Amino acid dipepetide frequency for Flammeovirgaceae bacterium 311

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.628AlaAla: 7.628 ± 0.084	0.705AlaCys: 0.705 ± 0.021	4.292AlaAsp: 4.292 ± 0.05	5.233AlaGlu: 5.233 ± 0.056	3.49AlaPhe: 3.49 ± 0.048	6.557AlaGly: 6.557 ± 0.074	1.423AlaHis: 1.423 ± 0.036	4.755AlaIle: 4.755 ± 0.06	3.67AlaLys: 3.67 ± 0.047	8.102AlaLeu: 8.102 ± 0.087	1.838AlaMet: 1.838 ± 0.033	3.219AlaAsn: 3.219 ± 0.052	3.07AlaPro: 3.07 ± 0.048	3.261AlaGln: 3.261 ± 0.043	3.518AlaArg: 3.518 ± 0.043	4.794AlaSer: 4.794 ± 0.053	4.192AlaThr: 4.192 ± 0.066	5.415AlaVal: 5.415 ± 0.062	0.963AlaTrp: 0.963 ± 0.025	3.039AlaTyr: 3.039 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.475CysAla: 0.475 ± 0.018	0.135CysCys: 0.135 ± 0.009	0.336CysAsp: 0.336 ± 0.016	0.378CysGlu: 0.378 ± 0.013	0.39CysPhe: 0.39 ± 0.016	0.608CysGly: 0.608 ± 0.019	0.191CysHis: 0.191 ± 0.011	0.477CysIle: 0.477 ± 0.016	0.315CysLys: 0.315 ± 0.014	0.812CysLeu: 0.812 ± 0.024	0.179CysMet: 0.179 ± 0.01	0.346CysAsn: 0.346 ± 0.015	0.318CysPro: 0.318 ± 0.015	0.295CysGln: 0.295 ± 0.014	0.369CysArg: 0.369 ± 0.014	0.566CysSer: 0.566 ± 0.023	0.445CysThr: 0.445 ± 0.017	0.391CysVal: 0.391 ± 0.016	0.096CysTrp: 0.096 ± 0.007	0.309CysTyr: 0.309 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.808AspAla: 3.808 ± 0.049	0.341AspCys: 0.341 ± 0.016	2.282AspAsp: 2.282 ± 0.04	3.308AspGlu: 3.308 ± 0.054	2.715AspPhe: 2.715 ± 0.04	3.627AspGly: 3.627 ± 0.064	0.964AspHis: 0.964 ± 0.025	3.241AspIle: 3.241 ± 0.048	3.129AspLys: 3.129 ± 0.055	4.802AspLeu: 4.802 ± 0.056	1.152AspMet: 1.152 ± 0.026	2.366AspAsn: 2.366 ± 0.039	2.389AspPro: 2.389 ± 0.051	1.914AspGln: 1.914 ± 0.031	2.472AspArg: 2.472 ± 0.043	2.808AspSer: 2.808 ± 0.049	2.419AspThr: 2.419 ± 0.041	3.238AspVal: 3.238 ± 0.045	0.841AspTrp: 0.841 ± 0.02	2.365AspTyr: 2.365 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.642GluAla: 5.642 ± 0.071	0.32GluCys: 0.32 ± 0.014	3.25GluAsp: 3.25 ± 0.052	5.38GluGlu: 5.38 ± 0.082	2.389GluPhe: 2.389 ± 0.037	4.579GluGly: 4.579 ± 0.052	1.427GluHis: 1.427 ± 0.028	4.025GluIle: 4.025 ± 0.05	4.496GluLys: 4.496 ± 0.053	6.698GluLeu: 6.698 ± 0.084	1.644GluMet: 1.644 ± 0.032	3.18GluAsn: 3.18 ± 0.044	2.186GluPro: 2.186 ± 0.039	3.549GluGln: 3.549 ± 0.06	3.287GluArg: 3.287 ± 0.047	3.152GluSer: 3.152 ± 0.04	2.974GluThr: 2.974 ± 0.039	4.721GluVal: 4.721 ± 0.057	0.915GluTrp: 0.915 ± 0.025	2.246GluTyr: 2.246 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.118PheAla: 3.118 ± 0.047	0.414PheCys: 0.414 ± 0.013	2.409PheAsp: 2.409 ± 0.04	2.725PheGlu: 2.725 ± 0.042	2.35PhePhe: 2.35 ± 0.042	3.204PheGly: 3.204 ± 0.045	0.814PheHis: 0.814 ± 0.019	2.935PheIle: 2.935 ± 0.044	2.278PheLys: 2.278 ± 0.038	4.334PheLeu: 4.334 ± 0.07	1.14PheMet: 1.14 ± 0.025	2.287PheAsn: 2.287 ± 0.038	1.644PhePro: 1.644 ± 0.035	1.49PheGln: 1.49 ± 0.028	2.319PheArg: 2.319 ± 0.036	3.736PheSer: 3.736 ± 0.049	2.882PheThr: 2.882 ± 0.049	2.749PheVal: 2.749 ± 0.041	0.64PheTrp: 0.64 ± 0.021	1.965PheTyr: 1.965 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.304GlyAla: 5.304 ± 0.062	0.642GlyCys: 0.642 ± 0.031	3.271GlyAsp: 3.271 ± 0.05	4.232GlyGlu: 4.232 ± 0.048	3.459GlyPhe: 3.459 ± 0.046	5.46GlyGly: 5.46 ± 0.091	1.326GlyHis: 1.326 ± 0.027	4.941GlyIle: 4.941 ± 0.062	4.363GlyLys: 4.363 ± 0.051	6.761GlyLeu: 6.761 ± 0.073	1.808GlyMet: 1.808 ± 0.035	3.479GlyAsn: 3.479 ± 0.06	1.911GlyPro: 1.911 ± 0.035	2.586GlyGln: 2.586 ± 0.045	3.321GlyArg: 3.321 ± 0.047	4.748GlySer: 4.748 ± 0.086	4.237GlyThr: 4.237 ± 0.086	4.788GlyVal: 4.788 ± 0.061	1.093GlyTrp: 1.093 ± 0.026	3.039GlyTyr: 3.039 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.362HisAla: 1.362 ± 0.031	0.183HisCys: 0.183 ± 0.009	0.935HisAsp: 0.935 ± 0.023	1.201HisGlu: 1.201 ± 0.027	1.13HisPhe: 1.13 ± 0.024	1.293HisGly: 1.293 ± 0.031	0.619HisHis: 0.619 ± 0.022	1.294HisIle: 1.294 ± 0.033	1.109HisLys: 1.109 ± 0.028	2.171HisLeu: 2.171 ± 0.041	0.444HisMet: 0.444 ± 0.014	0.93HisAsn: 0.93 ± 0.024	1.18HisPro: 1.18 ± 0.028	0.994HisGln: 0.994 ± 0.026	0.995HisArg: 0.995 ± 0.022	1.168HisSer: 1.168 ± 0.023	1.176HisThr: 1.176 ± 0.026	1.068HisVal: 1.068 ± 0.024	0.34HisTrp: 0.34 ± 0.015	1.038HisTyr: 1.038 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.919IleAla: 4.919 ± 0.059	0.619IleCys: 0.619 ± 0.017	3.471IleAsp: 3.471 ± 0.045	3.842IleGlu: 3.842 ± 0.052	2.802IlePhe: 2.802 ± 0.042	4.39IleGly: 4.39 ± 0.052	1.206IleHis: 1.206 ± 0.027	4.073IleIle: 4.073 ± 0.059	3.424IleLys: 3.424 ± 0.044	5.595IleLeu: 5.595 ± 0.064	1.298IleMet: 1.298 ± 0.027	3.215IleAsn: 3.215 ± 0.047	2.772IlePro: 2.772 ± 0.039	2.264IleGln: 2.264 ± 0.037	3.452IleArg: 3.452 ± 0.047	4.714IleSer: 4.714 ± 0.055	3.799IleThr: 3.799 ± 0.059	3.547IleVal: 3.547 ± 0.049	0.767IleTrp: 0.767 ± 0.02	2.248IleTyr: 2.248 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.752LysAla: 