Amino acid dipepetide frequency for Datura leaf curl virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.204AlaAla: 8.204 ± 1.867
0.912AlaCys: 0.912 ± 0.743
0.912AlaAsp: 0.912 ± 0.637
3.646AlaGlu: 3.646 ± 1.623
0.912AlaPhe: 0.912 ± 0.817
0.0AlaGly: 0.0 ± 0.0
0.912AlaHis: 0.912 ± 1.047
3.646AlaIle: 3.646 ± 1.264
3.646AlaLys: 3.646 ± 1.13
8.204AlaLeu: 8.204 ± 2.369
0.0AlaMet: 0.0 ± 0.0
0.912AlaAsn: 0.912 ± 0.637
2.735AlaPro: 2.735 ± 0.947
4.558AlaGln: 4.558 ± 1.711
5.469AlaArg: 5.469 ± 2.171
0.912AlaSer: 0.912 ± 0.743
4.558AlaThr: 4.558 ± 1.954
1.823AlaVal: 1.823 ± 1.569
1.823AlaTrp: 1.823 ± 1.274
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.912CysAla: 0.912 ± 0.637
1.823CysCys: 1.823 ± 2.094
0.0CysAsp: 0.0 ± 0.0
0.912CysGlu: 0.912 ± 0.743
0.0CysPhe: 0.0 ± 0.0
1.823CysGly: 1.823 ± 0.818
0.912CysHis: 0.912 ± 0.817
0.912CysIle: 0.912 ± 1.078
0.912CysLys: 0.912 ± 0.743
0.0CysLeu: 0.0 ± 0.0
1.823CysMet: 1.823 ± 1.051
0.912CysAsn: 0.912 ± 0.637
3.646CysPro: 3.646 ± 2.09
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.823CysSer: 1.823 ± 1.634
0.912CysThr: 0.912 ± 0.743
1.823CysVal: 1.823 ± 1.485
0.912CysTrp: 0.912 ± 1.142
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.735AspAla: 2.735 ± 1.911
0.0AspCys: 0.0 ± 0.0
3.646AspAsp: 3.646 ± 1.529
1.823AspGlu: 1.823 ± 0.783
2.735AspPhe: 2.735 ± 0.876
5.469AspGly: 5.469 ± 1.861
0.912AspHis: 0.912 ± 0.817
3.646AspIle: 3.646 ± 1.687
0.912AspLys: 0.912 ± 0.637
7.293AspLeu: 7.293 ± 2.745
0.0AspMet: 0.0 ± 0.0
1.823AspAsn: 1.823 ± 1.165
1.823AspPro: 1.823 ± 1.045
0.912AspGln: 0.912 ± 0.637
2.735AspArg: 2.735 ± 1.387
5.469AspSer: 5.469 ± 2.952
0.912AspThr: 0.912 ± 0.817
6.381AspVal: 6.381 ± 2.145
1.823AspTrp: 1.823 ± 1.274
1.823AspTyr: 1.823 ± 1.045
0.0AspXaa: 0.0 ± 0.0
Glu
3.646GluAla: 3.646 ± 1.167
0.0GluCys: 0.0 ± 0.0
0.912GluAsp: 0.912 ± 1.078
5.469GluGlu: 5.469 ± 1.806
2.735GluPhe: 2.735 ± 1.378
3.646GluGly: 3.646 ± 0.965
0.912GluHis: 0.912 ± 1.142
0.0GluIle: 0.0 ± 0.0
3.646GluLys: 3.646 ± 2.549
3.646GluLeu: 3.646 ± 1.694
0.0GluMet: 0.0 ± 0.0
3.646GluAsn: 3.646 ± 2.083
2.735GluPro: 2.735 ± 0.947
3.646GluGln: 3.646 ± 1.256
0.0GluArg: 0.0 ± 0.0
2.735GluSer: 2.735 ± 1.093
1.823GluThr: 1.823 ± 1.561
2.735GluVal: 2.735 ± 1.395
1.823GluTrp: 1.823 ± 0.818
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
0.912PheAla: 0.912 ± 0.637
0.912PheCys: 0.912 ± 0.743
3.646PheAsp: 3.646 ± 1.567
0.912PheGlu: 0.912 ± 0.637
1.823PhePhe: 1.823 ± 1.485
1.823PheGly: 1.823 ± 1.165
2.735PheHis: 2.735 ± 0.947
3.646PheIle: 3.646 ± 1.732
3.646PheLys: 3.646 ± 2.057
7.293PheLeu: 7.293 ± 1.634
0.912PheMet: 0.912 ± 0.637
3.646PheAsn: 3.646 ± 1.878
2.735PhePro: 2.735 ± 1.093
6.381PheGln: 6.381 ± 1.72
3.646PheArg: 3.646 ± 1.252
0.0PheSer: 0.0 ± 0.0
0.912PheThr: 0.912 ± 0.817
0.0PheVal: 0.0 ± 0.0
0.0PheTrp: 0.0 ± 0.0
0.912PheTyr: 0.912 ± 0.743
0.0PheXaa: 0.0 ± 0.0
Gly
1.823GlyAla: 1.823 ± 1.274
1.823GlyCys: 1.823 ± 1.073
2.735GlyAsp: 2.735 ± 1.22
0.912GlyGlu: 0.912 ± 1.142
2.735GlyPhe: 2.735 ± 1.857
3.646GlyGly: 3.646 ± 1.13
2.735GlyHis: 2.735 ± 1.093
4.558GlyIle: 4.558 ± 1.347
4.558GlyLys: 4.558 ± 1.949
2.735GlyLeu: 2.735 ± 1.768
1.823GlyMet: 1.823 ± 1.165
1.823GlyAsn: 1.823 ± 1.073
4.558GlyPro: 4.558 ± 1.949
2.735GlyGln: 2.735 ± 1.22
0.912GlyArg: 0.912 ± 0.637
3.646GlySer: 3.646 ± 1.167
5.469GlyThr: 5.469 ± 1.457
1.823GlyVal: 1.823 ± 1.567
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
3.646HisAla: 3.646 ± 1.344
2.735HisCys: 2.735 ± 1.093
1.823HisAsp: 1.823 ± 1.569
0.0HisGlu: 0.0 ± 0.0
3.646HisPhe: 3.646 ± 1.4
1.823HisGly: 1.823 ± 1.267
0.912HisHis: 0.912 ± 0.817
1.823HisIle: 1.823 ± 0.818
1.823HisLys: 1.823 ± 1.569
0.912HisLeu: 0.912 ± 0.637
0.0HisMet: 0.0 ± 0.0
4.558HisAsn: 4.558 ± 1.974
5.469HisPro: 5.469 ± 1.82
2.735HisGln: 2.735 ± 0.876
2.735HisArg: 2.735 ± 1.757
0.0HisSer: 0.0 ± 0.0
3.646HisThr: 3.646 ± 2.215
2.735HisVal: 2.735 ± 1.453
0.0HisTrp: 0.0 ± 0.0
1.823HisTyr: 1.823 ± 0.818
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
0.0IleCys: 0.0 ± 0.0
1.823IleAsp: 1.823 ± 1.274
2.735IleGlu: 2.735 ± 1.911
3.646IlePhe: 3.646 ± 2.549
0.912IleGly: 0.912 ± 0.743
1.823IleHis: 1.823 ± 1.274
6.381IleIle: 6.381 ± 3.028
6.381IleLys: 6.381 ± 0.811
0.0IleLeu: 0.0 ± 0.0
1.823IleMet: 1.823 ± 1.275
2.735IleAsn: 2.735 ± 1.438
1.823IlePro: 1.823 ± 1.274
6.381IleGln: 6.381 ± 2.642
6.381IleArg: 6.381 ± 1.318
6.381IleSer: 6.381 ± 3.171
4.558IleThr: 4.558 ± 2.925
2.735IleVal: 2.735 ± 1.387
0.912IleTrp: 0.912 ± 1.142
2.735IleTyr: 2.735 ± 2.228
0.0IleXaa: 0.0 ± 0.0
Lys
6.381LysAla: 6.381 ± 2.669
0.912LysCys: 0.912 ± 0.637
1.823LysAsp: 1.823 ± 1.274
4.558LysGlu: 4.558 ± 2.382
1.823LysPhe: 1.823 ± 1.165
1.823LysGly: 1.823 ± 1.274
2.735LysHis: 2.735 ± 1.22
1.823LysIle: 1.823 ± 1.165
0.912LysLys: 0.912 ± 0.743
2.735LysLeu: 2.735 ± 1.274
0.0LysMet: 0.0 ± 0.0
4.558LysAsn: 4.558 ± 2.382
2.735LysPro: 2.735 ± 0.947
1.823LysGln: 1.823 ± 1.116
4.558LysArg: 4.558 ± 2.688
6.381LysSer: 6.381 ± 1.532
1.823LysThr: 1.823 ± 1.029
4.558LysVal: 4.558 ± 2.097
0.0LysTrp: 0.0 ± 0.0
3.646LysTyr: 3.646 ± 1.054
0.0LysXaa: 0.0 ± 0.0
Leu
2.735LeuAla: 2.735 ± 1.093
2.735LeuCys: 2.735 ± 1.504
6.381LeuAsp: 6.381 ± 2.375
4.558LeuGlu: 4.558 ± 1.52
1.823LeuPhe: 1.823 ± 0.818
5.469LeuGly: 5.469 ± 2.047
2.735LeuHis: 2.735 ± 2.078
6.381LeuIle: 6.381 ± 2.862
4.558LeuLys: 4.558 ± 2.278
3.646LeuLeu: 3.646 ± 1.738
0.912LeuMet: 0.912 ± 1.078
4.558LeuAsn: 4.558 ± 1.121
0.912LeuPro: 0.912 ± 0.637
1.823LeuGln: 1.823 ± 1.561
3.646LeuArg: 3.646 ± 2.364
3.646LeuSer: 3.646 ± 2.286
2.735LeuThr: 2.735 ± 1.21
1.823LeuVal: 1.823 ± 1.485
0.0LeuTrp: 0.0 ± 0.0
4.558LeuTyr: 4.558 ± 1.986
0.0LeuXaa: 0.0 ± 0.0
Met
0.912MetAla: 0.912 ± 0.743
0.0MetCys: 0.0 ± 0.0
6.381MetAsp: 6.381 ± 2.963
0.912MetGlu: 0.912 ± 1.078
1.823MetPhe: 1.823 ± 1.485
2.735MetGly: 2.735 ± 1.504
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.823MetLys: 1.823 ± 1.485
4.558MetLeu: 4.558 ± 2.338
0.912MetMet: 0.912 ± 1.078
0.0MetAsn: 0.0 ± 0.0
0.912MetPro: 0.912 ± 0.637
0.912MetGln: 0.912 ± 0.817
0.912MetArg: 0.912 ± 0.743
2.735MetSer: 2.735 ± 2.094
0.912MetThr: 0.912 ± 1.142
0.0MetVal: 0.0 ± 0.0
1.823MetTrp: 1.823 ± 1.045
1.823MetTyr: 1.823 ± 1.485
0.0MetXaa: 0.0 ± 0.0
Asn
1.823AsnAla: 1.823 ± 0.783
2.735AsnCys: 2.735 ± 1.506
3.646AsnAsp: 3.646 ± 1.13
1.823AsnGlu: 1.823 ± 1.116
2.735AsnPhe: 2.735 ± 1.052
0.912AsnGly: 0.912 ± 1.142
6.381AsnHis: 6.381 ± 2.623
2.735AsnIle: 2.735 ± 0.947
1.823AsnLys: 1.823 ± 1.443
2.735AsnLeu: 2.735 ± 1.274
1.823AsnMet: 1.823 ± 1.304
1.823AsnAsn: 1.823 ± 0.818
3.646AsnPro: 3.646 ± 0.994
1.823AsnGln: 1.823 ± 0.783
1.823AsnArg: 1.823 ± 1.143
7.293AsnSer: 7.293 ± 2.821
2.735AsnThr: 2.735 ± 1.344
4.558AsnVal: 4.558 ± 2.152
0.0AsnTrp: 0.0 ± 0.0
0.912AsnTyr: 0.912 ± 0.637
0.0AsnXaa: 0.0 ± 0.0
Pro
0.912ProAla: 0.912 ± 0.817
1.823ProCys: 1.823 ± 1.116
2.735ProAsp: 2.735 ± 1.342
1.823ProGlu: 1.823 ± 1.045
0.912ProPhe: 0.912 ± 0.637
2.735ProGly: 2.735 ± 0.899
4.558ProHis: 4.558 ± 2.018
5.469ProIle: 5.469 ± 1.702
6.381ProLys: 6.381 ± 3.23
3.646ProLeu: 3.646 ± 1.421
5.469ProMet: 5.469 ± 2.271
4.558ProAsn: 4.558 ± 2.018
1.823ProPro: 1.823 ± 1.143
3.646ProGln: 3.646 ± 1.262
4.558ProArg: 4.558 ± 1.387
6.381ProSer: 6.381 ± 2.465
1.823ProThr: 1.823 ± 1.274
1.823ProVal: 1.823 ± 1.485
0.912ProTrp: 0.912 ± 0.637
1.823ProTyr: 1.823 ± 1.485
0.0ProXaa: 0.0 ± 0.0
Gln
5.469GlnAla: 5.469 ± 3.23
0.912GlnCys: 0.912 ± 1.142
1.823GlnAsp: 1.823 ± 0.818
1.823GlnGlu: 1.823 ± 0.783
5.469GlnPhe: 5.469 ± 3.823
2.735GlnGly: 2.735 ± 1.22
1.823GlnHis: 1.823 ± 1.443
3.646GlnIle: 3.646 ± 1.488
0.0GlnLys: 0.0 ± 0.0
0.912GlnLeu: 0.912 ± 1.078
0.912GlnMet: 0.912 ± 0.637
2.735GlnAsn: 2.735 ± 2.033
3.646GlnPro: 3.646 ± 2.533
3.646GlnGln: 3.646 ± 1.472
2.735GlnArg: 2.735 ± 1.052
5.469GlnSer: 5.469 ± 1.966
1.823GlnThr: 1.823 ± 1.029
8.204GlnVal: 8.204 ± 1.817
0.0GlnTrp: 0.0 ± 0.0
0.912GlnTyr: 0.912 ± 0.637
0.0GlnXaa: 0.0 ± 0.0
Arg
3.646ArgAla: 3.646 ± 1.86
1.823ArgCys: 1.823 ± 1.116
5.469ArgAsp: 5.469 ± 2.342
1.823ArgGlu: 1.823 ± 1.143
3.646ArgPhe: 3.646 ± 2.184
3.646ArgGly: 3.646 ± 1.432
1.823ArgHis: 1.823 ± 1.045
3.646ArgIle: 3.646 ± 2.083
3.646ArgLys: 3.646 ± 1.776
2.735ArgLeu: 2.735 ± 1.298
0.912ArgMet: 0.912 ± 0.743
1.823ArgAsn: 1.823 ± 0.818
6.381ArgPro: 6.381 ± 2.384
2.735ArgGln: 2.735 ± 1.685
8.204ArgArg: 8.204 ± 3.692
4.558ArgSer: 4.558 ± 1.51
2.735ArgThr: 2.735 ± 1.395
5.469ArgVal: 5.469 ± 1.001
0.0ArgTrp: 0.0 ± 0.0
0.912ArgTyr: 0.912 ± 1.047
0.0ArgXaa: 0.0 ± 0.0
Ser
2.735SerAla: 2.735 ± 1.217
0.912SerCys: 0.912 ± 0.637
3.646SerAsp: 3.646 ± 1.13
1.823SerGlu: 1.823 ± 1.143
3.646SerPhe: 3.646 ± 1.732
3.646SerGly: 3.646 ± 1.567
2.735SerHis: 2.735 ± 1.342
3.646SerIle: 3.646 ± 0.994
3.646SerLys: 3.646 ± 1.693
4.558SerLeu: 4.558 ± 1.834
2.735SerMet: 2.735 ± 3.234
4.558SerAsn: 4.558 ± 1.207
9.116SerPro: 9.116 ± 1.677
0.912SerGln: 0.912 ± 0.637
5.469SerArg: 5.469 ± 3.03
13.674SerSer: 13.674 ± 5.404
4.558SerThr: 4.558 ± 2.103
4.558SerVal: 4.558 ± 2.334
0.912SerTrp: 0.912 ± 0.743
3.646SerTyr: 3.646 ± 1.13
0.0SerXaa: 0.0 ± 0.0
Thr
2.735ThrAla: 2.735 ± 0.876
0.0ThrCys: 0.0 ± 0.0
0.912ThrAsp: 0.912 ± 1.142
0.912ThrGlu: 0.912 ± 0.743
0.912ThrPhe: 0.912 ± 0.637
3.646ThrGly: 3.646 ± 1.117
4.558ThrHis: 4.558 ± 1.874
2.735ThrIle: 2.735 ± 1.196
0.912ThrLys: 0.912 ± 0.637
2.735ThrLeu: 2.735 ± 1.947
2.735ThrMet: 2.735 ± 0.876
3.646ThrAsn: 3.646 ± 1.256
4.558ThrPro: 4.558 ± 2.549
5.469ThrGln: 5.469 ± 1.68
1.823ThrArg: 1.823 ± 1.116
1.823ThrSer: 1.823 ± 2.156
1.823ThrThr: 1.823 ± 1.443
3.646ThrVal: 3.646 ± 1.687
0.912ThrTrp: 0.912 ± 1.142
3.646ThrTyr: 3.646 ± 1.344
0.0ThrXaa: 0.0 ± 0.0
Val
1.823ValAla: 1.823 ± 1.274
0.0ValCys: 0.0 ± 0.0
2.735ValAsp: 2.735 ± 1.217
3.646ValGlu: 3.646 ± 3.138
2.735ValPhe: 2.735 ± 2.184
1.823ValGly: 1.823 ± 1.073
1.823ValHis: 1.823 ± 1.267
3.646ValIle: 3.646 ± 1.311
5.469ValLys: 5.469 ± 1.74
2.735ValLeu: 2.735 ± 3.427
2.735ValMet: 2.735 ± 1.387
2.735ValAsn: 2.735 ± 2.129
3.646ValPro: 3.646 ± 0.965
3.646ValGln: 3.646 ± 1.693
4.558ValArg: 4.558 ± 2.229
5.469ValSer: 5.469 ± 1.895
3.646ValThr: 3.646 ± 1.256
1.823ValVal: 1.823 ± 1.569
1.823ValTrp: 1.823 ± 1.165
3.646ValTyr: 3.646 ± 0.994
0.0ValXaa: 0.0 ± 0.0
Trp
1.823TrpAla: 1.823 ± 1.274
0.0TrpCys: 0.0 ± 0.0
0.912TrpAsp: 0.912 ± 1.047
0.912TrpGlu: 0.912 ± 1.142
0.0TrpPhe: 0.0 ± 0.0
0.912TrpGly: 0.912 ± 0.637
0.912TrpHis: 0.912 ± 1.142
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
1.823TrpMet: 1.823 ± 1.165
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.912TrpGln: 0.912 ± 0.637
1.823TrpArg: 1.823 ± 0.818
0.0TrpSer: 0.0 ± 0.0
1.823TrpThr: 1.823 ± 1.165
0.912TrpVal: 0.912 ± 0.637
0.0TrpTrp: 0.0 ± 0.0
0.912TrpTyr: 0.912 ± 0.637
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.912TyrAla: 0.912 ± 0.743
0.0TyrCys: 0.0 ± 0.0
0.912TyrAsp: 0.912 ± 0.743
2.735TyrGlu: 2.735 ± 1.58
2.735TyrPhe: 2.735 ± 1.585
1.823TyrGly: 1.823 ± 0.783
0.912TyrHis: 0.912 ± 0.637
1.823TyrIle: 1.823 ± 1.274
0.912TyrLys: 0.912 ± 0.637
4.558TyrLeu: 4.558 ± 1.33
1.823TyrMet: 1.823 ± 1.132
3.646TyrAsn: 3.646 ± 1.054
0.912TyrPro: 0.912 ± 0.637
0.0TyrGln: 0.0 ± 0.0
3.646TyrArg: 3.646 ± 2.971
2.735TyrSer: 2.735 ± 1.22
0.912TyrThr: 0.912 ± 0.817
2.735TyrVal: 2.735 ± 1.093
0.0TyrTrp: 0.0 ± 0.0
0.912TyrTyr: 0.912 ± 0.817
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1098 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski