Amino acid dipepetide frequency for Rana tigrina ranavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.81AlaAla: 9.81 ± 0.869
1.793AlaCys: 1.793 ± 0.25
3.958AlaAsp: 3.958 ± 0.306
5.581AlaGlu: 5.581 ± 0.507
2.909AlaPhe: 2.909 ± 0.332
6.968AlaGly: 6.968 ± 0.546
1.86AlaHis: 1.86 ± 0.235
2.605AlaIle: 2.605 ± 0.262
4.431AlaLys: 4.431 ± 0.456
6.968AlaLeu: 6.968 ± 0.493
3.146AlaMet: 3.146 ± 0.31
1.759AlaAsn: 1.759 ± 0.207
5.108AlaPro: 5.108 ± 0.877
2.571AlaGln: 2.571 ± 0.368
4.973AlaArg: 4.973 ± 0.477
5.954AlaSer: 5.954 ± 0.637
4.059AlaThr: 4.059 ± 0.372
8.457AlaVal: 8.457 ± 0.641
1.353AlaTrp: 1.353 ± 0.263
2.639AlaTyr: 2.639 ± 0.298
0.0AlaXaa: 0.0 ± 0.0
Cys
1.793CysAla: 1.793 ± 0.261
0.575CysCys: 0.575 ± 0.134
1.252CysAsp: 1.252 ± 0.187
0.981CysGlu: 0.981 ± 0.182
0.507CysPhe: 0.507 ± 0.143
1.59CysGly: 1.59 ± 0.293
0.507CysHis: 0.507 ± 0.13
0.677CysIle: 0.677 ± 0.191
1.353CysLys: 1.353 ± 0.197
1.387CysLeu: 1.387 ± 0.286
0.71CysMet: 0.71 ± 0.173
0.609CysAsn: 0.609 ± 0.158
1.455CysPro: 1.455 ± 0.283
0.541CysGln: 0.541 ± 0.143
1.624CysArg: 1.624 ± 0.267
1.759CysSer: 1.759 ± 0.257
0.71CysThr: 0.71 ± 0.144
1.556CysVal: 1.556 ± 0.244
0.474CysTrp: 0.474 ± 0.121
0.677CysTyr: 0.677 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
5.142AspAla: 5.142 ± 0.403
1.319AspCys: 1.319 ± 0.214
3.417AspAsp: 3.417 ± 0.402
3.146AspGlu: 3.146 ± 0.369
1.894AspPhe: 1.894 ± 0.289
4.803AspGly: 4.803 ± 0.449
1.015AspHis: 1.015 ± 0.169
2.74AspIle: 2.74 ± 0.322
2.605AspLys: 2.605 ± 0.264
5.176AspLeu: 5.176 ± 0.431
2.233AspMet: 2.233 ± 0.282
1.86AspAsn: 1.86 ± 0.332
4.905AspPro: 4.905 ± 0.566
1.624AspGln: 1.624 ± 0.298
3.755AspArg: 3.755 ± 0.338
4.567AspSer: 4.567 ± 0.43
2.943AspThr: 2.943 ± 0.474
4.567AspVal: 4.567 ± 0.421
0.947AspTrp: 0.947 ± 0.205
2.334AspTyr: 2.334 ± 0.306
0.0AspXaa: 0.0 ± 0.0
Glu
5.683GluAla: 5.683 ± 0.479
1.15GluCys: 1.15 ± 0.248
3.856GluAsp: 3.856 ± 0.475
3.62GluGlu: 3.62 ± 0.615
1.759GluPhe: 1.759 ± 0.218
3.484GluGly: 3.484 ± 0.36
0.812GluHis: 0.812 ± 0.156
1.691GluIle: 1.691 ± 0.21
2.808GluLys: 2.808 ± 0.32
3.62GluLeu: 3.62 ± 0.308
1.996GluMet: 1.996 ± 0.309
1.082GluAsn: 1.082 ± 0.201
2.808GluPro: 2.808 ± 0.391
1.894GluGln: 1.894 ± 0.541
3.89GluArg: 3.89 ± 0.365
3.687GluSer: 3.687 ± 0.405
3.822GluThr: 3.822 ± 0.366
3.349GluVal: 3.349 ± 0.357
1.15GluTrp: 1.15 ± 0.181
2.097GluTyr: 2.097 ± 0.3
0.0GluXaa: 0.0 ± 0.0
Phe
2.841PheAla: 2.841 ± 0.324
0.677PheCys: 0.677 ± 0.164
1.455PheAsp: 1.455 ± 0.218
1.86PheGlu: 1.86 ± 0.227
1.184PhePhe: 1.184 ± 0.245
2.639PheGly: 2.639 ± 0.322
0.575PheHis: 0.575 ± 0.163
1.15PheIle: 1.15 ± 0.206
1.421PheLys: 1.421 ± 0.198
2.875PheLeu: 2.875 ± 0.268
0.947PheMet: 0.947 ± 0.185
1.218PheAsn: 1.218 ± 0.207
1.928PhePro: 1.928 ± 0.247
0.744PheGln: 0.744 ± 0.139
2.436PheArg: 2.436 ± 0.296
2.672PheSer: 2.672 ± 0.289
2.097PheThr: 2.097 ± 0.314
2.875PheVal: 2.875 ± 0.315
0.338PheTrp: 0.338 ± 0.104
1.116PheTyr: 1.116 ± 0.178
0.0PheXaa: 0.0 ± 0.0
Gly
5.886GlyAla: 5.886 ± 0.462
1.556GlyCys: 1.556 ± 0.29
4.567GlyAsp: 4.567 ± 0.429
3.45GlyGlu: 3.45 ± 0.288
2.672GlyPhe: 2.672 ± 0.314
5.581GlyGly: 5.581 ± 0.517
1.725GlyHis: 1.725 ± 0.268
2.402GlyIle: 2.402 ± 0.31
4.228GlyLys: 4.228 ± 0.379
5.548GlyLeu: 5.548 ± 0.516
1.793GlyMet: 1.793 ± 0.275
1.387GlyAsn: 1.387 ± 0.251
4.465GlyPro: 4.465 ± 0.674
1.928GlyGln: 1.928 ± 0.239
5.548GlyArg: 5.548 ± 0.66
5.92GlySer: 5.92 ± 0.483
4.533GlyThr: 4.533 ± 0.44
5.784GlyVal: 5.784 ± 0.491
1.387GlyTrp: 1.387 ± 0.239
2.436GlyTyr: 2.436 ± 0.291
0.0GlyXaa: 0.0 ± 0.0
His
1.759HisAla: 1.759 ± 0.197
0.237HisCys: 0.237 ± 0.084
1.082HisAsp: 1.082 ± 0.186
0.643HisGlu: 0.643 ± 0.159
0.575HisPhe: 0.575 ± 0.126
1.827HisGly: 1.827 ± 0.243
0.677HisHis: 0.677 ± 0.295
0.88HisIle: 0.88 ± 0.17
0.778HisLys: 0.778 ± 0.186
2.3HisLeu: 2.3 ± 0.29
0.609HisMet: 0.609 ± 0.142
0.575HisAsn: 0.575 ± 0.195
1.59HisPro: 1.59 ± 0.291
1.759HisGln: 1.759 ± 0.917
1.387HisArg: 1.387 ± 0.242
1.252HisSer: 1.252 ± 0.239
1.421HisThr: 1.421 ± 0.208
2.097HisVal: 2.097 ± 0.248
0.237HisTrp: 0.237 ± 0.101
0.812HisTyr: 0.812 ± 0.171
0.0HisXaa: 0.0 ± 0.0
Ile
2.3IleAla: 2.3 ± 0.314
0.541IleCys: 0.541 ± 0.137
2.03IleAsp: 2.03 ± 0.287
1.759IleGlu: 1.759 ± 0.268
1.218IlePhe: 1.218 ± 0.202
1.827IleGly: 1.827 ± 0.251
1.522IleHis: 1.522 ± 0.369
1.285IleIle: 1.285 ± 0.213
2.571IleLys: 2.571 ± 0.288
3.687IleLeu: 3.687 ± 0.319
1.285IleMet: 1.285 ± 0.144
0.981IleAsn: 0.981 ± 0.212
2.199IlePro: 2.199 ± 0.301
0.744IleGln: 0.744 ± 0.146
2.875IleArg: 2.875 ± 0.268
2.605IleSer: 2.605 ± 0.296
1.691IleThr: 1.691 ± 0.31
3.011IleVal: 3.011 ± 0.38
0.237IleTrp: 0.237 ± 0.085
0.981IleTyr: 0.981 ± 0.214
0.0IleXaa: 0.0 ± 0.0
Lys
4.398LysAla: 4.398 ± 0.51
1.218LysCys: 1.218 ± 0.227
2.774LysAsp: 2.774 ± 0.348
2.943LysGlu: 2.943 ± 0.366
1.455LysPhe: 1.455 ± 0.219
3.89LysGly: 3.89 ± 0.384
0.812LysHis: 0.812 ± 0.175
2.571LysIle: 2.571 ± 0.289
3.586LysLys: 3.586 ± 0.472
4.025LysLeu: 4.025 ± 0.401
2.063LysMet: 2.063 ± 0.252
1.624LysAsn: 1.624 ± 0.231
3.349LysPro: 3.349 ± 0.477
1.455LysGln: 1.455 ± 0.22
4.837LysArg: 4.837 ± 0.595
3.822LysSer: 3.822 ± 0.715
4.059LysThr: 4.059 ± 0.382
3.383LysVal: 3.383 ± 0.236
0.609LysTrp: 0.609 ± 0.158
1.894LysTyr: 1.894 ± 0.211
0.0LysXaa: 0.0 ± 0.0
Leu
6.461LeuAla: 6.461 ± 0.5
1.928LeuCys: 1.928 ± 0.278
5.311LeuAsp: 5.311 ± 0.364
5.006LeuGlu: 5.006 ± 0.492
2.706LeuPhe: 2.706 ± 0.279
5.311LeuGly: 5.311 ± 0.51
1.759LeuHis: 1.759 ± 0.282
2.875LeuIle: 2.875 ± 0.3
4.939LeuLys: 4.939 ± 0.432
6.326LeuLeu: 6.326 ± 0.493
2.3LeuMet: 2.3 ± 0.29
2.639LeuAsn: 2.639 ± 0.238
4.33LeuPro: 4.33 ± 0.453
1.59LeuGln: 1.59 ± 0.218
6.19LeuArg: 6.19 ± 0.503
6.326LeuSer: 6.326 ± 0.443
5.277LeuThr: 5.277 ± 0.507
5.446LeuVal: 5.446 ± 0.343
1.015LeuTrp: 1.015 ± 0.22
2.503LeuTyr: 2.503 ± 0.228
0.0LeuXaa: 0.0 ± 0.0
Met
3.281MetAla: 3.281 ± 0.403
0.913MetCys: 0.913 ± 0.19
2.165MetAsp: 2.165 ± 0.226
1.928MetGlu: 1.928 ± 0.259
1.218MetPhe: 1.218 ± 0.201
2.774MetGly: 2.774 ± 0.265
0.71MetHis: 0.71 ± 0.154
0.575MetIle: 0.575 ± 0.109
0.88MetLys: 0.88 ± 0.18
2.097MetLeu: 2.097 ± 0.236
0.778MetMet: 0.778 ± 0.172
0.372MetAsn: 0.372 ± 0.109
1.522MetPro: 1.522 ± 0.199
0.677MetGln: 0.677 ± 0.137
2.03MetArg: 2.03 ± 0.274
3.044MetSer: 3.044 ± 0.392
2.368MetThr: 2.368 ± 0.224
2.368MetVal: 2.368 ± 0.35
0.507MetTrp: 0.507 ± 0.141
0.744MetTyr: 0.744 ± 0.215
0.0MetXaa: 0.0 ± 0.0
Asn
2.503AsnAla: 2.503 ± 0.278
0.541AsnCys: 0.541 ± 0.145
1.015AsnAsp: 1.015 ± 0.173
0.88AsnGlu: 0.88 ± 0.153
0.71AsnPhe: 0.71 ± 0.142
1.759AsnGly: 1.759 ± 0.204
0.474AsnHis: 0.474 ± 0.125
1.455AsnIle: 1.455 ± 0.271
0.947AsnLys: 0.947 ± 0.127
2.672AsnLeu: 2.672 ± 0.336
0.981AsnMet: 0.981 ± 0.218
0.846AsnAsn: 0.846 ± 0.214
2.537AsnPro: 2.537 ± 0.422
0.778AsnGln: 0.778 ± 0.145
1.624AsnArg: 1.624 ± 0.207
1.522AsnSer: 1.522 ± 0.175
1.252AsnThr: 1.252 ± 0.271
2.841AsnVal: 2.841 ± 0.306
0.406AsnTrp: 0.406 ± 0.105
0.846AsnTyr: 0.846 ± 0.176
0.0AsnXaa: 0.0 ± 0.0
Pro
6.36ProAla: 6.36 ± 0.866
1.082ProCys: 1.082 ± 0.251
4.33ProAsp: 4.33 ± 0.499
3.958ProGlu: 3.958 ± 0.412
2.03ProPhe: 2.03 ± 0.251
4.296ProGly: 4.296 ± 0.49
1.827ProHis: 1.827 ± 0.247
2.063ProIle: 2.063 ± 0.279
3.417ProLys: 3.417 ± 0.499
4.431ProLeu: 4.431 ± 0.524
1.285ProMet: 1.285 ± 0.182
1.59ProAsn: 1.59 ± 0.236
4.093ProPro: 4.093 ± 0.577
2.266ProGln: 2.266 ± 0.466
3.856ProArg: 3.856 ± 0.605
5.108ProSer: 5.108 ± 0.499
2.808ProThr: 2.808 ± 0.373
6.393ProVal: 6.393 ± 0.715
1.049ProTrp: 1.049 ± 0.212
1.556ProTyr: 1.556 ± 0.236
0.0ProXaa: 0.0 ± 0.0
Gln
2.3GlnAla: 2.3 ± 0.284
0.71GlnCys: 0.71 ± 0.156
2.03GlnAsp: 2.03 ± 0.342
2.165GlnGlu: 2.165 ± 0.601
0.744GlnPhe: 0.744 ± 0.158
1.827GlnGly: 1.827 ± 0.261
1.252GlnHis: 1.252 ± 0.576
1.488GlnIle: 1.488 ± 0.399
1.184GlnLys: 1.184 ± 0.19
1.759GlnLeu: 1.759 ± 0.292
0.677GlnMet: 0.677 ± 0.173
0.609GlnAsn: 0.609 ± 0.129
1.725GlnPro: 1.725 ± 0.349
2.469GlnGln: 2.469 ± 0.991
2.199GlnArg: 2.199 ± 0.473
2.063GlnSer: 2.063 ± 0.281
1.894GlnThr: 1.894 ± 0.341
1.996GlnVal: 1.996 ± 0.301
0.304GlnTrp: 0.304 ± 0.119
0.677GlnTyr: 0.677 ± 0.111
0.0GlnXaa: 0.0 ± 0.0
Arg
5.243ArgAla: 5.243 ± 0.487
1.049ArgCys: 1.049 ± 0.197
4.702ArgAsp: 4.702 ± 0.437
3.89ArgGlu: 3.89 ± 0.357
1.928ArgPhe: 1.928 ± 0.252
5.412ArgGly: 5.412 ± 0.534
1.793ArgHis: 1.793 ± 0.247
2.097ArgIle: 2.097 ± 0.256
4.499ArgLys: 4.499 ± 0.626
6.021ArgLeu: 6.021 ± 0.446
2.199ArgMet: 2.199 ± 0.27
2.199ArgAsn: 2.199 ± 0.361
4.465ArgPro: 4.465 ± 0.609
1.962ArgGln: 1.962 ± 0.321
5.852ArgArg: 5.852 ± 0.566
4.195ArgSer: 4.195 ± 0.522
3.789ArgThr: 3.789 ± 0.486
5.446ArgVal: 5.446 ± 0.431
1.015ArgTrp: 1.015 ± 0.177
2.503ArgTyr: 2.503 ± 0.332
0.0ArgXaa: 0.0 ± 0.0
Ser
5.987SerAla: 5.987 ± 0.537
1.624SerCys: 1.624 ± 0.233
5.209SerAsp: 5.209 ± 0.392
4.025SerGlu: 4.025 ± 0.486
2.808SerPhe: 2.808 ± 0.317
5.649SerGly: 5.649 ± 0.51
1.624SerHis: 1.624 ± 0.255
2.165SerIle: 2.165 ± 0.307
3.687SerLys: 3.687 ± 0.43
6.19SerLeu: 6.19 ± 0.562
1.996SerMet: 1.996 ± 0.299
1.827SerAsn: 1.827 ± 0.253
5.142SerPro: 5.142 ± 0.972
2.03SerGln: 2.03 ± 0.29
4.499SerArg: 4.499 ± 0.543
5.243SerSer: 5.243 ± 0.44
3.653SerThr: 3.653 ± 0.465
6.461SerVal: 6.461 ± 0.564
1.184SerTrp: 1.184 ± 0.19
1.827SerTyr: 1.827 ± 0.199
0.0SerXaa: 0.0 ± 0.0
Thr
5.717ThrAla: 5.717 ± 0.457
1.049ThrCys: 1.049 ± 0.177
3.552ThrAsp: 3.552 ± 0.368
2.233ThrGlu: 2.233 ± 0.28
2.537ThrPhe: 2.537 ± 0.276
4.973ThrGly: 4.973 ± 0.526
0.609ThrHis: 0.609 ± 0.129
2.3ThrIle: 2.3 ± 0.223
2.605ThrLys: 2.605 ± 0.368
4.939ThrLeu: 4.939 ± 0.424
1.86ThrMet: 1.86 ± 0.228
1.319ThrAsn: 1.319 ± 0.213
4.668ThrPro: 4.668 ± 0.754
1.759ThrGln: 1.759 ± 0.261
3.484ThrArg: 3.484 ± 0.328
3.349ThrSer: 3.349 ± 0.52
1.827ThrThr: 1.827 ± 0.321
6.157ThrVal: 6.157 ± 0.402
0.44ThrTrp: 0.44 ± 0.179
1.252ThrTyr: 1.252 ± 0.228
0.0ThrXaa: 0.0 ± 0.0
Val
6.258ValAla: 6.258 ± 0.5
1.725ValCys: 1.725 ± 0.264
4.736ValAsp: 4.736 ± 0.417
4.093ValGlu: 4.093 ± 0.434
2.841ValPhe: 2.841 ± 0.279
4.939ValGly: 4.939 ± 0.577
2.233ValHis: 2.233 ± 0.31
2.469ValIle: 2.469 ± 0.275
6.157ValLys: 6.157 ± 0.674
6.63ValLeu: 6.63 ± 0.529
2.706ValMet: 2.706 ± 0.328
2.503ValAsn: 2.503 ± 0.341
4.668ValPro: 4.668 ± 0.497
2.097ValGln: 2.097 ± 0.254
6.562ValArg: 6.562 ± 0.534
6.461ValSer: 6.461 ± 0.506
5.108ValThr: 5.108 ± 0.529
6.664ValVal: 6.664 ± 0.577
1.082ValTrp: 1.082 ± 0.174
2.469ValTyr: 2.469 ± 0.285
0.0ValXaa: 0.0 ± 0.0
Trp
0.947TrpAla: 0.947 ± 0.242
0.338TrpCys: 0.338 ± 0.098
1.184TrpAsp: 1.184 ± 0.192
0.778TrpGlu: 0.778 ± 0.186
0.541TrpPhe: 0.541 ± 0.138
0.913TrpGly: 0.913 ± 0.19
0.237TrpHis: 0.237 ± 0.104
0.474TrpIle: 0.474 ± 0.142
0.913TrpLys: 0.913 ± 0.18
1.353TrpLeu: 1.353 ± 0.212
0.44TrpMet: 0.44 ± 0.126
0.609TrpAsn: 0.609 ± 0.144
0.778TrpPro: 0.778 ± 0.178
0.237TrpGln: 0.237 ± 0.073
0.913TrpArg: 0.913 ± 0.176
0.778TrpSer: 0.778 ± 0.146
1.455TrpThr: 1.455 ± 0.246
0.677TrpVal: 0.677 ± 0.17
0.203TrpTrp: 0.203 ± 0.076
0.44TrpTyr: 0.44 ± 0.125
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.233TyrAla: 2.233 ± 0.277
0.71TyrCys: 0.71 ± 0.18
2.368TyrAsp: 2.368 ± 0.285
1.319TyrGlu: 1.319 ± 0.206
0.846TyrPhe: 0.846 ± 0.161
2.334TyrGly: 2.334 ± 0.302
0.474TyrHis: 0.474 ± 0.131
1.387TyrIle: 1.387 ± 0.213
1.759TyrLys: 1.759 ± 0.256
2.233TyrLeu: 2.233 ± 0.245
0.913TyrMet: 0.913 ± 0.161
0.981TyrAsn: 0.981 ± 0.193
2.063TyrPro: 2.063 ± 0.269
0.947TyrGln: 0.947 ± 0.172
1.725TyrArg: 1.725 ± 0.226
2.503TyrSer: 2.503 ± 0.292
1.86TyrThr: 1.86 ± 0.32
2.875TyrVal: 2.875 ± 0.323
0.271TyrTrp: 0.271 ± 0.111
0.88TyrTyr: 0.88 ± 0.205
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 103 proteins (29563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski