Amino acid dipepetide frequency for Tissierella creatinophila DSM 6911

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.28AlaAla: 3.28 ± 0.095
0.446AlaCys: 0.446 ± 0.024
2.488AlaAsp: 2.488 ± 0.072
3.107AlaGlu: 3.107 ± 0.079
2.234AlaPhe: 2.234 ± 0.06
3.675AlaGly: 3.675 ± 0.074
0.785AlaHis: 0.785 ± 0.037
5.781AlaIle: 5.781 ± 0.096
4.513AlaLys: 4.513 ± 0.09
5.681AlaLeu: 5.681 ± 0.101
1.586AlaMet: 1.586 ± 0.053
2.495AlaAsn: 2.495 ± 0.062
1.34AlaPro: 1.34 ± 0.046
1.386AlaGln: 1.386 ± 0.041
2.013AlaArg: 2.013 ± 0.057
3.335AlaSer: 3.335 ± 0.07
2.708AlaThr: 2.708 ± 0.067
3.381AlaVal: 3.381 ± 0.071
0.306AlaTrp: 0.306 ± 0.021
1.861AlaTyr: 1.861 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.386CysAla: 0.386 ± 0.023
0.091CysCys: 0.091 ± 0.013
0.482CysAsp: 0.482 ± 0.027
0.521CysGlu: 0.521 ± 0.028
0.312CysPhe: 0.312 ± 0.023
0.736CysGly: 0.736 ± 0.036
0.155CysHis: 0.155 ± 0.016
0.732CysIle: 0.732 ± 0.033
0.616CysLys: 0.616 ± 0.033
0.537CysLeu: 0.537 ± 0.026
0.177CysMet: 0.177 ± 0.015
0.433CysAsn: 0.433 ± 0.027
0.393CysPro: 0.393 ± 0.031
0.172CysGln: 0.172 ± 0.017
0.255CysArg: 0.255 ± 0.021
0.515CysSer: 0.515 ± 0.028
0.394CysThr: 0.394 ± 0.025
0.434CysVal: 0.434 ± 0.026
0.051CysTrp: 0.051 ± 0.009
0.253CysTyr: 0.253 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
2.709AspAla: 2.709 ± 0.065
0.456AspCys: 0.456 ± 0.028
2.854AspAsp: 2.854 ± 0.076
5.052AspGlu: 5.052 ± 0.099
2.972AspPhe: 2.972 ± 0.061
3.694AspGly: 3.694 ± 0.08
0.678AspHis: 0.678 ± 0.033
7.51AspIle: 7.51 ± 0.11
5.798AspLys: 5.798 ± 0.091
5.9AspLeu: 5.9 ± 0.093
1.636AspMet: 1.636 ± 0.047
3.07AspAsn: 3.07 ± 0.065
1.672AspPro: 1.672 ± 0.056
0.919AspGln: 0.919 ± 0.043
2.384AspArg: 2.384 ± 0.066
3.316AspSer: 3.316 ± 0.077
2.646AspThr: 2.646 ± 0.064
3.375AspVal: 3.375 ± 0.071
0.426AspTrp: 0.426 ± 0.022
2.724AspTyr: 2.724 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
3.943GluAla: 3.943 ± 0.08
0.417GluCys: 0.417 ± 0.03
5.371GluAsp: 5.371 ± 0.099
8.192GluGlu: 8.192 ± 0.123
3.119GluPhe: 3.119 ± 0.072
4.77GluGly: 4.77 ± 0.092
0.883GluHis: 0.883 ± 0.037
8.108GluIle: 8.108 ± 0.115
8.818GluLys: 8.818 ± 0.135
7.232GluLeu: 7.232 ± 0.108
2.273GluMet: 2.273 ± 0.051
5.176GluAsn: 5.176 ± 0.085
1.564GluPro: 1.564 ± 0.053
1.68GluGln: 1.68 ± 0.054
2.957GluArg: 2.957 ± 0.074
3.784GluSer: 3.784 ± 0.085
3.504GluThr: 3.504 ± 0.069
5.085GluVal: 5.085 ± 0.081
0.484GluTrp: 0.484 ± 0.026
3.093GluTyr: 3.093 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
2.16PheAla: 2.16 ± 0.054
0.351PheCys: 0.351 ± 0.022
2.515PheAsp: 2.515 ± 0.061
2.835PheGlu: 2.835 ± 0.06
2.009PhePhe: 2.009 ± 0.064
2.807PheGly: 2.807 ± 0.059
0.576PheHis: 0.576 ± 0.032
4.809PheIle: 4.809 ± 0.11
4.002PheLys: 4.002 ± 0.073
4.244PheLeu: 4.244 ± 0.097
1.126PheMet: 1.126 ± 0.04
2.636PheAsn: 2.636 ± 0.061
1.387PhePro: 1.387 ± 0.046
0.954PheGln: 0.954 ± 0.041
1.384PheArg: 1.384 ± 0.042
3.074PheSer: 3.074 ± 0.074
2.425PheThr: 2.425 ± 0.052
2.504PheVal: 2.504 ± 0.063
0.28PheTrp: 0.28 ± 0.021
1.619PheTyr: 1.619 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
3.736GlyAla: 3.736 ± 0.094
0.603GlyCys: 0.603 ± 0.031
3.466GlyAsp: 3.466 ± 0.087
4.899GlyGlu: 4.899 ± 0.088
3.22GlyPhe: 3.22 ± 0.068
4.638GlyGly: 4.638 ± 0.112
0.981GlyHis: 0.981 ± 0.04
6.748GlyIle: 6.748 ± 0.125
5.833GlyLys: 5.833 ± 0.104
6.031GlyLeu: 6.031 ± 0.108
1.895GlyMet: 1.895 ± 0.052
3.123GlyAsn: 3.123 ± 0.069
1.241GlyPro: 1.241 ± 0.041
1.493GlyGln: 1.493 ± 0.047
2.57GlyArg: 2.57 ± 0.06
3.815GlySer: 3.815 ± 0.066
3.465GlyThr: 3.465 ± 0.072
4.746GlyVal: 4.746 ± 0.085
0.433GlyTrp: 0.433 ± 0.026
2.778GlyTyr: 2.778 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
0.716HisAla: 0.716 ± 0.033
0.147HisCys: 0.147 ± 0.015
0.72HisAsp: 0.72 ± 0.032
0.829HisGlu: 0.829 ± 0.032
0.612HisPhe: 0.612 ± 0.031
0.989HisGly: 0.989 ± 0.042
0.299HisHis: 0.299 ± 0.021
1.376HisIle: 1.376 ± 0.045
0.98HisLys: 0.98 ± 0.035
1.314HisLeu: 1.314 ± 0.047
0.31HisMet: 0.31 ± 0.018
0.703HisAsn: 0.703 ± 0.029
0.698HisPro: 0.698 ± 0.033
0.35HisGln: 0.35 ± 0.02
0.595HisArg: 0.595 ± 0.033
0.835HisSer: 0.835 ± 0.032
0.623HisThr: 0.623 ± 0.03
0.709HisVal: 0.709 ± 0.029
0.088HisTrp: 0.088 ± 0.011
0.533HisTyr: 0.533 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.629IleAla: 5.629 ± 0.092
0.878IleCys: 0.878 ± 0.038
7.025IleAsp: 7.025 ± 0.113
8.645IleGlu: 8.645 ± 0.131
4.299IlePhe: 4.299 ± 0.1
6.542IleGly: 6.542 ± 0.11
1.239IleHis: 1.239 ± 0.043
10.016IleIle: 10.016 ± 0.175
9.037IleLys: 9.037 ± 0.127
9.494IleLeu: 9.494 ± 0.142
2.385IleMet: 2.385 ± 0.067
5.781IleAsn: 5.781 ± 0.107
3.362IlePro: 3.362 ± 0.074
2.252IleGln: 2.252 ± 0.06
3.361IleArg: 3.361 ± 0.064
7.088IleSer: 7.088 ± 0.102
4.814IleThr: 4.814 ± 0.084
6.424IleVal: 6.424 ± 0.128
0.58IleTrp: 0.58 ± 0.032
3.666IleTyr: 3.666 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
4.705LysAla: 4.705 ± 0.087
0.497LysCys: 0.497 ± 0.032
7.087LysAsp: 7.087 ± 0.129
9.861LysGlu: 9.861 ± 0.118
3.117LysPhe: 3.117 ± 0.069
5.366LysGly: 5.366 ± 0.106
1.064LysHis: 1.064 ± 0.041
8.278LysIle: 8.278 ± 0.113
8.211LysLys: 8.211 ± 0.119
7.33LysLeu: 7.33 ± 0.1
2.409LysMet: 2.409 ± 0.065
5.681LysAsn: 5.681 ± 0.09
2.132LysPro: 2.132 ± 0.052
2.094LysGln: 2.094 ± 0.058
3.734LysArg: 3.734 ± 0.076
5.27LysSer: 5.27 ± 0.087
4.697LysThr: 4.697 ± 0.085
5.306LysVal: 5.306 ± 0.093
0.622LysTrp: 0.622 ± 0.03
3.634LysTyr: 3.634 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
4.938LeuAla: 4.938 ± 0.109
0.657LeuCys: 0.657 ± 0.032
5.877LeuAsp: 5.877 ± 0.101
7.963LeuGlu: 7.963 ± 0.116
3.996LeuPhe: 3.996 ± 0.089
6.406LeuGly: 6.406 ± 0.113
1.077LeuHis: 1.077 ± 0.036
8.637LeuIle: 8.637 ± 0.128
8.987LeuLys: 8.987 ± 0.105
8.259LeuLeu: 8.259 ± 0.123
2.301LeuMet: 2.301 ± 0.054
5.996LeuAsn: 5.996 ± 0.095
3.032LeuPro: 3.032 ± 0.071
2.129LeuGln: 2.129 ± 0.056
3.304LeuArg: 3.304 ± 0.071
6.822LeuSer: 6.822 ± 0.102
4.465LeuThr: 4.465 ± 0.079
5.391LeuVal: 5.391 ± 0.084
0.563LeuTrp: 0.563 ± 0.028
3.056LeuTyr: 3.056 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
1.755MetAla: 1.755 ± 0.054
0.153MetCys: 0.153 ± 0.016
1.777MetAsp: 1.777 ± 0.05
2.278MetGlu: 2.278 ± 0.053
0.935MetPhe: 0.935 ± 0.039
1.971MetGly: 1.971 ± 0.056
0.279MetHis: 0.279 ± 0.021
2.527MetIle: 2.527 ± 0.058
2.687MetLys: 2.687 ± 0.065
2.084MetLeu: 2.084 ± 0.056
0.768MetMet: 0.768 ± 0.032
1.482MetAsn: 1.482 ± 0.051
0.791MetPro: 0.791 ± 0.031
0.612MetGln: 0.612 ± 0.029
0.883MetArg: 0.883 ± 0.036
1.601MetSer: 1.601 ± 0.045
1.277MetThr: 1.277 ± 0.043
1.671MetVal: 1.671 ± 0.042
0.142MetTrp: 0.142 ± 0.014
0.77MetTyr: 0.77 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.533AsnAla: 2.533 ± 0.065
0.466AsnCys: 0.466 ± 0.024
2.677AsnAsp: 2.677 ± 0.063
3.752AsnGlu: 3.752 ± 0.073
2.338AsnPhe: 2.338 ± 0.061
3.236AsnGly: 3.236 ± 0.074
0.931AsnHis: 0.931 ± 0.04
6.991AsnIle: 6.991 ± 0.125
5.459AsnLys: 5.459 ± 0.092
5.825AsnLeu: 5.825 ± 0.101
1.557AsnMet: 1.557 ± 0.051
3.196AsnAsn: 3.196 ± 0.072
2.254AsnPro: 2.254 ± 0.064
1.316AsnGln: 1.316 ± 0.044
2.212AsnArg: 2.212 ± 0.061
3.458AsnSer: 3.458 ± 0.073
2.786AsnThr: 2.786 ± 0.054
2.88AsnVal: 2.88 ± 0.068
0.472AsnTrp: 0.472 ± 0.024
2.275AsnTyr: 2.275 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
