Amino acid dipepetide frequency for Arthrobacter sp. CAU 1506

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.108AlaAla: 21.108 ± 0.193
0.759AlaCys: 0.759 ± 0.027
7.408AlaAsp: 7.408 ± 0.09
8.631AlaGlu: 8.631 ± 0.106
3.648AlaPhe: 3.648 ± 0.058
13.616AlaGly: 13.616 ± 0.142
2.206AlaHis: 2.206 ± 0.04
4.803AlaIle: 4.803 ± 0.07
3.484AlaLys: 3.484 ± 0.063
12.664AlaLeu: 12.664 ± 0.133
2.878AlaMet: 2.878 ± 0.046
2.68AlaAsn: 2.68 ± 0.053
6.026AlaPro: 6.026 ± 0.079
4.015AlaGln: 4.015 ± 0.057
7.773AlaArg: 7.773 ± 0.088
6.971AlaSer: 6.971 ± 0.079
6.558AlaThr: 6.558 ± 0.077
11.594AlaVal: 11.594 ± 0.132
1.684AlaTrp: 1.684 ± 0.041
2.289AlaTyr: 2.289 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.749CysAla: 0.749 ± 0.025
0.068CysCys: 0.068 ± 0.007
0.336CysAsp: 0.336 ± 0.015
0.305CysGlu: 0.305 ± 0.015
0.225CysPhe: 0.225 ± 0.014
0.712CysGly: 0.712 ± 0.027
0.164CysHis: 0.164 ± 0.011
0.24CysIle: 0.24 ± 0.012
0.104CysLys: 0.104 ± 0.01
0.593CysLeu: 0.593 ± 0.024
0.104CysMet: 0.104 ± 0.011
0.135CysAsn: 0.135 ± 0.01
0.335CysPro: 0.335 ± 0.019
0.173CysGln: 0.173 ± 0.013
0.453CysArg: 0.453 ± 0.019
0.433CysSer: 0.433 ± 0.018
0.409CysThr: 0.409 ± 0.019
0.446CysVal: 0.446 ± 0.018
0.107CysTrp: 0.107 ± 0.009
0.137CysTyr: 0.137 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.212AspAla: 7.212 ± 0.079
0.319AspCys: 0.319 ± 0.018
3.339AspAsp: 3.339 ± 0.059
3.627AspGlu: 3.627 ± 0.067
1.867AspPhe: 1.867 ± 0.042
5.917AspGly: 5.917 ± 0.09
1.168AspHis: 1.168 ± 0.032
2.332AspIle: 2.332 ± 0.046
1.398AspLys: 1.398 ± 0.035
5.837AspLeu: 5.837 ± 0.075
0.955AspMet: 0.955 ± 0.031
1.112AspAsn: 1.112 ± 0.032
3.836AspPro: 3.836 ± 0.055
1.857AspGln: 1.857 ± 0.041
3.915AspArg: 3.915 ± 0.065
2.852AspSer: 2.852 ± 0.044
2.675AspThr: 2.675 ± 0.053
4.901AspVal: 4.901 ± 0.058
0.9AspTrp: 0.9 ± 0.028
1.375AspTyr: 1.375 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.592GluAla: 7.592 ± 0.097
0.314GluCys: 0.314 ± 0.016
3.215GluAsp: 3.215 ± 0.055
3.576GluGlu: 3.576 ± 0.065
1.82GluPhe: 1.82 ± 0.041
4.018GluGly: 4.018 ± 0.059
1.623GluHis: 1.623 ± 0.028
2.625GluIle: 2.625 ± 0.046
1.625GluLys: 1.625 ± 0.045
6.934GluLeu: 6.934 ± 0.085
1.065GluMet: 1.065 ± 0.034
1.418GluAsn: 1.418 ± 0.035
3.145GluPro: 3.145 ± 0.063
2.689GluGln: 2.689 ± 0.046
4.5GluArg: 4.5 ± 0.068
2.965GluSer: 2.965 ± 0.057
3.129GluThr: 3.129 ± 0.053
4.423GluVal: 4.423 ± 0.068
0.783GluTrp: 0.783 ± 0.024
1.169GluTyr: 1.169 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.952PheAla: 3.952 ± 0.067
0.242PheCys: 0.242 ± 0.015
2.195PheAsp: 2.195 ± 0.048
1.746PheGlu: 1.746 ± 0.043
1.152PhePhe: 1.152 ± 0.037
3.424PheGly: 3.424 ± 0.06
0.632PheHis: 0.632 ± 0.023
1.352PheIle: 1.352 ± 0.032
0.716PheLys: 0.716 ± 0.026
2.884PheLeu: 2.884 ± 0.053
0.585PheMet: 0.585 ± 0.023
0.856PheAsn: 0.856 ± 0.03
1.5PhePro: 1.5 ± 0.035
0.867PheGln: 0.867 ± 0.023
1.826PheArg: 1.826 ± 0.043
1.903PheSer: 1.903 ± 0.037
2.04PheThr: 2.04 ± 0.04
2.426PheVal: 2.426 ± 0.044
0.516PheTrp: 0.516 ± 0.024
0.738PheTyr: 0.738 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.091GlyAla: 10.091 ± 0.102
0.687GlyCys: 0.687 ± 0.028
4.308GlyAsp: 4.308 ± 0.062
4.833GlyGlu: 4.833 ± 0.059
3.216GlyPhe: 3.216 ± 0.051
7.984GlyGly: 7.984 ± 0.107
2.048GlyHis: 2.048 ± 0.04
4.649GlyIle: 4.649 ± 0.067
2.866GlyLys: 2.866 ± 0.056
9.393GlyLeu: 9.393 ± 0.09
2.269GlyMet: 2.269 ± 0.044
2.19GlyAsn: 2.19 ± 0.05
4.366GlyPro: 4.366 ± 0.059
3.221GlyGln: 3.221 ± 0.053
6.328GlyArg: 6.328 ± 0.078
5.925GlySer: 5.925 ± 0.066
5.935GlyThr: 5.935 ± 0.08
6.939GlyVal: 6.939 ± 0.081
1.663GlyTrp: 1.663 ± 0.04
2.323GlyTyr: 2.323 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.358HisAla: 2.358 ± 0.05
0.171HisCys: 0.171 ± 0.013
1.201HisAsp: 1.201 ± 0.032
1.142HisGlu: 1.142 ± 0.029
0.66HisPhe: 0.66 ± 0.024
2.093HisGly: 2.093 ± 0.045
0.646HisHis: 0.646 ± 0.026
0.758HisIle: 0.758 ± 0.027
0.442HisLys: 0.442 ± 0.018
2.086HisLeu: 2.086 ± 0.04
0.38HisMet: 0.38 ± 0.02
0.468HisAsn: 0.468 ± 0.02
1.497HisPro: 1.497 ± 0.039
0.708HisGln: 0.708 ± 0.025
1.688HisArg: 1.688 ± 0.038
1.123HisSer: 1.123 ± 0.03
1.076HisThr: 1.076 ± 0.032
1.619HisVal: 1.619 ± 0.038
0.323HisTrp: 0.323 ± 0.017
0.507HisTyr: 0.507 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
5.634IleAla: 5.634 ± 0.081
0.341IleCys: 0.341 ± 0.017
2.672IleAsp: 2.672 ± 0.055
2.455IleGlu: 2.455 ± 0.049
1.333IlePhe: 1.333 ± 0.039
4.343IleGly: 4.343 ± 0.062
0.852IleHis: 0.852 ± 0.03
1.875IleIle: 1.875 ± 0.043
1.122IleLys: 1.122 ± 0.037
3.693IleLeu: 3.693 ± 0.058
0.755IleMet: 0.755 ± 0.025
1.199IleAsn: 1.199 ± 0.032
2.37IlePro: 2.37 ± 0.051
1.122IleGln: 1.122 ± 0.029
2.665IleArg: 2.665 ± 0.047
2.606IleSer: 2.606 ± 0.053
2.584IleThr: 2.584 ± 0.048
3.53IleVal: 3.53 ± 0.055
0.508IleTrp: 0.508 ± 0.022
0.844IleTyr: 0.844 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.196LysAla: 3.196 ± 0.056
0.087LysCys: 0.087 ± 0.008
1.537LysAsp: 1.537 ± 0.044
1.41LysGlu: 1.41 ± 0.039
0.759LysPhe: 0.759 ± 0.029
1.868LysGly: 1.868 ± 0.044
0.588LysHis: 0.588 ± 0.022
1.3LysIle: 1.3 ± 0.04
0.957LysLys: 0.957 ± 0.038
2.636LysLeu: 2.636 ± 0.049
0.587LysMet: 0.587 ± 0.023
0.744LysAsn: 0.744 ± 0.028
1.65LysPro: 1.65 ± 0.038
0.851LysGln: 0.851 ± 0.033
1.724LysArg: 1.724 ± 0.041
1.483LysSer: 1.483 ± 0.041
1.618LysThr: 1.618 ± 0.04
2.226LysVal: 2.226 ± 0.046
0.302LysTrp: 0.302 ± 0.017
0.626LysTyr: 0.626 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.924LeuAla: 14.924 ± 0.147
0.628LeuCys: 0.628 ± 0.025
6.273LeuAsp: 6.273 ± 0.076
5.681LeuGlu: 5.681 ± 0.082
2.853LeuPhe: 2.853 ± 0.053
9.092LeuGly: 9.092 ± 0.103
1.988LeuHis: 1.988 ± 0.046
4.122LeuIle: 4.122 ± 0.067
2.596LeuLys: 2.596 ± 0.05
10.953LeuLeu: 10.953 ± 0.151
1.984LeuMet: 1.984 ± 0.045
2.355LeuAsn: 2.355 ± 0.044
5.798LeuPro: 5.798 ± 0.069
3.198LeuGln: 3.198 ± 0.05
6.977LeuArg: 6.977 ± 0.076
5.914LeuSer: 5.914 ± 0.068
5.915LeuThr: 5.915 ± 0.075
8.527LeuVal: 8.527 ± 0.107
1.236LeuTrp: 1.236 ± 0.035
1.74LeuTyr: 1.74 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.739MetAla: 2.739 ± 0.046
0.131MetCys: 0.131 ± 0.011
1.123MetAsp: 1.123 ± 0.031
0.998MetGlu: 0.998 ± 0.028
0.594MetPhe: 0.594 ± 0.022
1.614MetGly: 1.614 ± 0.036
0.391MetHis: 0.391 ± 0.017
0.913MetIle: 0.913 ± 0.027
0.556MetLys: 0.556 ± 0.024
2.136MetLeu: 2.136 ± 0.045
0.429MetMet: 0.429 ± 0.021
0.567MetAsn: 0.567 ± 0.02
1.254MetPro: 1.254 ± 0.033
0.646MetGln: 0.646 ± 0.023
1.259MetArg: 1.259 ± 0.035
1.479MetSer: 1.479 ± 0.032
1.588MetThr: 1.588 ± 0.033
1.664MetVal: 1.664 ± 0.036
0.221MetTrp: 0.221 ± 0.015
0.327MetTyr: 0.327 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.717AsnAla: 2.717 ± 0.054
0.171AsnCys: 0.171 ± 0.011
1.271AsnAsp: 1.271 ± 0.03
1.15AsnGlu: 1.15 ± 0.033
0.79AsnPhe: 0.79 ± 0.025
2.26AsnGly: 2.26 ± 0.047
0.524AsnHis: 0.524 ± 0.022
1.03AsnIle: 1.03 ± 0.029
0.622AsnLys: 0.622 ± 0.023
2.275AsnLeu: 2.275 ± 0.048
0.456AsnMet: 0.456 ± 0.02
0.633AsnAsn: 0.633 ± 0.025
1.743AsnPro: 1.743 ± 0.037
0.763AsnGln: 0.763 ± 0.025
1.558AsnArg: 1.558 ± 0.04
1.269AsnSer: 1.269 ± 0.037
1.336AsnThr: 1.336 ± 0.036
1.883AsnVal: 1.883 ± 0.043
0.374AsnTrp: 0.374 ± 0.016
0.555AsnTyr: 0.555 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
7.795ProAla: 7.795 ± 0.098
0.204ProCys: 0.204 ± 0.013
3.919ProAsp: 3.919 ± 0.06
4.347ProGlu: 4.347 ± 0.055
1.623ProPhe: 1.623 ± 0.034
5.499ProGly: 5.499 ± 0.068
1.128ProHis: 1.128 ± 0.029
1.727ProIle: 1.727 ± 0.042
1.301ProLys: 1.301 ± 0.034
5.009ProLeu: 5.009 ± 0.072
1.059ProMet: 1.059 ± 0.031
1.112ProAsn: 1.112 ± 0.03
2.333ProPro: 2.333 ± 0.057
1.824ProGln: 1.824 ± 0.043
3.079ProArg: 3.079 ± 0.061
3.016ProSer: 3.016 ± 0.06
2.782ProThr: 2.782 ± 0.045
4.944ProVal: 4.944 ± 0.056
0.781ProTrp: 0.781 ± 0.029
1.085ProTyr: 1.085 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.338GlnAla: 4.338 ± 0.057
0.159GlnCys: 0.159 ± 0.011
1.787GlnAsp: 1.787 ± 0.041
1.88GlnGlu: 1.88 ± 0.043
0.931GlnPhe: 0.931 ± 0.026
2.298GlnGly: 2.298 ± 0.051
0.784GlnHis: 0.784 ± 0.026
1.555GlnIle: 1.555 ± 0.039
0.771GlnLys: 0.771 ± 0.027
4.0GlnLeu: 4.0 ± 0.063
0.689GlnMet: 0.689 ± 0.026
0.75GlnAsn: 0.75 ± 0.028
1.942GlnPro: 1.942 ± 0.042
1.691GlnGln: 1.691 ± 0.051
2.616GlnArg: 2.616 ± 0.049
1.65GlnSer: 1.65 ± 0.037
1.664GlnThr: 1.664 ± 0.035
2.626GlnVal: 2.626 ± 0.047
0.532GlnTrp: 0.532 ± 0.024
0.634GlnTyr: 0.634 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
7.12ArgAla: 7.12 ± 0.08
0.404ArgCys: 0.404 ± 0.018
3.546ArgAsp: 3.546 ± 0.061
4.016ArgGlu: 4.016 ± 0.062
2.205ArgPhe: 2.205 ± 0.039
4.996ArgGly: 4.996 ± 0.063
1.611ArgHis: 1.611 ± 0.037
3.352ArgIle: 3.352 ± 0.046
1.949ArgLys: 1.949 ± 0.045
7.155ArgLeu: 7.155 ± 0.091
1.613ArgMet: 1.613 ± 0.038
1.704ArgAsn: 1.704 ± 0.039
3.73ArgPro: 3.73 ± 0.067
2.577ArgGln: 2.577 ± 0.044
6.033ArgArg: 6.033 ± 0.096
4.051ArgSer: 4.051 ± 0.065
3.996ArgThr: 3.996 ± 0.063
4.639ArgVal: 4.639 ± 0.068
1.123ArgTrp: 1.123 ± 0.031
1.582ArgTyr: 1.582 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
7.284SerAla: 7.284 ± 0.077
0.333SerCys: 0.333 ± 0.016
2.921SerAsp: 2.921 ± 0.055
2.947SerGlu: 2.947 ± 0.055
1.955SerPhe: 1.955 ± 0.043
6.089SerGly: 6.089 ± 0.072
1.116SerHis: 1.116 ± 0.028
2.343SerIle: 2.343 ± 0.043
1.398SerLys: 1.398 ± 0.032
5.585SerLeu: 5.585 ± 0.075
1.383SerMet: 1.383 ± 0.032
1.308SerAsn: 1.308 ± 0.029
3.211SerPro: 3.211 ± 0.053
1.727SerGln: 1.727 ± 0.038
3.749SerArg: 3.749 ± 0.052
3.539SerSer: 3.539 ± 0.061
3.401SerThr: 3.401 ± 0.061
4.644SerVal: 4.644 ± 0.062
0.89SerTrp: 0.89 ± 0.03
1.416SerTyr: 1.416 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.8ThrAla: 7.8 ± 0.094
0.313ThrCys: 0.313 ± 0.017
3.281ThrAsp: 3.281 ± 0.051
3.23ThrGlu: 3.23 ± 0.055
1.772ThrPhe: 1.772 ± 0.048
5.933ThrGly: 5.933 ± 0.079
1.079ThrHis: 1.079 ± 0.031
2.337ThrIle: 2.337 ± 0.054
1.345ThrLys: 1.345 ± 0.036
5.323ThrLeu: 5.323 ± 0.063
1.086ThrMet: 1.086 ± 0.029
1.237ThrAsn: 1.237 ± 0.029
3.294ThrPro: 3.294 ± 0.051
1.488ThrGln: 1.488 ± 0.039
3.122ThrArg: 3.122 ± 0.05
3.175ThrSer: 3.175 ± 0.06
3.328ThrThr: 3.328 ± 0.053
5.666ThrVal: 5.666 ± 0.076
0.727ThrTrp: 0.727 ± 0.025
1.226ThrTyr: 1.226 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
10.331ValAla: 10.331 ± 0.1
0.585ValCys: 0.585 ± 0.02
5.022ValAsp: 5.022 ± 0.075
4.818ValGlu: 4.818 ± 0.064
2.781ValPhe: 2.781 ± 0.05
6.431ValGly: 6.431 ± 0.081
1.67ValHis: 1.67 ± 0.041
3.727ValIle: 3.727 ± 0.059
1.989ValLys: 1.989 ± 0.046
9.443ValLeu: 9.443 ± 0.122
1.695ValMet: 1.695 ± 0.039
1.988ValAsn: 1.988 ± 0.039
4.713ValPro: 4.713 ± 0.068
2.51ValGln: 2.51 ± 0.039
5.394ValArg: 5.394 ± 0.074
4.873ValSer: 4.873 ± 0.069
4.779ValThr: 4.779 ± 0.07
7.892ValVal: 7.892 ± 0.088
1.056ValTrp: 1.056 ± 0.031
1.525ValTyr: 1.525 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.468TrpAla: 1.468 ± 0.032
0.113TrpCys: 0.113 ± 0.01
0.754TrpAsp: 0.754 ± 0.026
0.682TrpGlu: 0.682 ± 0.024
0.548TrpPhe: 0.548 ± 0.02
1.015TrpGly: 1.015 ± 0.031
0.361TrpHis: 0.361 ± 0.019
0.696TrpIle: 0.696 ± 0.024
0.432TrpLys: 0.432 ± 0.019
1.881TrpLeu: 1.881 ± 0.045
0.332TrpMet: 0.332 ± 0.016
0.403TrpAsn: 0.403 ± 0.018
0.702TrpPro: 0.702 ± 0.024
0.629TrpGln: 0.629 ± 0.022
1.055TrpArg: 1.055 ± 0.034
0.807TrpSer: 0.807 ± 0.025
0.84TrpThr: 0.84 ± 0.028
1.046TrpVal: 1.046 ± 0.033
0.326TrpTrp: 0.326 ± 0.019
0.309TrpTyr: 0.309 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.387TyrAla: 2.387 ± 0.049
0.2TyrCys: 0.2 ± 0.013
1.285TyrAsp: 1.285 ± 0.028
1.155TyrGlu: 1.155 ± 0.032
0.822TyrPhe: 0.822 ± 0.027
2.03TyrGly: 2.03 ± 0.049
0.367TyrHis: 0.367 ± 0.017
0.768TyrIle: 0.768 ± 0.023
0.478TyrLys: 0.478 ± 0.021
2.277TyrLeu: 2.277 ± 0.045
0.328TyrMet: 0.328 ± 0.015
0.519TyrAsn: 0.519 ± 0.025
1.12TyrPro: 1.12 ± 0.033
0.739TyrGln: 0.739 ± 0.028
1.689TyrArg: 1.689 ± 0.038
1.201TyrSer: 1.201 ± 0.033
1.11TyrThr: 1.11 ± 0.03
1.587TyrVal: 1.587 ± 0.04
0.346TyrTrp: 0.346 ± 0.017
0.506TyrTyr: 0.506 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3726 proteins (1222125 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski