Amino acid dipepetide frequency for Caulobacter phage Ccr5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.539AlaAla: 14.539 ± 0.714
0.999AlaCys: 0.999 ± 0.125
7.23AlaAsp: 7.23 ± 0.351
7.5AlaGlu: 7.5 ± 0.419
4.487AlaPhe: 4.487 ± 0.278
9.339AlaGly: 9.339 ± 0.708
2.061AlaHis: 2.061 ± 0.168
5.121AlaIle: 5.121 ± 0.254
5.486AlaLys: 5.486 ± 0.411
10.512AlaLeu: 10.512 ± 0.567
3.536AlaMet: 3.536 ± 0.245
3.092AlaAsn: 3.092 ± 0.298
6.088AlaPro: 6.088 ± 0.323
4.503AlaGln: 4.503 ± 0.337
7.515AlaArg: 7.515 ± 0.407
5.851AlaSer: 5.851 ± 0.476
5.898AlaThr: 5.898 ± 0.408
7.389AlaVal: 7.389 ± 0.361
2.125AlaTrp: 2.125 ± 0.209
3.409AlaTyr: 3.409 ± 0.234
0.0AlaXaa: 0.0 ± 0.0
Cys
0.967CysAla: 0.967 ± 0.133
0.174CysCys: 0.174 ± 0.061
0.634CysAsp: 0.634 ± 0.103
0.634CysGlu: 0.634 ± 0.111
0.222CysPhe: 0.222 ± 0.058
0.666CysGly: 0.666 ± 0.103
0.238CysHis: 0.238 ± 0.078
0.317CysIle: 0.317 ± 0.083
0.238CysLys: 0.238 ± 0.065
0.793CysLeu: 0.793 ± 0.109
0.222CysMet: 0.222 ± 0.061
0.159CysAsn: 0.159 ± 0.047
0.444CysPro: 0.444 ± 0.09
0.396CysGln: 0.396 ± 0.083
0.999CysArg: 0.999 ± 0.141
0.365CysSer: 0.365 ± 0.082
0.444CysThr: 0.444 ± 0.088
0.65CysVal: 0.65 ± 0.104
0.127CysTrp: 0.127 ± 0.041
0.444CysTyr: 0.444 ± 0.083
0.0CysXaa: 0.0 ± 0.0
Asp
7.626AspAla: 7.626 ± 0.448
0.634AspCys: 0.634 ± 0.1
3.789AspAsp: 3.789 ± 0.312
4.883AspGlu: 4.883 ± 0.365
2.362AspPhe: 2.362 ± 0.219
6.041AspGly: 6.041 ± 0.285
1.49AspHis: 1.49 ± 0.19
3.028AspIle: 3.028 ± 0.242
2.378AspLys: 2.378 ± 0.186
6.517AspLeu: 6.517 ± 0.303
1.57AspMet: 1.57 ± 0.177
1.506AspAsn: 1.506 ± 0.144
4.233AspPro: 4.233 ± 0.275
1.776AspGln: 1.776 ± 0.165
3.853AspArg: 3.853 ± 0.276
1.934AspSer: 1.934 ± 0.191
3.028AspThr: 3.028 ± 0.291
4.883AspVal: 4.883 ± 0.298
1.3AspTrp: 1.3 ± 0.164
2.347AspTyr: 2.347 ± 0.17
0.0AspXaa: 0.0 ± 0.0
Glu
9.133GluAla: 9.133 ± 0.54
0.365GluCys: 0.365 ± 0.081
4.249GluAsp: 4.249 ± 0.325
4.265GluGlu: 4.265 ± 0.368
2.743GluPhe: 2.743 ± 0.25
4.138GluGly: 4.138 ± 0.248
1.522GluHis: 1.522 ± 0.186
3.599GluIle: 3.599 ± 0.23
2.711GluLys: 2.711 ± 0.268
3.599GluLeu: 3.599 ± 0.278
1.681GluMet: 1.681 ± 0.161
1.649GluAsn: 1.649 ± 0.155
3.044GluPro: 3.044 ± 0.262
2.188GluGln: 2.188 ± 0.181
4.963GluArg: 4.963 ± 0.4
2.077GluSer: 2.077 ± 0.188
4.424GluThr: 4.424 ± 0.284
4.455GluVal: 4.455 ± 0.27
0.872GluTrp: 0.872 ± 0.133
1.411GluTyr: 1.411 ± 0.168
0.0GluXaa: 0.0 ± 0.0
Phe
3.742PheAla: 3.742 ± 0.243
0.365PheCys: 0.365 ± 0.098
3.266PheAsp: 3.266 ± 0.322
2.267PheGlu: 2.267 ± 0.213
1.284PhePhe: 1.284 ± 0.185
2.426PheGly: 2.426 ± 0.185
1.157PheHis: 1.157 ± 0.163
1.538PheIle: 1.538 ± 0.139
1.808PheLys: 1.808 ± 0.202
3.171PheLeu: 3.171 ± 0.234
0.84PheMet: 0.84 ± 0.119
1.173PheAsn: 1.173 ± 0.144
1.665PhePro: 1.665 ± 0.154
1.157PheGln: 1.157 ± 0.149
2.188PheArg: 2.188 ± 0.176
2.093PheSer: 2.093 ± 0.219
2.093PheThr: 2.093 ± 0.238
2.394PheVal: 2.394 ± 0.197
0.65PheTrp: 0.65 ± 0.097
1.205PheTyr: 1.205 ± 0.13
0.0PheXaa: 0.0 ± 0.0
Gly
8.594GlyAla: 8.594 ± 0.719
0.571GlyCys: 0.571 ± 0.092
5.391GlyAsp: 5.391 ± 0.326
5.137GlyGlu: 5.137 ± 0.347
3.219GlyPhe: 3.219 ± 0.211
9.862GlyGly: 9.862 ± 2.496
1.697GlyHis: 1.697 ± 0.161
2.283GlyIle: 2.283 ± 0.191
4.202GlyLys: 4.202 ± 0.276
6.326GlyLeu: 6.326 ± 0.417
1.871GlyMet: 1.871 ± 0.172
1.919GlyAsn: 1.919 ± 0.286
2.87GlyPro: 2.87 ± 0.212
2.759GlyGln: 2.759 ± 0.244
5.613GlyArg: 5.613 ± 0.329
4.915GlySer: 4.915 ± 0.479
4.519GlyThr: 4.519 ± 0.685
5.914GlyVal: 5.914 ± 0.41
1.839GlyTrp: 1.839 ± 0.192
2.775GlyTyr: 2.775 ± 0.26
0.0GlyXaa: 0.0 ± 0.0
His
2.616HisAla: 2.616 ± 0.242
0.349HisCys: 0.349 ± 0.074
1.617HisAsp: 1.617 ± 0.18
1.332HisGlu: 1.332 ± 0.157
0.809HisPhe: 0.809 ± 0.122
2.172HisGly: 2.172 ± 0.194
0.507HisHis: 0.507 ± 0.096
0.698HisIle: 0.698 ± 0.119
0.634HisLys: 0.634 ± 0.099
1.887HisLeu: 1.887 ± 0.182
0.412HisMet: 0.412 ± 0.084
0.603HisAsn: 0.603 ± 0.096
1.221HisPro: 1.221 ± 0.155
0.618HisGln: 0.618 ± 0.117
1.332HisArg: 1.332 ± 0.165
0.745HisSer: 0.745 ± 0.117
0.999HisThr: 0.999 ± 0.138
1.49HisVal: 1.49 ± 0.164
0.523HisTrp: 0.523 ± 0.09
0.856HisTyr: 0.856 ± 0.102
0.0HisXaa: 0.0 ± 0.0
Ile
5.613IleAla: 5.613 ± 0.295
0.428IleCys: 0.428 ± 0.087
3.139IleAsp: 3.139 ± 0.194
3.869IleGlu: 3.869 ± 0.297
1.221IlePhe: 1.221 ± 0.146
3.52IleGly: 3.52 ± 0.29
1.126IleHis: 1.126 ± 0.163
2.093IleIle: 2.093 ± 0.203
2.22IleLys: 2.22 ± 0.17
3.409IleLeu: 3.409 ± 0.218
0.745IleMet: 0.745 ± 0.109
1.49IleAsn: 1.49 ± 0.166
2.315IlePro: 2.315 ± 0.211
1.411IleGln: 1.411 ± 0.142
2.743IleArg: 2.743 ± 0.17
2.061IleSer: 2.061 ± 0.163
2.854IleThr: 2.854 ± 0.226
3.488IleVal: 3.488 ± 0.292
0.634IleTrp: 0.634 ± 0.107
1.237IleTyr: 1.237 ± 0.115
0.0IleXaa: 0.0 ± 0.0
Lys
6.136LysAla: 6.136 ± 0.397
0.19LysCys: 0.19 ± 0.052
2.616LysAsp: 2.616 ± 0.229
2.061LysGlu: 2.061 ± 0.214
1.443LysPhe: 1.443 ± 0.149
2.917LysGly: 2.917 ± 0.256
1.015LysHis: 1.015 ± 0.153
2.125LysIle: 2.125 ± 0.195
2.378LysLys: 2.378 ± 0.213
3.869LysLeu: 3.869 ± 0.351
0.888LysMet: 0.888 ± 0.114
1.11LysAsn: 1.11 ± 0.114
2.632LysPro: 2.632 ± 0.245
1.094LysGln: 1.094 ± 0.156
3.583LysArg: 3.583 ± 0.302
2.41LysSer: 2.41 ± 0.176
3.314LysThr: 3.314 ± 0.243
3.552LysVal: 3.552 ± 0.26
0.729LysTrp: 0.729 ± 0.114
0.856LysTyr: 0.856 ± 0.115
0.0LysXaa: 0.0 ± 0.0
Leu
9.83LeuAla: 9.83 ± 0.448
0.872LeuCys: 0.872 ± 0.153
6.041LeuAsp: 6.041 ± 0.34
5.137LeuGlu: 5.137 ± 0.329
2.537LeuPhe: 2.537 ± 0.208
6.612LeuGly: 6.612 ± 0.396
1.871LeuHis: 1.871 ± 0.185
3.948LeuIle: 3.948 ± 0.258
4.233LeuLys: 4.233 ± 0.314
6.184LeuLeu: 6.184 ± 0.297
1.617LeuMet: 1.617 ± 0.191
2.727LeuAsn: 2.727 ± 0.239
4.17LeuPro: 4.17 ± 0.277
2.489LeuGln: 2.489 ± 0.204
5.787LeuArg: 5.787 ± 0.375
4.82LeuSer: 4.82 ± 0.382
5.423LeuThr: 5.423 ± 0.269
5.058LeuVal: 5.058 ± 0.259
1.316LeuTrp: 1.316 ± 0.137
2.14LeuTyr: 2.14 ± 0.186
0.0LeuXaa: 0.0 ± 0.0
Met
2.505MetAla: 2.505 ± 0.215
0.111MetCys: 0.111 ± 0.045
1.126MetAsp: 1.126 ± 0.146
0.967MetGlu: 0.967 ± 0.139
0.682MetPhe: 0.682 ± 0.109
1.49MetGly: 1.49 ± 0.195
0.381MetHis: 0.381 ± 0.08
1.395MetIle: 1.395 ± 0.15
1.046MetLys: 1.046 ± 0.135
1.808MetLeu: 1.808 ± 0.153
0.349MetMet: 0.349 ± 0.091
0.745MetAsn: 0.745 ± 0.104
1.348MetPro: 1.348 ± 0.17
0.634MetGln: 0.634 ± 0.116
1.887MetArg: 1.887 ± 0.221
1.839MetSer: 1.839 ± 0.174
2.41MetThr: 2.41 ± 0.206
1.395MetVal: 1.395 ± 0.161
0.254MetTrp: 0.254 ± 0.073
0.285MetTyr: 0.285 ± 0.061
0.0MetXaa: 0.0 ± 0.0
Asn
3.409AsnAla: 3.409 ± 0.261
0.301AsnCys: 0.301 ± 0.064
1.728AsnAsp: 1.728 ± 0.169
1.316AsnGlu: 1.316 ± 0.166
0.951AsnPhe: 0.951 ± 0.122
3.124AsnGly: 3.124 ± 0.384
0.539AsnHis: 0.539 ± 0.106
1.411AsnIle: 1.411 ± 0.16
1.126AsnLys: 1.126 ± 0.149
2.806AsnLeu: 2.806 ± 0.23
0.476AsnMet: 0.476 ± 0.089
1.031AsnAsn: 1.031 ± 0.138
1.919AsnPro: 1.919 ± 0.156
0.713AsnGln: 0.713 ± 0.108
1.839AsnArg: 1.839 ± 0.204
1.237AsnSer: 1.237 ± 0.169
1.633AsnThr: 1.633 ± 0.233
1.839AsnVal: 1.839 ± 0.193
0.46AsnTrp: 0.46 ± 0.092
0.777AsnTyr: 0.777 ± 0.122
0.0AsnXaa: 0.0 ± 0.0
Pro
6.184ProAla: 6.184 ± 0.317
0.444ProCys: 0.444 ± 0.096
3.758ProAsp: 3.758 ± 0.231
3.9ProGlu: 3.9 ± 0.259
2.045ProPhe: 2.045 ± 0.208
4.582ProGly: 4.582 ± 0.332
1.157ProHis: 1.157 ± 0.145
2.505ProIle: 2.505 ± 0.201
2.093ProLys: 2.093 ± 0.193
3.71ProLeu: 3.71 ± 0.276
1.11ProMet: 1.11 ± 0.136
1.697ProAsn: 1.697 ± 0.169
3.187ProPro: 3.187 ± 0.362
1.728ProGln: 1.728 ± 0.167
2.759ProArg: 2.759 ± 0.252
2.822ProSer: 2.822 ± 0.29
3.266ProThr: 3.266 ± 0.263
3.456ProVal: 3.456 ± 0.262
0.729ProTrp: 0.729 ± 0.104
1.633ProTyr: 1.633 ± 0.172
0.0ProXaa: 0.0 ± 0.0
Gln
4.424GlnAla: 4.424 ± 0.337
0.206GlnCys: 0.206 ± 0.057
1.982GlnAsp: 1.982 ± 0.205
2.029GlnGlu: 2.029 ± 0.222
1.173GlnPhe: 1.173 ± 0.148
2.473GlnGly: 2.473 ± 0.265
0.555GlnHis: 0.555 ± 0.086
1.792GlnIle: 1.792 ± 0.148
1.601GlnLys: 1.601 ± 0.171
1.681GlnLeu: 1.681 ± 0.211
0.809GlnMet: 0.809 ± 0.113
0.888GlnAsn: 0.888 ± 0.121
1.728GlnPro: 1.728 ± 0.183
1.253GlnGln: 1.253 ± 0.153
2.616GlnArg: 2.616 ± 0.221
1.348GlnSer: 1.348 ± 0.153
1.966GlnThr: 1.966 ± 0.169
2.236GlnVal: 2.236 ± 0.172
0.507GlnTrp: 0.507 ± 0.092
0.856GlnTyr: 0.856 ± 0.121
0.0GlnXaa: 0.0 ± 0.0
Arg
7.072ArgAla: 7.072 ± 0.44
0.777ArgCys: 0.777 ± 0.124
4.44ArgAsp: 4.44 ± 0.342
4.122ArgGlu: 4.122 ± 0.317
2.949ArgPhe: 2.949 ± 0.234
4.661ArgGly: 4.661 ± 0.296
1.554ArgHis: 1.554 ± 0.19
2.838ArgIle: 2.838 ± 0.248
3.124ArgLys: 3.124 ± 0.269
6.754ArgLeu: 6.754 ± 0.433
1.95ArgMet: 1.95 ± 0.225
2.029ArgAsn: 2.029 ± 0.145
3.25ArgPro: 3.25 ± 0.275
2.251ArgGln: 2.251 ± 0.207
6.073ArgArg: 6.073 ± 0.515
3.013ArgSer: 3.013 ± 0.261
3.441ArgThr: 3.441 ± 0.235
4.566ArgVal: 4.566 ± 0.284
1.49ArgTrp: 1.49 ± 0.144
2.822ArgTyr: 2.822 ± 0.222
0.0ArgXaa: 0.0 ± 0.0
Ser
4.868SerAla: 4.868 ± 0.305
0.46SerCys: 0.46 ± 0.098
2.917SerAsp: 2.917 ± 0.261
2.87SerGlu: 2.87 ± 0.231
1.966SerPhe: 1.966 ± 0.249
5.074SerGly: 5.074 ± 0.642
1.031SerHis: 1.031 ± 0.12
2.394SerIle: 2.394 ± 0.204
2.125SerLys: 2.125 ± 0.18
3.964SerLeu: 3.964 ± 0.254
1.348SerMet: 1.348 ± 0.172
1.395SerAsn: 1.395 ± 0.149
2.695SerPro: 2.695 ± 0.175
1.475SerGln: 1.475 ± 0.187
3.504SerArg: 3.504 ± 0.279
2.711SerSer: 2.711 ± 0.25
3.171SerThr: 3.171 ± 0.299
3.155SerVal: 3.155 ± 0.216
0.793SerTrp: 0.793 ± 0.113
1.712SerTyr: 1.712 ± 0.175
0.0SerXaa: 0.0 ± 0.0
Thr
7.119ThrAla: 7.119 ± 0.527
0.46ThrCys: 0.46 ± 0.091
3.377ThrAsp: 3.377 ± 0.252
3.155ThrGlu: 3.155 ± 0.212
2.394ThrPhe: 2.394 ± 0.258
5.026ThrGly: 5.026 ± 0.465
1.268ThrHis: 1.268 ± 0.18
3.155ThrIle: 3.155 ± 0.324
2.014ThrLys: 2.014 ± 0.202
5.724ThrLeu: 5.724 ± 0.303
1.205ThrMet: 1.205 ± 0.134
1.57ThrAsn: 1.57 ± 0.186
4.535ThrPro: 4.535 ± 0.34
1.95ThrGln: 1.95 ± 0.174
3.837ThrArg: 3.837 ± 0.228
2.854ThrSer: 2.854 ± 0.27
3.456ThrThr: 3.456 ± 0.372
4.265ThrVal: 4.265 ± 0.4
0.999ThrTrp: 0.999 ± 0.132
2.14ThrTyr: 2.14 ± 0.25
0.0ThrXaa: 0.0 ± 0.0
Val
7.404ValAla: 7.404 ± 0.358
0.888ValCys: 0.888 ± 0.152
4.582ValAsp: 4.582 ± 0.266
4.788ValGlu: 4.788 ± 0.292
2.394ValPhe: 2.394 ± 0.209
4.313ValGly: 4.313 ± 0.353
1.379ValHis: 1.379 ± 0.138
3.393ValIle: 3.393 ± 0.274
3.235ValLys: 3.235 ± 0.247
6.057ValLeu: 6.057 ± 0.344
1.3ValMet: 1.3 ± 0.137
2.093ValAsn: 2.093 ± 0.206
3.361ValPro: 3.361 ± 0.319
2.267ValGln: 2.267 ± 0.169
4.487ValArg: 4.487 ± 0.31
3.9ValSer: 3.9 ± 0.276
4.55ValThr: 4.55 ± 0.344
5.248ValVal: 5.248 ± 0.294
1.332ValTrp: 1.332 ± 0.142
2.125ValTyr: 2.125 ± 0.215
0.0ValXaa: 0.0 ± 0.0
Trp
1.649TrpAla: 1.649 ± 0.153
0.206TrpCys: 0.206 ± 0.051
1.205TrpAsp: 1.205 ± 0.137
1.031TrpGlu: 1.031 ± 0.116
0.713TrpPhe: 0.713 ± 0.117
1.205TrpGly: 1.205 ± 0.155
0.238TrpHis: 0.238 ± 0.063
0.682TrpIle: 0.682 ± 0.085
1.046TrpLys: 1.046 ± 0.149
1.538TrpLeu: 1.538 ± 0.186
0.349TrpMet: 0.349 ± 0.083
0.872TrpAsn: 0.872 ± 0.133
0.745TrpPro: 0.745 ± 0.111
0.381TrpGln: 0.381 ± 0.08
1.348TrpArg: 1.348 ± 0.154
0.983TrpSer: 0.983 ± 0.142
1.395TrpThr: 1.395 ± 0.168
1.173TrpVal: 1.173 ± 0.153
0.365TrpTrp: 0.365 ± 0.083
0.333TrpTyr: 0.333 ± 0.072
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.266TyrAla: 3.266 ± 0.207
0.333TyrCys: 0.333 ± 0.07
2.093TyrAsp: 2.093 ± 0.191
1.823TyrGlu: 1.823 ± 0.191
0.888TyrPhe: 0.888 ± 0.13
2.632TyrGly: 2.632 ± 0.224
0.634TyrHis: 0.634 ± 0.104
1.3TyrIle: 1.3 ± 0.146
1.221TyrLys: 1.221 ± 0.157
2.505TyrLeu: 2.505 ± 0.204
0.365TyrMet: 0.365 ± 0.062
0.888TyrAsn: 0.888 ± 0.119
1.316TyrPro: 1.316 ± 0.145
1.078TyrGln: 1.078 ± 0.135
2.251TyrArg: 2.251 ± 0.179
1.649TyrSer: 1.649 ± 0.178
2.22TyrThr: 2.22 ± 0.215
2.489TyrVal: 2.489 ± 0.231
0.412TyrTrp: 0.412 ± 0.084
0.983TyrTyr: 0.983 ± 0.119
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 321 proteins (63071 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski