Amino acid dipepetide frequency for Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens) (Trichoderma virens)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.556AlaAla: 9.556 ± 0.063	1.125AlaCys: 1.125 ± 0.016	4.31AlaAsp: 4.31 ± 0.03	5.086AlaGlu: 5.086 ± 0.039	3.233AlaPhe: 3.233 ± 0.028	5.618AlaGly: 5.618 ± 0.041	1.741AlaHis: 1.741 ± 0.017	4.74AlaIle: 4.74 ± 0.035	4.243AlaLys: 4.243 ± 0.03	7.847AlaLeu: 7.847 ± 0.046	2.028AlaMet: 2.028 ± 0.02	3.148AlaAsn: 3.148 ± 0.026	4.484AlaPro: 4.484 ± 0.039	3.429AlaGln: 3.429 ± 0.033	4.674AlaArg: 4.674 ± 0.03	7.322AlaSer: 7.322 ± 0.044	5.254AlaThr: 5.254 ± 0.032	5.471AlaVal: 5.471 ± 0.035	1.226AlaTrp: 1.226 ± 0.018	2.237AlaTyr: 2.237 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.962CysAla: 0.962 ± 0.013	0.271CysCys: 0.271 ± 0.008	0.713CysAsp: 0.713 ± 0.012	0.611CysGlu: 0.611 ± 0.011	0.598CysPhe: 0.598 ± 0.011	0.996CysGly: 0.996 ± 0.016	0.344CysHis: 0.344 ± 0.008	0.793CysIle: 0.793 ± 0.012	0.542CysLys: 0.542 ± 0.012	1.318CysLeu: 1.318 ± 0.018	0.271CysMet: 0.271 ± 0.006	0.482CysAsn: 0.482 ± 0.01	0.662CysPro: 0.662 ± 0.015	0.507CysGln: 0.507 ± 0.01	0.768CysArg: 0.768 ± 0.014	0.978CysSer: 0.978 ± 0.014	0.709CysThr: 0.709 ± 0.014	0.812CysVal: 0.812 ± 0.013	0.218CysTrp: 0.218 ± 0.006	0.39CysTyr: 0.39 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.908AspAla: 4.908 ± 0.029	0.671AspCys: 0.671 ± 0.012	4.386AspAsp: 4.386 ± 0.035	4.564AspGlu: 4.564 ± 0.039	2.279AspPhe: 2.279 ± 0.022	4.285AspGly: 4.285 ± 0.034	1.206AspHis: 1.206 ± 0.016	3.362AspIle: 3.362 ± 0.025	2.616AspLys: 2.616 ± 0.023	5.006AspLeu: 5.006 ± 0.036	1.332AspMet: 1.332 ± 0.016	1.964AspAsn: 1.964 ± 0.021	3.063AspPro: 3.063 ± 0.023	1.851AspGln: 1.851 ± 0.017	2.863AspArg: 2.863 ± 0.024	4.082AspSer: 4.082 ± 0.031	2.847AspThr: 2.847 ± 0.023	3.772AspVal: 3.772 ± 0.032	0.905AspTrp: 0.905 ± 0.014	1.63AspTyr: 1.63 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.629GluAla: 5.629 ± 0.045	0.655GluCys: 0.655 ± 0.011	4.058GluAsp: 4.058 ± 0.035	5.268GluGlu: 5.268 ± 0.054	2.02GluPhe: 2.02 ± 0.02	3.472GluGly: 3.472 ± 0.029	1.351GluHis: 1.351 ± 0.015	3.213GluIle: 3.213 ± 0.026	3.636GluLys: 3.636 ± 0.033	5.323GluLeu: 5.323 ± 0.038	1.536GluMet: 1.536 ± 0.016	2.261GluAsn: 2.261 ± 0.023	2.682GluPro: 2.682 ± 0.028	2.436GluGln: 2.436 ± 0.027	3.673GluArg: 3.673 ± 0.035	4.225GluSer: 4.225 ± 0.029	3.426GluThr: 3.426 ± 0.027	3.414GluVal: 3.414 ± 0.03	0.917GluTrp: 0.917 ± 0.015	1.714GluTyr: 1.714 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.13PheAla: 3.13 ± 0.025	0.602PheCys: 0.602 ± 0.01	2.362PheAsp: 2.362 ± 0.022	2.175PheGlu: 2.175 ± 0.02	1.714PhePhe: 1.714 ± 0.021	2.919PheGly: 2.919 ± 0.027	0.915PheHis: 0.915 ± 0.013	2.051PheIle: 2.051 ± 0.022	1.574PheLys: 1.574 ± 0.017	3.528PheLeu: 3.528 ± 0.031	0.819PheMet: 0.819 ± 0.011	1.511PheAsn: 1.511 ± 0.015	1.926PhePro: 1.926 ± 0.02	1.479PheGln: 1.479 ± 0.018	1.944PheArg: 1.944 ± 0.018	3.104PheSer: 3.104 ± 0.026	2.198PheThr: 2.198 ± 0.019	2.43PheVal: 2.43 ± 0.023	0.678PheTrp: 0.678 ± 0.011	1.165PheTyr: 1.165 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.251GlyAla: 5.251 ± 0.038	0.919GlyCys: 0.919 ± 0.013	3.711GlyAsp: 3.711 ± 0.03	3.567GlyGlu: 3.567 ± 0.029	2.818GlyPhe: 2.818 ± 0.026	5.516GlyGly: 5.516 ± 0.055	1.711GlyHis: 1.711 ± 0.022	3.824GlyIle: 3.824 ± 0.026	3.509GlyLys: 3.509 ± 0.032	6.077GlyLeu: 6.077 ± 0.039	1.563GlyMet: 1.563 ± 0.016	2.642GlyAsn: 2.642 ± 0.024	3.168GlyPro: 3.168 ± 0.031	2.557GlyGln: 2.557 ± 0.024	4.003GlyArg: 4.003 ± 0.032	5.656GlySer: 5.656 ± 0.044	3.856GlyThr: 3.856 ± 0.035	4.256GlyVal: 4.256 ± 0.03	1.193GlyTrp: 1.193 ± 0.014	2.153GlyTyr: 2.153 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.758HisAla: 1.758 ± 0.018	0.34HisCys: 0.34 ± 0.008	1.346HisAsp: 1.346 ± 0.019	1.316HisGlu: 1.316 ± 0.018	0.935HisPhe: 0.935 ± 0.013	1.713HisGly: 1.713 ± 0.02	0.888HisHis: 0.888 ± 0.017	1.316HisIle: 1.316 ± 0.016	0.963HisLys: 0.963 ± 0.013	2.273HisLeu: 2.273 ± 0.022	0.522HisMet: 0.522 ± 0.008	0.868HisAsn: 0.868 ± 0.013	1.513HisPro: 1.513 ± 0.018	1.024HisGln: 1.024 ± 0.017	1.447HisArg: 1.447 ± 0.019	1.743HisSer: 1.743 ± 0.019	1.183HisThr: 1.183 ± 0.015	1.428HisVal: 1.428 ± 0.018	0.375HisTrp: 0.375 ± 0.007	0.697HisTyr: 0.697 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.473IleAla: 4.473 ± 0.03	0.848IleCys: 0.848 ± 0.012	3.088IleAsp: 3.088 ± 0.024	3.071IleGlu: 3.071 ± 0.028	2.202IlePhe: 2.202 ± 0.021	3.417IleGly: 3.417 ± 0.029	1.314IleHis: 1.314 ± 0.015	2.86IleIle: 2.86 ± 0.031	2.448IleLys: 2.448 ± 0.021	4.852IleLeu: 4.852 ± 0.034	1.102IleMet: 1.102 ± 0.014	2.035IleAsn: 2.035 ± 0.02	3.14IlePro: 3.14 ± 0.025	2.152IleGln: 2.152 ± 0.024	2.984IleArg: 2.984 ± 0.025	4.182IleSer: 4.182 ± 0.033	3.0IleThr: 3.0 ± 0.028	3.342IleVal: 3.342 ± 0.029	0.827IleTrp: 0.827 ± 0.013	1.529IleTyr: 1.529 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.412LysAla: 4.412 ± 0.036	0.533LysCys: 0.533 ± 0.012	2.876LysAsp: 2.876 ± 0.027	3.345LysGlu: 3.345 ± 0.032	1.589LysPhe: 1.589 ± 0.018	2.981LysGly: 2.981 ± 0.028	1.14LysHis: 1.14 ± 0.015	2.436LysIle: 2.436 ± 0.023	3.278LysLys: 3.278 ± 0.038	4.362LysLeu: 4.362 ± 0.032	1.104LysMet: 1.104 ± 0.015	1.787LysAsn: 1.787 ± 0.016	2.653LysPro: 2.653 ± 0.026	1.885LysGln: 1.885 ± 0.018	3.247LysArg: 3.247 ± 0.029	3.543LysSer: 3.543 ± 0.025	2.898LysThr: 2.898 ± 0.025	2.814LysVal: 2.814 ± 0.026	0.727LysTrp: 0.727 ± 0.014	1.446LysTyr: 1.446 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.994LeuAla: 7.994 ± 0.044	1.279LeuCys: 1.279 ± 0.018	5.376LeuAsp: 5.376 ± 0.033	5.582LeuGlu: 5.582 ± 0.044	3.427LeuPhe: 3.427 ± 0.029	6.044LeuGly: 6.044 ± 0.039	2.237LeuHis: 2.237 ± 0.021	4.309LeuIle: 4.309 ± 0.034	4.305LeuLys: 4.305 ± 0.033	8.689LeuLeu: 8.689 ± 0.058	1.872LeuMet: 1.872 ± 0.018	3.279LeuAsn: 3.279 ± 0.024	5.351LeuPro: 5.351 ± 0.036	3.994LeuGln: 3.994 ± 0.033	5.633LeuArg: 5.633 ± 0.036	7.424LeuSer: 7.424 ± 0.041	4.789LeuThr: 4.789 ± 0.033	5.552LeuVal: 5.552 ± 0.038	1.297LeuTrp: 1.297 ± 0.014	2.432LeuTyr: 2.432 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.386MetAla: 2.386 ± 0.02	0.25MetCys: 0.25 ± 0.007	1.306MetAsp: 1.306 ± 0.016	1.329MetGlu: 1.329 ± 0.016	0.74MetPhe: 0.74 ± 0.012	1.468MetGly: 1.468 ± 0.018	0.483MetHis: 0.483 ± 0.01	1.067MetIle: 1.067 ± 0.014	1.042MetLys: 1.042 ± 0.013	1.944MetLeu: 1.944 ± 0.015	0.609MetMet: 0.609 ± 0.013	0.832MetAsn: 0.832 ± 0.013	1.324MetPro: 1.324 ± 0.017	0.888MetGln: 0.888 ± 0.014	1.286MetArg: 1.286 ± 0.017	1.844MetSer: 1.844 ± 0.02	1.311MetThr: 1.311 ± 0.016	1.332MetVal: 1.332 ± 0.017	0.28MetTrp: 0.28 ± 0.007	0.552MetTyr: 0.552 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.173AsnAla: 3.173 ± 0.029	0.487AsnCys: 0.487 ± 0.011	2.034AsnAsp: 2.034 ± 0.019	2.024AsnGlu: 2.024 ± 0.022	1.46AsnPhe: 1.46 ± 0.019	3.119AsnGly: 3.119 ± 0.032	0.868AsnHis: 0.868 ± 0.012	2.239AsnIle: 2.239 ± 0.02	1.675AsnLys: 1.675 ± 0.015	3.373AsnLeu: 3.373 ± 0.025	0.9AsnMet: 0.9 ± 0.014	1.579AsnAsn: 1.579 ± 0.021	2.396AsnPro: 2.396 ± 0.022	1.383AsnGln: 1.383 ± 0.018	1.932AsnArg: 1.932 ± 0.019	2.824AsnSer: 2.824 ± 0.023	2.179AsnThr: 2.179 ± 0.023	2.326AsnVal: 2.326 ± 0.019	0.615AsnTrp: 0.615 ± 0.012	1.113AsnTyr: 1.113 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	4.786ProAla: 4.786 ± 0.043	0.55ProCys: 0.55 ± 0.012	3.134ProAsp: 3.134 ± 0.028	3.631ProGlu: 3.631 ± 0.028	2.05ProPhe: 2.05 ± 0.019	3.733ProGly: 3.733 ± 0.035	1.223ProHis: 1.223 ± 0.016	2.573ProIle: 2.573 ± 0.024	2.634ProLys: 2.634 ± 0.022	4.764ProLeu: 4.764 ± 0.032	1.106ProMet: 1.106 ± 0.015	2.194ProAsn: 2.194 ± 0.022	4.613ProPro: 4.613 ± 0.066	2.327ProGln: 2.327 ± 0.03	3.12ProArg: 3.12 ± 0.029	5.472ProSer: 5.472 ± 0.042	3.616ProThr: 3.616 ± 0.029	3.377ProVal: 3.377 ± 0.03	0.758ProTrp: 0.758 ± 0.014	1.455ProTyr: 1.455 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.504GlnAla: 3.504 ± 0.034	0.468GlnCys: 0.468 ± 0.008	2.151GlnAsp: 2.151 ± 0.019	2.408GlnGlu: 2.408 ± 0.023	1.388GlnPhe: 1.388 ± 0.016	2.46GlnGly: 2.46 ± 0.023	1.053GlnHis: 1.053 ± 0.017	1.994GlnIle: 1.994 ± 0.022	1.971GlnLys: 1.971 ± 0.02	3.684GlnLeu: 3.684 ± 0.027	0.912GlnMet: 0.912 ± 0.014	1.526GlnAsn: 1.526 ± 0.019	2.456GlnPro: 2.456 ± 0.029	2.481GlnGln: 2.481 ± 0.046	2.593GlnArg: 2.593 ± 0.024	3.052GlnSer: 3.052 ± 0.03	2.279GlnThr: 2.279 ± 0.021	2.237GlnVal: 2.237 ± 0.025	0.609GlnTrp: 0.609 ± 0.01	1.189GlnTyr: 1.189 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.408ArgAla: 4.408 ± 0.033	0.737ArgCys: 0.737 ± 0.013	3.342ArgAsp: 3.342 ± 0.026	3.638ArgGlu: 3.638 ± 0.035	2.138ArgPhe: 2.138 ± 0.02	3.578ArgGly: 3.578 ± 0.03	1.528ArgHis: 1.528 ± 0.017	3.017ArgIle: 3.017 ± 0.024	3.231ArgLys: 3.231 ± 0.025	5.538ArgLeu: 5.538 ± 0.036	1.286ArgMet: 1.286 ± 0.017	2.22ArgAsn: 2.22 ± 0.02	3.276ArgPro: 3.276 ± 0.03	2.596ArgGln: 2.596 ± 0.021	4.745ArgArg: 4.745 ± 0.041	4.422ArgSer: 4.422 ± 0.039	3.024ArgThr: 3.024 ± 0.025	3.254ArgVal: 3.254 ± 0.02	0.917ArgTrp: 0.917 ± 0.013	1.672ArgTyr: 1.672 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.462SerAla: 6.462 ± 0.043	0.938SerCys: 0.938 ± 0.014	4.177SerAsp: 4.177 ± 0.03	4.006SerGlu: 4.006 ± 0.03	3.095SerPhe: 3.095 ± 0.025	5.544SerGly: 5.544 ± 0.041	1.933SerHis: 1.933 ± 0.017	4.316SerIle: 4.316 ± 0.035	3.772SerLys: 3.772 ± 0.03	7.351SerLeu: 7.351 ± 0.041	1.738SerMet: 1.738 ± 0.021	3.057SerAsn: 3.057 ± 0.025	4.958SerPro: 4.958 ± 0.048	3.339SerGln: 3.339 ± 0.031	4.826SerArg: 4.826 ± 0.042	8.296SerSer: 8.296 ± 0.067	5.158SerThr: 5.158 ± 0.041	4.551SerVal: 4.551 ± 0.029	1.208SerTrp: 1.208 ± 0.014	2.128SerTyr: 2.128 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.186ThrAla: 5.186 ± 0.031	0.766ThrCys: 0.766 ± 0.013	2.78ThrAsp: 2.78 ± 0.024	3.055ThrGlu: 3.055 ± 0.024	2.226ThrPhe: 2.226 ± 0.019	4.057ThrGly: 4.057 ± 0.029	1.216ThrHis: 1.216 ± 0.015	3.268ThrIle: 3.268 ± 0.028	2.671ThrLys: 2.671 ± 0.02	5.19ThrLeu: 5.19 ± 0.029	1.216ThrMet: 1.216 ± 0.016	2.128ThrAsn: 2.128 ± 0.02	3.894ThrPro: 3.894 ± 0.035	2.011ThrGln: 2.011 ± 0.02	2.969ThrArg: 2.969 ± 0.024	4.933ThrSer: 4.933 ± 0.036	4.002ThrThr: 4.002 ± 0.046	3.672ThrVal: 3.672 ± 0.032	0.893ThrTrp: 0.893 ± 0.012	1.621ThrTyr: 1.621 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.356ValAla: 5.356 ± 0.037	0.845ValCys: 0.845 ± 0.014	3.749ValAsp: 3.749 ± 0.028	3.779ValGlu: 3.779 ± 0.032	2.499ValPhe: 2.499 ± 0.023	3.922ValGly: 3.922 ± 0.034	1.361ValHis: 1.361 ± 0.017	3.143ValIle: 3.143 ± 0.028	2.937ValLys: 2.937 ± 0.025	5.604ValLeu: 5.604 ± 0.037	1.322ValMet: 1.322 ± 0.016	2.323ValAsn: 2.323 ± 0.023	3.438ValPro: 3.438 ± 0.025	2.356ValGln: 2.356 ± 0.02	3.276ValArg: 3.276 ± 0.029	4.592ValSer: 4.592 ± 0.026	3.506ValThr: 3.506 ± 0.026	4.324ValVal: 4.324 ± 0.035	0.879ValTrp: 0.879 ± 0.013	1.732ValTyr: 1.732 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.245TrpAla: 1.245 ± 0.017	0.206TrpCys: 0.206 ± 0.006	0.987TrpAsp: 0.987 ± 0.015	0.878TrpGlu: 0.878 ± 0.013	0.575TrpPhe: 0.575 ± 0.011	0.966TrpGly: 0.966 ± 0.013	0.373TrpHis: 0.373 ± 0.009	0.851TrpIle: 0.851 ± 0.013	0.828TrpLys: 0.828 ± 0.011	1.424TrpLeu: 1.424 ± 0.019	0.378TrpMet: 0.378 ± 0.008	0.684TrpAsn: 0.684 ± 0.012	0.635TrpPro: 0.635 ± 0.013	0.611TrpGln: 0.611 ± 0.011	0.975TrpArg: 0.975 ± 0.013	1.084TrpSer: 1.084 ± 0.014	0.945TrpThr: 0.945 ± 0.012	0.923TrpVal: 0.923 ± 0.013	0.298TrpTrp: 0.298 ± 0.008	0.44TrpTyr: 0.44 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.196TyrAla: 2.196 ± 0.022	0.457TyrCys: 0.457 ± 0.01	1.711TyrAsp: 1.711 ± 0.018	1.578TyrGlu: 1.578 ± 0.02	1.239TyrPhe: 1.239 ± 0.016	2.139TyrGly: 2.139 ± 0.022	0.763TyrHis: 0.763 ± 0.011	1.495TyrIle: 1.495 ± 0.018	1.177TyrLys: 1.177 ± 0.016	2.717TyrLeu: 2.717 ± 0.022	0.656TyrMet: 0.656 ± 0.011	1.179TyrAsn: 1.179 ± 0.015	1.482TyrPro: 1.482 ± 0.02	1.109TyrGln: 1.109 ± 0.014	1.61TyrArg: 1.61 ± 0.016	2.073TyrSer: 2.073 ± 0.02	1.575TyrThr: 1.575 ± 0.016	1.655TyrVal: 1.655 ± 0.019	0.485TyrTrp: 0.485 ± 0.01	0.956TyrTyr: 0.956 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12389 proteins (5835099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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