ± 0.736
0.733AsnTrp: 0.733 ± 0.524
2.747AsnTyr: 2.747 ± 0.654
0.0AsnXaa: 0.0 ± 0.0
Pro
1.099ProAla: 1.099 ± 0.535
0.366ProCys: 0.366 ± 0.237
4.212ProAsp: 4.212 ± 0.915
4.212ProGlu: 4.212 ± 0.587
1.099ProPhe: 1.099 ± 0.386
3.114ProGly: 3.114 ± 0.727
0.549ProHis: 0.549 ± 0.387
1.648ProIle: 1.648 ± 0.514
1.832ProLys: 1.832 ± 0.661
1.648ProLeu: 1.648 ± 0.531
0.916ProMet: 0.916 ± 0.393
3.114ProAsn: 3.114 ± 0.79
1.832ProPro: 1.832 ± 0.693
0.916ProGln: 0.916 ± 0.394
2.564ProArg: 2.564 ± 0.648
3.297ProSer: 3.297 ± 0.743
2.93ProThr: 2.93 ± 0.826
2.564ProVal: 2.564 ± 0.568
0.366ProTrp: 0.366 ± 0.249
1.648ProTyr: 1.648 ± 0.356
0.0ProXaa: 0.0 ± 0.0
Gln
4.029GlnAla: 4.029 ± 0.544
0.183GlnCys: 0.183 ± 0.159
2.564GlnAsp: 2.564 ± 0.575
1.282GlnGlu: 1.282 ± 0.363
1.832GlnPhe: 1.832 ± 0.722
1.832GlnGly: 1.832 ± 0.715
0.733GlnHis: 0.733 ± 0.351
2.381GlnIle: 2.381 ± 0.533
1.282GlnLys: 1.282 ± 0.598
1.648GlnLeu: 1.648 ± 0.633
0.183GlnMet: 0.183 ± 0.209
2.747GlnAsn: 2.747 ± 0.691
0.549GlnPro: 0.549 ± 0.277
1.282GlnGln: 1.282 ± 0.501
2.564GlnArg: 2.564 ± 0.628
1.282GlnSer: 1.282 ± 0.33
1.832GlnThr: 1.832 ± 0.59
2.381GlnVal: 2.381 ± 0.647
0.733GlnTrp: 0.733 ± 0.381
1.648GlnTyr: 1.648 ± 0.559
0.0GlnXaa: 0.0 ± 0.0
Arg
4.029ArgAla: 4.029 ± 0.748
0.549ArgCys: 0.549 ± 0.462
4.212ArgAsp: 4.212 ± 1.411
3.846ArgGlu: 3.846 ± 1.225
1.648ArgPhe: 1.648 ± 0.64
2.93ArgGly: 2.93 ± 0.692
1.465ArgHis: 1.465 ± 0.575
2.564ArgIle: 2.564 ± 0.681
3.846ArgLys: 3.846 ± 0.999
4.762ArgLeu: 4.762 ± 0.934
2.381ArgMet: 2.381 ± 0.63
2.747ArgAsn: 2.747 ± 0.487
2.198ArgPro: 2.198 ± 0.447
2.564ArgGln: 2.564 ± 0.529
3.114ArgArg: 3.114 ± 0.737
4.396ArgSer: 4.396 ± 1.132
1.832ArgThr: 1.832 ± 0.563
4.029ArgVal: 4.029 ± 0.651
1.099ArgTrp: 1.099 ± 0.455
3.48ArgTyr: 3.48 ± 0.6
0.0ArgXaa: 0.0 ± 0.0
Ser
6.044SerAla: 6.044 ± 1.087
0.549SerCys: 0.549 ± 0.347
6.044SerAsp: 6.044 ± 1.26
3.297SerGlu: 3.297 ± 0.473
3.663SerPhe: 3.663 ± 0.68
6.044SerGly: 6.044 ± 1.506
1.832SerHis: 1.832 ± 0.65
3.846SerIle: 3.846 ± 0.934
4.762SerLys: 4.762 ± 1.023
6.044SerLeu: 6.044 ± 1.04
2.015SerMet: 2.015 ± 0.692
2.747SerAsn: 2.747 ± 0.728
2.198SerPro: 2.198 ± 0.417
2.564SerGln: 2.564 ± 0.696
4.212SerArg: 4.212 ± 1.05
5.495SerSer: 5.495 ± 1.134
4.212SerThr: 4.212 ± 1.192
5.311SerVal: 5.311 ± 0.853
2.015SerTrp: 2.015 ± 0.553
1.465SerTyr: 1.465 ± 0.486
0.0SerXaa: 0.0 ± 0.0
Thr
5.311ThrAla: 5.311 ± 1.079
0.183ThrCys: 0.183 ± 0.183
2.93ThrAsp: 2.93 ± 0.777
2.747ThrGlu: 2.747 ± 0.56
2.564ThrPhe: 2.564 ± 0.74
3.846ThrGly: 3.846 ± 0.682
0.549ThrHis: 0.549 ± 0.294
6.227ThrIle: 6.227 ± 1.407
3.297ThrLys: 3.297 ± 1.068
4.579ThrLeu: 4.579 ± 0.699
1.282ThrMet: 1.282 ± 0.565
3.114ThrAsn: 3.114 ± 0.805
3.663ThrPro: 3.663 ± 1.002
1.648ThrGln: 1.648 ± 0.383
3.48ThrArg: 3.48 ± 0.913
3.846ThrSer: 3.846 ± 1.072
3.663ThrThr: 3.663 ± 0.748
5.311ThrVal: 5.311 ± 1.098
1.648ThrTrp: 1.648 ± 0.551
4.029ThrTyr: 4.029 ± 0.922
0.0ThrXaa: 0.0 ± 0.0
Val
5.128ValAla: 5.128 ± 0.896
0.916ValCys: 0.916 ± 0.428
4.945ValAsp: 4.945 ± 0.869
2.93ValGlu: 2.93 ± 0.702
2.564ValPhe: 2.564 ± 0.554
3.846ValGly: 3.846 ± 1.167
1.465ValHis: 1.465 ± 0.526
4.212ValIle: 4.212 ± 1.023
5.128ValLys: 5.128 ± 1.101
4.212ValLeu: 4.212 ± 1.08
1.465ValMet: 1.465 ± 0.464
3.114ValAsn: 3.114 ± 0.65
3.48ValPro: 3.48 ± 0.93
1.465ValGln: 1.465 ± 0.376
4.212ValArg: 4.212 ± 0.635
5.495ValSer: 5.495 ± 1.128
3.114ValThr: 3.114 ± 0.772
4.212ValVal: 4.212 ± 0.986
2.015ValTrp: 2.015 ± 0.609
2.198ValTyr: 2.198 ± 0.7
0.0ValXaa: 0.0 ± 0.0
Trp
1.099TrpAla: 1.099 ± 0.496
0.183TrpCys: 0.183 ± 0.159
1.648TrpAsp: 1.648 ± 0.637
1.099TrpGlu: 1.099 ± 0.441
0.549TrpPhe: 0.549 ± 0.258
2.564TrpGly: 2.564 ± 1.144
0.366TrpHis: 0.366 ± 0.295
1.099TrpIle: 1.099 ± 0.361
0.916TrpLys: 0.916 ± 0.45
2.198TrpLeu: 2.198 ± 0.543
0.183TrpMet: 0.183 ± 0.171
0.916TrpAsn: 0.916 ± 0.383
0.549TrpPro: 0.549 ± 0.316
0.733TrpGln: 0.733 ± 0.288
0.916TrpArg: 0.916 ± 0.273
1.099TrpSer: 1.099 ± 0.476
0.916TrpThr: 0.916 ± 0.4
0.916TrpVal: 0.916 ± 0.452
0.183TrpTrp: 0.183 ± 0.159
0.916TrpTyr: 0.916 ± 0.37
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.029TyrAla: 4.029 ± 0.906
0.916TyrCys: 0.916 ± 0.412
2.747TyrAsp: 2.747 ± 0.743
1.648TyrGlu: 1.648 ± 0.53
1.465TyrPhe: 1.465 ± 0.473
4.579TyrGly: 4.579 ± 0.931
0.549TyrHis: 0.549 ± 0.381
1.465TyrIle: 1.465 ± 0.556
0.916TyrLys: 0.916 ± 0.459
2.93TyrLeu: 2.93 ± 0.653
0.733TyrMet: 0.733 ± 0.408
2.381TyrAsn: 2.381 ± 0.73
1.465TyrPro: 1.465 ± 0.367
0.916TyrGln: 0.916 ± 0.366
3.297TyrArg: 3.297 ± 0.685
4.579TyrSer: 4.579 ± 0.875
2.015TyrThr: 2.015 ± 0.671
2.747TyrVal: 2.747 ± 0.831
0.733TyrTrp: 0.733 ± 0.409
2.198TyrTyr: 2.198 ± 0.558
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 22 proteins (5461 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski