Amino acid dipepetide frequency for Streptomyces sp. 769

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.947AlaAla: 22.947 ± 0.151	1.196AlaCys: 1.196 ± 0.02	8.637AlaAsp: 8.637 ± 0.073	8.534AlaGlu: 8.534 ± 0.075	3.583AlaPhe: 3.583 ± 0.036	13.822AlaGly: 13.822 ± 0.089	3.326AlaHis: 3.326 ± 0.037	3.379AlaIle: 3.379 ± 0.038	2.649AlaLys: 2.649 ± 0.044	15.363AlaLeu: 15.363 ± 0.102	2.608AlaMet: 2.608 ± 0.033	1.838AlaAsn: 1.838 ± 0.028	8.166AlaPro: 8.166 ± 0.083	4.024AlaGln: 4.024 ± 0.042	10.942AlaArg: 10.942 ± 0.081	5.6AlaSer: 5.6 ± 0.047	7.439AlaThr: 7.439 ± 0.057	12.329AlaVal: 12.329 ± 0.076	1.839AlaTrp: 1.839 ± 0.024	2.549AlaTyr: 2.549 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.234CysAla: 1.234 ± 0.026	0.114CysCys: 0.114 ± 0.008	0.515CysAsp: 0.515 ± 0.013	0.398CysGlu: 0.398 ± 0.012	0.223CysPhe: 0.223 ± 0.01	1.041CysGly: 1.041 ± 0.023	0.218CysHis: 0.218 ± 0.009	0.188CysIle: 0.188 ± 0.009	0.126CysLys: 0.126 ± 0.007	0.813CysLeu: 0.813 ± 0.019	0.139CysMet: 0.139 ± 0.007	0.13CysAsn: 0.13 ± 0.007	0.555CysPro: 0.555 ± 0.014	0.193CysGln: 0.193 ± 0.008	0.733CysArg: 0.733 ± 0.018	0.487CysSer: 0.487 ± 0.015	0.553CysThr: 0.553 ± 0.015	0.664CysVal: 0.664 ± 0.015	0.143CysTrp: 0.143 ± 0.007	0.163CysTyr: 0.163 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.059AspAla: 8.059 ± 0.071	0.443AspCys: 0.443 ± 0.014	3.503AspAsp: 3.503 ± 0.044	3.58AspGlu: 3.58 ± 0.04	1.571AspPhe: 1.571 ± 0.023	6.459AspGly: 6.459 ± 0.054	1.557AspHis: 1.557 ± 0.026	1.734AspIle: 1.734 ± 0.026	1.031AspLys: 1.031 ± 0.023	6.013AspLeu: 6.013 ± 0.046	0.771AspMet: 0.771 ± 0.018	0.854AspAsn: 0.854 ± 0.017	4.467AspPro: 4.467 ± 0.043	1.609AspGln: 1.609 ± 0.025	5.228AspArg: 5.228 ± 0.052	2.217AspSer: 2.217 ± 0.025	3.196AspThr: 3.196 ± 0.033	4.369AspVal: 4.369 ± 0.036	1.008AspTrp: 1.008 ± 0.023	1.074AspTyr: 1.074 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	7.032GluAla: 7.032 ± 0.06	0.387GluCys: 0.387 ± 0.011	2.567GluAsp: 2.567 ± 0.035	3.284GluGlu: 3.284 ± 0.042	1.406GluPhe: 1.406 ± 0.025	4.06GluGly: 4.06 ± 0.045	1.566GluHis: 1.566 ± 0.026	2.109GluIle: 2.109 ± 0.029	1.246GluLys: 1.246 ± 0.021	6.645GluLeu: 6.645 ± 0.055	0.85GluMet: 0.85 ± 0.019	0.913GluAsn: 0.913 ± 0.02	3.2GluPro: 3.2 ± 0.04	2.232GluGln: 2.232 ± 0.033	5.469GluArg: 5.469 ± 0.052	2.306GluSer: 2.306 ± 0.027	2.677GluThr: 2.677 ± 0.034	4.267GluVal: 4.267 ± 0.045	0.733GluTrp: 0.733 ± 0.017	0.943GluTyr: 0.943 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.748PheAla: 3.748 ± 0.04	0.279PheCys: 0.279 ± 0.011	1.873PheAsp: 1.873 ± 0.032	1.299PheGlu: 1.299 ± 0.024	0.849PhePhe: 0.849 ± 0.019	2.901PheGly: 2.901 ± 0.035	0.662PheHis: 0.662 ± 0.015	0.655PheIle: 0.655 ± 0.016	0.445PheLys: 0.445 ± 0.012	2.589PheLeu: 2.589 ± 0.035	0.371PheMet: 0.371 ± 0.011	0.506PheAsn: 0.506 ± 0.014	1.435PhePro: 1.435 ± 0.022	0.67PheGln: 0.67 ± 0.017	1.848PheArg: 1.848 ± 0.026	1.422PheSer: 1.422 ± 0.022	1.908PheThr: 1.908 ± 0.029	2.097PheVal: 2.097 ± 0.029	0.4PheTrp: 0.4 ± 0.012	0.52PheTyr: 0.52 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	11.763GlyAla: 11.763 ± 0.09	0.943GlyCys: 0.943 ± 0.017	5.01GlyAsp: 5.01 ± 0.046	4.863GlyGlu: 4.863 ± 0.047	2.744GlyPhe: 2.744 ± 0.038	9.157GlyGly: 9.157 ± 0.107	2.569GlyHis: 2.569 ± 0.033	3.449GlyIle: 3.449 ± 0.039	2.291GlyLys: 2.291 ± 0.037	9.347GlyLeu: 9.347 ± 0.063	2.016GlyMet: 2.016 ± 0.031	1.734GlyAsn: 1.734 ± 0.032	5.682GlyPro: 5.682 ± 0.056	2.758GlyGln: 2.758 ± 0.036	8.358GlyArg: 8.358 ± 0.064	5.147GlySer: 5.147 ± 0.047	6.488GlyThr: 6.488 ± 0.062	7.219GlyVal: 7.219 ± 0.059	1.657GlyTrp: 1.657 ± 0.026	2.199GlyTyr: 2.199 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.981HisAla: 2.981 ± 0.036	0.25HisCys: 0.25 ± 0.01	1.472HisAsp: 1.472 ± 0.023	1.172HisGlu: 1.172 ± 0.019	0.677HisPhe: 0.677 ± 0.017	2.714HisGly: 2.714 ± 0.033	0.867HisHis: 0.867 ± 0.021	0.688HisIle: 0.688 ± 0.016	0.382HisLys: 0.382 ± 0.012	2.765HisLeu: 2.765 ± 0.037	0.352HisMet: 0.352 ± 0.01	0.389HisAsn: 0.389 ± 0.013	2.159HisPro: 2.159 ± 0.029	0.781HisGln: 0.781 ± 0.016	2.519HisArg: 2.519 ± 0.034	1.102HisSer: 1.102 ± 0.021	1.531HisThr: 1.531 ± 0.03	1.671HisVal: 1.671 ± 0.025	0.406HisTrp: 0.406 ± 0.01	0.499HisTyr: 0.499 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.748IleAla: 4.748 ± 0.044	0.289IleCys: 0.289 ± 0.01	2.213IleAsp: 2.213 ± 0.031	1.927IleGlu: 1.927 ± 0.028	0.636IlePhe: 0.636 ± 0.017	3.472IleGly: 3.472 ± 0.041	0.589IleHis: 0.589 ± 0.016	0.782IleIle: 0.782 ± 0.02	0.711IleLys: 0.711 ± 0.018	2.247IleLeu: 2.247 ± 0.035	0.419IleMet: 0.419 ± 0.014	0.681IleAsn: 0.681 ± 0.015	1.765IlePro: 1.765 ± 0.027	0.711IleGln: 0.711 ± 0.017	2.31IleArg: 2.31 ± 0.029	1.595IleSer: 1.595 ± 0.026	2.109IleThr: 2.109 ± 0.033	2.522IleVal: 2.522 ± 0.031	0.362IleTrp: 0.362 ± 0.01	0.473IleTyr: 0.473 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.613LysAla: 2.613 ± 0.04	0.108LysCys: 0.108 ± 0.007	1.239LysAsp: 1.239 ± 0.027	1.125LysGlu: 1.125 ± 0.025	0.423LysPhe: 0.423 ± 0.013	1.716LysGly: 1.716 ± 0.039	0.44LysHis: 0.44 ± 0.013	0.789LysIle: 0.789 ± 0.019	0.748LysLys: 0.748 ± 0.026	1.863LysLeu: 1.863 ± 0.029	0.376LysMet: 0.376 ± 0.014	0.489LysAsn: 0.489 ± 0.015	1.251LysPro: 1.251 ± 0.025	0.653LysGln: 0.653 ± 0.018	1.355LysArg: 1.355 ± 0.023	1.065LysSer: 1.065 ± 0.022	1.158LysThr: 1.158 ± 0.026	1.712LysVal: 1.712 ± 0.028	0.248LysTrp: 0.248 ± 0.009	0.386LysTyr: 0.386 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	16.171LeuAla: 16.171 ± 0.106	0.916LeuCys: 0.916 ± 0.02	6.619LeuAsp: 6.619 ± 0.057	4.291LeuGlu: 4.291 ± 0.048	2.577LeuPhe: 2.577 ± 0.034	9.197LeuGly: 9.197 ± 0.06	2.557LeuHis: 2.557 ± 0.035	3.223LeuIle: 3.223 ± 0.039	1.835LeuLys: 1.835 ± 0.03	11.412LeuLeu: 11.412 ± 0.091	1.602LeuMet: 1.602 ± 0.026	1.613LeuAsn: 1.613 ± 0.026	6.91LeuPro: 6.91 ± 0.052	2.241LeuGln: 2.241 ± 0.026	8.987LeuArg: 8.987 ± 0.067	5.18LeuSer: 5.18 ± 0.046	7.121LeuThr: 7.121 ± 0.071	8.596LeuVal: 8.596 ± 0.067	1.345LeuTrp: 1.345 ± 0.023	1.737LeuTyr: 1.737 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.353MetAla: 2.353 ± 0.033	0.138MetCys: 0.138 ± 0.007	0.93MetAsp: 0.93 ± 0.017	0.729MetGlu: 0.729 ± 0.015	0.422MetPhe: 0.422 ± 0.014	1.35MetGly: 1.35 ± 0.025	0.386MetHis: 0.386 ± 0.012	0.622MetIle: 0.622 ± 0.015	0.397MetLys: 0.397 ± 0.013	1.681MetLeu: 1.681 ± 0.024	0.324MetMet: 0.324 ± 0.011	0.412MetAsn: 0.412 ± 0.013	1.182MetPro: 1.182 ± 0.023	0.435MetGln: 0.435 ± 0.01	1.42MetArg: 1.42 ± 0.022	1.231MetSer: 1.231 ± 0.021	1.496MetThr: 1.496 ± 0.022	1.338MetVal: 1.338 ± 0.022	0.216MetTrp: 0.216 ± 0.01	0.312MetTyr: 0.312 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.167AsnAla: 2.167 ± 0.03	0.157AsnCys: 0.157 ± 0.007	0.895AsnAsp: 0.895 ± 0.02	0.728AsnGlu: 0.728 ± 0.016	0.432AsnPhe: 0.432 ± 0.014	1.838AsnGly: 1.838 ± 0.035	0.409AsnHis: 0.409 ± 0.012	0.591AsnIle: 0.591 ± 0.015	0.394AsnLys: 0.394 ± 0.013	1.578AsnLeu: 1.578 ± 0.026	0.286AsnMet: 0.286 ± 0.01	0.377AsnAsn: 0.377 ± 0.014	1.309AsnPro: 1.309 ± 0.026	0.49AsnGln: 0.49 ± 0.015	1.221AsnArg: 1.221 ± 0.021	0.877AsnSer: 0.877 ± 0.02	1.037AsnThr: 1.037 ± 0.02	1.242AsnVal: 1.242 ± 0.022	0.279AsnTrp: 0.279 ± 0.01	0.387AsnTyr: 0.387 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	9.458ProAla: 9.458 ± 0.086	0.404ProCys: 0.404 ± 0.013	4.781ProAsp: 4.781 ± 0.046	4.332ProGlu: 4.332 ± 0.04	1.564ProPhe: 1.564 ± 0.022	6.937ProGly: 6.937 ± 0.061	1.699ProHis: 1.699 ± 0.027	1.337ProIle: 1.337 ± 0.024	1.141ProLys: 1.141 ± 0.025	5.666ProLeu: 5.666 ± 0.052	1.083ProMet: 1.083 ± 0.021	0.875ProAsn: 0.875 ± 0.018	3.989ProPro: 3.989 ± 0.067	2.043ProGln: 2.043 ± 0.033	4.477ProArg: 4.477 ± 0.047	3.22ProSer: 3.22 ± 0.04	3.616ProThr: 3.616 ± 0.037	5.499ProVal: 5.499 ± 0.045	0.943ProTrp: 0.943 ± 0.017	1.33ProTyr: 1.33 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.908GlnAla: 3.908 ± 0.044	0.204GlnCys: 0.204 ± 0.008	1.483GlnAsp: 1.483 ± 0.028	1.507GlnGlu: 1.507 ± 0.022	0.667GlnPhe: 0.667 ± 0.017	2.315GlnGly: 2.315 ± 0.031	0.815GlnHis: 0.815 ± 0.02	1.079GlnIle: 1.079 ± 0.019	0.578GlnLys: 0.578 ± 0.016	3.34GlnLeu: 3.34 ± 0.039	0.518GlnMet: 0.518 ± 0.015	0.467GlnAsn: 0.467 ± 0.014	1.811GlnPro: 1.811 ± 0.038	1.4GlnGln: 1.4 ± 0.032	2.645GlnArg: 2.645 ± 0.03	1.234GlnSer: 1.234 ± 0.02	1.312GlnThr: 1.312 ± 0.021	2.355GlnVal: 2.355 ± 0.031	0.518GlnTrp: 0.518 ± 0.013	0.549GlnTyr: 0.549 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.569ArgAla: 10.569 ± 0.079	0.738ArgCys: 0.738 ± 0.015	4.25ArgAsp: 4.25 ± 0.045	4.569ArgGlu: 4.569 ± 0.047	2.305ArgPhe: 2.305 ± 0.032	6.232ArgGly: 6.232 ± 0.054	2.431ArgHis: 2.431 ± 0.031	3.354ArgIle: 3.354 ± 0.039	1.626ArgLys: 1.626 ± 0.028	9.097ArgLeu: 9.097 ± 0.076	1.825ArgMet: 1.825 ± 0.028	1.41ArgAsn: 1.41 ± 0.024	5.815ArgPro: 5.815 ± 0.052	2.548ArgGln: 2.548 ± 0.031	8.61ArgArg: 8.61 ± 0.084	4.13ArgSer: 4.13 ± 0.044	5.757ArgThr: 5.757 ± 0.047	5.46ArgVal: 5.46 ± 0.053	1.435ArgTrp: 1.435 ± 0.022	1.807ArgTyr: 1.807 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.57SerAla: 6.57 ± 0.049	0.438SerCys: 0.438 ± 0.011	2.435SerAsp: 2.435 ± 0.029	2.127SerGlu: 2.127 ± 0.031	1.456SerPhe: 1.456 ± 0.026	5.718SerGly: 5.718 ± 0.054	1.06SerHis: 1.06 ± 0.02	1.315SerIle: 1.315 ± 0.024	0.936SerLys: 0.936 ± 0.02	4.642SerLeu: 4.642 ± 0.055	1.017SerMet: 1.017 ± 0.021	0.812SerAsn: 0.812 ± 0.02	3.221SerPro: 3.221 ± 0.035	1.267SerGln: 1.267 ± 0.024	3.657SerArg: 3.657 ± 0.038	2.708SerSer: 2.708 ± 0.045	2.93SerThr: 2.93 ± 0.037	3.822SerVal: 3.822 ± 0.037	0.924SerTrp: 0.924 ± 0.016	1.141SerTyr: 1.141 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	9.486ThrAla: 9.486 ± 0.065	0.472ThrCys: 0.472 ± 0.012	3.663ThrAsp: 3.663 ± 0.038	3.117ThrGlu: 3.117 ± 0.031	1.582ThrPhe: 1.582 ± 0.024	6.818ThrGly: 6.818 ± 0.064	1.333ThrHis: 1.333 ± 0.022	1.616ThrIle: 1.616 ± 0.029	1.07ThrLys: 1.07 ± 0.021	5.771ThrLeu: 5.771 ± 0.052	0.953ThrMet: 0.953 ± 0.021	0.97ThrAsn: 0.97 ± 0.019	4.31ThrPro: 4.31 ± 0.045	1.303ThrGln: 1.303 ± 0.021	3.984ThrArg: 3.984 ± 0.034	3.044ThrSer: 3.044 ± 0.034	3.918ThrThr: 3.918 ± 0.044	5.977ThrVal: 5.977 ± 0.049	0.85ThrTrp: 0.85 ± 0.02	1.223ThrTyr: 1.223 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	10.606ValAla: 10.606 ± 0.068	0.785ValCys: 0.785 ± 0.016	4.547ValAsp: 4.547 ± 0.041	4.497ValGlu: 4.497 ± 0.046	2.281ValPhe: 2.281 ± 0.028	6.383ValGly: 6.383 ± 0.059	2.053ValHis: 2.053 ± 0.031	2.735ValIle: 2.735 ± 0.035	1.496ValLys: 1.496 ± 0.03	9.4ValLeu: 9.4 ± 0.07	1.348ValMet: 1.348 ± 0.022	1.526ValAsn: 1.526 ± 0.026	5.242ValPro: 5.242 ± 0.05	2.087ValGln: 2.087 ± 0.027	7.054ValArg: 7.054 ± 0.054	3.901ValSer: 3.901 ± 0.04	5.178ValThr: 5.178 ± 0.038	7.385ValVal: 7.385 ± 0.063	1.062ValTrp: 1.062 ± 0.019	1.417ValTyr: 1.417 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.666TrpAla: 1.666 ± 0.029	0.192TrpCys: 0.192 ± 0.008	0.811TrpAsp: 0.811 ± 0.018	0.727TrpGlu: 0.727 ± 0.018	0.482TrpPhe: 0.482 ± 0.014	1.106TrpGly: 1.106 ± 0.021	0.434TrpHis: 0.434 ± 0.014	0.512TrpIle: 0.512 ± 0.014	0.323TrpLys: 0.323 ± 0.012	1.827TrpLeu: 1.827 ± 0.025	0.285TrpMet: 0.285 ± 0.01	0.358TrpAsn: 0.358 ± 0.012	0.842TrpPro: 0.842 ± 0.02	0.659TrpGln: 0.659 ± 0.017	1.374TrpArg: 1.374 ± 0.023	0.902TrpSer: 0.902 ± 0.019	0.956TrpThr: 0.956 ± 0.018	0.944TrpVal: 0.944 ± 0.02	0.34TrpTrp: 0.34 ± 0.012	0.324TrpTyr: 0.324 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.693TyrAla: 2.693 ± 0.029	0.179TyrCys: 0.179 ± 0.008	1.301TyrAsp: 1.301 ± 0.025	1.085TyrGlu: 1.085 ± 0.02	0.597TyrPhe: 0.597 ± 0.015	2.156TyrGly: 2.156 ± 0.031	0.406TyrHis: 0.406 ± 0.012	0.401TyrIle: 0.401 ± 0.014	0.334TyrLys: 0.334 ± 0.011	2.072TyrLeu: 2.072 ± 0.03	0.229TyrMet: 0.229 ± 0.008	0.339TyrAsn: 0.339 ± 0.01	1.082TyrPro: 1.082 ± 0.018	0.602TyrGln: 0.602 ± 0.016	1.777TyrArg: 1.777 ± 0.026	0.829TyrSer: 0.829 ± 0.018	1.081TyrThr: 1.081 ± 0.021	1.513TyrVal: 1.513 ± 0.027	0.358TyrTrp: 0.358 ± 0.011	0.393TyrTyr: 0.393 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9427 proteins (2889423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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