Amino acid dipepetide frequency for Macaca nemestrina (Pig-tailed macaque)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.769AlaAla: 6.769 ± 0.033	1.384AlaCys: 1.384 ± 0.009	2.901AlaAsp: 2.901 ± 0.012	4.818AlaGlu: 4.818 ± 0.022	2.632AlaPhe: 2.632 ± 0.013	4.728AlaGly: 4.728 ± 0.022	1.549AlaHis: 1.549 ± 0.008	2.764AlaIle: 2.764 ± 0.012	3.438AlaLys: 3.438 ± 0.015	7.047AlaLeu: 7.047 ± 0.025	1.487AlaMet: 1.487 ± 0.008	2.024AlaAsn: 2.024 ± 0.011	4.144AlaPro: 4.144 ± 0.024	3.277AlaGln: 3.277 ± 0.017	3.649AlaArg: 3.649 ± 0.015	5.712AlaSer: 5.712 ± 0.018	3.618AlaThr: 3.618 ± 0.016	4.671AlaVal: 4.671 ± 0.016	0.801AlaTrp: 0.801 ± 0.006	1.504AlaTyr: 1.504 ± 0.009	0.0AlaXaa: 0.0 ± 0.0
Cys	1.222CysAla: 1.222 ± 0.009	0.655CysCys: 0.655 ± 0.008	1.013CysAsp: 1.013 ± 0.01	1.324CysGlu: 1.324 ± 0.012	0.836CysPhe: 0.836 ± 0.006	1.776CysGly: 1.776 ± 0.018	0.678CysHis: 0.678 ± 0.006	0.956CysIle: 0.956 ± 0.008	1.187CysLys: 1.187 ± 0.011	2.187CysLeu: 2.187 ± 0.013	0.418CysMet: 0.418 ± 0.005	0.828CysAsn: 0.828 ± 0.008	1.385CysPro: 1.385 ± 0.012	1.076CysGln: 1.076 ± 0.01	1.301CysArg: 1.301 ± 0.01	2.021CysSer: 2.021 ± 0.011	1.099CysThr: 1.099 ± 0.01	1.31CysVal: 1.31 ± 0.01	0.297CysTrp: 0.297 ± 0.003	0.57CysTyr: 0.57 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	2.858AspAla: 2.858 ± 0.013	1.074AspCys: 1.074 ± 0.01	2.656AspAsp: 2.656 ± 0.014	3.505AspGlu: 3.505 ± 0.014	2.115AspPhe: 2.115 ± 0.009	3.319AspGly: 3.319 ± 0.016	1.138AspHis: 1.138 ± 0.008	2.59AspIle: 2.59 ± 0.012	2.555AspLys: 2.555 ± 0.012	5.007AspLeu: 5.007 ± 0.017	1.108AspMet: 1.108 ± 0.006	1.682AspAsn: 1.682 ± 0.013	2.902AspPro: 2.902 ± 0.014	1.839AspGln: 1.839 ± 0.008	2.413AspArg: 2.413 ± 0.011	4.191AspSer: 4.191 ± 0.021	2.46AspThr: 2.46 ± 0.01	3.063AspVal: 3.063 ± 0.014	0.626AspTrp: 0.626 ± 0.005	1.486AspTyr: 1.486 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	5.305GluAla: 5.305 ± 0.024	1.522GluCys: 1.522 ± 0.018	4.513GluAsp: 4.513 ± 0.019	8.116GluGlu: 8.116 ± 0.04	2.046GluPhe: 2.046 ± 0.01	4.208GluGly: 4.208 ± 0.017	1.537GluHis: 1.537 ± 0.009	3.175GluIle: 3.175 ± 0.014	5.56GluLys: 5.56 ± 0.027	6.567GluLeu: 6.567 ± 0.025	1.694GluMet: 1.694 ± 0.008	3.204GluAsn: 3.204 ± 0.015	3.271GluPro: 3.271 ± 0.015	3.2GluGln: 3.2 ± 0.017	4.074GluArg: 4.074 ± 0.019	4.421GluSer: 4.421 ± 0.018	3.449GluThr: 3.449 ± 0.015	4.191GluVal: 4.191 ± 0.017	0.706GluTrp: 0.706 ± 0.006	1.613GluTyr: 1.613 ± 0.01	0.0GluXaa: 0.0 ± 0.0
Phe	1.942PheAla: 1.942 ± 0.01	0.919PheCys: 0.919 ± 0.008	1.679PheAsp: 1.679 ± 0.009	2.019PheGlu: 2.019 ± 0.009	1.566PhePhe: 1.566 ± 0.012	2.188PheGly: 2.188 ± 0.012	1.048PheHis: 1.048 ± 0.006	1.811PheIle: 1.811 ± 0.011	1.81PheLys: 1.81 ± 0.011	4.01PheLeu: 4.01 ± 0.019	0.774PheMet: 0.774 ± 0.006	1.348PheAsn: 1.348 ± 0.008	1.995PhePro: 1.995 ± 0.012	1.809PheGln: 1.809 ± 0.009	1.985PheArg: 1.985 ± 0.01	3.412PheSer: 3.412 ± 0.016	2.036PheThr: 2.036 ± 0.012	2.096PheVal: 2.096 ± 0.011	0.486PheTrp: 0.486 ± 0.005	1.158PheTyr: 1.158 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	4.494GlyAla: 4.494 ± 0.025	1.274GlyCys: 1.274 ± 0.009	3.147GlyAsp: 3.147 ± 0.014	4.23GlyGlu: 4.23 ± 0.022	2.395GlyPhe: 2.395 ± 0.016	5.017GlyGly: 5.017 ± 0.031	1.683GlyHis: 1.683 ± 0.011	2.761GlyIle: 2.761 ± 0.013	3.891GlyLys: 3.891 ± 0.021	5.866GlyLeu: 5.866 ± 0.023	1.309GlyMet: 1.309 ± 0.009	2.343GlyAsn: 2.343 ± 0.011	4.24GlyPro: 4.24 ± 0.036	2.764GlyGln: 2.764 ± 0.014	3.763GlyArg: 3.763 ± 0.016	5.81GlySer: 5.81 ± 0.025	3.579GlyThr: 3.579 ± 0.015	3.532GlyVal: 3.532 ± 0.016	0.793GlyTrp: 0.793 ± 0.007	1.735GlyTyr: 1.735 ± 0.013	0.0GlyXaa: 0.0 ± 0.0
His	1.32HisAla: 1.32 ± 0.008	0.745HisCys: 0.745 ± 0.006	0.894HisAsp: 0.894 ± 0.005	1.352HisGlu: 1.352 ± 0.009	1.078HisPhe: 1.078 ± 0.007	1.541HisGly: 1.541 ± 0.008	0.908HisHis: 0.908 ± 0.008	1.255HisIle: 1.255 ± 0.008	1.31HisLys: 1.31 ± 0.011	2.933HisLeu: 2.933 ± 0.012	0.594HisMet: 0.594 ± 0.005	0.873HisAsn: 0.873 ± 0.005	1.666HisPro: 1.666 ± 0.01	1.386HisGln: 1.386 ± 0.014	1.61HisArg: 1.61 ± 0.012	2.334HisSer: 2.334 ± 0.013	1.582HisThr: 1.582 ± 0.015	1.472HisVal: 1.472 ± 0.009	0.351HisTrp: 0.351 ± 0.004	0.793HisTyr: 0.793 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	2.575IleAla: 2.575 ± 0.013	1.08IleCys: 1.08 ± 0.009	2.022IleAsp: 2.022 ± 0.011	2.621IleGlu: 2.621 ± 0.011	1.883IlePhe: 1.883 ± 0.011	2.195IleGly: 2.195 ± 0.012	1.404IleHis: 1.404 ± 0.013	2.365IleIle: 2.365 ± 0.014	2.644IleLys: 2.644 ± 0.013	4.553IleLeu: 4.553 ± 0.019	0.993IleMet: 0.993 ± 0.007	1.837IleAsn: 1.837 ± 0.012	2.598IlePro: 2.598 ± 0.013	2.306IleGln: 2.306 ± 0.013	2.371IleArg: 2.371 ± 0.011	3.704IleSer: 3.704 ± 0.016	2.549IleThr: 2.549 ± 0.013	2.469IleVal: 2.469 ± 0.012	0.505IleTrp: 0.505 ± 0.005	1.37IleTyr: 1.37 ± 0.009	0.0IleXaa: 0.0 ± 0.0
Lys	4.03LysAla: 4.03 ± 0.016	1.204LysCys: 1.204 ± 0.014	3.17LysAsp: 3.17 ± 0.016	5.241LysGlu: 5.241 ± 0.023	1.739LysPhe: 1.739 ± 0.01	3.263LysGly: 3.263 ± 0.017	1.427LysHis: 1.427 ± 0.009	2.831LysIle: 2.831 ± 0.014	4.756LysLys: 4.756 ± 0.025	5.218LysLeu: 5.218 ± 0.019	1.442LysMet: 1.442 ± 0.008	2.432LysAsn: 2.432 ± 0.012	3.188LysPro: 3.188 ± 0.02	2.661LysGln: 2.661 ± 0.015	3.331LysArg: 3.331 ± 0.017	3.945LysSer: 3.945 ± 0.02	3.131LysThr: 3.131 ± 0.013	3.48LysVal: 3.48 ± 0.014	0.607LysTrp: 0.607 ± 0.006	1.567LysTyr: 1.567 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	6.726LeuAla: 6.726 ± 0.022	2.184LeuCys: 2.184 ± 0.011	4.702LeuAsp: 4.702 ± 0.02	7.29LeuGlu: 7.29 ± 0.027	3.33LeuPhe: 3.33 ± 0.017	5.849LeuGly: 5.849 ± 0.023	2.73LeuHis: 2.73 ± 0.013	3.873LeuIle: 3.873 ± 0.017	5.867LeuLys: 5.867 ± 0.02	10.709LeuLeu: 10.709 ± 0.042	2.01LeuMet: 2.01 ± 0.011	3.507LeuAsn: 3.507 ± 0.014	5.997LeuPro: 5.997 ± 0.026	5.842LeuGln: 5.842 ± 0.024	5.922LeuArg: 5.922 ± 0.022	7.954LeuSer: 7.954 ± 0.023	5.08LeuThr: 5.08 ± 0.015	5.452LeuVal: 5.452 ± 0.019	1.137LeuTrp: 1.137 ± 0.008	2.516LeuTyr: 2.516 ± 0.011	0.0LeuXaa: 0.0 ± 0.0
Met	1.909MetAla: 1.909 ± 0.01	0.4MetCys: 0.4 ± 0.004	1.266MetAsp: 1.266 ± 0.008	1.909MetGlu: 1.909 ± 0.009	0.72MetPhe: 0.72 ± 0.006	1.299MetGly: 1.299 ± 0.009	0.478MetHis: 0.478 ± 0.005	0.85MetIle: 0.85 ± 0.007	1.46MetLys: 1.46 ± 0.008	1.953MetLeu: 1.953 ± 0.011	0.576MetMet: 0.576 ± 0.006	0.907MetAsn: 0.907 ± 0.007	1.096MetPro: 1.096 ± 0.008	0.931MetGln: 0.931 ± 0.007	1.038MetArg: 1.038 ± 0.007	1.559MetSer: 1.559 ± 0.009	1.125MetThr: 1.125 ± 0.007	1.382MetVal: 1.382 ± 0.008	0.241MetTrp: 0.241 ± 0.003	0.552MetTyr: 0.552 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.05AsnAla: 2.05 ± 0.012	0.844AsnCys: 0.844 ± 0.008	1.535AsnAsp: 1.535 ± 0.01	2.283AsnGlu: 2.283 ± 0.012	1.477AsnPhe: 1.477 ± 0.009	2.466AsnGly: 2.466 ± 0.015	0.96AsnHis: 0.96 ± 0.007	2.108AsnIle: 2.108 ± 0.012	2.228AsnLys: 2.228 ± 0.012	3.768AsnLeu: 3.768 ± 0.013	0.921AsnMet: 0.921 ± 0.006	1.544AsnAsn: 1.544 ± 0.01	2.163AsnPro: 2.163 ± 0.011	1.684AsnGln: 1.684 ± 0.009	1.858AsnArg: 1.858 ± 0.009	3.146AsnSer: 3.146 ± 0.014	1.962AsnThr: 1.962 ± 0.01	2.192AsnVal: 2.192 ± 0.011	0.448AsnTrp: 0.448 ± 0.004	1.125AsnTyr: 1.125 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	4.867ProAla: 4.867 ± 0.024	1.149ProCys: 1.149 ± 0.01	2.779ProAsp: 2.779 ± 0.011	4.454ProGlu: 4.454 ± 0.018	1.914ProPhe: 1.914 ± 0.01	5.275ProGly: 5.275 ± 0.048	1.442ProHis: 1.442 ± 0.01	1.894ProIle: 1.894 ± 0.01	2.765ProLys: 2.765 ± 0.016	5.232ProLeu: 5.232 ± 0.023	1.037ProMet: 1.037 ± 0.007	1.831ProAsn: 1.831 ± 0.01	6.066ProPro: 6.066 ± 0.044	2.847ProGln: 2.847 ± 0.015	3.368ProArg: 3.368 ± 0.017	5.708ProSer: 5.708 ± 0.024	3.13ProThr: 3.13 ± 0.018	3.794ProVal: 3.794 ± 0.017	0.703ProTrp: 0.703 ± 0.007	1.574ProTyr: 1.574 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.555GlnAla: 3.555 ± 0.018	0.968GlnCys: 0.968 ± 0.008	2.341GlnAsp: 2.341 ± 0.012	3.992GlnGlu: 3.992 ± 0.02	1.39GlnPhe: 1.39 ± 0.009	2.878GlnGly: 2.878 ± 0.015	1.318GlnHis: 1.318 ± 0.009	1.994GlnIle: 1.994 ± 0.009	3.012GlnLys: 3.012 ± 0.017	4.78GlnLeu: 4.78 ± 0.019	1.127GlnMet: 1.127 ± 0.008	1.869GlnAsn: 1.869 ± 0.009	2.83GlnPro: 2.83 ± 0.016	3.187GlnGln: 3.187 ± 0.03	3.015GlnArg: 3.015 ± 0.014	3.159GlnSer: 3.159 ± 0.016	2.308GlnThr: 2.308 ± 0.012	2.831GlnVal: 2.831 ± 0.012	0.553GlnTrp: 0.553 ± 0.004	1.146GlnTyr: 1.146 ± 0.007	0.0GlnXaa: 0.0 ± 0.0
Arg	3.833ArgAla: 3.833 ± 0.015	1.229ArgCys: 1.229 ± 0.01	2.754ArgAsp: 2.754 ± 0.012	4.029ArgGlu: 4.029 ± 0.018	1.848ArgPhe: 1.848 ± 0.01	3.633ArgGly: 3.633 ± 0.018	1.563ArgHis: 1.563 ± 0.01	2.453ArgIle: 2.453 ± 0.012	3.707ArgLys: 3.707 ± 0.014	5.417ArgLeu: 5.417 ± 0.021	1.211ArgMet: 1.211 ± 0.008	2.136ArgAsn: 2.136 ± 0.01	3.24ArgPro: 3.24 ± 0.016	2.659ArgGln: 2.659 ± 0.015	4.355ArgArg: 4.355 ± 0.02	4.29ArgSer: 4.29 ± 0.022	2.842ArgThr: 2.842 ± 0.012	3.135ArgVal: 3.135 ± 0.014	0.707ArgTrp: 0.707 ± 0.006	1.429ArgTyr: 1.429 ± 0.008	0.0ArgXaa: 0.0 ± 0.0
Ser	5.288SerAla: 5.288 ± 0.021	1.855SerCys: 1.855 ± 0.013	3.884SerAsp: 3.884 ± 0.019	5.241SerGlu: 5.241 ± 0.022	3.03SerPhe: 3.03 ± 0.011	5.629SerGly: 5.629 ± 0.024	2.16SerHis: 2.16 ± 0.012	3.202SerIle: 3.202 ± 0.011	4.1SerLys: 4.1 ± 0.018	8.227SerLeu: 8.227 ± 0.022	1.601SerMet: 1.601 ± 0.009	2.73SerAsn: 2.73 ± 0.013	6.026SerPro: 6.026 ± 0.03	3.911SerGln: 3.911 ± 0.017	4.554SerArg: 4.554 ± 0.023	9.388SerSer: 9.388 ± 0.043	4.462SerThr: 4.462 ± 0.02	4.839SerVal: 4.839 ± 0.016	1.065SerTrp: 1.065 ± 0.008	2.058SerTyr: 2.058 ± 0.012	0.0SerXaa: 0.0 ± 0.0
Thr	3.761ThrAla: 3.761 ± 0.015	1.297ThrCys: 1.297 ± 0.013	2.465ThrAsp: 2.465 ± 0.011	3.545ThrGlu: 3.545 ± 0.015	2.085ThrPhe: 2.085 ± 0.011	3.603ThrGly: 3.603 ± 0.016	1.343ThrHis: 1.343 ± 0.01	2.372ThrIle: 2.372 ± 0.011	2.669ThrLys: 2.669 ± 0.012	5.278ThrLeu: 5.278 ± 0.018	1.112ThrMet: 1.112 ± 0.007	1.75ThrAsn: 1.75 ± 0.01	3.576ThrPro: 3.576 ± 0.018	2.321ThrGln: 2.321 ± 0.011	2.488ThrArg: 2.488 ± 0.01	4.645ThrSer: 4.645 ± 0.019	3.035ThrThr: 3.035 ± 0.027	3.823ThrVal: 3.823 ± 0.014	0.694ThrTrp: 0.694 ± 0.006	1.408ThrTyr: 1.408 ± 0.009	0.0ThrXaa: 0.0 ± 0.0
Val	4.234ValAla: 4.234 ± 0.018	1.429ValCys: 1.429 ± 0.009	2.95ValAsp: 2.95 ± 0.012	3.863ValGlu: 3.863 ± 0.015	2.371ValPhe: 2.371 ± 0.012	3.37ValGly: 3.37 ± 0.016	1.57ValHis: 1.57 ± 0.011	2.881ValIle: 2.881 ± 0.015	3.382ValLys: 3.382 ± 0.014	6.099ValLeu: 6.099 ± 0.019	1.324ValMet: 1.324 ± 0.008	2.266ValAsn: 2.266 ± 0.012	3.624ValPro: 3.624 ± 0.015	2.741ValGln: 2.741 ± 0.011	3.024ValArg: 3.024 ± 0.014	4.805ValSer: 4.805 ± 0.018	3.721ValThr: 3.721 ± 0.017	3.923ValVal: 3.923 ± 0.016	0.712ValTrp: 0.712 ± 0.005	1.607ValTyr: 1.607 ± 0.01	0.0ValXaa: 0.0 ± 0.0
Trp	0.798TrpAla: 0.798 ± 0.007	0.252TrpCys: 0.252 ± 0.003	0.645TrpAsp: 0.645 ± 0.005	0.818TrpGlu: 0.818 ± 0.006	0.436TrpPhe: 0.436 ± 0.004	0.738TrpGly: 0.738 ± 0.007	0.312TrpHis: 0.312 ± 0.004	0.537TrpIle: 0.537 ± 0.005	0.805TrpLys: 0.805 ± 0.006	1.209TrpLeu: 1.209 ± 0.008	0.318TrpMet: 0.318 ± 0.004	0.539TrpAsn: 0.539 ± 0.005	0.531TrpPro: 0.531 ± 0.005	0.543TrpGln: 0.543 ± 0.005	0.739TrpArg: 0.739 ± 0.007	0.879TrpSer: 0.879 ± 0.007	0.673TrpThr: 0.673 ± 0.006	0.688TrpVal: 0.688 ± 0.005	0.197TrpTrp: 0.197 ± 0.003	0.332TrpTyr: 0.332 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.383TyrAla: 1.383 ± 0.008	0.676TyrCys: 0.676 ± 0.006	1.269TyrAsp: 1.269 ± 0.008	1.722TyrGlu: 1.722 ± 0.012	1.2TyrPhe: 1.2 ± 0.008	1.652TyrGly: 1.652 ± 0.011	0.748TyrHis: 0.748 ± 0.006	1.372TyrIle: 1.372 ± 0.009	1.517TyrLys: 1.517 ± 0.012	2.62TyrLeu: 2.62 ± 0.013	0.594TyrMet: 0.594 ± 0.005	1.113TyrAsn: 1.113 ± 0.008	1.291TyrPro: 1.291 ± 0.009	1.272TyrGln: 1.272 ± 0.007	1.609TyrArg: 1.609 ± 0.009	2.167TyrSer: 2.167 ± 0.013	1.431TyrThr: 1.431 ± 0.008	1.551TyrVal: 1.551 ± 0.009	0.357TyrTrp: 0.357 ± 0.005	0.935TyrTyr: 0.935 ± 0.008	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.032XaaXaa: 0.032 ± 0.015

Statistics based on 45002 proteins (24382028 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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