Amino acid dipepetide frequency for Pomacea canaliculata (Golden apple snail)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.188AlaAla: 6.188 ± 0.041	1.546AlaCys: 1.546 ± 0.018	3.728AlaAsp: 3.728 ± 0.024	4.139AlaGlu: 4.139 ± 0.033	2.417AlaPhe: 2.417 ± 0.015	4.483AlaGly: 4.483 ± 0.036	1.533AlaHis: 1.533 ± 0.015	3.022AlaIle: 3.022 ± 0.034	3.591AlaLys: 3.591 ± 0.089	5.885AlaLeu: 5.885 ± 0.031	1.673AlaMet: 1.673 ± 0.017	2.506AlaAsn: 2.506 ± 0.043	2.996AlaPro: 2.996 ± 0.027	2.701AlaGln: 2.701 ± 0.026	3.774AlaArg: 3.774 ± 0.033	6.005AlaSer: 6.005 ± 0.03	4.105AlaThr: 4.105 ± 0.029	5.197AlaVal: 5.197 ± 0.027	0.697AlaTrp: 0.697 ± 0.009	1.572AlaTyr: 1.572 ± 0.014	0.0AlaXaa: 0.0 ± 0.0
Cys	1.312CysAla: 1.312 ± 0.015	0.64CysCys: 0.64 ± 0.013	1.354CysAsp: 1.354 ± 0.018	1.222CysGlu: 1.222 ± 0.018	0.795CysPhe: 0.795 ± 0.009	1.584CysGly: 1.584 ± 0.018	0.682CysHis: 0.682 ± 0.009	0.984CysIle: 0.984 ± 0.013	1.082CysLys: 1.082 ± 0.016	2.185CysLeu: 2.185 ± 0.021	0.481CysMet: 0.481 ± 0.009	0.918CysAsn: 0.918 ± 0.014	1.372CysPro: 1.372 ± 0.045	1.154CysGln: 1.154 ± 0.016	1.427CysArg: 1.427 ± 0.017	2.115CysSer: 2.115 ± 0.027	1.417CysThr: 1.417 ± 0.023	1.61CysVal: 1.61 ± 0.02	0.263CysTrp: 0.263 ± 0.006	0.622CysTyr: 0.622 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.338AspAla: 3.338 ± 0.021	1.184AspCys: 1.184 ± 0.016	4.002AspAsp: 4.002 ± 0.035	3.786AspGlu: 3.786 ± 0.025	2.31AspPhe: 2.31 ± 0.019	3.669AspGly: 3.669 ± 0.029	1.362AspHis: 1.362 ± 0.015	3.13AspIle: 3.13 ± 0.022	2.976AspLys: 2.976 ± 0.022	4.983AspLeu: 4.983 ± 0.026	1.35AspMet: 1.35 ± 0.012	2.48AspAsn: 2.48 ± 0.02	2.538AspPro: 2.538 ± 0.02	1.899AspGln: 1.899 ± 0.017	2.817AspArg: 2.817 ± 0.02	4.528AspSer: 4.528 ± 0.029	3.153AspThr: 3.153 ± 0.018	4.173AspVal: 4.173 ± 0.026	0.668AspTrp: 0.668 ± 0.011	1.633AspTyr: 1.633 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	4.279GluAla: 4.279 ± 0.031	1.217GluCys: 1.217 ± 0.021	4.14GluAsp: 4.14 ± 0.026	6.097GluGlu: 6.097 ± 0.056	1.842GluPhe: 1.842 ± 0.016	3.605GluGly: 3.605 ± 0.025	1.424GluHis: 1.424 ± 0.016	2.867GluIle: 2.867 ± 0.022	4.43GluLys: 4.43 ± 0.04	5.179GluLeu: 5.179 ± 0.037	1.63GluMet: 1.63 ± 0.015	2.924GluAsn: 2.924 ± 0.022	2.464GluPro: 2.464 ± 0.093	2.731GluGln: 2.731 ± 0.029	3.745GluArg: 3.745 ± 0.031	4.183GluSer: 4.183 ± 0.03	3.577GluThr: 3.577 ± 0.023	4.195GluVal: 4.195 ± 0.025	0.657GluTrp: 0.657 ± 0.008	1.515GluTyr: 1.515 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.152PheAla: 2.152 ± 0.018	0.894PheCys: 0.894 ± 0.011	2.03PheAsp: 2.03 ± 0.018	1.912PheGlu: 1.912 ± 0.021	1.566PhePhe: 1.566 ± 0.015	2.189PheGly: 2.189 ± 0.019	1.029PheHis: 1.029 ± 0.01	1.79PheIle: 1.79 ± 0.015	1.667PheLys: 1.667 ± 0.014	3.624PheLeu: 3.624 ± 0.023	0.817PheMet: 0.817 ± 0.01	1.477PheAsn: 1.477 ± 0.014	1.769PhePro: 1.769 ± 0.014	1.576PheGln: 1.576 ± 0.013	1.96PheArg: 1.96 ± 0.016	3.279PheSer: 3.279 ± 0.044	2.295PheThr: 2.295 ± 0.018	2.557PheVal: 2.557 ± 0.019	0.453PheTrp: 0.453 ± 0.01	1.202PheTyr: 1.202 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	3.913GlyAla: 3.913 ± 0.029	1.349GlyCys: 1.349 ± 0.022	3.558GlyAsp: 3.558 ± 0.028	3.519GlyGlu: 3.519 ± 0.025	2.331GlyPhe: 2.331 ± 0.019	4.974GlyGly: 4.974 ± 0.05	1.784GlyHis: 1.784 ± 0.017	2.748GlyIle: 2.748 ± 0.022	3.327GlyLys: 3.327 ± 0.024	5.269GlyLeu: 5.269 ± 0.236	1.434GlyMet: 1.434 ± 0.016	2.567GlyAsn: 2.567 ± 0.018	2.575GlyPro: 2.575 ± 0.035	2.896GlyGln: 2.896 ± 0.027	3.647GlyArg: 3.647 ± 0.029	5.437GlySer: 5.437 ± 0.038	3.582GlyThr: 3.582 ± 0.031	4.171GlyVal: 4.171 ± 0.029	0.856GlyTrp: 0.856 ± 0.02	1.942GlyTyr: 1.942 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.561HisAla: 1.561 ± 0.013	0.642HisCys: 0.642 ± 0.01	1.275HisAsp: 1.275 ± 0.012	1.335HisGlu: 1.335 ± 0.012	1.05HisPhe: 1.05 ± 0.011	1.652HisGly: 1.652 ± 0.016	1.163HisHis: 1.163 ± 0.019	1.249HisIle: 1.249 ± 0.013	1.251HisLys: 1.251 ± 0.013	2.798HisLeu: 2.798 ± 0.021	0.638HisMet: 0.638 ± 0.008	1.024HisAsn: 1.024 ± 0.011	1.609HisPro: 1.609 ± 0.016	1.347HisGln: 1.347 ± 0.033	1.629HisArg: 1.629 ± 0.016	2.229HisSer: 2.229 ± 0.02	1.489HisThr: 1.489 ± 0.013	1.916HisVal: 1.916 ± 0.018	0.331HisTrp: 0.331 ± 0.008	0.795HisTyr: 0.795 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	2.887IleAla: 2.887 ± 0.019	1.043IleCys: 1.043 ± 0.013	2.314IleAsp: 2.314 ± 0.019	2.394IleGlu: 2.394 ± 0.019	1.897IlePhe: 1.897 ± 0.018	2.397IleGly: 2.397 ± 0.02	1.195IleHis: 1.195 ± 0.013	2.481IleIle: 2.481 ± 0.02	2.45IleLys: 2.45 ± 0.018	4.271IleLeu: 4.271 ± 0.027	1.041IleMet: 1.041 ± 0.01	2.03IleAsn: 2.03 ± 0.018	2.425IlePro: 2.425 ± 0.017	1.971IleGln: 1.971 ± 0.015	2.371IleArg: 2.371 ± 0.017	3.866IleSer: 3.866 ± 0.036	2.879IleThr: 2.879 ± 0.021	3.101IleVal: 3.101 ± 0.02	0.466IleTrp: 0.466 ± 0.007	1.283IleTyr: 1.283 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.49LysAla: 3.49 ± 0.027	1.048LysCys: 1.048 ± 0.013	3.209LysAsp: 3.209 ± 0.023	4.279LysGlu: 4.279 ± 0.041	1.675LysPhe: 1.675 ± 0.036	2.923LysGly: 2.923 ± 0.02	1.362LysHis: 1.362 ± 0.016	2.48LysIle: 2.48 ± 0.018	4.065LysLys: 4.065 ± 0.04	4.547LysLeu: 4.547 ± 0.03	1.376LysMet: 1.376 ± 0.014	2.217LysAsn: 2.217 ± 0.017	2.436LysPro: 2.436 ± 0.024	2.481LysGln: 2.481 ± 0.02	3.286LysArg: 3.286 ± 0.024	4.182LysSer: 4.182 ± 0.096	3.266LysThr: 3.266 ± 0.023	3.43LysVal: 3.43 ± 0.025	0.569LysTrp: 0.569 ± 0.008	1.434LysTyr: 1.434 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	6.232LeuAla: 6.232 ± 0.033	2.131LeuCys: 2.131 ± 0.022	4.724LeuAsp: 4.724 ± 0.03	5.585LeuGlu: 5.585 ± 0.036	3.061LeuPhe: 3.061 ± 0.022	5.051LeuGly: 5.051 ± 0.231	2.761LeuHis: 2.761 ± 0.023	3.513LeuIle: 3.513 ± 0.025	4.92LeuLys: 4.92 ± 0.031	9.044LeuLeu: 9.044 ± 0.05	2.104LeuMet: 2.104 ± 0.017	3.417LeuAsn: 3.417 ± 0.021	5.226LeuPro: 5.226 ± 0.029	5.086LeuGln: 5.086 ± 0.032	5.229LeuArg: 5.229 ± 0.032	7.619LeuSer: 7.619 ± 0.035	5.728LeuThr: 5.728 ± 0.034	5.713LeuVal: 5.713 ± 0.03	1.022LeuTrp: 1.022 ± 0.011	2.477LeuTyr: 2.477 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	1.982MetAla: 1.982 ± 0.016	0.535MetCys: 0.535 ± 0.009	1.298MetAsp: 1.298 ± 0.012	1.684MetGlu: 1.684 ± 0.016	0.864MetPhe: 0.864 ± 0.009	1.259MetGly: 1.259 ± 0.014	0.518MetHis: 0.518 ± 0.007	0.902MetIle: 0.902 ± 0.01	1.364MetLys: 1.364 ± 0.013	2.117MetLeu: 2.117 ± 0.02	0.703MetMet: 0.703 ± 0.01	0.875MetAsn: 0.875 ± 0.01	1.137MetPro: 1.137 ± 0.014	1.039MetGln: 1.039 ± 0.013	1.197MetArg: 1.197 ± 0.012	1.984MetSer: 1.984 ± 0.015	1.54MetThr: 1.54 ± 0.015	1.438MetVal: 1.438 ± 0.012	0.267MetTrp: 0.267 ± 0.005	0.664MetTyr: 0.664 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.404AsnAla: 2.404 ± 0.02	0.949AsnCys: 0.949 ± 0.016	2.071AsnAsp: 2.071 ± 0.019	2.154AsnGlu: 2.154 ± 0.017	1.613AsnPhe: 1.613 ± 0.015	2.691AsnGly: 2.691 ± 0.025	0.979AsnHis: 0.979 ± 0.012	2.458AsnIle: 2.458 ± 0.019	2.185AsnLys: 2.185 ± 0.016	3.543AsnLeu: 3.543 ± 0.021	1.042AsnMet: 1.042 ± 0.011	2.029AsnAsn: 2.029 ± 0.022	2.007AsnPro: 2.007 ± 0.015	1.568AsnGln: 1.568 ± 0.016	2.018AsnArg: 2.018 ± 0.018	3.546AsnSer: 3.546 ± 0.043	2.587AsnThr: 2.587 ± 0.021	2.743AsnVal: 2.743 ± 0.019	0.471AsnTrp: 0.471 ± 0.008	1.195AsnTyr: 1.195 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	3.812ProAla: 3.812 ± 0.031	1.084ProCys: 1.084 ± 0.02	2.844ProAsp: 2.844 ± 0.022	3.162ProGlu: 3.162 ± 0.02	1.704ProPhe: 1.704 ± 0.015	3.475ProGly: 3.475 ± 0.047	1.389ProHis: 1.389 ± 0.014	1.745ProIle: 1.745 ± 0.013	2.274ProLys: 2.274 ± 0.03	4.339ProLeu: 4.339 ± 0.026	0.93ProMet: 0.93 ± 0.011	1.772ProAsn: 1.772 ± 0.015	4.439ProPro: 4.439 ± 0.044	2.301ProGln: 2.301 ± 0.02	3.052ProArg: 3.052 ± 0.09	5.118ProSer: 5.118 ± 0.052	3.265ProThr: 3.265 ± 0.042	3.771ProVal: 3.771 ± 0.028	0.555ProTrp: 0.555 ± 0.009	1.318ProTyr: 1.318 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.142GlnAla: 3.142 ± 0.024	1.0GlnCys: 1.0 ± 0.021	2.302GlnAsp: 2.302 ± 0.018	3.536GlnGlu: 3.536 ± 0.099	1.366GlnPhe: 1.366 ± 0.014	2.588GlnGly: 2.588 ± 0.03	1.436GlnHis: 1.436 ± 0.015	1.824GlnIle: 1.824 ± 0.016	2.505GlnLys: 2.505 ± 0.02	4.213GlnLeu: 4.213 ± 0.033	1.095GlnMet: 1.095 ± 0.013	1.873GlnAsn: 1.873 ± 0.017	2.591GlnPro: 2.591 ± 0.065	3.373GlnGln: 3.373 ± 0.061	2.887GlnArg: 2.887 ± 0.025	3.321GlnSer: 3.321 ± 0.022	2.765GlnThr: 2.765 ± 0.021	2.926GlnVal: 2.926 ± 0.032	0.532GlnTrp: 0.532 ± 0.008	1.153GlnTyr: 1.153 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	3.757ArgAla: 3.757 ± 0.109	1.382ArgCys: 1.382 ± 0.019	3.053ArgAsp: 3.053 ± 0.022	3.683ArgGlu: 3.683 ± 0.031	1.89ArgPhe: 1.89 ± 0.014	3.328ArgGly: 3.328 ± 0.026	1.82ArgHis: 1.82 ± 0.017	2.291ArgIle: 2.291 ± 0.016	3.417ArgLys: 3.417 ± 0.023	5.501ArgLeu: 5.501 ± 0.034	1.33ArgMet: 1.33 ± 0.011	2.193ArgAsn: 2.193 ± 0.017	2.861ArgPro: 2.861 ± 0.024	3.028ArgGln: 3.028 ± 0.025	4.488ArgArg: 4.488 ± 0.035	4.423ArgSer: 4.423 ± 0.034	3.044ArgThr: 3.044 ± 0.024	3.408ArgVal: 3.408 ± 0.021	0.749ArgTrp: 0.749 ± 0.01	1.54ArgTyr: 1.54 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	5.898SerAla: 5.898 ± 0.053	2.009SerCys: 2.009 ± 0.022	4.786SerAsp: 4.786 ± 0.031	4.72SerGlu: 4.72 ± 0.032	3.127SerPhe: 3.127 ± 0.02	5.706SerGly: 5.706 ± 0.035	2.352SerHis: 2.352 ± 0.033	3.349SerIle: 3.349 ± 0.022	4.036SerLys: 4.036 ± 0.028	7.827SerLeu: 7.827 ± 0.037	1.8SerMet: 1.8 ± 0.016	3.091SerAsn: 3.091 ± 0.022	5.128SerPro: 5.128 ± 0.041	4.234SerGln: 4.234 ± 0.094	4.675SerArg: 4.675 ± 0.03	10.157SerSer: 10.157 ± 0.08	5.413SerThr: 5.413 ± 0.034	5.651SerVal: 5.651 ± 0.033	0.913SerTrp: 0.913 ± 0.01	2.086SerTyr: 2.086 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	4.652ThrAla: 4.652 ± 0.047	1.772ThrCys: 1.772 ± 0.027	3.292ThrAsp: 3.292 ± 0.026	3.472ThrGlu: 3.472 ± 0.024	2.389ThrPhe: 2.389 ± 0.019	4.036ThrGly: 4.036 ± 0.034	1.393ThrHis: 1.393 ± 0.014	2.651ThrIle: 2.651 ± 0.019	2.778ThrLys: 2.778 ± 0.02	5.32ThrLeu: 5.32 ± 0.031	1.311ThrMet: 1.311 ± 0.012	2.34ThrAsn: 2.34 ± 0.023	3.613ThrPro: 3.613 ± 0.033	2.36ThrGln: 2.36 ± 0.019	3.057ThrArg: 3.057 ± 0.028	6.219ThrSer: 6.219 ± 0.035	4.688ThrThr: 4.688 ± 0.058	4.496ThrVal: 4.496 ± 0.031	0.783ThrTrp: 0.783 ± 0.011	1.651ThrTyr: 1.651 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.619ValAla: 4.619 ± 0.026	1.847ValCys: 1.847 ± 0.022	3.84ValAsp: 3.84 ± 0.027	3.918ValGlu: 3.918 ± 0.026	2.672ValPhe: 2.672 ± 0.019	3.834ValGly: 3.834 ± 0.033	1.744ValHis: 1.744 ± 0.015	3.266ValIle: 3.266 ± 0.021	3.429ValLys: 3.429 ± 0.021	6.23ValLeu: 6.23 ± 0.035	1.618ValMet: 1.618 ± 0.014	2.708ValAsn: 2.708 ± 0.02	3.326ValPro: 3.326 ± 0.025	2.988ValGln: 2.988 ± 0.041	3.504ValArg: 3.504 ± 0.021	5.664ValSer: 5.664 ± 0.035	4.971ValThr: 4.971 ± 0.037	5.188ValVal: 5.188 ± 0.038	0.843ValTrp: 0.843 ± 0.012	2.002ValTyr: 2.002 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.657TrpAla: 0.657 ± 0.011	0.265TrpCys: 0.265 ± 0.006	0.61TrpAsp: 0.61 ± 0.009	0.651TrpGlu: 0.651 ± 0.008	0.423TrpPhe: 0.423 ± 0.007	0.647TrpGly: 0.647 ± 0.011	0.303TrpHis: 0.303 ± 0.006	0.522TrpIle: 0.522 ± 0.008	0.676TrpLys: 0.676 ± 0.009	1.135TrpLeu: 1.135 ± 0.012	0.34TrpMet: 0.34 ± 0.007	0.549TrpAsn: 0.549 ± 0.011	0.483TrpPro: 0.483 ± 0.009	0.559TrpGln: 0.559 ± 0.008	0.817TrpArg: 0.817 ± 0.01	0.907TrpSer: 0.907 ± 0.011	0.8TrpThr: 0.8 ± 0.012	0.744TrpVal: 0.744 ± 0.018	0.205TrpTrp: 0.205 ± 0.005	0.351TrpTyr: 0.351 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.483TyrAla: 1.483 ± 0.014	0.682TyrCys: 0.682 ± 0.024	1.549TyrAsp: 1.549 ± 0.016	1.454TyrGlu: 1.454 ± 0.015	1.248TyrPhe: 1.248 ± 0.014	1.789TyrGly: 1.789 ± 0.019	0.755TyrHis: 0.755 ± 0.011	1.489TyrIle: 1.489 ± 0.015	1.333TyrLys: 1.333 ± 0.015	2.632TyrLeu: 2.632 ± 0.018	0.654TyrMet: 0.654 ± 0.008	1.266TyrAsn: 1.266 ± 0.015	1.352TyrPro: 1.352 ± 0.017	1.138TyrGln: 1.138 ± 0.012	1.601TyrArg: 1.601 ± 0.014	2.177TyrSer: 2.177 ± 0.021	1.706TyrThr: 1.706 ± 0.017	1.782TyrVal: 1.782 ± 0.016	0.346TyrTrp: 0.346 ± 0.01	0.978TyrTyr: 0.978 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 21377 proteins (10621572 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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