Amino acid dipepetide frequency for Candidatus Sulfobium mesophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.637AlaAla: 7.637 ± 0.123	0.999AlaCys: 0.999 ± 0.041	4.225AlaAsp: 4.225 ± 0.078	5.62AlaGlu: 5.62 ± 0.102	3.578AlaPhe: 3.578 ± 0.068	6.917AlaGly: 6.917 ± 0.103	1.355AlaHis: 1.355 ± 0.038	5.435AlaIle: 5.435 ± 0.084	4.625AlaLys: 4.625 ± 0.09	8.187AlaLeu: 8.187 ± 0.13	2.221AlaMet: 2.221 ± 0.065	2.118AlaAsn: 2.118 ± 0.058	2.636AlaPro: 2.636 ± 0.075	1.957AlaGln: 1.957 ± 0.053	4.196AlaArg: 4.196 ± 0.073	4.912AlaSer: 4.912 ± 0.097	3.541AlaThr: 3.541 ± 0.078	6.621AlaVal: 6.621 ± 0.102	0.719AlaTrp: 0.719 ± 0.034	2.288AlaTyr: 2.288 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.841CysAla: 0.841 ± 0.037	0.176CysCys: 0.176 ± 0.016	0.522CysAsp: 0.522 ± 0.029	0.586CysGlu: 0.586 ± 0.031	0.476CysPhe: 0.476 ± 0.03	1.125CysGly: 1.125 ± 0.043	0.615CysHis: 0.615 ± 0.065	0.665CysIle: 0.665 ± 0.033	0.55CysLys: 0.55 ± 0.028	1.084CysLeu: 1.084 ± 0.041	0.282CysMet: 0.282 ± 0.02	0.363CysAsn: 0.363 ± 0.022	0.664CysPro: 0.664 ± 0.037	0.282CysGln: 0.282 ± 0.02	0.705CysArg: 0.705 ± 0.03	0.781CysSer: 0.781 ± 0.032	0.502CysThr: 0.502 ± 0.027	0.685CysVal: 0.685 ± 0.031	0.097CysTrp: 0.097 ± 0.012	0.332CysTyr: 0.332 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.029AspAla: 4.029 ± 0.071	0.617AspCys: 0.617 ± 0.033	2.541AspAsp: 2.541 ± 0.06	3.611AspGlu: 3.611 ± 0.081	2.664AspPhe: 2.664 ± 0.063	3.514AspGly: 3.514 ± 0.063	0.888AspHis: 0.888 ± 0.032	4.834AspIle: 4.834 ± 0.081	3.176AspLys: 3.176 ± 0.063	5.035AspLeu: 5.035 ± 0.078	1.461AspMet: 1.461 ± 0.044	1.757AspAsn: 1.757 ± 0.051	2.395AspPro: 2.395 ± 0.06	1.093AspGln: 1.093 ± 0.038	3.043AspArg: 3.043 ± 0.064	2.957AspSer: 2.957 ± 0.065	2.468AspThr: 2.468 ± 0.053	3.915AspVal: 3.915 ± 0.068	0.546AspTrp: 0.546 ± 0.029	1.833AspTyr: 1.833 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.374GluAla: 5.374 ± 0.094	0.564GluCys: 0.564 ± 0.029	3.461GluAsp: 3.461 ± 0.068	5.435GluGlu: 5.435 ± 0.117	2.468GluPhe: 2.468 ± 0.06	5.088GluGly: 5.088 ± 0.076	1.192GluHis: 1.192 ± 0.038	5.389GluIle: 5.389 ± 0.091	6.127GluLys: 6.127 ± 0.108	6.034GluLeu: 6.034 ± 0.102	2.005GluMet: 2.005 ± 0.053	2.521GluAsn: 2.521 ± 0.059	2.041GluPro: 2.041 ± 0.053	1.802GluGln: 1.802 ± 0.046	4.138GluArg: 4.138 ± 0.093	3.28GluSer: 3.28 ± 0.067	3.338GluThr: 3.338 ± 0.065	4.611GluVal: 4.611 ± 0.098	0.587GluTrp: 0.587 ± 0.023	1.869GluTyr: 1.869 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.071PheAla: 3.071 ± 0.077	0.606PheCys: 0.606 ± 0.025	2.511PheAsp: 2.511 ± 0.053	2.412PheGlu: 2.412 ± 0.058	2.547PhePhe: 2.547 ± 0.07	3.355PheGly: 3.355 ± 0.078	0.891PheHis: 0.891 ± 0.04	3.209PheIle: 3.209 ± 0.077	2.091PheLys: 2.091 ± 0.054	4.754PheLeu: 4.754 ± 0.09	1.177PheMet: 1.177 ± 0.04	1.541PheAsn: 1.541 ± 0.036	1.788PhePro: 1.788 ± 0.051	1.123PheGln: 1.123 ± 0.036	2.52PheArg: 2.52 ± 0.057	3.58PheSer: 3.58 ± 0.067	2.268PheThr: 2.268 ± 0.057	3.061PheVal: 3.061 ± 0.061	0.488PheTrp: 0.488 ± 0.026	1.579PheTyr: 1.579 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	5.626GlyAla: 5.626 ± 0.094	1.009GlyCys: 1.009 ± 0.038	3.802GlyAsp: 3.802 ± 0.068	4.654GlyGlu: 4.654 ± 0.084	3.544GlyPhe: 3.544 ± 0.075	5.921GlyGly: 5.921 ± 0.124	1.619GlyHis: 1.619 ± 0.046	6.303GlyIle: 6.303 ± 0.1	5.667GlyLys: 5.667 ± 0.087	7.376GlyLeu: 7.376 ± 0.116	2.315GlyMet: 2.315 ± 0.056	2.738GlyAsn: 2.738 ± 0.054	2.332GlyPro: 2.332 ± 0.061	2.006GlyGln: 2.006 ± 0.046	4.781GlyArg: 4.781 ± 0.078	4.592GlySer: 4.592 ± 0.075	4.156GlyThr: 4.156 ± 0.079	5.494GlyVal: 5.494 ± 0.096	0.819GlyTrp: 0.819 ± 0.036	2.723GlyTyr: 2.723 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.369HisAla: 1.369 ± 0.048	0.269HisCys: 0.269 ± 0.016	1.018HisAsp: 1.018 ± 0.04	1.17HisGlu: 1.17 ± 0.04	0.906HisPhe: 0.906 ± 0.032	1.536HisGly: 1.536 ± 0.047	0.47HisHis: 0.47 ± 0.028	1.404HisIle: 1.404 ± 0.048	0.931HisLys: 0.931 ± 0.042	1.825HisLeu: 1.825 ± 0.054	0.483HisMet: 0.483 ± 0.027	0.726HisAsn: 0.726 ± 0.029	1.081HisPro: 1.081 ± 0.035	0.463HisGln: 0.463 ± 0.029	1.078HisArg: 1.078 ± 0.041	1.233HisSer: 1.233 ± 0.037	0.914HisThr: 0.914 ± 0.034	1.187HisVal: 1.187 ± 0.044	0.21HisTrp: 0.21 ± 0.015	0.672HisTyr: 0.672 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.97IleAla: 5.97 ± 0.096	0.792IleCys: 0.792 ± 0.036	4.021IleAsp: 4.021 ± 0.077	4.899IleGlu: 4.899 ± 0.087	3.184IlePhe: 3.184 ± 0.064	5.595IleGly: 5.595 ± 0.087	1.238IleHis: 1.238 ± 0.043	5.139IleIle: 5.139 ± 0.093	4.501IleLys: 4.501 ± 0.084	6.559IleLeu: 6.559 ± 0.095	1.76IleMet: 1.76 ± 0.046	2.657IleAsn: 2.657 ± 0.058	3.116IlePro: 3.116 ± 0.07	1.692IleGln: 1.692 ± 0.049	4.292IleArg: 4.292 ± 0.072	5.398IleSer: 5.398 ± 0.077	3.951IleThr: 3.951 ± 0.066	5.209IleVal: 5.209 ± 0.08	0.631IleTrp: 0.631 ± 0.028	2.107IleTyr: 2.107 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.409LysAla: 5.409 ± 0.095	0.588LysCys: 0.588 ± 0.031	3.819LysAsp: 3.819 ± 0.075	5.634LysGlu: 5.634 ± 0.091	1.942LysPhe: 1.942 ± 0.051	5.52LysGly: 5.52 ± 0.103	1.055LysHis: 1.055 ± 0.041	4.957LysIle: 4.957 ± 0.086	6.149LysLys: 6.149 ± 0.119	5.003LysLeu: 5.003 ± 0.081	2.079LysMet: 2.079 ± 0.053	2.557LysAsn: 2.557 ± 0.062	2.434LysPro: 2.434 ± 0.061	1.584LysGln: 1.584 ± 0.051	3.711LysArg: 3.711 ± 0.07	3.371LysSer: 3.371 ± 0.066	3.775LysThr: 3.775 ± 0.08	4.572LysVal: 4.572 ± 0.087	0.617LysTrp: 0.617 ± 0.027	1.972LysTyr: 1.972 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	7.587LeuAla: 7.587 ± 0.107	1.038LeuCys: 1.038 ± 0.037	4.736LeuAsp: 4.736 ± 0.073	5.666LeuGlu: 5.666 ± 0.089	4.516LeuPhe: 4.516 ± 0.084	6.904LeuGly: 6.904 ± 0.111	1.728LeuHis: 1.728 ± 0.05	6.6LeuIle: 6.6 ± 0.104	7.067LeuLys: 7.067 ± 0.121	9.61LeuLeu: 9.61 ± 0.132	2.488LeuMet: 2.488 ± 0.053	3.315LeuAsn: 3.315 ± 0.07	4.346LeuPro: 4.346 ± 0.08	2.611LeuGln: 2.611 ± 0.061	6.081LeuArg: 6.081 ± 0.096	7.726LeuSer: 7.726 ± 0.1	5.072LeuThr: 5.072 ± 0.069	5.993LeuVal: 5.993 ± 0.104	0.893LeuTrp: 0.893 ± 0.036	2.857LeuTyr: 2.857 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.33MetAla: 2.33 ± 0.055	0.232MetCys: 0.232 ± 0.018	1.31MetAsp: 1.31 ± 0.043	1.792MetGlu: 1.792 ± 0.051	0.855MetPhe: 0.855 ± 0.034	2.074MetGly: 2.074 ± 0.051	0.517MetHis: 0.517 ± 0.027	1.772MetIle: 1.772 ± 0.05	2.536MetLys: 2.536 ± 0.06	2.445MetLeu: 2.445 ± 0.055	0.742MetMet: 0.742 ± 0.035	1.056MetAsn: 1.056 ± 0.034	1.365MetPro: 1.365 ± 0.041	0.724MetGln: 0.724 ± 0.032	1.665MetArg: 1.665 ± 0.044	1.834MetSer: 1.834 ± 0.054	1.479MetThr: 1.479 ± 0.048	1.723MetVal: 1.723 ± 0.051	0.19MetTrp: 0.19 ± 0.017	0.536MetTyr: 0.536 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.68AsnAla: 2.68 ± 0.058	0.433AsnCys: 0.433 ± 0.022	1.627AsnAsp: 1.627 ± 0.041	1.919AsnGlu: 1.919 ± 0.055	1.605AsnPhe: 1.605 ± 0.046	2.369AsnGly: 2.369 ± 0.06	0.552AsnHis: 0.552 ± 0.028	3.071AsnIle: 3.071 ± 0.056	2.057AsnLys: 2.057 ± 0.061	3.471AsnLeu: 3.471 ± 0.06	0.899AsnMet: 0.899 ± 0.033	1.343AsnAsn: 1.343 ± 0.042	2.057AsnPro: 2.057 ± 0.052	0.772AsnGln: 0.772 ± 0.035	1.907AsnArg: 1.907 ± 0.055	2.018AsnSer: 2.018 ± 0.056	1.643AsnThr: 1.643 ± 0.05	2.434AsnVal: 2.434 ± 0.054	0.394AsnTrp: 0.394 ± 0.019	1.17AsnTyr: 1.17 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.424ProAla: 3.424 ± 0.065	0.446ProCys: 0.446 ± 0.028	2.612ProAsp: 2.612 ± 0.064	3.47ProGlu: 3.47 ± 0.065	2.1ProPhe: 2.1 ± 0.049	3.165ProGly: 3.165 ± 0.061	0.813ProHis: 0.813 ± 0.034	2.118ProIle: 2.118 ± 0.052	2.166ProLys: 2.166 ± 0.056	3.944ProLeu: 3.944 ± 0.078	0.946ProMet: 0.946 ± 0.036	1.193ProAsn: 1.193 ± 0.047	1.645ProPro: 1.645 ± 0.051	1.102ProGln: 1.102 ± 0.036	1.683ProArg: 1.683 ± 0.051	2.669ProSer: 2.669 ± 0.057	1.729ProThr: 1.729 ± 0.051	3.825ProVal: 3.825 ± 0.078	0.441ProTrp: 0.441 ± 0.026	1.396ProTyr: 1.396 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.125GlnAla: 2.125 ± 0.062	0.262GlnCys: 0.262 ± 0.021	1.255GlnAsp: 1.255 ± 0.042	1.797GlnGlu: 1.797 ± 0.046	0.993GlnPhe: 0.993 ± 0.031	1.827GlnGly: 1.827 ± 0.05	0.464GlnHis: 0.464 ± 0.023	1.831GlnIle: 1.831 ± 0.047	2.014GlnLys: 2.014 ± 0.055	2.214GlnLeu: 2.214 ± 0.053	0.828GlnMet: 0.828 ± 0.034	0.973GlnAsn: 0.973 ± 0.031	0.993GlnPro: 0.993 ± 0.042	0.849GlnGln: 0.849 ± 0.039	1.606GlnArg: 1.606 ± 0.052	1.45GlnSer: 1.45 ± 0.048	1.305GlnThr: 1.305 ± 0.044	1.683GlnVal: 1.683 ± 0.045	0.286GlnTrp: 0.286 ± 0.02	0.827GlnTyr: 0.827 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.97ArgAla: 3.97 ± 0.083	0.642ArgCys: 0.642 ± 0.031	3.126ArgAsp: 3.126 ± 0.072	4.528ArgGlu: 4.528 ± 0.084	2.465ArgPhe: 2.465 ± 0.066	3.924ArgGly: 3.924 ± 0.071	1.259ArgHis: 1.259 ± 0.045	4.234ArgIle: 4.234 ± 0.083	4.171ArgLys: 4.171 ± 0.076	5.89ArgLeu: 5.89 ± 0.09	1.628ArgMet: 1.628 ± 0.04	2.111ArgAsn: 2.111 ± 0.048	2.056ArgPro: 2.056 ± 0.056	1.91ArgGln: 1.91 ± 0.048	3.637ArgArg: 3.637 ± 0.08	3.038ArgSer: 3.038 ± 0.059	2.739ArgThr: 2.739 ± 0.072	3.676ArgVal: 3.676 ± 0.075	0.59ArgTrp: 0.59 ± 0.033	1.915ArgTyr: 1.915 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	5.175SerAla: 5.175 ± 0.075	0.801SerCys: 0.801 ± 0.035	3.23SerAsp: 3.23 ± 0.064	4.071SerGlu: 4.071 ± 0.079	3.176SerPhe: 3.176 ± 0.072	5.915SerGly: 5.915 ± 0.098	1.214SerHis: 1.214 ± 0.039	4.06SerIle: 4.06 ± 0.078	3.348SerLys: 3.348 ± 0.075	6.836SerLeu: 6.836 ± 0.107	1.659SerMet: 1.659 ± 0.043	1.895SerAsn: 1.895 ± 0.052	2.837SerPro: 2.837 ± 0.075	1.569SerGln: 1.569 ± 0.045	3.574SerArg: 3.574 ± 0.067	4.347SerSer: 4.347 ± 0.081	2.855SerThr: 2.855 ± 0.069	4.681SerVal: 4.681 ± 0.075	0.599SerTrp: 0.599 ± 0.028	2.027SerTyr: 2.027 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	4.579ThrAla: 4.579 ± 0.078	0.515ThrCys: 0.515 ± 0.025	2.643ThrAsp: 2.643 ± 0.056	3.111ThrGlu: 3.111 ± 0.058	2.3ThrPhe: 2.3 ± 0.065	4.862ThrGly: 4.862 ± 0.092	0.9ThrHis: 0.9 ± 0.032	3.492ThrIle: 3.492 ± 0.072	2.628ThrLys: 2.628 ± 0.064	5.086ThrLeu: 5.086 ± 0.085	1.149ThrMet: 1.149 ± 0.037	1.582ThrAsn: 1.582 ± 0.046	2.291ThrPro: 2.291 ± 0.055	1.138ThrGln: 1.138 ± 0.04	2.261ThrArg: 2.261 ± 0.055	2.957ThrSer: 2.957 ± 0.062	2.577ThrThr: 2.577 ± 0.071	4.094ThrVal: 4.094 ± 0.082	0.52ThrTrp: 0.52 ± 0.026	1.445ThrTyr: 1.445 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	5.513ValAla: 5.513 ± 0.093	0.77ValCys: 0.77 ± 0.04	3.715ValAsp: 3.715 ± 0.072	4.416ValGlu: 4.416 ± 0.082	3.326ValPhe: 3.326 ± 0.064	4.784ValGly: 4.784 ± 0.078	1.279ValHis: 1.279 ± 0.04	5.572ValIle: 5.572 ± 0.093	4.499ValLys: 4.499 ± 0.076	7.331ValLeu: 7.331 ± 0.094	2.014ValMet: 2.014 ± 0.053	2.518ValAsn: 2.518 ± 0.057	3.043ValPro: 3.043 ± 0.059	1.664ValGln: 1.664 ± 0.037	4.08ValArg: 4.08 ± 0.069	4.998ValSer: 4.998 ± 0.084	3.915ValThr: 3.915 ± 0.081	5.395ValVal: 5.395 ± 0.095	0.574ValTrp: 0.574 ± 0.025	2.046ValTyr: 2.046 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.743TrpAla: 0.743 ± 0.032	0.115TrpCys: 0.115 ± 0.013	0.495TrpAsp: 0.495 ± 0.03	0.585TrpGlu: 0.585 ± 0.027	0.424TrpPhe: 0.424 ± 0.024	0.724TrpGly: 0.724 ± 0.028	0.247TrpHis: 0.247 ± 0.018	0.651TrpIle: 0.651 ± 0.025	0.691TrpLys: 0.691 ± 0.033	0.96TrpLeu: 0.96 ± 0.037	0.297TrpMet: 0.297 ± 0.018	0.381TrpAsn: 0.381 ± 0.023	0.368TrpPro: 0.368 ± 0.022	0.333TrpGln: 0.333 ± 0.02	0.559TrpArg: 0.559 ± 0.031	0.591TrpSer: 0.591 ± 0.032	0.492TrpThr: 0.492 ± 0.026	0.629TrpVal: 0.629 ± 0.03	0.176TrpTrp: 0.176 ± 0.017	0.311TrpTyr: 0.311 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.332TyrAla: 2.332 ± 0.053	0.458TyrCys: 0.458 ± 0.025	1.707TyrAsp: 1.707 ± 0.049	1.947TyrGlu: 1.947 ± 0.054	1.504TyrPhe: 1.504 ± 0.043	2.36TyrGly: 2.36 ± 0.052	0.647TyrHis: 0.647 ± 0.032	1.978TyrIle: 1.978 ± 0.051	1.755TyrLys: 1.755 ± 0.057	3.189TyrLeu: 3.189 ± 0.064	0.742TyrMet: 0.742 ± 0.03	1.078TyrAsn: 1.078 ± 0.04	1.401TyrPro: 1.401 ± 0.043	0.905TyrGln: 0.905 ± 0.037	1.992TyrArg: 1.992 ± 0.051	2.136TyrSer: 2.136 ± 0.053	1.411TyrThr: 1.411 ± 0.044	1.964TyrVal: 1.964 ± 0.057	0.397TyrTrp: 0.397 ± 0.024	1.182TyrTyr: 1.182 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2739 proteins (780115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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