1.388ProAla: 1.388 ± 0.047
0.244ProCys: 0.244 ± 0.018
1.631ProAsp: 1.631 ± 0.051
2.386ProGlu: 2.386 ± 0.077
1.489ProPhe: 1.489 ± 0.048
1.849ProGly: 1.849 ± 0.055
0.507ProHis: 0.507 ± 0.026
2.992ProIle: 2.992 ± 0.061
2.317ProLys: 2.317 ± 0.062
2.685ProLeu: 2.685 ± 0.069
0.744ProMet: 0.744 ± 0.033
1.487ProAsn: 1.487 ± 0.045
0.76ProPro: 0.76 ± 0.031
0.797ProGln: 0.797 ± 0.033
0.917ProArg: 0.917 ± 0.035
1.904ProSer: 1.904 ± 0.048
1.636ProThr: 1.636 ± 0.049
1.998ProVal: 1.998 ± 0.053
0.224ProTrp: 0.224 ± 0.018
1.217ProTyr: 1.217 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.313GlnAla: 1.313 ± 0.041
0.154GlnCys: 0.154 ± 0.014
1.262GlnAsp: 1.262 ± 0.039
1.96GlnGlu: 1.96 ± 0.063
0.862GlnPhe: 0.862 ± 0.035
1.544GlnGly: 1.544 ± 0.048
0.268GlnHis: 0.268 ± 0.019
2.223GlnIle: 2.223 ± 0.057
2.141GlnLys: 2.141 ± 0.052
1.887GlnLeu: 1.887 ± 0.053
0.702GlnMet: 0.702 ± 0.033
1.344GlnAsn: 1.344 ± 0.043
0.498GlnPro: 0.498 ± 0.026
0.599GlnGln: 0.599 ± 0.027
1.162GlnArg: 1.162 ± 0.04
1.355GlnSer: 1.355 ± 0.043
1.13GlnThr: 1.13 ± 0.042
1.371GlnVal: 1.371 ± 0.04
0.204GlnTrp: 0.204 ± 0.018
0.884GlnTyr: 0.884 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
1.907ArgAla: 1.907 ± 0.056
0.335ArgCys: 0.335 ± 0.022
2.384ArgAsp: 2.384 ± 0.06
3.458ArgGlu: 3.458 ± 0.074
1.692ArgPhe: 1.692 ± 0.047
2.334ArgGly: 2.334 ± 0.058
0.473ArgHis: 0.473 ± 0.025
3.414ArgIle: 3.414 ± 0.064
3.306ArgLys: 3.306 ± 0.069
3.382ArgLeu: 3.382 ± 0.072
0.994ArgMet: 0.994 ± 0.037
2.03ArgAsn: 2.03 ± 0.057
1.009ArgPro: 1.009 ± 0.036
0.977ArgGln: 0.977 ± 0.039
1.489ArgArg: 1.489 ± 0.055
1.826ArgSer: 1.826 ± 0.054
1.749ArgThr: 1.749 ± 0.05
2.506ArgVal: 2.506 ± 0.06
0.303ArgTrp: 0.303 ± 0.02
1.566ArgTyr: 1.566 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
2.967SerAla: 2.967 ± 0.072
0.462SerCys: 0.462 ± 0.026
2.972SerAsp: 2.972 ± 0.064
3.69SerGlu: 3.69 ± 0.069
3.385SerPhe: 3.385 ± 0.076
4.241SerGly: 4.241 ± 0.1
0.931SerHis: 0.931 ± 0.037
6.869SerIle: 6.869 ± 0.104
5.375SerLys: 5.375 ± 0.087
6.723SerLeu: 6.723 ± 0.119
1.706SerMet: 1.706 ± 0.053
3.361SerAsn: 3.361 ± 0.059
1.829SerPro: 1.829 ± 0.05
1.71SerGln: 1.71 ± 0.052
2.301SerArg: 2.301 ± 0.055
4.376SerSer: 4.376 ± 0.095
3.26SerThr: 3.26 ± 0.068
3.513SerVal: 3.513 ± 0.068
0.417SerTrp: 0.417 ± 0.023
2.483SerTyr: 2.483 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
2.766ThrAla: 2.766 ± 0.069
0.389ThrCys: 0.389 ± 0.025
2.7ThrAsp: 2.7 ± 0.062
2.861ThrGlu: 2.861 ± 0.059
2.089ThrPhe: 2.089 ± 0.058
3.686ThrGly: 3.686 ± 0.079
0.811ThrHis: 0.811 ± 0.034
5.373ThrIle: 5.373 ± 0.093
3.858ThrLys: 3.858 ± 0.069
4.932ThrLeu: 4.932 ± 0.094
1.229ThrMet: 1.229 ± 0.042
2.66ThrAsn: 2.66 ± 0.063
1.927ThrPro: 1.927 ± 0.046
1.19ThrGln: 1.19 ± 0.044
1.796ThrArg: 1.796 ± 0.051
3.158ThrSer: 3.158 ± 0.073
2.752ThrThr: 2.752 ± 0.072
3.032ThrVal: 3.032 ± 0.069
0.338ThrTrp: 0.338 ± 0.024
1.674ThrTyr: 1.674 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
3.491ValAla: 3.491 ± 0.079
0.49ValCys: 0.49 ± 0.024
3.838ValAsp: 3.838 ± 0.075
4.871ValGlu: 4.871 ± 0.081
2.778ValPhe: 2.778 ± 0.066
4.211ValGly: 4.211 ± 0.087
0.872ValHis: 0.872 ± 0.039
5.513ValIle: 5.513 ± 0.087
5.098ValLys: 5.098 ± 0.089
6.16ValLeu: 6.16 ± 0.102
1.47ValMet: 1.47 ± 0.047
3.253ValAsn: 3.253 ± 0.064
1.94ValPro: 1.94 ± 0.044
1.187ValGln: 1.187 ± 0.038
2.015ValArg: 2.015 ± 0.058
4.083ValSer: 4.083 ± 0.089
2.684ValThr: 2.684 ± 0.06
4.061ValVal: 4.061 ± 0.082
0.324ValTrp: 0.324 ± 0.022
2.271ValTyr: 2.271 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.344TrpAla: 0.344 ± 0.024
0.064TrpCys: 0.064 ± 0.009
0.472TrpAsp: 0.472 ± 0.028
0.507TrpGlu: 0.507 ± 0.026
0.288TrpPhe: 0.288 ± 0.021
0.461TrpGly: 0.461 ± 0.026
0.1TrpHis: 0.1 ± 0.013
0.678TrpIle: 0.678 ± 0.031
0.496TrpLys: 0.496 ± 0.026
0.568TrpLeu: 0.568 ± 0.026
0.204TrpMet: 0.204 ± 0.017
0.407TrpAsn: 0.407 ± 0.028
0.158TrpPro: 0.158 ± 0.016
0.196TrpGln: 0.196 ± 0.016
0.273TrpArg: 0.273 ± 0.02
0.39TrpSer: 0.39 ± 0.024
0.323TrpThr: 0.323 ± 0.025
0.37TrpVal: 0.37 ± 0.021
0.086TrpTrp: 0.086 ± 0.01
0.228TrpTyr: 0.228 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.737TyrAla: 1.737 ± 0.052
0.344TyrCys: 0.344 ± 0.021
2.195TyrAsp: 2.195 ± 0.064
2.784TyrGlu: 2.784 ± 0.062
1.952TyrPhe: 1.952 ± 0.055
2.555TyrGly: 2.555 ± 0.065
0.516TyrHis: 0.516 ± 0.026
3.942TyrIle: 3.942 ± 0.078
3.564TyrLys: 3.564 ± 0.069
3.591TyrLeu: 3.591 ± 0.082
0.971TyrMet: 0.971 ± 0.038
2.298TyrAsn: 2.298 ± 0.06
1.185TyrPro: 1.185 ± 0.041
0.85TyrGln: 0.85 ± 0.035
1.53TyrArg: 1.53 ± 0.046
2.563TyrSer: 2.563 ± 0.06
1.881TyrThr: 1.881 ± 0.053
1.854TyrVal: 1.854 ± 0.051
0.272TyrTrp: 0.272 ± 0.021
1.585TyrTyr: 1.585 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2530 proteins (746299 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski