Amino acid dipepetide frequency for Neotoma lepida (Desert woodrat)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.759AlaAla: 6.759 ± 0.052	1.43AlaCys: 1.43 ± 0.015	2.87AlaAsp: 2.87 ± 0.017	4.706AlaGlu: 4.706 ± 0.031	2.619AlaPhe: 2.619 ± 0.021	4.667AlaGly: 4.667 ± 0.031	1.663AlaHis: 1.663 ± 0.016	2.812AlaIle: 2.812 ± 0.021	3.358AlaLys: 3.358 ± 0.025	7.436AlaLeu: 7.436 ± 0.038	1.581AlaMet: 1.581 ± 0.015	1.985AlaAsn: 1.985 ± 0.018	4.191AlaPro: 4.191 ± 0.038	3.274AlaGln: 3.274 ± 0.026	3.684AlaArg: 3.684 ± 0.028	5.958AlaSer: 5.958 ± 0.031	3.714AlaThr: 3.714 ± 0.024	4.864AlaVal: 4.864 ± 0.025	0.846AlaTrp: 0.846 ± 0.011	1.56AlaTyr: 1.56 ± 0.016	0.111AlaXaa: 0.111 ± 0.004
Cys	1.306CysAla: 1.306 ± 0.016	0.656CysCys: 0.656 ± 0.012	0.991CysAsp: 0.991 ± 0.012	1.215CysGlu: 1.215 ± 0.017	0.882CysPhe: 0.882 ± 0.011	1.601CysGly: 1.601 ± 0.016	0.7CysHis: 0.7 ± 0.01	0.894CysIle: 0.894 ± 0.012	1.07CysLys: 1.07 ± 0.013	2.282CysLeu: 2.282 ± 0.019	0.429CysMet: 0.429 ± 0.007	0.732CysAsn: 0.732 ± 0.01	1.457CysPro: 1.457 ± 0.02	1.076CysGln: 1.076 ± 0.014	1.287CysArg: 1.287 ± 0.013	2.083CysSer: 2.083 ± 0.02	1.151CysThr: 1.151 ± 0.015	1.332CysVal: 1.332 ± 0.015	0.31CysTrp: 0.31 ± 0.007	0.634CysTyr: 0.634 ± 0.01	0.041CysXaa: 0.041 ± 0.002
Asp	2.809AspAla: 2.809 ± 0.019	1.054AspCys: 1.054 ± 0.014	2.616AspAsp: 2.616 ± 0.031	3.222AspGlu: 3.222 ± 0.025	2.075AspPhe: 2.075 ± 0.016	3.221AspGly: 3.221 ± 0.026	1.132AspHis: 1.132 ± 0.011	2.663AspIle: 2.663 ± 0.027	2.384AspLys: 2.384 ± 0.021	4.942AspLeu: 4.942 ± 0.027	1.175AspMet: 1.175 ± 0.012	1.663AspAsn: 1.663 ± 0.018	2.915AspPro: 2.915 ± 0.021	1.812AspGln: 1.812 ± 0.016	2.45AspArg: 2.45 ± 0.022	4.212AspSer: 4.212 ± 0.025	2.59AspThr: 2.59 ± 0.017	2.993AspVal: 2.993 ± 0.024	0.624AspTrp: 0.624 ± 0.009	1.404AspTyr: 1.404 ± 0.016	0.085AspXaa: 0.085 ± 0.003
Glu	5.309GluAla: 5.309 ± 0.034	1.152GluCys: 1.152 ± 0.014	4.332GluAsp: 4.332 ± 0.03	7.801GluGlu: 7.801 ± 0.069	1.964GluPhe: 1.964 ± 0.016	4.191GluGly: 4.191 ± 0.027	1.517GluHis: 1.517 ± 0.014	2.856GluIle: 2.856 ± 0.022	4.899GluLys: 4.899 ± 0.044	6.403GluLeu: 6.403 ± 0.035	1.657GluMet: 1.657 ± 0.015	2.799GluAsn: 2.799 ± 0.022	3.293GluPro: 3.293 ± 0.024	3.136GluGln: 3.136 ± 0.026	3.794GluArg: 3.794 ± 0.03	4.228GluSer: 4.228 ± 0.029	3.299GluThr: 3.299 ± 0.024	4.2GluVal: 4.2 ± 0.028	0.705GluTrp: 0.705 ± 0.009	1.492GluTyr: 1.492 ± 0.014	0.109GluXaa: 0.109 ± 0.004
Phe	1.993PheAla: 1.993 ± 0.016	1.015PheCys: 1.015 ± 0.011	1.621PheAsp: 1.621 ± 0.013	1.863PheGlu: 1.863 ± 0.015	1.632PhePhe: 1.632 ± 0.017	2.199PheGly: 2.199 ± 0.021	1.056PheHis: 1.056 ± 0.011	1.818PheIle: 1.818 ± 0.02	1.677PheLys: 1.677 ± 0.016	4.279PheLeu: 4.279 ± 0.03	0.77PheMet: 0.77 ± 0.009	1.251PheAsn: 1.251 ± 0.012	2.108PhePro: 2.108 ± 0.016	1.811PheGln: 1.811 ± 0.015	1.955PheArg: 1.955 ± 0.017	3.441PheSer: 3.441 ± 0.025	2.039PheThr: 2.039 ± 0.017	2.177PheVal: 2.177 ± 0.02	0.519PheTrp: 0.519 ± 0.007	1.23PheTyr: 1.23 ± 0.014	0.059PheXaa: 0.059 ± 0.003
Gly	4.533GlyAla: 4.533 ± 0.031	1.333GlyCys: 1.333 ± 0.017	3.163GlyAsp: 3.163 ± 0.023	3.885GlyGlu: 3.885 ± 0.028	2.373GlyPhe: 2.373 ± 0.021	4.866GlyGly: 4.866 ± 0.041	1.761GlyHis: 1.761 ± 0.016	2.677GlyIle: 2.677 ± 0.02	3.602GlyLys: 3.602 ± 0.025	6.136GlyLeu: 6.136 ± 0.034	1.309GlyMet: 1.309 ± 0.014	2.287GlyAsn: 2.287 ± 0.017	4.31GlyPro: 4.31 ± 0.045	2.86GlyGln: 2.86 ± 0.023	3.721GlyArg: 3.721 ± 0.029	5.8GlySer: 5.8 ± 0.035	3.71GlyThr: 3.71 ± 0.027	3.661GlyVal: 3.661 ± 0.023	0.82GlyTrp: 0.82 ± 0.011	1.7GlyTyr: 1.7 ± 0.018	0.104GlyXaa: 0.104 ± 0.004
His	1.312HisAla: 1.312 ± 0.012	0.766HisCys: 0.766 ± 0.013	0.883HisAsp: 0.883 ± 0.01	1.262HisGlu: 1.262 ± 0.013	1.149HisPhe: 1.149 ± 0.012	1.605HisGly: 1.605 ± 0.015	0.936HisHis: 0.936 ± 0.014	1.234HisIle: 1.234 ± 0.013	1.232HisLys: 1.232 ± 0.014	3.027HisLeu: 3.027 ± 0.02	0.622HisMet: 0.622 ± 0.008	0.871HisAsn: 0.871 ± 0.01	1.739HisPro: 1.739 ± 0.015	1.263HisGln: 1.263 ± 0.013	1.66HisArg: 1.66 ± 0.016	2.365HisSer: 2.365 ± 0.017	1.444HisThr: 1.444 ± 0.015	1.526HisVal: 1.526 ± 0.014	0.392HisTrp: 0.392 ± 0.007	0.872HisTyr: 0.872 ± 0.014	0.043HisXaa: 0.043 ± 0.002
Ile	2.494IleAla: 2.494 ± 0.021	1.059IleCys: 1.059 ± 0.013	1.87IleAsp: 1.87 ± 0.016	2.31IleGlu: 2.31 ± 0.021	1.861IlePhe: 1.861 ± 0.02	2.148IleGly: 2.148 ± 0.018	1.258IleHis: 1.258 ± 0.014	2.397IleIle: 2.397 ± 0.027	2.328IleLys: 2.328 ± 0.019	4.601IleLeu: 4.601 ± 0.031	1.019IleMet: 1.019 ± 0.013	1.708IleAsn: 1.708 ± 0.016	2.588IlePro: 2.588 ± 0.017	2.178IleGln: 2.178 ± 0.018	2.263IleArg: 2.263 ± 0.018	3.654IleSer: 3.654 ± 0.025	2.622IleThr: 2.622 ± 0.025	2.458IleVal: 2.458 ± 0.019	0.537IleTrp: 0.537 ± 0.009	1.392IleTyr: 1.392 ± 0.012	0.065IleXaa: 0.065 ± 0.003
Lys	4.032LysAla: 4.032 ± 0.028	1.023LysCys: 1.023 ± 0.014	3.014LysAsp: 3.014 ± 0.024	4.788LysGlu: 4.788 ± 0.038	1.671LysPhe: 1.671 ± 0.016	3.164LysGly: 3.164 ± 0.027	1.339LysHis: 1.339 ± 0.013	2.472LysIle: 2.472 ± 0.022	4.485LysLys: 4.485 ± 0.045	4.992LysLeu: 4.992 ± 0.032	1.478LysMet: 1.478 ± 0.015	2.143LysAsn: 2.143 ± 0.018	2.914LysPro: 2.914 ± 0.023	2.493LysGln: 2.493 ± 0.021	3.181LysArg: 3.181 ± 0.025	3.64LysSer: 3.64 ± 0.028	2.918LysThr: 2.918 ± 0.018	3.424LysVal: 3.424 ± 0.026	0.585LysTrp: 0.585 ± 0.009	1.499LysTyr: 1.499 ± 0.015	0.084LysXaa: 0.084 ± 0.003
Leu	7.124LeuAla: 7.124 ± 0.038	2.306LeuCys: 2.306 ± 0.02	4.774LeuAsp: 4.774 ± 0.027	7.069LeuGlu: 7.069 ± 0.045	3.494LeuPhe: 3.494 ± 0.027	6.224LeuGly: 6.224 ± 0.031	2.879LeuHis: 2.879 ± 0.025	3.798LeuIle: 3.798 ± 0.025	5.568LeuLys: 5.568 ± 0.032	11.283LeuLeu: 11.283 ± 0.058	2.077LeuMet: 2.077 ± 0.016	3.364LeuAsn: 3.364 ± 0.022	6.206LeuPro: 6.206 ± 0.034	5.921LeuGln: 5.921 ± 0.039	6.093LeuArg: 6.093 ± 0.036	8.314LeuSer: 8.314 ± 0.035	5.224LeuThr: 5.224 ± 0.025	5.851LeuVal: 5.851 ± 0.031	1.255LeuTrp: 1.255 ± 0.013	2.637LeuTyr: 2.637 ± 0.023	0.152LeuXaa: 0.152 ± 0.005
Met	2.016MetAla: 2.016 ± 0.015	0.408MetCys: 0.408 ± 0.007	1.278MetAsp: 1.278 ± 0.013	1.856MetGlu: 1.856 ± 0.018	0.758MetPhe: 0.758 ± 0.009	1.355MetGly: 1.355 ± 0.015	0.463MetHis: 0.463 ± 0.007	0.841MetIle: 0.841 ± 0.01	1.425MetLys: 1.425 ± 0.015	2.155MetLeu: 2.155 ± 0.02	0.613MetMet: 0.613 ± 0.012	0.865MetAsn: 0.865 ± 0.011	1.155MetPro: 1.155 ± 0.013	0.935MetGln: 0.935 ± 0.01	1.055MetArg: 1.055 ± 0.011	1.652MetSer: 1.652 ± 0.014	1.2MetThr: 1.2 ± 0.013	1.524MetVal: 1.524 ± 0.017	0.246MetTrp: 0.246 ± 0.005	0.592MetTyr: 0.592 ± 0.009	0.033MetXaa: 0.033 ± 0.002
Asn	1.97AsnAla: 1.97 ± 0.016	0.818AsnCys: 0.818 ± 0.012	1.442AsnAsp: 1.442 ± 0.016	1.967AsnGlu: 1.967 ± 0.018	1.436AsnPhe: 1.436 ± 0.013	2.305AsnGly: 2.305 ± 0.02	0.902AsnHis: 0.902 ± 0.011	1.986AsnIle: 1.986 ± 0.017	1.984AsnLys: 1.984 ± 0.018	3.532AsnLeu: 3.532 ± 0.022	0.903AsnMet: 0.903 ± 0.011	1.345AsnAsn: 1.345 ± 0.016	2.17AsnPro: 2.17 ± 0.018	1.523AsnGln: 1.523 ± 0.013	1.761AsnArg: 1.761 ± 0.016	2.936AsnSer: 2.936 ± 0.019	1.908AsnThr: 1.908 ± 0.016	2.111AsnVal: 2.111 ± 0.017	0.433AsnTrp: 0.433 ± 0.008	1.075AsnTyr: 1.075 ± 0.013	0.056AsnXaa: 0.056 ± 0.003
Pro	4.837ProAla: 4.837 ± 0.035	1.211ProCys: 1.211 ± 0.017	2.76ProAsp: 2.76 ± 0.022	4.543ProGlu: 4.543 ± 0.028	1.964ProPhe: 1.964 ± 0.017	5.26ProGly: 5.26 ± 0.055	1.495ProHis: 1.495 ± 0.014	1.87ProIle: 1.87 ± 0.015	2.836ProLys: 2.836 ± 0.026	5.459ProLeu: 5.459 ± 0.031	1.131ProMet: 1.131 ± 0.013	1.812ProAsn: 1.812 ± 0.015	5.796ProPro: 5.796 ± 0.063	2.948ProGln: 2.948 ± 0.023	3.397ProArg: 3.397 ± 0.026	5.831ProSer: 5.831 ± 0.04	3.208ProThr: 3.208 ± 0.025	3.921ProVal: 3.921 ± 0.028	0.753ProTrp: 0.753 ± 0.01	1.393ProTyr: 1.393 ± 0.014	0.105ProXaa: 0.105 ± 0.004
Gln	3.622GlnAla: 3.622 ± 0.029	0.93GlnCys: 0.93 ± 0.013	2.396GlnAsp: 2.396 ± 0.02	3.897GlnGlu: 3.897 ± 0.035	1.322GlnPhe: 1.322 ± 0.014	2.961GlnGly: 2.961 ± 0.021	1.293GlnHis: 1.293 ± 0.011	1.844GlnIle: 1.844 ± 0.016	2.879GlnLys: 2.879 ± 0.023	4.85GlnLeu: 4.85 ± 0.036	1.124GlnMet: 1.124 ± 0.011	1.766GlnAsn: 1.766 ± 0.016	2.864GlnPro: 2.864 ± 0.025	3.062GlnGln: 3.062 ± 0.043	2.909GlnArg: 2.909 ± 0.022	3.123GlnSer: 3.123 ± 0.024	2.292GlnThr: 2.292 ± 0.019	2.957GlnVal: 2.957 ± 0.02	0.547GlnTrp: 0.547 ± 0.009	1.143GlnTyr: 1.143 ± 0.014	0.075GlnXaa: 0.075 ± 0.003
Arg	3.991ArgAla: 3.991 ± 0.031	1.216ArgCys: 1.216 ± 0.014	2.736ArgAsp: 2.736 ± 0.024	3.906ArgGlu: 3.906 ± 0.031	1.874ArgPhe: 1.874 ± 0.016	3.581ArgGly: 3.581 ± 0.028	1.531ArgHis: 1.531 ± 0.015	2.226ArgIle: 2.226 ± 0.018	3.588ArgLys: 3.588 ± 0.026	5.46ArgLeu: 5.46 ± 0.033	1.208ArgMet: 1.208 ± 0.013	2.013ArgAsn: 2.013 ± 0.016	3.222ArgPro: 3.222 ± 0.024	2.624ArgGln: 2.624 ± 0.024	4.284ArgArg: 4.284 ± 0.038	4.197ArgSer: 4.197 ± 0.031	2.766ArgThr: 2.766 ± 0.019	3.261ArgVal: 3.261 ± 0.023	0.714ArgTrp: 0.714 ± 0.009	1.442ArgTyr: 1.442 ± 0.014	0.08ArgXaa: 0.08 ± 0.003
Ser	5.321SerAla: 5.321 ± 0.028	1.943SerCys: 1.943 ± 0.02	3.751SerAsp: 3.751 ± 0.021	5.055SerGlu: 5.055 ± 0.034	3.068SerPhe: 3.068 ± 0.02	5.731SerGly: 5.731 ± 0.037	2.207SerHis: 2.207 ± 0.016	3.216SerIle: 3.216 ± 0.024	3.919SerLys: 3.919 ± 0.025	8.567SerLeu: 8.567 ± 0.036	1.661SerMet: 1.661 ± 0.015	2.511SerAsn: 2.511 ± 0.02	6.096SerPro: 6.096 ± 0.046	3.922SerGln: 3.922 ± 0.031	4.51SerArg: 4.51 ± 0.029	9.184SerSer: 9.184 ± 0.062	4.521SerThr: 4.521 ± 0.03	5.055SerVal: 5.055 ± 0.027	1.12SerTrp: 1.12 ± 0.012	2.087SerTyr: 2.087 ± 0.017	0.137SerXaa: 0.137 ± 0.004
Thr	3.831ThrAla: 3.831 ± 0.021	1.318ThrCys: 1.318 ± 0.017	2.425ThrAsp: 2.425 ± 0.018	3.482ThrGlu: 3.482 ± 0.022	2.135ThrPhe: 2.135 ± 0.017	3.506ThrGly: 3.506 ± 0.027	1.331ThrHis: 1.331 ± 0.013	2.437ThrIle: 2.437 ± 0.02	2.572ThrLys: 2.572 ± 0.019	5.539ThrLeu: 5.539 ± 0.03	1.293ThrMet: 1.293 ± 0.018	1.652ThrAsn: 1.652 ± 0.016	3.64ThrPro: 3.64 ± 0.029	2.394ThrGln: 2.394 ± 0.018	2.483ThrArg: 2.483 ± 0.019	4.65ThrSer: 4.65 ± 0.033	2.978ThrThr: 2.978 ± 0.027	3.968ThrVal: 3.968 ± 0.024	0.704ThrTrp: 0.704 ± 0.01	1.405ThrTyr: 1.405 ± 0.014	0.093ThrXaa: 0.093 ± 0.003
Val	4.446ValAla: 4.446 ± 0.027	1.478ValCys: 1.478 ± 0.014	2.954ValAsp: 2.954 ± 0.021	3.811ValGlu: 3.811 ± 0.025	2.474ValPhe: 2.474 ± 0.021	3.491ValGly: 3.491 ± 0.022	1.602ValHis: 1.602 ± 0.013	2.881ValIle: 2.881 ± 0.022	3.295ValLys: 3.295 ± 0.023	6.561ValLeu: 6.561 ± 0.033	1.395ValMet: 1.395 ± 0.016	2.148ValAsn: 2.148 ± 0.019	3.855ValPro: 3.855 ± 0.026	2.782ValGln: 2.782 ± 0.021	3.053ValArg: 3.053 ± 0.022	5.077ValSer: 5.077 ± 0.028	3.98ValThr: 3.98 ± 0.027	4.291ValVal: 4.291 ± 0.033	0.751ValTrp: 0.751 ± 0.011	1.637ValTyr: 1.637 ± 0.013	0.098ValXaa: 0.098 ± 0.003
Trp	0.853TrpAla: 0.853 ± 0.011	0.252TrpCys: 0.252 ± 0.006	0.661TrpAsp: 0.661 ± 0.011	0.825TrpGlu: 0.825 ± 0.011	0.447TrpPhe: 0.447 ± 0.007	0.766TrpGly: 0.766 ± 0.013	0.324TrpHis: 0.324 ± 0.007	0.542TrpIle: 0.542 ± 0.008	0.82TrpLys: 0.82 ± 0.01	1.271TrpLeu: 1.271 ± 0.014	0.315TrpMet: 0.315 ± 0.006	0.522TrpAsn: 0.522 ± 0.008	0.564TrpPro: 0.564 ± 0.008	0.545TrpGln: 0.545 ± 0.008	0.758TrpArg: 0.758 ± 0.01	0.913TrpSer: 0.913 ± 0.01	0.713TrpThr: 0.713 ± 0.012	0.782TrpVal: 0.782 ± 0.01	0.193TrpTrp: 0.193 ± 0.004	0.358TrpTyr: 0.358 ± 0.007	0.015TrpXaa: 0.015 ± 0.001
Tyr	1.397TyrAla: 1.397 ± 0.013	0.722TyrCys: 0.722 ± 0.011	1.408TyrAsp: 1.408 ± 0.023	1.544TyrGlu: 1.544 ± 0.014	1.261TyrPhe: 1.261 ± 0.015	1.627TyrGly: 1.627 ± 0.016	0.777TyrHis: 0.777 ± 0.011	1.287TyrIle: 1.287 ± 0.014	1.358TyrLys: 1.358 ± 0.015	2.7TyrLeu: 2.7 ± 0.019	0.634TyrMet: 0.634 ± 0.009	1.079TyrAsn: 1.079 ± 0.013	1.354TyrPro: 1.354 ± 0.014	1.227TyrGln: 1.227 ± 0.013	1.542TyrArg: 1.542 ± 0.014	2.2TyrSer: 2.2 ± 0.017	1.484TyrThr: 1.484 ± 0.017	1.581TyrVal: 1.581 ± 0.014	0.369TyrTrp: 0.369 ± 0.007	1.054TyrTyr: 1.054 ± 0.017	0.039TyrXaa: 0.039 ± 0.002
Xaa	0.13XaaAla: 0.13 ± 0.004	0.038XaaCys: 0.038 ± 0.002	0.095XaaAsp: 0.095 ± 0.003	0.13XaaGlu: 0.13 ± 0.004	0.053XaaPhe: 0.053 ± 0.003	0.141XaaGly: 0.141 ± 0.004	0.038XaaHis: 0.038 ± 0.002	0.058XaaIle: 0.058 ± 0.003	0.063XaaLys: 0.063 ± 0.003	0.142XaaLeu: 0.142 ± 0.004	0.031XaaMet: 0.031 ± 0.002	0.045XaaAsn: 0.045 ± 0.003	0.093XaaPro: 0.093 ± 0.003	0.068XaaGln: 0.068 ± 0.003	0.081XaaArg: 0.081 ± 0.003	0.123XaaSer: 0.123 ± 0.003	0.074XaaThr: 0.074 ± 0.003	0.123XaaVal: 0.123 ± 0.003	0.019XaaTrp: 0.019 ± 0.001	0.039XaaTyr: 0.039 ± 0.002	0.079XaaXaa: 0.079 ± 0.016

Statistics based on 24274 proteins (8997059 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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