4.752 ± 0.058	0.257LysCys: 0.257 ± 0.014	3.067LysAsp: 3.067 ± 0.05	4.476LysGlu: 4.476 ± 0.059	1.859LysPhe: 1.859 ± 0.033	4.03LysGly: 4.03 ± 0.049	1.129LysHis: 1.129 ± 0.024	3.693LysIle: 3.693 ± 0.045	4.005LysLys: 4.005 ± 0.057	5.329LysLeu: 5.329 ± 0.065	1.376LysMet: 1.376 ± 0.028	2.812LysAsn: 2.812 ± 0.041	2.459LysPro: 2.459 ± 0.038	2.504LysGln: 2.504 ± 0.04	2.556LysArg: 2.556 ± 0.038	3.083LysSer: 3.083 ± 0.043	2.901LysThr: 2.901 ± 0.044	3.835LysVal: 3.835 ± 0.052	0.711LysTrp: 0.711 ± 0.019	1.969LysTyr: 1.969 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	7.896LeuAla: 7.896 ± 0.086	0.798LeuCys: 0.798 ± 0.026	4.772LeuAsp: 4.772 ± 0.06	6.714LeuGlu: 6.714 ± 0.07	4.565LeuPhe: 4.565 ± 0.061	6.234LeuGly: 6.234 ± 0.071	2.184LeuHis: 2.184 ± 0.037	5.974LeuIle: 5.974 ± 0.071	6.015LeuLys: 6.015 ± 0.058	11.694LeuLeu: 11.694 ± 0.149	2.491LeuMet: 2.491 ± 0.041	4.781LeuAsn: 4.781 ± 0.063	4.776LeuPro: 4.776 ± 0.058	5.328LeuGln: 5.328 ± 0.071	4.721LeuArg: 4.721 ± 0.06	6.949LeuSer: 6.949 ± 0.067	5.133LeuThr: 5.133 ± 0.055	6.373LeuVal: 6.373 ± 0.07	1.132LeuTrp: 1.132 ± 0.031	3.821LeuTyr: 3.821 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.99MetAla: 1.99 ± 0.037	0.129MetCys: 0.129 ± 0.009	1.125MetAsp: 1.125 ± 0.03	1.538MetGlu: 1.538 ± 0.029	0.823MetPhe: 0.823 ± 0.021	1.673MetGly: 1.673 ± 0.038	0.52MetHis: 0.52 ± 0.016	1.33MetIle: 1.33 ± 0.029	1.634MetLys: 1.634 ± 0.03	2.572MetLeu: 2.572 ± 0.039	0.584MetMet: 0.584 ± 0.018	1.114MetAsn: 1.114 ± 0.023	1.175MetPro: 1.175 ± 0.024	1.205MetGln: 1.205 ± 0.025	1.09MetArg: 1.09 ± 0.029	1.262MetSer: 1.262 ± 0.027	0.902MetThr: 0.902 ± 0.023	1.529MetVal: 1.529 ± 0.034	0.207MetTrp: 0.207 ± 0.01	0.69MetTyr: 0.69 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.304AsnAla: 3.304 ± 0.052	0.347AsnCys: 0.347 ± 0.015	2.116AsnAsp: 2.116 ± 0.035	2.655AsnGlu: 2.655 ± 0.046	2.182AsnPhe: 2.182 ± 0.038	3.314AsnGly: 3.314 ± 0.072	0.87AsnHis: 0.87 ± 0.022	3.351AsnIle: 3.351 ± 0.048	2.747AsnLys: 2.747 ± 0.043	4.571AsnLeu: 4.571 ± 0.061	1.066AsnMet: 1.066 ± 0.024	2.57AsnAsn: 2.57 ± 0.051	2.698AsnPro: 2.698 ± 0.042	1.948AsnGln: 1.948 ± 0.033	2.458AsnArg: 2.458 ± 0.041	3.006AsnSer: 3.006 ± 0.048	2.913AsnThr: 2.913 ± 0.049	2.494AsnVal: 2.494 ± 0.045	0.676AsnTrp: 0.676 ± 0.018	2.107AsnTyr: 2.107 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.982ProAla: 3.982 ± 0.058	0.236ProCys: 0.236 ± 0.011	2.841ProAsp: 2.841 ± 0.043	3.511ProGlu: 3.511 ± 0.046	1.96ProPhe: 1.96 ± 0.04	3.049ProGly: 3.049 ± 0.047	0.919ProHis: 0.919 ± 0.024	2.181ProIle: 2.181 ± 0.037	1.952ProLys: 1.952 ± 0.03	4.123ProLeu: 4.123 ± 0.051	0.852ProMet: 0.852 ± 0.021	1.762ProAsn: 1.762 ± 0.038	1.327ProPro: 1.327 ± 0.03	1.836ProGln: 1.836 ± 0.033	1.484ProArg: 1.484 ± 0.033	2.159ProSer: 2.159 ± 0.033	1.95ProThr: 1.95 ± 0.044	3.441ProVal: 3.441 ± 0.048	0.516ProTrp: 0.516 ± 0.017	1.693ProTyr: 1.693 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.482GlnAla: 3.482 ± 0.047	0.206GlnCys: 0.206 ± 0.011	1.969GlnAsp: 1.969 ± 0.039	3.668GlnGlu: 3.668 ± 0.056	1.58GlnPhe: 1.58 ± 0.028	2.587GlnGly: 2.587 ± 0.044	1.154GlnHis: 1.154 ± 0.026	2.369GlnIle: 2.369 ± 0.035	2.652GlnLys: 2.652 ± 0.044	4.981GlnLeu: 4.981 ± 0.059	1.005GlnMet: 1.005 ± 0.023	1.983GlnAsn: 1.983 ± 0.039	1.918GlnPro: 1.918 ± 0.037	3.346GlnGln: 3.346 ± 0.065	2.064GlnArg: 2.064 ± 0.037	2.127GlnSer: 2.127 ± 0.034	2.099GlnThr: 2.099 ± 0.038	2.792GlnVal: 2.792 ± 0.044	0.619GlnTrp: 0.619 ± 0.02	1.674GlnTyr: 1.674 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	3.08ArgAla: 3.08 ± 0.035	0.271ArgCys: 0.271 ± 0.012	2.178ArgAsp: 2.178 ± 0.034	3.318ArgGlu: 3.318 ± 0.047	2.396ArgPhe: 2.396 ± 0.034	2.816ArgGly: 2.816 ± 0.044	1.044ArgHis: 1.044 ± 0.027	3.243ArgIle: 3.243 ± 0.043	2.967ArgLys: 2.967 ± 0.044	5.19ArgLeu: 5.19 ± 0.06	1.243ArgMet: 1.243 ± 0.025	2.426ArgAsn: 2.426 ± 0.04	1.726ArgPro: 1.726 ± 0.037	2.444ArgGln: 2.444 ± 0.045	2.364ArgArg: 2.364 ± 0.04	2.814ArgSer: 2.814 ± 0.045	2.347ArgThr: 2.347 ± 0.037	2.921ArgVal: 2.921 ± 0.048	0.709ArgTrp: 0.709 ± 0.021	2.272ArgTyr: 2.272 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.599SerAla: 4.599 ± 0.06	0.602SerCys: 0.602 ± 0.019	2.963SerAsp: 2.963 ± 0.051	3.329SerGlu: 3.329 ± 0.045	3.356SerPhe: 3.356 ± 0.043	5.135SerGly: 5.135 ± 0.077	1.19SerHis: 1.19 ± 0.025	4.117SerIle: 4.117 ± 0.055	3.168SerLys: 3.168 ± 0.046	6.742SerLeu: 6.742 ± 0.065	1.446SerMet: 1.446 ± 0.029	2.743SerAsn: 2.743 ± 0.05	2.544SerPro: 2.544 ± 0.043	2.249SerGln: 2.249 ± 0.038	3.095SerArg: 3.095 ± 0.048	4.297SerSer: 4.297 ± 0.08	3.324SerThr: 3.324 ± 0.048	3.838SerVal: 3.838 ± 0.047	0.997SerTrp: 0.997 ± 0.024	2.626SerTyr: 2.626 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.817ThrAla: 4.817 ± 0.072	0.311ThrCys: 0.311 ± 0.013	3.088ThrAsp: 3.088 ± 0.065	3.192ThrGlu: 3.192 ± 0.048	2.478ThrPhe: 2.478 ± 0.038	4.408ThrGly: 4.408 ± 0.059	1.062ThrHis: 1.062 ± 0.024	3.556ThrIle: 3.556 ± 0.054	2.32ThrLys: 2.32 ± 0.038	5.301ThrLeu: 5.301 ± 0.067	0.874ThrMet: 0.874 ± 0.022	2.387ThrAsn: 2.387 ± 0.05	2.709ThrPro: 2.709 ± 0.046	1.702ThrGln: 1.702 ± 0.029	2.243ThrArg: 2.243 ± 0.034	3.292ThrSer: 3.292 ± 0.053	3.298ThrThr: 3.298 ± 0.07	3.594ThrVal: 3.594 ± 0.062	0.6ThrTrp: 0.6 ± 0.018	2.275ThrTyr: 2.275 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.336ValAla: 5.336 ± 0.067	0.511ValCys: 0.511 ± 0.017	3.135ValAsp: 3.135 ± 0.042	4.269ValGlu: 4.269 ± 0.066	2.874ValPhe: 2.874 ± 0.042	4.008ValGly: 4.008 ± 0.054	1.304ValHis: 1.304 ± 0.027	3.834ValIle: 3.834 ± 0.051	3.637ValLys: 3.637 ± 0.047	6.909ValLeu: 6.909 ± 0.086	1.466ValMet: 1.466 ± 0.031	3.04ValAsn: 3.04 ± 0.047	2.847ValPro: 2.847 ± 0.05	2.663ValGln: 2.663 ± 0.04	2.914ValArg: 2.914 ± 0.044	4.23ValSer: 4.23 ± 0.054	3.445ValThr: 3.445 ± 0.065	5.12ValVal: 5.12 ± 0.069	0.787ValTrp: 0.787 ± 0.022	2.526ValTyr: 2.526 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.923TrpAla: 0.923 ± 0.025	0.087TrpCys: 0.087 ± 0.007	0.667TrpAsp: 0.667 ± 0.02	0.845TrpGlu: 0.845 ± 0.022	0.576TrpPhe: 0.576 ± 0.02	1.119TrpGly: 1.119 ± 0.025	0.324TrpHis: 0.324 ± 0.014	0.766TrpIle: 0.766 ± 0.022	0.739TrpLys: 0.739 ± 0.022	1.421TrpLeu: 1.421 ± 0.032	0.371TrpMet: 0.371 ± 0.015	0.631TrpAsn: 0.631 ± 0.019	0.43TrpPro: 0.43 ± 0.018	0.813TrpGln: 0.813 ± 0.024	0.653TrpArg: 0.653 ± 0.02	0.802TrpSer: 0.802 ± 0.02	0.605TrpThr: 0.605 ± 0.019	0.872TrpVal: 0.872 ± 0.025	0.219TrpTrp: 0.219 ± 0.012	0.531TrpTyr: 0.531 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.747TyrAla: 2.747 ± 0.044	0.317TyrCys: 0.317 ± 0.014	2.015TyrAsp: 2.015 ± 0.034	2.245TyrGlu: 2.245 ± 0.039	2.059TyrPhe: 2.059 ± 0.04	2.675TyrGly: 2.675 ± 0.052	0.962TyrHis: 0.962 ± 0.023	2.261TyrIle: 2.261 ± 0.036	2.181TyrLys: 2.181 ± 0.035	4.242TyrLeu: 4.242 ± 0.056	0.814TyrMet: 0.814 ± 0.023	2.122TyrAsn: 2.122 ± 0.04	1.694TyrPro: 1.694 ± 0.037	1.884TyrGln: 1.884 ± 0.036	2.395TyrArg: 2.395 ± 0.036	2.654TyrSer: 2.654 ± 0.046	2.467TyrThr: 2.467 ± 0.051	2.13TyrVal: 2.13 ± 0.037	0.568TyrTrp: 0.568 ± 0.016	1.912TyrTyr: 1.912 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5332 proteins (1897602 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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