Amino acid dipepetide frequency for Batrachochytrium dendrobatidis (strain JEL423)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.053AlaAla: 6.053 ± 0.055	1.041AlaCys: 1.041 ± 0.016	3.67AlaAsp: 3.67 ± 0.026	3.631AlaGlu: 3.631 ± 0.034	2.699AlaPhe: 2.699 ± 0.029	3.581AlaGly: 3.581 ± 0.039	1.745AlaHis: 1.745 ± 0.019	4.597AlaIle: 4.597 ± 0.033	3.915AlaLys: 3.915 ± 0.035	6.605AlaLeu: 6.605 ± 0.045	1.788AlaMet: 1.788 ± 0.021	3.081AlaAsn: 3.081 ± 0.028	2.958AlaPro: 2.958 ± 0.037	2.912AlaGln: 2.912 ± 0.031	3.062AlaArg: 3.062 ± 0.029	7.026AlaSer: 7.026 ± 0.049	4.79AlaThr: 4.79 ± 0.038	4.53AlaVal: 4.53 ± 0.038	0.649AlaTrp: 0.649 ± 0.011	1.792AlaTyr: 1.792 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.844CysAla: 0.844 ± 0.015	0.303CysCys: 0.303 ± 0.01	0.807CysAsp: 0.807 ± 0.012	0.683CysGlu: 0.683 ± 0.013	0.678CysPhe: 0.678 ± 0.013	0.909CysGly: 0.909 ± 0.022	0.421CysHis: 0.421 ± 0.009	1.137CysIle: 1.137 ± 0.016	0.834CysLys: 0.834 ± 0.014	1.36CysLeu: 1.36 ± 0.018	0.383CysMet: 0.383 ± 0.011	0.714CysAsn: 0.714 ± 0.014	0.635CysPro: 0.635 ± 0.012	0.602CysGln: 0.602 ± 0.012	0.721CysArg: 0.721 ± 0.013	1.334CysSer: 1.334 ± 0.02	0.885CysThr: 0.885 ± 0.014	0.891CysVal: 0.891 ± 0.013	0.166CysTrp: 0.166 ± 0.007	0.394CysTyr: 0.394 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.175AspAla: 4.175 ± 0.037	0.785AspCys: 0.785 ± 0.015	3.609AspAsp: 3.609 ± 0.04	3.575AspGlu: 3.575 ± 0.033	2.124AspPhe: 2.124 ± 0.027	3.097AspGly: 3.097 ± 0.03	1.459AspHis: 1.459 ± 0.019	3.923AspIle: 3.923 ± 0.033	2.642AspLys: 2.642 ± 0.026	5.24AspLeu: 5.24 ± 0.038	1.635AspMet: 1.635 ± 0.019	2.183AspAsn: 2.183 ± 0.024	2.73AspPro: 2.73 ± 0.023	2.613AspGln: 2.613 ± 0.031	2.62AspArg: 2.62 ± 0.03	5.242AspSer: 5.242 ± 0.039	3.723AspThr: 3.723 ± 0.031	3.322AspVal: 3.322 ± 0.03	0.647AspTrp: 0.647 ± 0.013	1.637AspTyr: 1.637 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	3.558GluAla: 3.558 ± 0.033	0.824GluCys: 0.824 ± 0.012	2.796GluAsp: 2.796 ± 0.031	3.185GluGlu: 3.185 ± 0.042	2.221GluPhe: 2.221 ± 0.025	1.984GluGly: 1.984 ± 0.023	1.508GluHis: 1.508 ± 0.026	3.375GluIle: 3.375 ± 0.031	3.511GluLys: 3.511 ± 0.039	5.521GluLeu: 5.521 ± 0.053	1.506GluMet: 1.506 ± 0.019	2.547GluAsn: 2.547 ± 0.028	2.186GluPro: 2.186 ± 0.028	2.654GluGln: 2.654 ± 0.031	2.714GluArg: 2.714 ± 0.03	5.37GluSer: 5.37 ± 0.04	3.486GluThr: 3.486 ± 0.032	2.534GluVal: 2.534 ± 0.029	0.598GluTrp: 0.598 ± 0.013	1.838GluTyr: 1.838 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.44PheAla: 2.44 ± 0.026	0.602PheCys: 0.602 ± 0.012	2.513PheAsp: 2.513 ± 0.025	2.455PheGlu: 2.455 ± 0.025	1.455PhePhe: 1.455 ± 0.019	2.638PheGly: 2.638 ± 0.031	0.906PheHis: 0.906 ± 0.014	2.231PheIle: 2.231 ± 0.023	2.379PheLys: 2.379 ± 0.025	3.235PheLeu: 3.235 ± 0.033	0.883PheMet: 0.883 ± 0.013	1.751PheAsn: 1.751 ± 0.018	1.712PhePro: 1.712 ± 0.022	1.765PheGln: 1.765 ± 0.02	1.608PheArg: 1.608 ± 0.022	3.454PheSer: 3.454 ± 0.033	2.192PheThr: 2.192 ± 0.024	2.472PheVal: 2.472 ± 0.027	0.431PheTrp: 0.431 ± 0.01	1.061PheTyr: 1.061 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	3.163GlyAla: 3.163 ± 0.032	0.797GlyCys: 0.797 ± 0.014	2.493GlyAsp: 2.493 ± 0.027	2.237GlyGlu: 2.237 ± 0.022	2.236GlyPhe: 2.236 ± 0.026	3.164GlyGly: 3.164 ± 0.052	1.369GlyHis: 1.369 ± 0.017	3.491GlyIle: 3.491 ± 0.029	2.98GlyLys: 2.98 ± 0.027	4.7GlyLeu: 4.7 ± 0.038	1.403GlyMet: 1.403 ± 0.021	2.433GlyAsn: 2.433 ± 0.028	1.963GlyPro: 1.963 ± 0.028	2.069GlyGln: 2.069 ± 0.026	2.458GlyArg: 2.458 ± 0.027	5.169GlySer: 5.169 ± 0.041	3.142GlyThr: 3.142 ± 0.033	3.33GlyVal: 3.33 ± 0.033	0.603GlyTrp: 0.603 ± 0.013	1.66GlyTyr: 1.66 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.897HisAla: 1.897 ± 0.02	0.434HisCys: 0.434 ± 0.01	1.468HisAsp: 1.468 ± 0.02	1.275HisGlu: 1.275 ± 0.019	1.023HisPhe: 1.023 ± 0.015	1.448HisGly: 1.448 ± 0.019	1.028HisHis: 1.028 ± 0.022	1.839HisIle: 1.839 ± 0.021	1.253HisLys: 1.253 ± 0.017	2.457HisLeu: 2.457 ± 0.026	0.628HisMet: 0.628 ± 0.012	1.18HisAsn: 1.18 ± 0.017	1.542HisPro: 1.542 ± 0.021	1.417HisGln: 1.417 ± 0.02	1.379HisArg: 1.379 ± 0.022	2.821HisSer: 2.821 ± 0.034	1.823HisThr: 1.823 ± 0.024	1.525HisVal: 1.525 ± 0.021	0.241HisTrp: 0.241 ± 0.009	0.796HisTyr: 0.796 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.396IleAla: 4.396 ± 0.031	1.006IleCys: 1.006 ± 0.017	3.923IleAsp: 3.923 ± 0.033	3.517IleGlu: 3.517 ± 0.03	2.174IlePhe: 2.174 ± 0.028	3.154IleGly: 3.154 ± 0.029	1.719IleHis: 1.719 ± 0.02	3.252IleIle: 3.252 ± 0.032	3.638IleLys: 3.638 ± 0.032	5.552IleLeu: 5.552 ± 0.042	1.366IleMet: 1.366 ± 0.017	2.69IleAsn: 2.69 ± 0.026	3.5IlePro: 3.5 ± 0.033	3.271IleGln: 3.271 ± 0.032	2.994IleArg: 2.994 ± 0.027	5.864IleSer: 5.864 ± 0.041	3.387IleThr: 3.387 ± 0.024	3.878IleVal: 3.878 ± 0.03	0.677IleTrp: 0.677 ± 0.014	1.667IleTyr: 1.667 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.726LysAla: 3.726 ± 0.028	0.797LysCys: 0.797 ± 0.015	2.918LysAsp: 2.918 ± 0.031	3.322LysGlu: 3.322 ± 0.032	1.809LysPhe: 1.809 ± 0.019	2.268LysGly: 2.268 ± 0.024	1.696LysHis: 1.696 ± 0.021	3.152LysIle: 3.152 ± 0.033	3.953LysLys: 3.953 ± 0.042	5.591LysLeu: 5.591 ± 0.038	1.364LysMet: 1.364 ± 0.02	2.619LysAsn: 2.619 ± 0.023	3.027LysPro: 3.027 ± 0.031	2.9LysGln: 2.9 ± 0.031	3.335LysArg: 3.335 ± 0.029	5.459LysSer: 5.459 ± 0.043	3.718LysThr: 3.718 ± 0.031	2.921LysVal: 2.921 ± 0.026	0.599LysTrp: 0.599 ± 0.011	1.834LysTyr: 1.834 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	6.848LeuAla: 6.848 ± 0.043	1.474LeuCys: 1.474 ± 0.021	5.894LeuAsp: 5.894 ± 0.038	5.866LeuGlu: 5.866 ± 0.056	3.734LeuPhe: 3.734 ± 0.034	4.658LeuGly: 4.658 ± 0.034	2.483LeuHis: 2.483 ± 0.023	4.831LeuIle: 4.831 ± 0.041	5.654LeuLys: 5.654 ± 0.047	8.473LeuLeu: 8.473 ± 0.067	2.012LeuMet: 2.012 ± 0.022	4.164LeuAsn: 4.164 ± 0.031	4.787LeuPro: 4.787 ± 0.039	4.641LeuGln: 4.641 ± 0.037	4.232LeuArg: 4.232 ± 0.035	8.51LeuSer: 8.51 ± 0.056	5.016LeuThr: 5.016 ± 0.032	5.802LeuVal: 5.802 ± 0.042	0.925LeuTrp: 0.925 ± 0.015	2.573LeuTyr: 2.573 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.869MetAla: 1.869 ± 0.021	0.331MetCys: 0.331 ± 0.009	1.706MetAsp: 1.706 ± 0.017	1.314MetGlu: 1.314 ± 0.019	0.963MetPhe: 0.963 ± 0.014	1.253MetGly: 1.253 ± 0.02	0.741MetHis: 0.741 ± 0.014	1.401MetIle: 1.401 ± 0.02	1.128MetLys: 1.128 ± 0.016	2.226MetLeu: 2.226 ± 0.025	0.656MetMet: 0.656 ± 0.012	1.096MetAsn: 1.096 ± 0.015	1.209MetPro: 1.209 ± 0.018	1.197MetGln: 1.197 ± 0.018	1.148MetArg: 1.148 ± 0.016	2.205MetSer: 2.205 ± 0.026	1.54MetThr: 1.54 ± 0.021	1.406MetVal: 1.406 ± 0.018	0.233MetTrp: 0.233 ± 0.008	0.753MetTyr: 0.753 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.402AsnAla: 3.402 ± 0.028	0.574AsnCys: 0.574 ± 0.011	2.673AsnAsp: 2.673 ± 0.026	2.423AsnGlu: 2.423 ± 0.03	1.406AsnPhe: 1.406 ± 0.02	2.733AsnGly: 2.733 ± 0.028	1.303AsnHis: 1.303 ± 0.019	3.082AsnIle: 3.082 ± 0.026	2.082AsnLys: 2.082 ± 0.022	3.997AsnLeu: 3.997 ± 0.031	1.157AsnMet: 1.157 ± 0.016	2.093AsnAsn: 2.093 ± 0.025	2.687AsnPro: 2.687 ± 0.029	2.312AsnGln: 2.312 ± 0.027	2.102AsnArg: 2.102 ± 0.022	4.411AsnSer: 4.411 ± 0.039	3.453AsnThr: 3.453 ± 0.028	2.611AsnVal: 2.611 ± 0.027	0.426AsnTrp: 0.426 ± 0.01	1.159AsnTyr: 1.159 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	3.474ProAla: 3.474 ± 0.04	0.595ProCys: 0.595 ± 0.012	2.546ProAsp: 2.546 ± 0.026	2.588ProGlu: 2.588 ± 0.025	1.965ProPhe: 1.965 ± 0.022	2.222ProGly: 2.222 ± 0.029	1.221ProHis: 1.221 ± 0.018	3.276ProIle: 3.276 ± 0.027	2.685ProLys: 2.685 ± 0.026	4.381ProLeu: 4.381 ± 0.037	1.069ProMet: 1.069 ± 0.021	2.512ProAsn: 2.512 ± 0.028	2.959ProPro: 2.959 ± 0.058	2.03ProGln: 2.03 ± 0.03	1.929ProArg: 1.929 ± 0.025	5.515ProSer: 5.515 ± 0.052	3.87ProThr: 3.87 ± 0.036	3.362ProVal: 3.362 ± 0.036	0.389ProTrp: 0.389 ± 0.01	1.289ProTyr: 1.289 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	2.957GlnAla: 2.957 ± 0.037	0.618GlnCys: 0.618 ± 0.011	2.363GlnAsp: 2.363 ± 0.027	2.458GlnGlu: 2.458 ± 0.029	1.67GlnPhe: 1.67 ± 0.019	1.837GlnGly: 1.837 ± 0.021	1.538GlnHis: 1.538 ± 0.019	2.669GlnIle: 2.669 ± 0.028	2.617GlnLys: 2.617 ± 0.026	4.754GlnLeu: 4.754 ± 0.045	1.125GlnMet: 1.125 ± 0.016	2.098GlnAsn: 2.098 ± 0.024	2.587GlnPro: 2.587 ± 0.033	3.486GlnGln: 3.486 ± 0.06	2.354GlnArg: 2.354 ± 0.023	4.891GlnSer: 4.891 ± 0.04	3.032GlnThr: 3.032 ± 0.03	2.505GlnVal: 2.505 ± 0.024	0.465GlnTrp: 0.465 ± 0.012	1.395GlnTyr: 1.395 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	2.872ArgAla: 2.872 ± 0.031	0.646ArgCys: 0.646 ± 0.014	2.469ArgAsp: 2.469 ± 0.029	2.419ArgGlu: 2.419 ± 0.028	1.97ArgPhe: 1.97 ± 0.024	2.179ArgGly: 2.179 ± 0.031	1.398ArgHis: 1.398 ± 0.018	3.158ArgIle: 3.158 ± 0.029	3.074ArgLys: 3.074 ± 0.033	5.005ArgLeu: 5.005 ± 0.04	1.227ArgMet: 1.227 ± 0.015	2.163ArgAsn: 2.163 ± 0.02	2.181ArgPro: 2.181 ± 0.027	2.335ArgGln: 2.335 ± 0.023	2.97ArgArg: 2.97 ± 0.035	4.195ArgSer: 4.195 ± 0.04	2.609ArgThr: 2.609 ± 0.028	2.812ArgVal: 2.812 ± 0.026	0.465ArgTrp: 0.465 ± 0.012	1.444ArgTyr: 1.444 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.645SerAla: 6.645 ± 0.048	1.24SerCys: 1.24 ± 0.018	5.398SerAsp: 5.398 ± 0.038	4.405SerGlu: 4.405 ± 0.039	3.503SerPhe: 3.503 ± 0.032	5.069SerGly: 5.069 ± 0.046	2.587SerHis: 2.587 ± 0.029	6.353SerIle: 6.353 ± 0.044	5.881SerLys: 5.881 ± 0.044	8.426SerLeu: 8.426 ± 0.05	2.25SerMet: 2.25 ± 0.024	5.243SerAsn: 5.243 ± 0.04	4.723SerPro: 4.723 ± 0.048	4.195SerGln: 4.195 ± 0.04	4.48SerArg: 4.48 ± 0.042	10.666SerSer: 10.666 ± 0.085	7.985SerThr: 7.985 ± 0.066	5.611SerVal: 5.611 ± 0.036	0.81SerTrp: 0.81 ± 0.015	2.176SerTyr: 2.176 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.003ThrAla: 5.003 ± 0.037	0.943ThrCys: 0.943 ± 0.014	3.601ThrAsp: 3.601 ± 0.037	3.129ThrGlu: 3.129 ± 0.032	2.369ThrPhe: 2.369 ± 0.024	3.465ThrGly: 3.465 ± 0.035	1.81ThrHis: 1.81 ± 0.021	4.021ThrIle: 4.021 ± 0.031	3.363ThrLys: 3.363 ± 0.032	6.132ThrLeu: 6.132 ± 0.038	1.475ThrMet: 1.475 ± 0.019	3.018ThrAsn: 3.018 ± 0.026	3.964ThrPro: 3.964 ± 0.04	2.644ThrGln: 2.644 ± 0.028	2.828ThrArg: 2.828 ± 0.026	6.398ThrSer: 6.398 ± 0.049	5.186ThrThr: 5.186 ± 0.075	4.171ThrVal: 4.171 ± 0.034	0.543ThrTrp: 0.543 ± 0.011	1.515ThrTyr: 1.515 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.424ValAla: 4.424 ± 0.035	1.034ValCys: 1.034 ± 0.016	3.882ValAsp: 3.882 ± 0.031	3.477ValGlu: 3.477 ± 0.033	2.536ValPhe: 2.536 ± 0.024	3.081ValGly: 3.081 ± 0.029	1.539ValHis: 1.539 ± 0.017	3.252ValIle: 3.252 ± 0.028	3.287ValLys: 3.287 ± 0.03	5.485ValLeu: 5.485 ± 0.038	1.401ValMet: 1.401 ± 0.018	2.528ValAsn: 2.528 ± 0.024	2.873ValPro: 2.873 ± 0.033	2.626ValGln: 2.626 ± 0.026	2.634ValArg: 2.634 ± 0.024	5.804ValSer: 5.804 ± 0.037	3.287ValThr: 3.287 ± 0.031	4.104ValVal: 4.104 ± 0.039	0.66ValTrp: 0.66 ± 0.014	1.886ValTyr: 1.886 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.589TrpAla: 0.589 ± 0.011	0.162TrpCys: 0.162 ± 0.008	0.612TrpAsp: 0.612 ± 0.014	0.513TrpGlu: 0.513 ± 0.011	0.407TrpPhe: 0.407 ± 0.008	0.442TrpGly: 0.442 ± 0.01	0.282TrpHis: 0.282 ± 0.008	0.713TrpIle: 0.713 ± 0.015	0.695TrpLys: 0.695 ± 0.014	0.872TrpLeu: 0.872 ± 0.016	0.312TrpMet: 0.312 ± 0.008	0.571TrpAsn: 0.571 ± 0.016	0.349TrpPro: 0.349 ± 0.009	0.414TrpGln: 0.414 ± 0.011	0.556TrpArg: 0.556 ± 0.011	0.849TrpSer: 0.849 ± 0.014	0.67TrpThr: 0.67 ± 0.012	0.569TrpVal: 0.569 ± 0.01	0.175TrpTrp: 0.175 ± 0.007	0.293TrpTyr: 0.293 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.79TyrAla: 1.79 ± 0.022	0.494TyrCys: 0.494 ± 0.012	1.642TyrAsp: 1.642 ± 0.02	1.443TyrGlu: 1.443 ± 0.018	1.237TyrPhe: 1.237 ± 0.018	1.676TyrGly: 1.676 ± 0.02	0.723TyrHis: 0.723 ± 0.012	1.873TyrIle: 1.873 ± 0.025	1.436TyrLys: 1.436 ± 0.019	2.565TyrLeu: 2.565 ± 0.025	0.733TyrMet: 0.733 ± 0.012	1.401TyrAsn: 1.401 ± 0.021	1.304TyrPro: 1.304 ± 0.02	1.338TyrGln: 1.338 ± 0.02	1.468TyrArg: 1.468 ± 0.017	2.462TyrSer: 2.462 ± 0.026	1.783TyrThr: 1.783 ± 0.02	1.447TyrVal: 1.447 ± 0.018	0.346TyrTrp: 0.346 ± 0.01	0.965TyrTyr: 0.965 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9531 proteins (4695730 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---