Amino acid dipepetide frequency for Candidatus Regiella insecticola 5.15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.408AlaAla: 7.408 ± 0.146
0.914AlaCys: 0.914 ± 0.044
4.187AlaAsp: 4.187 ± 0.088
5.289AlaGlu: 5.289 ± 0.119
2.981AlaPhe: 2.981 ± 0.075
5.714AlaGly: 5.714 ± 0.128
1.755AlaHis: 1.755 ± 0.06
6.16AlaIle: 6.16 ± 0.118
4.873AlaLys: 4.873 ± 0.106
9.61AlaLeu: 9.61 ± 0.156
2.286AlaMet: 2.286 ± 0.061
3.293AlaAsn: 3.293 ± 0.073
2.798AlaPro: 2.798 ± 0.072
3.869AlaGln: 3.869 ± 0.09
4.346AlaArg: 4.346 ± 0.093
4.78AlaSer: 4.78 ± 0.101
4.314AlaThr: 4.314 ± 0.103
5.429AlaVal: 5.429 ± 0.097
0.895AlaTrp: 0.895 ± 0.037
2.114AlaTyr: 2.114 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.804CysAla: 0.804 ± 0.043
0.227CysCys: 0.227 ± 0.022
0.623CysAsp: 0.623 ± 0.034
0.584CysGlu: 0.584 ± 0.036
0.546CysPhe: 0.546 ± 0.032
0.902CysGly: 0.902 ± 0.038
0.405CysHis: 0.405 ± 0.028
0.734CysIle: 0.734 ± 0.038
0.488CysLys: 0.488 ± 0.03
1.167CysLeu: 1.167 ± 0.048
0.244CysMet: 0.244 ± 0.02
0.412CysAsn: 0.412 ± 0.029
0.453CysPro: 0.453 ± 0.032
0.631CysGln: 0.631 ± 0.04
0.621CysArg: 0.621 ± 0.036
0.766CysSer: 0.766 ± 0.041
0.499CysThr: 0.499 ± 0.031
0.679CysVal: 0.679 ± 0.036
0.19CysTrp: 0.19 ± 0.021
0.422CysTyr: 0.422 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.759AspAla: 3.759 ± 0.086
0.581AspCys: 0.581 ± 0.033
2.765AspAsp: 2.765 ± 0.095
3.168AspGlu: 3.168 ± 0.072
2.193AspPhe: 2.193 ± 0.062
2.979AspGly: 2.979 ± 0.098
1.115AspHis: 1.115 ± 0.047
4.126AspIle: 4.126 ± 0.089
3.26AspLys: 3.26 ± 0.091
4.917AspLeu: 4.917 ± 0.099
1.267AspMet: 1.267 ± 0.047
2.698AspAsn: 2.698 ± 0.079
2.271AspPro: 2.271 ± 0.074
2.06AspGln: 2.06 ± 0.071
2.65AspArg: 2.65 ± 0.074
2.903AspSer: 2.903 ± 0.077
2.7AspThr: 2.7 ± 0.077
3.205AspVal: 3.205 ± 0.077
0.738AspTrp: 0.738 ± 0.039
1.91AspTyr: 1.91 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.514GluAla: 4.514 ± 0.087
0.472GluCys: 0.472 ± 0.029
2.31GluAsp: 2.31 ± 0.073
3.397GluGlu: 3.397 ± 0.103
1.812GluPhe: 1.812 ± 0.062
3.547GluGly: 3.547 ± 0.086
1.368GluHis: 1.368 ± 0.042
4.375GluIle: 4.375 ± 0.1
4.932GluLys: 4.932 ± 0.113
5.823GluLeu: 5.823 ± 0.106
1.448GluMet: 1.448 ± 0.053
3.09GluAsn: 3.09 ± 0.078
1.65GluPro: 1.65 ± 0.054
3.53GluGln: 3.53 ± 0.09
3.462GluArg: 3.462 ± 0.111
2.829GluSer: 2.829 ± 0.077
2.885GluThr: 2.885 ± 0.082
3.447GluVal: 3.447 ± 0.089
0.57GluTrp: 0.57 ± 0.033
1.422GluTyr: 1.422 ± 0.055
0.002GluXaa: 0.002 ± 0.002
Phe
2.805PheAla: 2.805 ± 0.068
0.595PheCys: 0.595 ± 0.034
2.275PheAsp: 2.275 ± 0.067
1.938PheGlu: 1.938 ± 0.066
1.846PhePhe: 1.846 ± 0.076
2.561PheGly: 2.561 ± 0.073
0.899PheHis: 0.899 ± 0.042
2.992PheIle: 2.992 ± 0.083
1.784PheLys: 1.784 ± 0.057
3.371PheLeu: 3.371 ± 0.09
0.967PheMet: 0.967 ± 0.038
2.103PheAsn: 2.103 ± 0.062
1.387PhePro: 1.387 ± 0.056
1.285PheGln: 1.285 ± 0.049
1.72PheArg: 1.72 ± 0.062
3.445PheSer: 3.445 ± 0.086
2.31PheThr: 2.31 ± 0.066
2.086PheVal: 2.086 ± 0.062
0.459PheTrp: 0.459 ± 0.032
1.317PheTyr: 1.317 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.736GlyAla: 4.736 ± 0.113
0.877GlyCys: 0.877 ± 0.042
3.434GlyAsp: 3.434 ± 0.112
3.856GlyGlu: 3.856 ± 0.088
2.602GlyPhe: 2.602 ± 0.079
4.595GlyGly: 4.595 ± 0.14
1.559GlyHis: 1.559 ± 0.057
4.915GlyIle: 4.915 ± 0.107
4.27GlyLys: 4.27 ± 0.105
6.387GlyLeu: 6.387 ± 0.103
1.932GlyMet: 1.932 ± 0.065
2.779GlyAsn: 2.779 ± 0.106
1.171GlyPro: 1.171 ± 0.048
2.787GlyGln: 2.787 ± 0.075
3.377GlyArg: 3.377 ± 0.082
4.074GlySer: 4.074 ± 0.098
3.053GlyThr: 3.053 ± 0.084
4.39GlyVal: 4.39 ± 0.1
0.908GlyTrp: 0.908 ± 0.043
2.343GlyTyr: 2.343 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.823HisAla: 1.823 ± 0.06
0.386HisCys: 0.386 ± 0.028
1.196HisAsp: 1.196 ± 0.046
1.159HisGlu: 1.159 ± 0.042
1.2HisPhe: 1.2 ± 0.049
1.313HisGly: 1.313 ± 0.047
0.952HisHis: 0.952 ± 0.045
1.794HisIle: 1.794 ± 0.058
1.01HisLys: 1.01 ± 0.046
2.594HisLeu: 2.594 ± 0.072
0.475HisMet: 0.475 ± 0.03
0.997HisAsn: 0.997 ± 0.044
1.276HisPro: 1.276 ± 0.052
1.548HisGln: 1.548 ± 0.057
1.37HisArg: 1.37 ± 0.06
1.479HisSer: 1.479 ± 0.057
1.061HisThr: 1.061 ± 0.049
1.195HisVal: 1.195 ± 0.05
0.422HisTrp: 0.422 ± 0.028
1.063HisTyr: 1.063 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.428IleAla: 6.428 ± 0.124
0.816IleCys: 0.816 ± 0.039
4.349IleAsp: 4.349 ± 0.092
4.519IleGlu: 4.519 ± 0.101
2.55IlePhe: 2.55 ± 0.081
4.693IleGly: 4.693 ± 0.116
1.498IleHis: 1.498 ± 0.057
4.501IleIle: 4.501 ± 0.102
4.549IleLys: 4.549 ± 0.103
6.286IleLeu: 6.286 ± 0.115
1.448IleMet: 1.448 ± 0.052
3.854IleAsn: 3.854 ± 0.096
2.951IlePro: 2.951 ± 0.074
2.63IleGln: 2.63 ± 0.069
3.56IleArg: 3.56 ± 0.079
4.691IleSer: 4.691 ± 0.086
4.462IleThr: 4.462 ± 0.096
3.935IleVal: 3.935 ± 0.097
0.697IleTrp: 0.697 ± 0.036
1.947IleTyr: 1.947 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.342LysAla: 4.342 ± 0.097
0.433LysCys: 0.433 ± 0.027
2.569LysAsp: 2.569 ± 0.063
3.636LysGlu: 3.636 ± 0.098
1.629LysPhe: 1.629 ± 0.054
3.447LysGly: 3.447 ± 0.1
1.093LysHis: 1.093 ± 0.04
4.753LysIle: 4.753 ± 0.106
4.791LysLys: 4.791 ± 0.11
5.938LysLeu: 5.938 ± 0.099
1.574LysMet: 1.574 ± 0.054
3.617LysAsn: 3.617 ± 0.091
2.206LysPro: 2.206 ± 0.072
3.088LysGln: 3.088 ± 0.071
3.142LysArg: 3.142 ± 0.077
3.325LysSer: 3.325 ± 0.082
3.29LysThr: 3.29 ± 0.076
3.155LysVal: 3.155 ± 0.084
0.56LysTrp: 0.56 ± 0.037
1.498LysTyr: 1.498 ± 0.065
0.002LysXaa: 0.002 ± 0.002
Leu
10.158LeuAla: 10.158 ± 0.145
1.322LeuCys: 1.322 ± 0.057
5.387LeuAsp: 5.387 ± 0.102
5.505LeuGlu: 5.505 ± 0.104
4.262LeuPhe: 4.262 ± 0.104
6.175LeuGly: 6.175 ± 0.116
2.398LeuHis: 2.398 ± 0.054
7.155LeuIle: 7.155 ± 0.132
5.727LeuLys: 5.727 ± 0.099
12.077LeuLeu: 12.077 ± 0.193
2.89LeuMet: 2.89 ± 0.074
4.912LeuAsn: 4.912 ± 0.111
5.344LeuPro: 5.344 ± 0.129
4.758LeuGln: 4.758 ± 0.098
5.768LeuArg: 5.768 ± 0.108
8.022LeuSer: 8.022 ± 0.127
6.398LeuThr: 6.398 ± 0.099
6.138LeuVal: 6.138 ± 0.113
1.232LeuTrp: 1.232 ± 0.05
2.816LeuTyr: 2.816 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
2.398MetAla: 2.398 ± 0.061
0.185MetCys: 0.185 ± 0.018
0.96MetAsp: 0.96 ± 0.042
1.22MetGlu: 1.22 ± 0.058
0.712MetPhe: 0.712 ± 0.033
1.646MetGly: 1.646 ± 0.062
0.47MetHis: 0.47 ± 0.029
1.653MetIle: 1.653 ± 0.07
1.531MetLys: 1.531 ± 0.049
2.835MetLeu: 2.835 ± 0.064
0.801MetMet: 0.801 ± 0.042
1.222MetAsn: 1.222 ± 0.049
1.274MetPro: 1.274 ± 0.048
1.161MetGln: 1.161 ± 0.046
1.318MetArg: 1.318 ± 0.053
1.694MetSer: 1.694 ± 0.057
1.65MetThr: 1.65 ± 0.05
1.542MetVal: 1.542 ± 0.058
0.2MetTrp: 0.2 ± 0.02
0.479MetTyr: 0.479 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.649AsnAla: 3.649 ± 0.08
0.442AsnCys: 0.442 ± 0.03
2.452AsnAsp: 2.452 ± 0.101
2.52AsnGlu: 2.52 ± 0.065
1.72AsnPhe: 1.72 ± 0.052
2.881AsnGly: 2.881 ± 0.093
1.246AsnHis: 1.246 ± 0.05
3.345AsnIle: 3.345 ± 0.09
2.992AsnLys: 2.992 ± 0.078
4.429AsnLeu: 4.429 ± 0.098
1.0AsnMet: 1.0 ± 0.043
2.687AsnAsn: 2.687 ± 0.08
2.223AsnPro: 2.223 ± 0.062
2.356AsnGln: 2.356 ± 0.068
2.422AsnArg: 2.422 ± 0.069
2.731AsnSer: 2.731 ± 0.066
2.652AsnThr: 2.652 ± 0.081
2.478AsnVal: 2.478 ± 0.067
0.575AsnTrp: 0.575 ± 0.035
1.505AsnTyr: 1.505 ± 0.063
0.002AsnXaa: 0.002 ± 0.002
Pro
3.282ProAla: 3.282 ± 0.076
0.464ProCys: 0.464 ± 0.031
2.234ProAsp: 2.234 ± 0.073
2.722ProGlu: 2.722 ± 0.082
1.588ProPhe: 1.588 ± 0.05
2.452ProGly: 2.452 ± 0.06
0.962ProHis: 0.962 ± 0.038
2.567ProIle: 2.567 ± 0.074
1.884ProLys: 1.884 ± 0.063
4.856ProLeu: 4.856 ± 0.109
1.017ProMet: 1.017 ± 0.042
1.564ProAsn: 1.564 ± 0.06
1.705ProPro: 1.705 ± 0.061
1.936ProGln: 1.936 ± 0.053
1.685ProArg: 1.685 ± 0.062
2.617ProSer: 2.617 ± 0.075
2.337ProThr: 2.337 ± 0.066
2.626ProVal: 2.626 ± 0.068
0.512ProTrp: 0.512 ± 0.032
1.28ProTyr: 1.28 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
4.512GlnAla: 4.512 ± 0.11
0.499GlnCys: 0.499 ± 0.034
1.99GlnAsp: 1.99 ± 0.055
2.463GlnGlu: 2.463 ± 0.077
1.696GlnPhe: 1.696 ± 0.05
3.264GlnGly: 3.264 ± 0.071
1.465GlnHis: 1.465 ± 0.053
3.142GlnIle: 3.142 ± 0.073
2.663GlnLys: 2.663 ± 0.074
5.77GlnLeu: 5.77 ± 0.124
1.056GlnMet: 1.056 ± 0.043
1.934GlnAsn: 1.934 ± 0.061
2.073GlnPro: 2.073 ± 0.069
4.205GlnGln: 4.205 ± 0.109
3.175GlnArg: 3.175 ± 0.089
2.665GlnSer: 2.665 ± 0.064
2.217GlnThr: 2.217 ± 0.07
2.811GlnVal: 2.811 ± 0.074
0.688GlnTrp: 0.688 ± 0.035
1.496GlnTyr: 1.496 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
4.12ArgAla: 4.12 ± 0.088
0.644ArgCys: 0.644 ± 0.035
2.805ArgAsp: 2.805 ± 0.078
3.21ArgGlu: 3.21 ± 0.087
2.361ArgPhe: 2.361 ± 0.056
3.088ArgGly: 3.088 ± 0.078
1.466ArgHis: 1.466 ± 0.051
3.623ArgIle: 3.623 ± 0.092
2.741ArgLys: 2.741 ± 0.079
6.25ArgLeu: 6.25 ± 0.121
1.226ArgMet: 1.226 ± 0.048
2.071ArgAsn: 2.071 ± 0.058
1.975ArgPro: 1.975 ± 0.071
3.214ArgGln: 3.214 ± 0.093
3.253ArgArg: 3.253 ± 0.077
2.815ArgSer: 2.815 ± 0.066
2.408ArgThr: 2.408 ± 0.065
3.336ArgVal: 3.336 ± 0.063
0.751ArgTrp: 0.751 ± 0.041
2.047ArgTyr: 2.047 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
5.374SerAla: 5.374 ± 0.11
0.714SerCys: 0.714 ± 0.038
3.277SerAsp: 3.277 ± 0.071
3.41SerGlu: 3.41 ± 0.076
2.252SerPhe: 2.252 ± 0.069
4.597SerGly: 4.597 ± 0.104
1.703SerHis: 1.703 ± 0.052
4.168SerIle: 4.168 ± 0.097
3.014SerLys: 3.014 ± 0.078
7.219SerLeu: 7.219 ± 0.121
1.492SerMet: 1.492 ± 0.054
2.692SerAsn: 2.692 ± 0.077
2.535SerPro: 2.535 ± 0.069
2.848SerGln: 2.848 ± 0.074
3.21SerArg: 3.21 ± 0.073
4.296SerSer: 4.296 ± 0.117
3.467SerThr: 3.467 ± 0.088
4.15SerVal: 4.15 ± 0.084
0.767SerTrp: 0.767 ± 0.038
1.797SerTyr: 1.797 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
4.738ThrAla: 4.738 ± 0.099
0.49ThrCys: 0.49 ± 0.03
2.975ThrAsp: 2.975 ± 0.076
3.212ThrGlu: 3.212 ± 0.081
2.001ThrPhe: 2.001 ± 0.062
3.843ThrGly: 3.843 ± 0.093
1.361ThrHis: 1.361 ± 0.054
3.229ThrIle: 3.229 ± 0.08
2.471ThrLys: 2.471 ± 0.081
7.225ThrLeu: 7.225 ± 0.117
1.074ThrMet: 1.074 ± 0.037
1.888ThrAsn: 1.888 ± 0.066
2.798ThrPro: 2.798 ± 0.07
2.561ThrGln: 2.561 ± 0.07
2.659ThrArg: 2.659 ± 0.067
2.966ThrSer: 2.966 ± 0.069
3.086ThrThr: 3.086 ± 0.08
3.761ThrVal: 3.761 ± 0.098
0.568ThrTrp: 0.568 ± 0.03
1.265ThrTyr: 1.265 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
5.224ValAla: 5.224 ± 0.11
0.677ValCys: 0.677 ± 0.036
3.462ValAsp: 3.462 ± 0.078
3.443ValGlu: 3.443 ± 0.087
2.291ValPhe: 2.291 ± 0.072
3.833ValGly: 3.833 ± 0.092
1.15ValHis: 1.15 ± 0.047
4.627ValIle: 4.627 ± 0.11
3.364ValLys: 3.364 ± 0.097
6.319ValLeu: 6.319 ± 0.118
1.86ValMet: 1.86 ± 0.064
2.901ValAsn: 2.901 ± 0.066
2.258ValPro: 2.258 ± 0.07
2.067ValGln: 2.067 ± 0.061
2.927ValArg: 2.927 ± 0.069
4.225ValSer: 4.225 ± 0.094
3.684ValThr: 3.684 ± 0.089
4.018ValVal: 4.018 ± 0.09
0.59ValTrp: 0.59 ± 0.037
1.57ValTyr: 1.57 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.717TrpAla: 0.717 ± 0.033
0.202TrpCys: 0.202 ± 0.019
0.472TrpAsp: 0.472 ± 0.028
0.457TrpGlu: 0.457 ± 0.029
0.505TrpPhe: 0.505 ± 0.032
0.627TrpGly: 0.627 ± 0.033
0.407TrpHis: 0.407 ± 0.028
0.754TrpIle: 0.754 ± 0.04
0.503TrpLys: 0.503 ± 0.029
1.783TrpLeu: 1.783 ± 0.062
0.357TrpMet: 0.357 ± 0.022
0.407TrpAsn: 0.407 ± 0.029
0.538TrpPro: 0.538 ± 0.035
1.098TrpGln: 1.098 ± 0.051
0.751TrpArg: 0.751 ± 0.04
0.714TrpSer: 0.714 ± 0.035
0.35TrpThr: 0.35 ± 0.024
0.732TrpVal: 0.732 ± 0.038
0.163TrpTrp: 0.163 ± 0.017
0.377TrpTyr: 0.377 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.221TyrAla: 2.221 ± 0.068
0.462TyrCys: 0.462 ± 0.036
1.544TyrAsp: 1.544 ± 0.058
1.174TyrGlu: 1.174 ± 0.047
1.396TyrPhe: 1.396 ± 0.056
1.886TyrGly: 1.886 ± 0.051
1.043TyrHis: 1.043 ± 0.044
1.753TyrIle: 1.753 ± 0.067
1.237TyrLys: 1.237 ± 0.041
3.587TyrLeu: 3.587 ± 0.088
0.534TyrMet: 0.534 ± 0.035
1.185TyrAsn: 1.185 ± 0.049
1.405TyrPro: 1.405 ± 0.048
2.151TyrGln: 2.151 ± 0.055
1.988TyrArg: 1.988 ± 0.065
1.947TyrSer: 1.947 ± 0.063
1.348TyrThr: 1.348 ± 0.05
1.376TyrVal: 1.376 ± 0.046
0.429TyrTrp: 0.429 ± 0.027
1.071TyrTyr: 1.071 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.002XaaLys: 0.002 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.004XaaVal: 0.004 ± 0.003
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2269 proteins (540769 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski